Biochemistry of S-Adenosylmethionine and Related Compounds: Proceedings of a Conference held at the Lake of the Ozarks (Missouri) on October 26–29, 1981

Front Matter....Pages i-xx
Front Matter....Pages 1-1
S-Adenosylamino Acids Thirty Years Later: 1951–1981....Pages 3-10
Front Matter....Pages 11-11
Biological function and mechanism of cytochrome c methylation....Pages 13-22
Turnover in methyl groups in histones....Pages 23-29
Inhibition of protein carboxyl methyl esterification by 5’-methylthioadenosine....Pages 31-37
The protein-carboxyl methylating-demethylating system: Modulation of protein function....Pages 39-48
Protein carboxymethylation in murine neuroblastoma; Effect of methyltransferase inhibitors....Pages 49-53
Carboxylmethylation of rat pancreatic acinar cell zymogen granule membrane proteins....Pages 55-64
Why is ribosomal protein L11 of Escherichia coli methylated?....Pages 65-70
The complex nature of methyl-accepting chemotaxis proteins of enteric bacteria....Pages 71-74
Regulation of the level of methylation of a protein involved in bacterial chemotaxis....Pages 75-78
Methylation of receptors in chemotaxis of bacteria....Pages 79-82
Front Matter....Pages 83-90
Overviews on phospholipid methylation....Pages 91-98
The conversion of phosphatidylethanolamine to phosphatidylcholine in animal cells....Pages 99-106
Conversion of phosphatidylethanolamine to phosphatidylcholine by the methylation pathway in brain, and relation with the membrane structure....Pages 107-107
Partial purification and properties of phosphatidylethanolamine methyltransferase system from mouse liver microsomes....Pages 109-117
Deacylation-reacylation and membrane phospholipid methylation....Pages 119-128
The pharmacological inhibition of phospholipid methylation....Pages 129-138
Front Matter....Pages 139-142
Phospholipid methylation and cholinergic neurons....Pages 143-147
The effects of methylation inhibitors on depolarization-dependent exocytosis, phospholipid methylation, and protein carboxymethylation in clonal pheochromocytoma cells....Pages 149-153
An activation mechanism of platelet phospholipases....Pages 107-107
Receptor mediated regulation of phospholipid methyltransferase activity....Pages 155-164
Inhibition of norepinephrine uptake by inhibitors of methylation....Pages 165-172
Rat basophilic leukemia cell lines defective in phospholipid methyltransferase enzymes: Reconstitution by hybridization of IgE-mediated Ca2+ influx, phospholipid methylation and histamine release....Pages 173-185
Front Matter....Pages 187-194
On the stability of DNA substituted with 5-azacytosine....Pages 195-198
Mechanism of inhibition of DNA methyltransferase by 5-azacytosine substituted DNA....Pages 199-202
Effects of xylosyladenine and other inhibitors of methylation on induction of murine erythroleukemia cells....Pages 203-203
The mechanism of DNA methylation by the restriction endonuclease from E. coli K.....Pages 205-212
Organization of the trmD gene in E.coli K12....Pages 213-221
Methylation at specific sites in integrated adenovirus DNA plays a role in gene regulation....Pages 223-230
Effect of DNA methylation in vitro on the expression of SV40 and VSPV....Pages 231-238
Effect of N6-methyladenine (m6A) content in DNA on spontaneous reversion in non-glucosylated phage T2 gt—: Evidence for base analog mutagen activity....Pages 239-247
Inhibitory model of methylation in carcinogen modified DNA....Pages 249-253
The effect of the chronic administration of liver carcinogens and tumor promoters on the hepatic levels of S-adenosylmethionine in rats....Pages 255-258
Front Matter....Pages 259-265
Effects of cycloleucine on mitochondrial RNA....Pages 267-273
Effect of dimethylation of two adjacent adenines on the structure of 16S RNA....Pages 275-278
Front Matter....Pages 279-282
Ribosomal RNA methylation and resistance to the antibiotic thiostrepton....Pages 283-286
Methylation of snRNAs and 18S rRNA of Novikoff heptoma....Pages 287-287
Small RNPs in eucaryotic cells....Pages 289-296
Messenger RNA methylation in plants....Pages 297-301
Partial purification of the mRNA (guanine-7-) methyltransferase from wheat germ....Pages 287-287
Wheat germ mRNA capping and methylating enzymes....Pages 303-307
Evidence for a role of methylation in the processing of avian retrovirus RNA....Pages 309-312
Front Matter....Pages 313-320
tRNA methylation: On the role of modified nucleosides in transfer-RNA....Pages 321-328
Formation and function of modified nucleosides in bacterial transfer RNA....Pages 329-336
A study of the kinetic mechanisms of two enzymes involved in the metabolism of adenosylmethionine....Pages 337-340
The ribothymidine content of mammalian elongator tRNAs modulates ternary complex ribosomal A site binding....Pages 341-344
Studies of transfer RNA methylation in cell transformation....Pages 345-353
Genetic control of tRNA methylation in inbred mice....Pages 203-203
