Biological Reactive Intermediates VI: Chemical and Biological Mechanisms in Susceptibility to and Prevention of Environmental Diseases

Front Matter....Pages i-xv
Biological Reactive Intermediates and Mechanisms of Cell Death....Pages 1-10
Structure Activity Relationships for the Chemical Behaviour and Toxicity of Electrophilic Quinones/Quinone Methides....Pages 11-21
Use of Structure-Activity Relationships for Probing Biochemical Mechanisms: Glutathione Transferase Zeta Conjugation of Haloacids....Pages 23-31
Structure Toxicity Relationships - How Useful Are They in Predicting Toxicities of New Drugs?....Pages 33-43
Biological Reactive Intermediates in Drug Discovery and Development....Pages 45-51
Bioactivation of Toxicants by Cytochrome P450-Mediated Dehydrogenation Mechanisms....Pages 53-62
New Aspects of DNA Adduct Formation by the Carcinogens Crotonaldehyde and Acetaldehyde....Pages 63-71
Mechanisms of Ovotoxicity Induced by Environmental Chemicals: 4-Vinylcyclohexene Diepoxide as a Model Chemical....Pages 73-81
Mutagenicity and Carcinogenicity of Biological Reactive Intermediate’s Derived from a “Non-Genotoxic” Carcinogen....Pages 83-92
Reactive Metabolites of 1,3-Butadiene: DNA and Hemoglobin Adduct Formation and Potential Roles in Carcinogenicity....Pages 93-103
Chemistry and Biological Activity of Novel Selenium-Containing Compounds....Pages 105-112
Formation and Fate of Reactive Intermediates of Haloalkanes, Haloalkenes, and α-Haloacids....Pages 113-120
Human Epoxide Hydrolase is the Target of Germander Autoantibodies on the Surface of Human Hepatocytes: Enzymatic Implications....Pages 121-124
Structural Characterisation Of the Main Epichlorohydringuanosine Adducts....Pages 125-128
Adducts of the Chloroform Metabolite Phosgene....Pages 129-132
Oxygenation of Arachidonic Acid by Cyclooxygenases Generates Reactive Intermediates That Form Adducts with Proteins....Pages 133-137
Use of Isotopes and LC-MS-ESI-TOF for Mechanistic Studies of Tienilic Acid Metabolic Activation....Pages 139-144
Inhibition by Ticlopidine and Its Derivatives of Human Liver Cytochrome P450. Mechanism-Based Inactivation of CYP 2C19 by Ticlopidine....Pages 145-148
Microperoxidase 8 (MP8) as a Convenient Model for Hemoproteins: Formation and Characterisation of New Iron(II)-Nitrosoalkane Complexes of Biological Relevance....Pages 149-152
Hemoglobin Adducts in Rats Chronically Exposed to Room-Aged Cigarette Sidestream Smoke and Diesel Engine Exhaust....Pages 153-156
DNA Microarray Reveals Increased Expression of Thioredoxin Peroxidase in Thioredoxin-1 Transfected Cells and Its Functional Consequences....Pages 157-168
Reactive Nitrogen Species and Proteins: Biological Significance and Clinical Relevance....Pages 169-174
Bicarbonate Enhances Nitration and Oxidation Reactions in Biological Systems—Role of Reactive Oxygen and Nitrogen Species....Pages 175-182
Nitric Oxide and Peroxynitrite in Ozone-Induced Lung Injury....Pages 183-190
Antioxidant Reactions of Green Tea Catechins and Soy Isoflavones....Pages 191-197
Reactive Oxygen Species Analysis in Gastritis Patients and P53 Methylation Analysis in Gastric Tumor Cell Line Ags Infected by Helicobacter Pylori....Pages 199-202
Biological Reactive Intermediates that Mediate Chromium (VI) Toxicity....Pages 203-207
Involvement of Peroxynitrite on the Early Loss of P450 in Short-Term Hepatocyte Cultures....Pages 209-212
Lack of Correlation Between CYP2A6 Genotype and Smoking Habits....Pages 213-215
Free Radical Lipid Peroxidation and Monooxygenase Activity in Experimental Influenza Virus Infection after Treatment with Rimantadine....Pages 217-220
Oxidative Stress and the Structure/Activity Relationships of Ergopeptide Alkaloids....Pages 221-224
Multiple Oxidative Stress Parameters are Modulated in Vitro by Oxygenated Polycyclic Aromatic Hydrocarbons Identified in River Sediments....Pages 225-228
1, N 6 -Etheno-2’-Deoxyadenosine Adducts from Trans, Trans -2,4-Decadienal and Trans -2-Octenal....Pages 229-232
Hydrogen Peroxide Supports Hepatocyte P450 Catalysed Xenobiotic/Drug Metabolic Activation to form Cytotoxic Reactive Intermediates....Pages 233-236
NAD(P)H:Quinone Oxidoreductase (NQO1) Protects Astroglial Cells Against L-Dopa Toxicity....Pages 237-240
