Biomedical Advances in Aging

Front Matter....Pages i-xi
Front Matter....Pages 1-1
Brain Amyloidoses....Pages 3-24
Prions Causing Neurodegenerative Diseases....Pages 25-37
The Molecular Genetics of Alzheimer’s Disease....Pages 39-42
A Developmental Genetic Approach to the Analysis of Aging Processes....Pages 43-49
Alzheimer’s Disease....Pages 51-62
Evidence for the Molecular Basis of Aging and Sequestration of Mammalian Erythrocytes....Pages 63-73
α 1 á-Antichymotrypsin....Pages 75-88
Replication of Adenovirus 2 and Adeno-Associated Virus 2 in Young and Senescent Human Diploid Fibroblasts....Pages 89-107
Lactoferrin Immunoreactivity and Binding Sites in Neurons, Neuritic Plaques, and Neurofibrillary Tangles in Alzheimer’s Disease....Pages 109-124
Immunological Investigation of Thymic-Dependent Immunity in Normal Aging and in Patients with Senile Dementia of Alzheimer Type....Pages 125-133
Front Matter....Pages 135-135
Chronic Diseases and Disorders....Pages 137-142
Changes in Receptors and Signal Transduction Events during Aging....Pages 143-146
Molecular Aging of Membrane Molecules and Cellular Removal....Pages 147-161
Health Watch: A Longitudinal Prospective Study of Healthy Aging in 2200 Individuals....Pages 163-172
Plasma α-Tocopherol Levels in Men and Women of Different Ages....Pages 173-179
Polyenoic Fatty Acid Metabolism and Prostaglandin Biosynthesis in Aged Persons....Pages 181-185
Altered Phosphatidylinositol Breakdown in Polymorphonuclear Leukocytes with Aging....Pages 187-194
Rejoining of X-Ray-Induced DNA Double-Strand Breaks Declines in Unstimulated Human Lymphocytes Aging in Vivo ....Pages 195-206
Interventive Gerontology, Cloning, and Cryonics....Pages 207-220
Effects of Various Stimulators and Inhibitors on the Respiratory Burst of PMNL with Aging....Pages 221-228
Front Matter....Pages 135-135
Quantitative Approaches to Pathogenesis of Age-Related Metabolic Conditions....Pages 229-245
Front Matter....Pages 247-247
Nutritional Requirements in Aging....Pages 249-257
Influence of Dietary Restriction and Aging on Gene Expression in the Immune System of Rats....Pages 259-270
Zinc, Immunity, and Aging....Pages 271-281
Neuroendocrine Effects of Lifelong Dietary Restriction by Intermittent Feeding in Mice....Pages 283-290
Age-Associated Decline in Renal Response to Vasopressin....Pages 291-296
Obesity and Lipoproteins....Pages 297-302
Phenotype and Function of Lymphocyte Clones from Old and Young Subjects....Pages 303-311
Caloric Restriction and Longevity....Pages 313-317
Effect of Dietary Linolenate on the Pathogenesis of Fever....Pages 319-329
Poor Early Growth and Adult Mental and Somatic Health....Pages 331-346
Front Matter....Pages 347-347
Alterations in B Cells and Antibodies of Aged Mice....Pages 349-353
Molecular Genetic Analysis of Human Monoclonal Gammopathies....Pages 355-362
Developmental Aspects of T Lymphocytes in Aging....Pages 363-373
Role of the Thymus in Aging of the Immune System....Pages 375-384
Modulation of T-Cell Functions in Aging....Pages 385-390
Age-Related Decline in Immunological Resistance to Infection....Pages 391-400
The Clinical Significance of Immune Senescence....Pages 401-403
Immunosenescence and Human NK Cells....Pages 405-412
Regulation of the Expressed Idiotypic Repertoire in the Normal Immune Response of the Aged....Pages 413-424
Front Matter....Pages 347-347
Analysis of the Ability of Spleen Cells from Aged Mice to Produce Allospecific Cytotoxic Cells....Pages 425-432
Front Matter....Pages 433-433
Neuronal Populations in Normal and Abnormal Aging....Pages 435-440
An Optimistic View of the Aging Brain....Pages 441-449
Complex Maze Learning in Rodents....Pages 451-467
Age-Related Changes in Brain Protein Kinase C and Serotonin Release....Pages 469-476
Increased Blood Flow Augments CNS Axon Regeneration....Pages 477-484
Free and Bound Polyamines in Normal and Alzheimer Temporal Cortex....Pages 485-490
Neurochemical and Behavioral Effects of Bilateral Nucleus Basalis Lesions in the Aged Rat....Pages 491-496
Dopaminergic Neurons in the Substantia Nigra in Normal Aging and MPTP-Lesioned Mice....Pages 497-500
Synaptic Plasticity and Aging....Pages 501-510
Front Matter....Pages 511-511
Influenza and Aging....Pages 513-521
Age-Dependent Enhancement of Influenza Vaccine Responses by Thymosin in Chronic Hemodialysis Patients....Pages 523-530
Lipid and Lipoprotein Changes Due to Estrogen Replacement Therapies and Their Association with Prevention of Cardiovascular Disease in Postmenopausal Women....Pages 531-536
Immunopotentiating Activity of Thymopentin Treatment in Elderly Subjects....Pages 537-550
Thymopentin Therapy in Elderly Patients with Chronic Bronchitis....Pages 551-559
Aspirin and Risks of Cardiovascular Disease in the Physicians’ Health Study....Pages 561-569
Back Matter....Pages 571-586