Basic Immunology Functions and Disorders of the Immune System

Front Cover
Title page
Copyright page
PREFACE
Table of contents
Chapter 1: INTRODUCTION TO THE IMMUNE SYSTEM
	Innate and Adaptive Immunity
	Types of Adaptive Immunity
	Properties of Adaptive Immune Responses
	Cells of the Immune System
	Tissues of the Immune System
	Overview of Immune Responses to Microbes
	SUMMARY
Chapter 2: INNATE IMMUNITY
	Recognition of Microbes by the Innate Immune System
	Components of Innate Immunity
	Evasion of Innate Immunity by Microbes
	Role of Innate Immunity in Stimulating Adaptive Immune Responses
	SUMMARY
Chapter 3: ANTIGEN CAPTURE AND PRESENTATION TO LYMPHOCYTES
	Antigens Recognized by T Lymphocytes
	Capture of Protein Antigens by Antigen-Presenting Cells
	The Structure and Function of Major Histocompatibility Complex Molecules
	Processing and Presentation of Protein Antigens
	Antigens Recognized by B Cells and Other Lymphocytes
	SUMMARY
Chapter 4: ANTIGEN RECOGNITION IN THE ADAPTIVE IMMUNE SYSTEM
	Antigen Receptors of Lymphocytes
	Development of Immune Repertoires
	SUMMARY
Chapter 5: CELL-MEDIATED IMMUNE RESPONSES
	Phases of T Cell Responses
	Antigen Recognition and Costimulation
	Biochemical Pathways of T Cell Activation
	Functional Responses of T Lymphocytes to Antigen and Costimulation
	SUMMARY
Chapter 6: EFFECTOR MECHANISMS OF CELL-MEDIATED IMMUNITY
	Types of Cell-Mediated Immunity
	Migration of Effector T Lymphocytes to Sites of Infection
	Effector Functions of CD4+ Helper T Lymphocytes
	Effector Functions of CD8+ Cytotoxic T Lymphocytes
	Resistance of Pathogenic Microbes to Cell-Mediated Immunity
	SUMMARY
Chapter 7: HUMORAL IMMUNE RESPONSES
	Phases and Types of Humoral Immune Responses
	Stimulation of B Lymphocytes by Antigen
	The Function of Helper T Lymphocytes in Humoral Immune Responses to Protein Antigens
	Antibody Responses to T-Independent Antigens
	Regulation of Humoral Immune Responses: Antibody Feedback
	SUMMARY
Chapter 8: EFFECTOR MECHANISMS OF HUMORAL IMMUNITY
	Properties of Antibodies That Determine Their Effector Functions
	Neutralization of Microbes and Microbial Toxins
	Opsonization and Phagocytosis
	Antibody-Dependent Cellular Cytotoxicity
	IgE- and Eosinophil/Mast Cell–Mediated Reactions
	Activation of the Complement System
	Functions of Antibodies at Special Anatomic Sites
	Evasion of Humoral Immunity by Microbes
	Vaccination
	SUMMARY
Chapter 9: IMMUNOLOGICAL TOLERANCE AND AUTOIMMUNITY
	Immunological Tolerance: Significance and Mechanisms
	Central T Lymphocyte Tolerance
	Peripheral T Lymphocyte Tolerance
	B Lymphocyte Tolerance
	Autoimmunity: Principles and Pathogenesis
	Genetic Factors in Autoimmunity
	Role of Infections in Autoimmunity
	SUMMARY
Chapter 10: IMMUNE RESPONSES AGAINST TUMORS AND TRANSPLANTS
	Immune Responses against Tumors
	Immune Responses against Transplants
	SUMMARY
Chapter 11: HYPERSENSITIVITY
	Types of Hypersensitivity Reactions
	Immediate Hypersensitivity
	Diseases Caused by Antibodies and Antigen-Antibody Complexes
	Diseases Caused by T Lymphocytes
	SUMMARY
Chapter 12: CONGENITAL AND ACQUIRED IMMUNODEFICIENCIES
	Congenital (Primary) Immunodeficiencies
	Acquired (Secondary) Immunodeficiencies
	Acquired Immunodeficiency Syndrome
	SUMMARY
SUGGESTED READINGS
AppendixI: GLOSSARY
AppendixII: PRINCIPAL FEATURES OF CD MOLECULES
AppendixIII: CLINICAL CASES
INDEX