Biomedical Defense Principles to Counter DNA Deep Hacking

Front Cover
Biomedical Defense Principles to Counter DNA Deep Hacking
Biomedical Defense Principles to Counter DNA Deep Hacking
Copyright
Dedication
Contents
About the Author
Acknowledgment
1 - The miraculous architecture of the gene pyramid
	My name is DNA
	Initial thoughts
	Anatomy of DNA
	Watson and crick story
	DNA double helix
	What is a gene?
	What is the chromosome?
	Chromosomes in forensics
	The central dogma
	Proteins
	Amino acid
	RNA structure
	Transcription (phase-1 of central dogma)
	The transcription process
	Translation (phase-2 of central dogma) process
	Anatomy of CRISPR machine
	CRISPR structure
	Drawbacks and unethical issues
	Bio-hacking CRISPR, cracking the biological atom
	CRISPR cyber hacking
	Appendix
		Appendix-A: Glossary of DNA (courtesy MERIT CyberSecurity technical library)
		Appendix-B: Landmine Nobel sweet irony
		Appendix-C: CRISPER pioneers
	Recommended sources
2 - History of bio-hackers, psychological profiling, and fingerprinting of the bio-hacker
	The chemistry of DNA bio-hacking
	Hackers wear four colorful hats
	The emergence of DNA bio-hacking
	Hall of fame of DNA bio-hackers
	Advanced DNA bio-hacking technologies
	The cloud of malware of DNA bio-hacking
	Eysenck's theory
	Profiling, Dr. Edward Jones, our actor
	Our hypothetical DNA lab
	A change of belief
	Dr. Edward's DNA-hacking rationale
	Data guardian turned into hacker
	The ``toxic stress'' syndrome
	DNA-hacker fingerprinting
	The crime databases
	The combined DNA index system (CODIS)
	The national crime information center DB (NCIC)
		How does ransomware work?
		The story of the recent North Korean WannaCry ransomware attack
	What's the next step for Dr. Edward?
	Appendices
		Appendix-A Glossary: Courtesy of The National Academies of Sciences, Engineering, and Medicine
	Notes: Hans Eysenck
	Recommended sources
3 - The E. coli story as the carrier of DNA malware code
	What is Escherichia coli (E. coli)?
		Defense by offense
	The CRISPR-Cas immunity projects
	CODIS data bank structures
	The malicious code injection method
	Dr. Edward's bio-attack plan
	Strategic attack timeline
	Anatomy of spyware
	Spyware's spying process
	Digital malware data destruction process
	DNA sequence malware setup
	DNA fingerprinting
	Design of the DNA sequence malware
	The drone flight for malware delivery
	DNA genome browser
	Genome browser users
	Appendices
		Appendix-A SQL storage on DNA
		Appendix-B SQL command converted to DNA code
		Appendix-C DNA profiling (fingerprinting) technology
		Appendix-D how to convert gene sequence into protein
		Appendix-E the BLAST browser
		Appendix-F glossary of genome technology extracted from MERIT cybersecurity library
	Recommended sources
4 - CRISPR the magical knife, the good, the bad, and the ugly
	A warmup thought
	Crystal balling the future with blurry vision
	Game-changing discovery, an eureka moment
	Doudna and Charpentier get nobel
	Historical CRISPR ovation
	CRISPR the new sunrise of gene editing
	The grim side of CRISPR
	The partners who are racing for bio-genetics fame
		Jennifer A. Doudna
		Emmanuelle Charpentier
		Feng Zhang
		Embryo concerns
		A crack in the creation
		Doudna meets Charpentier
		Nobel 2020 winners in chemistry
		CRISPR timeline
		The impossible became possible
		The Frankenstein unfortunate legacy
	Genetic manipulation gone awry
	He Jiankui, China's Dr. Frankenstein
	Who is He Jiankui?
