Bioreduction in the Activation of Drugs. Proceedings of the Second Biochemical Pharmacology Symposium, Oxford, UK, 25–26 July 1985

Content: 
Pergamon Titles of Related Interest, Page ii
Inside Front Cover, Page iia
Front Matter, Page iii
Copyright, Page iv
OVERVIEW OF ENZYME SYSTEMS INVOLVED IN BIO-REDUCTION OF DRUGS AND IN REDOX CYCLING, Pages 1-6, H. KAPPUS
REGULATION OF REDUCTIVE PROCESSES BY GLUTATHIONE, Pages 7-13, DONALD J. REED
THE CRUCIAL ROLE OF LOW STEADY STATE OXYGEN PARTIAL PRESSURES IN HALOALKANE FREE-RADICAL-MEDIATED LIPID PEROXIDATION: POSSIBLE IMPLICATIONS IN HALOALKANE LIVER INJURY, Pages 15-19, HERBERT DE GROOT, THOMAS NOLL
Reductive role of glutathione in the redox cycling of oxidizable drugs, Pages 21-22, IAN WILSON, PETER WARDMAN, GERALD M. COHEN, MARY D'ARCY DOHERTY
Generation of photoemissive species during quinone redox cycling, Pages 22-24, HERIBERT WEFERS, HELMUT SIES
Chairman's Summary of Session A, Page 25, V. ULLRICH
REDUCTION BY THE GUT MICROFLORA OF ANIMALS AND MAN, Pages 27-32, IAN R. ROWLAND
THE METABOLIC ACTIVATION OF RONIDAZOLE [(1-METHYL-5-NITROIMIDAZOLE-2-YL)-METHYL CARBAMATE] TO REACTIVE METABOLITES BY MAMMALIAN, CECAL BACTERIAL AND T. FOETUS ENZYMES, Pages 33-36, GERALD T. MIWA, REGINA WANG, RAUL ALVARO, JOHN S. WALSH, ANTHONY Y.H. LU
REDUCTIVE ACTIVATION OF NITROIMIDAZOLES IN ANAEROBIC MICROORGANISMS, Pages 37-41, MIKLS MÜLLER
COMPARING THE REDUCTION OF NITROIMIDAZOLES IN BACTERIA AND MAMMALIAN TISSUES AND RELATING IT TO BIOLOGICAL ACTIVITY, Pages 43-51, PETER GOLDMAN, RONALD L. KOCH, TIN-CHUEN YEUNG, EWAN J.T. CHRYSTAL, BERNARD B. BEAULIEU JR., MARTHA A. MCLAFFERTY, GILLIAN SUDLOW
REDUCTION OF NITROIMIDAZOLES IN VITRO AND DNA DAMAGE, Pages 53-58, DAVID I. EDWARDS
In vitro reductive activation of nitroimidazoles, Pages 59-61, P.J. DECLERCK, C.J. DE RANTER
Inhibition of hydrogen production in drug-resistant and susceptible Trichomonas vaginalis strains by a range of nitroimidazole derivatives, Pages 61-64, D. LLOYD, N. YARLETT, N.C. YARLETT
The role of the gut flora in the reduction of sulphoxide containing drugs, Page 64, A.G. RENWICK, H.A. STRONG, C.F. GEORGE
Chairman's Summary of Session B, Page 65, D. LLOYD
THE ROLE OF MITOMYCIN ANTIBIOTICS IN THE CHEMOTHERAPY OF SOLID TUMORS, Pages 67-69, ALAN C. SARTORELLI
HYPOXIA-MEDIATED NITRO-HETEROCYCLIC DRUGS IN THE RADIO- AND CHEMOTHERAPY OF CANCER AN OVERVIEW, Pages 71-76, G.E. ADAMS, I.J. STRATFORD
BIOCHEMISTRY OF REDUCTION OF NITRO HETEROCYCLES, Pages 77-90, JOHN E. BIAGLOW, MARIE E. VARNES, LAURIE ROIZEN-TOWLE, EDWARD P. CLARK, EDWARD R. EPP, MYLES B. ASTOR, ERIC J. HALL
Toxicity of oxygen at amospheric concentration for newly explanted cancer cells, Pages 91-92, PETER ALEXANDER, PAUL V. SENIOR
The effect of bioreduction on the oncogenicity of nitroimidazoles, Pages 93-94, ERIC J. HALL, TOM K. HEI
Chairman's Summary of Session C, Pages 95-96, ERIC J. HALL
THE BIOLOGICAL PROPERTIES OF REDUCED NITROHETEROCYCLICS AND POSSIBLE UNDERLYING BIOCHEMICAL MECHANISMS, Pages 97-103, G.F. WHITMORE, A.J. VARGHESE
RSU 1069, A NITROIMIDAZOLE CONTAINING AN AZIRIDINE GROUP: BIOREDUCTION GREATLY INCREASES CYTOTOXICITY UNDER HYPOXIC CONDITIONS, Pages 105-109, IAN J. STRATFORD, PETER O'NEILL, PETER W. SHELDON, ANDREW R.J. SILVER, JACQUELINE M. WALLING, GERALD E. ADAMS
SENSITIZATION OF CANCER CHEMOTHERAPEUTIC AGENTS BY NITROHETEROCYCLICS, Pages 111-115, DIETMAR W. SIEMANN, R. TIMOTHY MULCAHY
Benznidazole: nitroreduction and inhibition of cytochrome P-450 in chemosensitization of tumour response to cytotoxic drugs, Pages 117-119, PAUL WORKMAN, MICHAEL I. WALTON, FRANCIS Y.F. LEE
Chairman's Summary of Session D, Pages 121-122, T.A. CONNORS