Bayesian Applications in Pharmaceutical Development

Preface
1. Introduction
2. Incorporation of Historical Control Data in Analysis of Clinical Trials
3. Practical considerations for building priors for confirmatory studies
4. The Practice of Prior Elicitation
5. Bayesian examples in preclinical in-vivo research
6. Planning a model-based Bayesian dose response study
7. Novel Designs for Early Phase Drug Combination Trials
8. Executing and Reporting Clinical Trial Simulations: Practical Recommendations for Best Practices
9. Reporting of Bayesian Analyses in Clinical Research: Some Recommendations
10. Handling missing data in clinical trials with Bayesian and Frequentist Approaches
11. Bayesian Applications in Pharmaceutical Development
12. Simulation for Bayesian Adaptive Designs – Step-by-Step Guide for Developing the Necessary R Code
13. Power Priors for Sample Size Determination in the Process Validation Life-Cycle
14. Bayesian Approaches in the Regulation of Medical Products
15. Computational tools
16. Software for Bayesian Computation - An Overview of Some Currently Available Tools
17. Considerations and Bayesian Applications in Pharmaceutical Development for Rare Diseases
18. Extrapolation Process in Pediatric Drug Development and Corresponding Bayesian Implementation for Validating Clinical Efficacy
19. BM- Appendix: A Brief Guide to Bayesian Model Checking