		Lulu and Nana
	Appendices
		Appendix-A: the human genome
		The Human Genome Project (HGP)
		Appendix-B: CRISPR glossary from MERIT cybersecurity archive library
	Recommended sources
5 - The genome vandalism. ``When ISIS meets CRISPR''
	A precious thought
	The next generation of bio-hacking
	ISIS, the army from hell
	ISIS was born
	The bitcoin story
	Bio-hacking is a money-making service
		ISIS meets CRISPR
	CRISPR 101
	DNA 101
	DNA physical and sequence data banking
	DNA ecosystem
	Anatomy of DNA synthesizers
	Anatomy of DNA sequencers
	Anatomy of CRISPR
	Miraculous power of CRISPR
	Autonomy of the human genome (NHG)
	Mapping of the genome
	Hard copy of the genome
	Bio vandalism and genetically engineered bioweaponry-the new paradigm shift
	Bio-hacking strategies and tools
	Hacking the prison computer systems, it really happened
	CRISPR the unethical sawing machine, gene-editing babies
	SARS-CoV-2 omicron variant
		The virus started in Wuhan, China
	Generating malicious DNA sequence
	DNA forensics, going back in time with reverse bio-hacking
	Genome vandalism
	Hacking the human genome databases
		What are the databases
	Bio-hacking DNA ecosystem
	Bio-hacking DNA data storage
		The Trojan horse saga
		The Trojan horse malware
	The ransom formula
	The Dillinger ransome
		DNA bio-hacking with website-powered ransom attack
		DNA bio-hacking with SQL injection (SQLI) attack
		DNA bio-hacking with microchip
		A word on RFID
		DNA bio-hacking with external buffer overflow payload
		DNA bio-hacking with internal sequenced malicious binary
	Appendices
		Appendix-A: Strategic terms used in DNA cyber hacking
		Appendix-B: The national center for biotechnology information (BCBI)
		Appendix-C: Immune-system arms race
		Appendix-D: DNA data format
	Recommended sources
6 - The E. Coli plasmids and COVID-19 saga, loaded directly into DNA
	DNA the new beast
	Anatomy of coronavirus
	Bio-hacking DNA with COVID-19
		The CORONA attack (Act-1)
		The CORONA attack (Act-2)
	Neuro-invasion of COVID-19 in the human brain
	E. Coli physical transport (spyware delivery)
	Pathogens transported into DNA lab
		Lab definitions
	DNA bio-hacking with FASTQ method
	Appendices
		Glossary of COVID-19-from MERIT CyberSecurity consulting
	References
7 - DNA fingerprinting, biohacking-as-a service to alter criminal records from DNA national Banks
	God created the fingers, we created the DNA fingerprinting
	DNA is the Holy Grail
	DNA profiling is the enemy of privacy
	Bio-medical engineering and bio-informatics
	Definition of forensic science
	In the beginning we had fingerprints
	Definition of human fingerprinting
	IAFIS-the integrated automated fingerprint identification system
	AFIS (automated fingerprint identification system) record layout; hacking IAFIS system
	The million stolen fingerprints
	DNA profiling
	Mitochondrial DNA
	The two bio-hacking scenarios
	Scenario-1: hacking the combined DNA index system (CODIS)
		Introduction
		Architecture of the almighty CODIS
		NDIS the smart DNA indexing engine of CODIS
		CODIS technology and DNA analysis
		Biohacking-as-a-service (BhaaS) organizations
		The strategy of attack on CODIS
		CODIS vulnerabilities
		REDIS: remote dictionary server (Redis)
		CODIS management
		CODIS storage stats
		Hacking CODIS execution
		Hacking the combined DNA index system (CODIS)
		Scenario-1 hacking CODIS DNA criminal database
		Hacker's zero day
		Scenario-2 hacking genome databanks
		Goals for the human genome project (HGP)
		Medical implications
			The human genome data resources
		First step in hacking HGP: knowing the CODIS system as a geneticist and system guru
		Blast search engine
		Important database tools
		The cancer moonshot project
		Hacking prerequisites
			Biometrics technologies
			Group-1 biological evidence
			Group-2 biometric evidence
			Group-3 external evidence
		Hacking biometrics technologies
		A snapshot of history
		The medical examiner system
		CODIS
		The onion router (TOR) and the dark web
			The onion router
		The dark web
	Appendix
		Appendix-A REDIS technology
		Appendix-B Glossary of CODIS
			ASCII
			Accredited laboratory
			Administrative removal
			Allele
			Arrestee
			Arrestee hit
			Arrestee index
			Assessment
			Auto searcher
			Base pair distance
			Benchwork match
			Biological child
			Biological father/mother
		Biological sibling
			Cambridge reference
			Candidate match
			Candidate profile
			Case disposition
			Case report
			Casework laboratory
			CJIS-WAN
			CMF
			CODIS
			CODIS administrator
			CODIS core loci
			CODIS information technology (IT) user
			CODIS custodian/supervisor
			CODIS user