GSH-Dependent Redox Regulation and Antioxidant Enzymes in the Formation of Resistance to Doxorubicin in K562 Human Erythroleukemia Cells....Pages 241-244
Opposite Effects of Oxidative Stress on Endothelial Cell Lines (ECV 304 and Eahy 926) Interaction With Extracellular Matrix....Pages 245-248
Hepatocyte Lysis Induced by Environmental Metal Toxins May Involve Apoptotic Death Signals Initiated by Mitochondrial Injury....Pages 249-252
Quantification of F-Ring and D-/E-Ring Isoprostanes and Neuroprostanes in Alzheimer’s Disease....Pages 253-256
Preventive Effect of Vitamin E on the Processes of Free Radical Lipid Peroxidation and Monooxygenase Enzyme Activity in Experimental Influenza Virus Infection....Pages 257-260
Lysosomal Oxidative Stress Cytotoxicity Induced by Nitrofurantoin Redox Cycling in Hepatocytes....Pages 261-265
Scavenging and Antioxidant Effects of Estrogen Derivatives in Cholesterol-Fed Rabbits....Pages 267-270
Inhibition of Oxidative Damage of Red Blood Cells and Liver Tissue by Genistein-8C-Glucoside....Pages 271-274
Effects of Several Wine Polyphenols on Lipid Peroxidation and Oxygen Activation in Rat Liver Microsomes....Pages 275-278
Chromosome Damage from Biological Reactive Intermediates of Benzene and 1,3-Butadiene in Leukemia....Pages 279-287
The Antitumor Agent Ecteinascidin 743: Characterization of Its Covalent Dna Adducts and Chemical Stability....Pages 289-299
Design of DNA Damaging Agents that Hijack Transcription Factors and Block DNA Repair....Pages 301-313
The Potential Role of Topoisomerase II Inhibition in Hydroquinone-Induced Alterations in the Maturation of Mouse Myeloblasts....Pages 315-318
Design and Characterization of a Novel « Family-Shuffling » Technology Adapted to Membrane Enzyme: Application to P450s Involved in Xenobiotic Metabolism....Pages 319-322
One-Electron Reduction of Quinones by the Neuronal Nitric-Oxide Synthase Reductase Domain....Pages 323-326
Purification, Biochemical Characterization and Comparative Enzyme Kinetics of Recombinant Human CYP2D6 1 and CYP2D6 2 Variants....Pages 327-330
Inhibitory Effects of Roquefortine on Hepatic Cytochromes P450....Pages 331-334
Association of Cytochromes P450 1A2 and 2B4: are the Interactions between Different p450 Species Involved in the Control of the Monooxygenase Activity and Coupling?....Pages 335-338
Inactivation of Polymorphic Variants of Human Glutathione Transferase Zeta (hGSTZ1-1) by Maleylacetone and Fumarylacetone....Pages 339-342
Structure-Activity Relationships of Cyclotetrapeptides: Interaction of Tentoxin Derivatives with Three Membrane Proteins....Pages 343-346
Triazolam Substrate Inhibition....Pages 347-350
Effect of the Microsomal System on Quinone Redox Cycling, Oxygen Activation, and Lipid Peroxidation....Pages 351-354
Reaction of Nucleic Acids with Triformylmethane; A Novel Dna-Modifying Agent....Pages 355-358
Are Blood-brain Interfaces Efficient in Protecting the Brain from Reactive Molecules ?....Pages 359-364
The Roles of P-Glycoprotein and MRP1 in the Blood-Brain and Blood-Cerebrospinal Fluid Barriers....Pages 365-372
Are Dopamine, Norepinephrine, and Serotonin Precursors of Biologically Reactive Intermediates Involved in the Pathogenesis of Neurodegenerative Brain Disorders?....Pages 373-396
Serotonergic Neurotoxicity of Methylenedioxyamphetamine and Methylenedioxymetamphetamine....Pages 397-406
Caspase Cascades in Chemically-Induced Apoptosis....Pages 407-420
Spermatogenesis by Sisyphus: Proliferating Stem Germ Cells Fail to Repopulate the Testis after ‘Irreversible’ Injury....Pages 421-428
The Interaction of 1,4-Benzoquinone, a Bioreactive Intermediate of Benzene, with Three Proteins Essential for Differentiation/ Maturation of the Mouse Myeloid Stem Cell....Pages 429-439
Hematopoietic Stem and Progenitor Cells as Targets for Biological Reactive Intermediates....Pages 441-449
Metabolism of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (Nnk) in A/J Mouse Lung And Effect of Cigarette Smoke Exposure on in Vivo Metabolism to Biological Reactive Intermediates....Pages 451-454
Pharmacokinetics of Benzene Following an Oral or Intradermal Dose in FVB and Tg.AC Mice....Pages 455-458
Metabolism of the Food Mutagen 2-Amino-3,8-Dimethylimidazo[4,5- f ]Quinoxaline in Human Hepatocytes....Pages 459-462
Preventive Effect of Selenium on T-2 Toxin Membrane Toxicity....Pages 463-466
