Bio-orthopaedics: A New Approach

Front Matter....Pages i-xix
Front Matter....Pages 1-1
The Optimization of Natural Healing....Pages 3-24
Overview of Orthobiology and Biomechanics....Pages 25-40
Education and Understanding Orthobiologics: Then and Now....Pages 41-46
Orthobiologics: Regulation in Different Parts of the World....Pages 47-63
Tissue Engineering and New Biomaterials....Pages 65-70
Physiology and Homeostasis of Musculoskeletal Structures, Injury Response, Healing Process, and Regenerative Medicine Approaches....Pages 71-85
Host Environment: Scaffolds and Signaling (Tissue Engineering) Articular Cartilage Regeneration: Cells, Scaffolds, and Growth Factors....Pages 87-103
Current State for Clinical Use of Stem Cells and Platelet-Rich Plasma....Pages 105-124
Xenografts: Biologic Combination Devices....Pages 125-133
Orthopedic Sports Disorders: Genetic and Molecular Aspects....Pages 135-138
Cell-Free Scaffolds for the Treatment of Chondral and Osteochondral Lesions....Pages 139-149
Understanding Scaffolds, Stem Cells, and Growth Factors....Pages 151-159
Cell Culture Approaches for Articular Cartilage: Repair and Regeneration....Pages 161-172
Gene Therapy....Pages 173-183
The Use of a Large Animal Model and Robotic Technology to Validate New Biotherapies for ACL Healing....Pages 185-196
Use of Stem Cells in Orthopaedics....Pages 197-204
Stem Cells in Joint Repair....Pages 205-211
Front Matter....Pages 213-213
Shoulder Muscle Architecture, Physiology, and Plasticity....Pages 215-225
Emerging Biological Approaches to Muscle Injuries....Pages 227-238
The Use of PRP in Athletes with Muscular Lesions or Classification of PRP Preparations....Pages 239-245
Front Matter....Pages 247-247
Basic Science of Tendons....Pages 249-273
Emerging Orthobiologic Approaches to Tendon Injuries....Pages 275-288
Front Matter....Pages 289-289
Ligament Histology, Composition, Anatomy, Injury, and Healing Mechanisms....Pages 291-312
Emerging Orthobiologic Approaches to Ligament Injury....Pages 313-324
Biological Augmentation in Acute ACL Repair....Pages 325-335
Front Matter....Pages 337-337
Current Concepts in Natural History of Meniscal Injury and Future Options in Meniscus Healing: Orthobiologics....Pages 339-353
Meniscus Scaffolds: Past, Present, and Future....Pages 355-362
Meniscus Restoration....Pages 363-373
Meniscus Scaffolds: 30 Years of Experience....Pages 375-388
Clinical Use of the Meniscal Scaffold....Pages 389-397
Scaffolds for Meniscus Regeneration....Pages 399-410
Building the Basis for Patient-Specific Meniscal Scaffolds....Pages 411-418
3D-Printed Artificial Meniscus....Pages 419-433
Front Matter....Pages 435-435
Bone Anatomy and the Biologic Healing Process of a Fracture....Pages 437-447
Clinical Orthobiologic Approach to Failure or Delay in Bone Healing....Pages 449-459
Avascular Necrosis of the Hip....Pages 461-472
Emerging Orthobiologic Approach to Fractures....Pages 473-478
Subchondral Bone: Healthy Soil for the Healthy Cartilage....Pages 479-486
Front Matter....Pages 487-487
Osteochondritis Dissecans: Pathoanatomy, Classification, and Advances in Biologic Surgical Treatment....Pages 489-501
Clinical Orthobiological Approach to Acute Cartilage Injury: Pros and Cons....Pages 503-515
Front Matter....Pages 487-487
Biologic Knee Arthroplasty for Cartilage Injury and Early Osteoarthritis....Pages 517-525
Bilayer Collagen Membrane in Articular Cartilage Defect Repair....Pages 527-536
Scaffold-Free Stem Cell-Based Tissue Engineering to Repair Cartilage and Its Potential Application to Other Musculoskeletal Tissues....Pages 537-551
Clinical Applications of Adipose Tissue-Derived Stem Cells....Pages 553-559
Orthokine....Pages 561-569
Joint Congruence Restoration in Osteochondral Defects: The Use of Mesenchymal Stem Cells with the “Sandwich” Technique....Pages 571-585
Biological Reconstruction in Patients with Osteochondral Defects: Postoperative Management and MRI Monitoring....Pages 587-598
The Role of Biological Treatments in Spine Disorders....Pages 599-618
Cell Culture Methods....Pages 619-635
Evolving Perspectives in Orthobiologic Approaches to Articular Cartilage Regeneration....Pages 637-649
Comprehensive Approach to Patellofemoral Chondral Lesion Treatments....Pages 651-663
Partial Anterior Cruciate Ligament Lesions: A Biological Approach to Repair....Pages 665-670
Osteochondral Repair Using a Hybrid Implant Composed of Stem Cells and Biomaterial....Pages 671-682
Back Matter....Pages 683-696