			CODIS user role (in the CODIS software)
			Contract laboratory
			Control certification form
			Cold hit
			Composite DNA profile
			Convicted offender
			Convicted offender index
			Convicted offender lab
			Convicted offender sample
			Convicted offender profile
			Conviction match
			Criminal justice agency
			Criminal history record
			DAO
			Databank coordinator
			DCJS
			DCJS match letter
			Deduced missing person
			Detainee
			Detainee index
			DNA analysis backlog elimination act
			DNA analyst
			DNA databank
			DNA hits
			DNA identification act
			DNA profile
			DNA record
			Elimination sample
			Employee
			Exact match
			Executive law article 49-B section 995
			Expert system
			Expungement
			Familial search
			FBI
			Forensic DNA laboratory
			Forensic DNA profile
			Forensic DNA testing
			Forensic hit (FH)
			Forensic index
			Forensic mixture category
			Forensic mixture index
			Forensic match letter
			Forensic partial category
			Forensic partial index
			Forensic SDIS only category
			Forensic SDIS only index
			Forensic sample
			Forensic targeted
			Forensic unknown
			Heteroplasmy
			High stringency
			High stringency match
			Homopolymeric regions
			Hypervariable region I
			Hypervariable region II
			Identification aided
			Identification confirmed
			Identifying information
			Identification pending (ID pending)
			Index offense
			Indictment
			Interpreting analyst
			Investigating agency
			Investigations aided (IA)
			Juvenile
			Keyboard search
			Keyboard search request
			Keyboard search result letter
			Known sample
			Laboratory
			Lab-types
			LDIS
			LDIS only specimen category
			LDIS only index
			Learning management system (LMS)
			Legal (sample)
			Legal index
			LINKAGE
			LINKAGE user
			Low copy number or low template DNA analysis
			Low copy number specimen category
			Low copy number profile
			Low stringency
			Low stringency match
			Marked/unmarked profile
			Match
			Match confirmation
			Match estimation utility
			Match manager
			Match report
			Match stringency
			Maternal relative
			Methodology
			Mis-match (search)
			Missing person
			Missing person index
			Mitochondrial DNA
			Mitotype
			Moderate match estimation (MME) value
			Moderate stringency
			Moderate stringency match
			NamUs
			NCIC
			NCIC miscellaneous field
			NCIC unidentified person file
			NCMEC
			NDIS
			NDIS standards for acceptance of DNA data
			Negative amplification blank
			Negative control
			Negative reagent blank
			NIST
			No match
			No suspect case
			NYPD
			NYS CODIS administrator
			NYS DNA databank
			NYSID number
			Obligate allele
			Offender
			Offender duplicate
			Offender hit (OH)
			Offender laboratory
			Offender match letter
			ORI
			Other (pattern)
			Ownership
			Partial locus
			Partial match
			Paternal relative
			Pedigree tree (index)
			Pending
			Perpetrator
			Personally identifiable information
			Platform
			Positive human DNA control
			Popstats
			Privacy act
			Proficiency testing
			Qualified auditor
			Qualified DNA analyst
			Quality assurance
			Quality control
			Ranks
			Reference sample
			Relatives of missing person (index)
			Requesting laboratory
			Required allele
			Required alleles specimen category (no longer exists under this name)
			Revised Cambridge reference sequence (rCRS)
			``Scientific reason''
			SDIS
			SDIS custodian
			Search
			Search stringency parameters
			Search results
			Searcher
			Single typed node
			Specimen/sample
			Specimen category
			Specimen ID
			Specimen manager
			Spouse
			Spouse index
			State defined #1, 2, 3, 4, five
			Statute of limitation
			Stringency
			Subject index
			Submission form
			Submitting agency
			Suspect
			Suspect case
			Target DNA profile
			Technical leader
			Technology
			Unidentified human (remains) index
			Unidentified person
			Upload
			User
			Use and dissemination agreement
			Waiting for more data
			Warm match/hit
			XML format
		Appendix-C glossary of the dark web
			Alias
			Bitcoin
			Blockchain
			Carding
			Clearnet
			Cryptocurrency
			Darknet
			Doxing
			Encryption
			Firewall
			Honeypot
			IP address (aka internet protocol)
			Malware
			Sandbox
			Spoofing
			Tor (aka the onion router)
			VPN
		Appendix-C the onion router (TOR) glossary
		Appendix-D the open system interconnection (OSI) model
	Recommended sources
8 - How to select a DNA bio attack. How to plan it, assess its damage, and its vulnerability
	DNA bioweaponry and DNA bio-hacking warfare
	CRISPR the two-edged sword
	CRISPR is the new DNA bio-bomb
	Life-extension and age reversing euphoria
	Why is synthesis biology the right arm for bio-hacking?
