Biochemistry of Chemical Carcinogenesis

Front Matter....Pages i-ix
Chemical Carcinogenesis and the Primary Prevention of Human Cancer....Pages 1-12
Metabolism of Chemical Carcinogens....Pages 13-24
Mechanisms of Chemical Carcinogenesis....Pages 25-35
Chemical Carcinogens Present in Nigerian (African) Foods and Drinks....Pages 37-43
Conversion Induced by Transforming Growth Factors α and β: The Role of “Wound Hormones” in Multistage Skin Carcinogenesis....Pages 45-53
Arachidonic Acid Metabolites as Endogeneous Mediators of Chromosomal Alterations and Tumor Development in Mouse Skin in Vivo ....Pages 55-64
Studies on the Mechanism of Conversion Effected by the Tumor Promoter TPA....Pages 65-73
Genotoxic Effect of Naturally Occurring and Cooked-Food-Related Mutagens....Pages 75-79
Biochemsistry of DNA Repair Patch Synthesis in UV-Irradiated Permeable Diploid Human Fibroblasts....Pages 81-88
Interactions of Carcinogens with Nucleic Acids....Pages 89-98
The Induction of Alkali Labile Sites in DNA of CHO Cells by Methyl Methan-Sulphonate and Dimethylsulfate and Its Relationship to the Inhibition of of Nascent DNA Chain Elongation....Pages 99-104
Functional Significance of Ribonucleic Acids Modified by Chemical Carcinogens: A Review....Pages 105-115
Evaluation of Carcinogenic and Non-Carcinogenic Metal Compounds by Their Interference in the Renaturation of Highly Polymerized DNA and Their Activation by Microsomes....Pages 117-123
Chemical Carcinogens and Oncogenes....Pages 125-134
 Ras P21 Level and Tyrosine Kinase Activity during Carcinogenesis of Human Colon Tumors....Pages 135-144
Utilization of Initiator Transfer Ribonucleic Acid Modified by Carcinogens Cholesteryl 14-Methylhexadecanoate and N -Methyl- N -Nitrosourea for Cell-Free Protein Synthesis....Pages 145-154
Effect of Thiram on Cytochrome P-450 Studied by the Cypia-Test....Pages 155-158
Translocation of Phosphatidate Phosphohydrolase from the Cytosol to Microsomal Membranes is Increased in Experimental Liver Tumors....Pages 159-166
Induction of Hepatoma in Seven-Day-Old C57BL/6 Mice with a Single dose of Aflatoxin and the Influence of Diethyldithiocarbamate....Pages 167-174
Inhibition of Chemical Carcinogenesis....Pages 175-182
Cremoprevention and Reduction of Cancer Risks Caused by Nitrosatable Drugs....Pages 183-188
Influence of Dietary Constituents in Chemical Carcinogenesis in Rats....Pages 189-201
Liver Glutamate and Glutamine Concentration in Hepatocarcinogenesis Experimental: Effect of Glutathione....Pages 203-209
Modification of Nitrosamine Carcinogenesis by Ascorbic Acid....Pages 211-218
Genetic Damage in Peripheral Lymphocytes of Chronic Alcoholics....Pages 219-226
Biochemical Markers of Cell Heterogeneity in Rat Mammary Tumors Induced by 7,12-Dimethylbenzanthracene (DMBA) and N-Methyl-N-Nitrosuorea (MNU)....Pages 227-233
Fate of Glutathione, Related Enzyme Activities and in Vitro Lymphocyte Transformation in Patients with Bronchial Carcinoma....Pages 235-241
Tumor Markers in Bronchioalveolar Lavage....Pages 243-247
Phosphorylation and Dephosphorylation of the Cytochrome P-450-Dependent Monooxygenase System: Regulatory Devices by Posttranslational Modification....Pages 249-255
Effect of S-Adenosyl-L-Methionine on Serum Lipoprotein in Experimental Hepatic Carcinogenesis....Pages 257-266
Back Matter....Pages 267-267