Modulation Influence of p-Chloromercuribenzoate on Plasma Membrane Na + -Ca 2+ Exchanger of the Secretory Cells of Chironomus Larvae Salivary Gland....Pages 467-470
Tobacco Toxicology Revisited....Pages 471-478
Functional Genomics of Oxidant-Induced Lung Injury....Pages 479-487
Mitochondrial-Derived Oxidants and Quartz Activation of Chemokine Gene Expression....Pages 489-496
Quinoids as Reactive Intermediates in Estrogen Carcinogenesis....Pages 497-507
Assessing Underlying Mechanisms of Quinoid-Induced Hematopoietic Cell Toxicity....Pages 509-512
Structure of the Malondialdehyde Deoxyguanosine Adduct M 1 G When Placed Opposite a Two-Base Deletion in the (CpG) 3 Frameshift Hotspot of the Salmonella Typhimurium hisd3052 Gene....Pages 513-516
A Sensitive Procedure for the Determination of Protein Bound 3,4-Dihydroxyphenyl-Alanine as a Marker for Posttranslational Protein Hydroxylation in Human Frontal Cortex, Liver, and Red Blood Cells....Pages 517-519
Reactive Metabolite Screen for Reducing Candidate Attrition in Drug Discovery....Pages 521-524
Metabolism of R,S Enantiomers of 3-Phenylamino-1,2-Propanediol, a Compound Associated with the Toxic Oil Syndrome, in C57BL/6- and A/J-Strain Mice....Pages 525-529
Cytochrome P450-Catalysed Irreversible Binding Examined in Precision-Cut Adrenal Slice Culture....Pages 531-534
Elevation of Glutathione Levels by Coffee Components and Its Potential Mechanisms....Pages 535-539
Inhibition of Carcinogenesis and Toxicity by Dietary Constituents....Pages 541-550
Modelling the Responses to Biological Reactive Intermediates....Pages 551-558
Interindividual Differences in Response to Chemoprotection Against Aflatoxin-Induced Hepatocarcinogenesis: Implications for Human Biotransformation Enzyme Polymorphisms....Pages 559-576
Sequestration of Biological Reactive Intermediates by Trapping as Covalent Enzyme-Intermediate Complex....Pages 577-586
Chemoprotection and Interindividual Differences in Response to Biological Reactive Intermediates....Pages 587-594
Oxidative Stress, Glucose-6-Phosphate Dehydrogenase and the Red Cell....Pages 595-605
Hepatocarcinogenesis in the Context of Strain Differences in Energy Metabolism Between Inbred Strains of Mice (C57BL/6J and C3H/He)....Pages 607-611
Characterization of hOGG1 Promoter Structure, Expression During Cell Cycle and Overexpression in Mammalian Cells....Pages 613-616
 hOGG1 Gene Alterations in Human Clear Cell Carcinomas of The Kidney: Effect of Single Mutations in hOGG1 Gene on Substrate Specificity of The hOgg1 Protein....Pages 617-620
Proinflammatory Cytokines mRNA Expression in Dependence of Suppressive Epitope of Retroviral Transmembrane p15E Peptide Activation at Multiple Sclerosis Patients....Pages 621-624
Determination of Nucleotide Excision Repair Capacity of Liver Cells in Vivo and in Vitro by a Cell-Free Assay....Pages 625-628
Dietary Induction of Phase II Enzymes: A Promising Strategy for Protection Against DNA-Reactive Intermediates in Man?....Pages 629-633
Concurrent Flavin-Containing Monooxygenase Down Regulation and Cytochrome P450 Induction by Dietary Indoles in the Rat: Implication for Drug-Drug Interactions....Pages 635-638
Reactive Intermediates in Biological Systems: What Have We Learned and Where Are We Going?....Pages 639-650
The Role of Toxicological Science in Risk Assessment and Risk Management....Pages 651-656
Covalent Binding of Chemical Residues: Health Impact....Pages 657-661
Identification of Hepatic Protein Targets of the Reactive Metabolites of the Non-hepatotoxic Regioisomer of Acetaminophen, 3’-Hydroxyacetanilide, in the Mouse in Vivo Using Two-Dimensional Gel Electrophoresis and Mass Spectrometry....Pages 663-673
Exocyclic DNA Adducts as Secondary Markers for Oxidative Stress: Applications in Human Cancer Etiology and Risk Assessment....Pages 675-686
Dose Dependent Induction of DNA Adducts, Gene Mutations, and Cell Proliferation by the Antiandrogenic Drug Cyproterone Acetate in Rat Liver....Pages 687-696
Dose-Dependent Differences in the Profile of Mutations Induced by Carcinogenic ( R,S,S,R ) Bay-and Fjord-Region Diol Epoxides of Polycyclic Aromatic Hydrocarbons....Pages 697-707
Nucleic Acid Microarray Technology For Toxicology: Promise And Practicalities....Pages 709-714
Use of Covalent Binding in Risk Assessment....Pages 715-722
Back Matter....Pages 723-728