	Bio-hacker hacking qualifications
	Bio-hack method-1(Boobytrap)
	Bio-hack method-2 (remote control)
	Stuxnet the devil's terminator
	Stuxnet missile architecture
	Now we have DNAxnet
	DNA bio-hacking categories
	DNAxnet work of the devil
	The possibilities to hack DNA databanks
	Josiah Zayner ``the first body biohacker'' story
	Zayner's pioneering work
	The awesome postmortem bio-hacking story
	Evaluation of the critical success factors (CSF) for DNA bio-hack mission
		DNA bio-hack success factors
			Factor-1: criticality of the mission, exhibited in the critical success factors
			Factor-2: evaluation the risk in DNA bio-hack mission
			Factor-3: evaluation of the vulnerability in DNA bio-hack mission
		Evaluation of success in DNA bio-hack mission
	Appendices
		Appendix-A Chinese scientist who produced genetically altered babies
		Making gene editing an equal playing field
		Appendix-B the story of stuxnet, the missile from hell
		Appendix-C glossary of hacking terms list of important terms used in the field of hacking
	Recommended sources
9 - The drone technology, transport strategy, and risk evaluation, and biomedical revolution
	Introduction
	Stepping a little deeper into DNA forensics
	The world of biohackers
	Knowing thy enemy
	Nanotechnology the new paradigm shift
	Nano technology, the sunrise of the future
	The nano DNA bio-hacking, a new disruptive technology
	Internet-of-Nano-Things (IoNT), the next thing in bio-hacking
		CODIS, the DNA crime profile system, the crime magnifier
	Memorandum of attach agreement with bio-hacking organization
	Strategy of attack of the nano Bio-drone
	Stage-1: Attack planning and engineering
	Stage-2: Drone flight
	Stage-3: bio-hack episode
		Targeted Killing with nano drones-the new DNA vandalism
	The launch of the nano DNA bio-drone attack
	Anatomy of the nano DNA biohack drone
		Anatomy of Nano-DNAxnet, the futuristic biohack nano chip
		Engineering of the DNAxnet nanochip
		DNAxnet nanochip components
		DNAxnet missile design specifications
		REDIS/CODIS technology
	Functionality of the zookeeper, the frontend traffic coordinator
	Functionalities of the CODIS/proxies, the smart IP filter
	Functionality of CODIS load balancer
	Functionalities of the REDIS Sentinel
	REDIS memory specifications
	CODIS transaction sequence
	The nano DNA-bio-drone attack
	Strategy of the attack
		Launching the attack
		DNAxnet delivery on board the nano-drone
	Then, what happened after the hack
	Removing CODIS records is slippery slope
		The digital immunity ecosystem (DIE) and The Smart Vaccine
	Appendix
		Appendix A
		Appendix B
	References
10 - Drone delivery methods and how to communicate with the destination
	History of drones
	Nanotechnology, the sunrise is so bright
	Bio-hacking services adopted drone nanotechnology
	Give law enforcement a hand
	Quantum computers, quantum supremacy
	Quantum computing, the fertile ground for bio-hackers
		Nano quantum computing
		Delivery methods
		Weaponized Nano Bio-Hacking (WNBH)
		Quantum droning and delivery
		Quantum Network
		Everything is connected
	Appendices
		Appendix-A: god and time
		Appendix-B: Shor's algorithm in the quantum computing
		Appendix-C: Glossary of quantum computing: National Academies of Sciences, Engineering, and Medicine. 2019.