Methyl-accepting tRNA from mammary tumors....Pages 357-369
Modified nucleosides from transfer ribonucleic acid as tumor markers....Pages 371-378
Methylene-tetrahydrofolate dependent biosynthesis of ribothymidine in transfer-RNA....Pages 379-384
Front Matter....Pages 385-388
Methylation of small molecules; An overview....Pages 389-397
Norepinephrine N-methyltransferase in brain....Pages 399-403
Front Matter....Pages 405-408
Biochemical consequences of adrenal phenylethanolamine N-methyltransferase (PNMT) inhibition....Pages 409-412
Conformational aspects of binding of substrates and inhibitors of phenylethanolamine N-methyltransferase (PNMT)....Pages 413-415
The use of phenylethanolamine N-methyltransferase inhibitors in elucidating the role of brain epinephrine in the control of cardiovascular function....Pages 417-424
Regulatory aspects of S-adenosylmethionine in the periphery and CNS....Pages 425-425
Aryl N-methyltransferase: Ring methylation of tryptamine....Pages 427-436
Enzymatic O-methylation of norepinephrine: Studies on the site of methylation by high pressure liquid chromatography....Pages 437-444
Relationships between the cellular localization and the physiological function of catechol-O-methyltransferase....Pages 425-425
Immunocytochemical localization of catechol-O-methyltransferase in normal and cancerous breast tissues....Pages 445-452
Implications of SAM in estrogen metabolism....Pages 453-456
Genetic, cellular, and biochemical analyses of the yeast Δ24-sterol methyltransferase....Pages 457-460
Methylation of nonpolar lipids: Identification and characterization....Pages 461-467
Front Matter....Pages 469-472
Alkyltransferases: Mechanistic studies and mechanism-based specific inhibitors....Pages 473-477
Critical factors in the catalysis of transmethylation....Pages 479-486
Further stereochemical studies on methyl transfer reactions....Pages 487-489
Front Matter....Pages 491-498
Biosynthesis and accumulation of decarboxylated S-adenosylmethionine....Pages 499-507
Aspects of polyamine metabolism in relationship to S-adenosylmethionine metabolism revealed by the use of α-difluoromethylornithine, an effective inhibitor of putrescine biosynthesis....Pages 509-512
Polyamine synthesis and metabolism in normal and virus-infected protoplasts and chloroplasts....Pages 513-520
The biosynthesis of spermidine as a key regulatory step in the hormonal induction of milk-protein synthesis in the organ culture of the mouse mammary gland....Pages 521-521
Alterations in methylation affect polyamine biosynthesis in mouse brain....Pages 523-532
Front Matter....Pages 533-537
Regulation of S-adenosylmethionine and S-adenosylhomocysteine levels in isolated rat liver....Pages 539-544
Adenosylmethionine metabolism in mammalian spermatozoa....Pages 545-545
Metabolism of exogenously administered SAM....Pages 547-555
Interactions of adenosylmethionine with methylenetetrahydrofolate reductase....Pages 557-565
1-Amino-1-cyclopropanecarboxylic acid synthase, a unique SAM-utilizing enzyme....Pages 567-575
Concerning the nonspecificity of methylation inhibitors....Pages 577-580
Recent results on biological activities of natural and synthetic analogues of S-adenosylhomocysteine....Pages 581-591
Adenosine dialdehyde: A potent inhibitor of S-adenosylhomocysteine hydrolase....Pages 593-593
Inhibition of Rous, sarcoma virus medicated cellular transformation by analogues of S-adenosyl-L-homocysteine....Pages 595-602
Inactivation of S-adenosylhomocysteine hydrolase: Mechanism and occurrence in vivo in disorders of purine nucleoside catabolism....Pages 603-611
Inactivation of S-adenosylhomocysteine hydrolase by 9-β-D-arabinofuranosyladenine (ara-A) in intact cells....Pages 613-616
Selection of mutant murine lymphoid cells partially deficient in S-adenosylhomocysteine hydrolase....Pages 617-620
Hypermethylation in the MSO-epileptogenic brain: Reversal by dilantin or phenobarbital....Pages 621-625
Binding of S-adenosylhomocysteine to isolated rat hepatocytes and purified plasma membranes from rat liver....Pages 627-636
Differential properties and regulation of methionine adenosyltransferase isoforms from the rat....Pages 637-644
Alterations in the substrate specificities of tumor-derived methionine adenosyltransferase isozymes....Pages 645-652
Front Matter....Pages 653-656
Regulation of cell growth by 5’-methylthioadenosine....Pages 657-665
Transport of 5’-methylthioadenosine in human erythrocytes....Pages 667-670
5’-methylthioadenosine phosphorylase as a chemotherapeutic target enzyme....Pages 671-674
The importance of methylthioadenosine phosphorylase deficiency in human malignancy....Pages 675-678
Front Matter....Pages 679-682
Methylthioribose as a precursor of the carbon chain of methionine....Pages 683-686
Methionine synthesis from 5’-methylthioadenosine in rat liver....Pages 687-690
Back Matter....Pages 691-691
....Pages 693-700