Biomarkers for Alzheimer’s Disease Drug Development

Front Matter ....Pages i-xv
Front Matter ....Pages 1-1
 Epidemiology of Dementia: The Burden on Society, the Challenges for Research  (Frank J. Wolters, M. Arfan Ikram)....Pages 3-14
 Population-Based Approaches to Alzheimer’s Disease Prevention  (Robert Perneczky)....Pages 15-29
 Systems Biology Methods for Alzheimer’s Disease Research Toward Molecular Signatures, Subtypes, and Stages and Precision Medicine: Application in Cohort Studies and Trials  (Juan I. Castrillo, Simone Lista, Harald Hampel, Craig W. Ritchie)....Pages 31-66
Front Matter ....Pages 67-67
 CSF Lipidomics Analysis: High-Resolution Mass Spectrometry Analytical Platform  (Paul L. Wood, Randall L. Woltjer)....Pages 69-74
 CSF N-Glycomics Using MALDI MS Techniques in Alzheimer’s Disease  (Angelo Palmigiano, Angela Messina, Rosaria Ornella Bua, Rita Barone, Luisa Sturiale, Mario Zappia et al.)....Pages 75-91
 MicroRNA Profiling of Alzheimer’s Disease Cerebrospinal Fluid  (Johannes Denk, Holger Jahn)....Pages 93-107
Front Matter ....Pages 109-109
 Validation of a Chemiluminescence Immunoassay for Measuring Amyloid-β in Human Blood Plasma  (Jonathan Vogelgsang, Jens Wiltfang, Hans W. Klafki)....Pages 111-124
 Mass Spectrometry-Based Metabolomic Multiplatform for Alzheimer’s Disease Research  (Raúl González-Domínguez, Álvaro González-Domínguez, Ana Sayago, Ángeles Fernández-Recamales)....Pages 125-137
 Blood-Based Biomarker Screening with Agnostic Biological Definitions for an Accurate Diagnosis Within the Dimensional Spectrum of Neurodegenerative Diseases  (Filippo Baldacci, Simone Lista, Sid E. O’Bryant, Roberto Ceravolo, Nicola Toschi, Harald Hampel et al.)....Pages 139-155
Front Matter ....Pages 157-157
 Functional Magnetic Resonance Imaging in Alzheimer’ Disease Drug Development  (Stefan Holiga, Ahmed Abdulkadir, Stefan Klöppel, Juergen Dukart)....Pages 159-163
 Neuroimaging Methods for MRI Analysis in CSF Biomarkers Studies  (Carles Falcon, Grégory Operto, José Luis Molinuevo, Juan Domingo Gispert)....Pages 165-184
 Hybrid PET-MRI in Alzheimer’s Disease Research  (Ismini C. Mainta, Maria I. Vargas, Sara Trombella, Giovanni B. Frisoni, Paul G. Unschuld, Valentina Garibotto)....Pages 185-200
Front Matter ....Pages 201-201
 Amyloid PET Imaging: Standardization and Integration with Other Alzheimer’s Disease Biomarkers  (Silvia Morbelli, Matteo Bauckneht)....Pages 203-212
 The Use of 18F-FDG PET in the Diagnostic Workup of Alzheimer’s Dementia  (Marion M. Ortner)....Pages 213-219
 Quantification of Tau Load in Alzheimer’s Disease Clinical Trials Using Positron Emission Tomography  (Tessa Timmers, Bart N. M. van Berckel, Adriaan A. Lammertsma, Rik Ossenkoppele)....Pages 221-229
 Imaging Neuroinflammation: Quantification of Astrocytosis in a Multitracer PET Approach  (Elena Rodriguez-Vieitez, Agneta Nordberg)....Pages 231-251
Front Matter ....Pages 253-253
 Unbiased Lipidomics and Metabolomics of Human Brain Samples  (Giuseppe Astarita, Matteo Stocchero, Giuseppe Paglia)....Pages 255-269
 Neuropathological Assessment as an Endpoint in Clinical Trial Design  (Steve Gentleman, Alan King Lun Liu)....Pages 271-279
Front Matter ....Pages 281-281
 Analysis of Micro-RNA Expression by qPCR on a Microfluidics Platform for Alzheimer’s Disease Biomarker Discovery  (Petros Takousis)....Pages 283-292
 Telomere Length Shortening in Alzheimer’s Disease: Procedures for a Causal Investigation Using Single Nucleotide Polymorphisms in a Mendelian Randomization Study  (Yiqiang Zhan, Sara Hägg)....Pages 293-306
 Quantifying miRNA Deregulation in Alzheimer’s Disease  (Ana L. Cardoso, Joana R. Guedes)....Pages 307-319
Front Matter ....Pages 321-321
 Imaging of Microglial Activation in Alzheimer’s Disease by [11C]PBR28 PET  (Cornelius K. Donat, Nazanin Mirzaei, Sac-Pharm Tang, Paul Edison, Magdalena Sastre)....Pages 323-339
 In Vivo Two-Photon Calcium Imaging of Hippocampal Neurons in Alzheimer Mouse Models  (Marc Aurel Busche)....Pages 341-351
Front Matter ....Pages 353-353
 Cognitive Assessment in Alzheimer’s Disease Clinical Trials  (Geraint Price)....Pages 355-362
 Data Mining and Machine Learning Methods for Dementia Research  (Rui Li)....Pages 363-370
Back Matter ....Pages 371-372