	Recommended sources
11 - The DNAxnet Bio warfare and evaluation of its impact
	What is DNA bio-hacking-as-a-service?
		Stuxnet is the devil's key to hell
		The bio DNAxnet, the fruit from hell
		The attack scenario
		Design of the bio DNAxnet nano-chip
		Bio DNAxnet missile uses UNIX
		How did the bio-hackers simulate the attack?
		Environmental data
		Hacking background and technical experience
		Results of the bio-hacking simulation model
		The dashboard screen
		The activity screen
		The graphics screens
		The launch of the DNAxnet Trojan daemon
		Post attack impact and tracking the CODIS sabotage
		Biohack risk computation
		Further bio-hacking success formulas
	Criticality is determined by number of components
		What is criticality?
		What is severity?
	Human critical survivability
	Appendices
		Appendix-A the complete story of stuxnet
			Two attack strategies
			The crack in the door
				Damages
				Historical background
	Recommended sources
12 - Storage and execution of DNA contaminated code
	We're still on crutches
	Even concert walls cry
	Solar winds crater
	The central dogma
		Stepping into God's domain, CRISPR gene editing
		Anatomy of CRISPR, the two-edge sword
		This is how CRISPR works
	A snap of CRISP history
	CRISPR the tool to hack the human genome
	Injecting bio-malware with CRISPR
	The three contamination attack scenarios
		Scenarios of DNA genes contamination and distribution
	Appendices
		Appendix-A: Glossary Of DNA And Protein (Courtesy of the National Center for Biotechnology Information); MERIT CyberSecurit ...
		Appendix-B: Glossary of CRISPR (Courtesy of the US Library of Medicine)
		Appendix-C: Glossary of Genetics (From MERIT Bio-Engineering Library)
	Recommended sources
13 - Encryption technology and camouflaging contaminated DNA-code injection
	In the beginning, there was Caesar's cipher
	Interesting facts about the man who broke the Enigma-Alan turing
	Alain Turing the hacker
	The universal Turing machine, the granddaddy of computing
	DNA gene bio-hacking technologies
	DNA bio-hacking with cryptography (first camouflage technology)
	DNA bio-hacking with cryptography, the holy grail of bio-hackers
		The Rosetta Stone story
		Bio-hackers the DNA Houdinis
		DNA bio-hacking with watermarking, (second camouflage technology)
		Bio-hackers and advantages of watermarking
		Watermarking and masking optimization
			Steganography background
		DNA bio-hacking with steganography-(third camouflage technology)
			Bio-hackers are playing the war drums
			The CODIS penetration plan
		CODIS bio-hacking process
		Bio-hacking with quantum cryptography
		Advantages of QC and quantum key distribution
		Bio-hackers are the masters of quantum key distribution (QKD)
	Bio-hacking reaction to quantum computing
		Google's quantum computer, the Sycamore
		Bio-hacking attack manifesto
			Bio-hacking with blockchain
				A slide of history
			Bio-enterprise-hackers, getting ready for bitcoin and blockchain
	Appendix
		Appendix-A: Quantum Cryptography Glossary. National Academies of Sciences, Engineering, and Medicine. 2019. Quantum Computi ...
	Recommended sources
14 - Forecast and detection of DNA surprise bio-attacks, bio-defense and eradication. How to secure DNA data files
	Bio-attack since the beginning of time
	The Plague of Kaffa
	Detection of surprise DNA bio-attack
	The story of GenBank DNA sequence database
	Building an autonomic AI-centric smart system to stop DNA bio-attack
		The DNA bio-response
		Could DNA protect itself?
	Government response to DNA bio-attack
	The DNA bio-hacking achilles' heel
	America is facing new type of bio-attack
		The view Covid-19 attack for DNA sabotage
	Biotechnology impact on bio-hacking
	The new plan for a national Bio-Defense Department (BDD)
	Architecture of the National DNA Defense Center Against the Unknown (NDDATU)
		Security measures of The National DNA Defense Center against the Unknown (NDDCATU)
	A look at the quantum computing
		How does quantum entanglement work?
		How does quantum teleportation work?
		Teleportation by optical tweezers
		Human teleportation, what?
	Our daily digital computers razzle dazzle will soon rest in peace
	Appendix
		Appendix-A: The SARS-CoV-2, National Institute of Allergy, and Infectious Diseases (NIAID)
			Profile of the Covid-19
			Coronavirus-2, The Delta variant
		Appendix-B: NCBI's GenBank Reactor … The source of medical knowledge
	Recommended source
15 - How to reverse engineer DNA and quantum bio-attacks
	Reverse engineering, tool of survival
		Anatomy of a DNA bio-hacking
		Anatomy of our DNA
		What is cryonics, death-2-life reverse engineering
		Bio-hackers love DNA treasures
		How to reverse engineer a DNA bio-attack
		Bio-hackers will simulate the future of the attack
		Portfolio of bio-hacking attacks
		The Turin reverse-engineering process that saved the war
		Cracking the Enigma
		Reverse engineering is breakdown, copy and rebuild engineering
		Reverse engineering strategy in DNA bio-hacking
		The four steps of reverse engineering
		Reverse engineering-reformulation-find from known protein the proper DNA
		Reverse-engineering implementation in quantum bio-attacks
		Digital circuitry and phenomenon of Moore's law
	And then, quantum computing prevailed
		How can bio-hacking penetrate quantum computing
		Bio-hacking strategic plan of attack
		Bio-hacking organizations attack targets
		Anatomy of the quantum computer
		Quantum hardware
		Software and tutorials from quantum computer hardware providers
		Quantum software and quantum programming
		Finally, quantum internet (QI), the favorite for bio-hacking
			The future dream
		Goals of bio-hacking organizations for quantum computing and quantum internet
		The other surprise, quantum internet of things
		Bio-hacking organizations are going after the Quantum Internet of Medical Things (QIoMT)
		Now the quantum cloud, capital of the quantum Internet of Medical Things (IoM)
	Design of quantum bio-hack applications for Internet of Medical Things (IoMT)
	Design of the quantum Internet of Medical Devices (IoMD), the medical yellow pages
	Testing the quantum killer application with simulation
	The architecture of a bio-med data center model
	Appendix
		Appendix-A: software companies that have Software Development Kits (SDKs) for quantum computing
		Appendix-B: companies giving access to quantum computers
		Appendix-C: technical comparison between classical software and quantum software
	Recommended sources
16 - CRISPR controversy with religion and ethics advocates to control evolution and embryology enhancement, and to  ...
	A thought from the launch pad
	CRISPR anatomy
	CRISPR the silent guillotine apparatus
	Bio-hackers are getting ready to use biological weapons
	Drones have become part of the bio-weaponry
	Let's not forget Dr. Zhang contribution in CRISPR
	CRISPR best invention in the world
	Peace between science and religion-injecting ``scriptural'' DNA into the body
		The Adrien Locatelli Saga
		Stepping into the domain of god
		CRISPR's religion enigma
		Playing hard ball CRISPR
		Bio-academia, intelligence enhancement, better education
	The blessing of bacteria
	What is more important DNA or religion (extracted from the telegraph 3-3-2019)
	Bio-hacking affinity for CRISPR
	Some atheistic arrogance
	The Dr. Francis Collins defense, director of the national institutes of health
	He Jiankui gene-editing scandal
	Religious communities are not happy
	Dr. Crick and Churchill arguments
	Nobel scientist happy to ``play god'' with DNA
	Now religion speaks about DNA
	Conflict between science and religion on evolution
	Where does CRISPR fit between creation and evolution
	FranCoise Baylis
	Weighing CRISPR on the scale
	Concluding thoughts
		Religion fighting religion
	Appendices
		Appendix-A: Glossary of CRISPR
		Appendix-B: Watch: meet one of the world's most groundbreaking scientists. He is 34
	Recommended sources
Epilog
Index
	A
	B
	C
	D
	E
	F
	G
	H
	I
	J
	K
	L
	M
	N
	O
	P
	Q
	R
	S
	T
	U
	V
	W
	Y
	Z
Meet Dr. Josiah Zayner, the Pasteur of biohacking…
Back Cover