Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases: Volume 1

Front Matter....Pages i-xxi
Functional Principles Implied in Neurological Symptoms....Pages 1-5
The Neurobiology of Alzheimer’s Disease....Pages 7-12
Role of Brain Monoamines and Other Neurotransmitters in Normal and Pathological Aging....Pages 13-18
Molecular Genetics of Alzheimer’s Disease....Pages 19-22
Proteins and Proteolysis in the Pathogenesis of Alzheimer’s Disease....Pages 23-27
Amyloid β Protein Precursors having Proteinase Inhibitor Regions are Highly Expressed in Alzheimer’s Disease Brains....Pages 29-35
Differential Expression of Three Types of Amyloid Protein Precursor mRNA in Alzheimer’s Disease Brain....Pages 37-40
Protease Inhibitor and Cholinergic System in Alzheimer’s Disease....Pages 41-46
Structure and Expression of mRNA for the Mouse Homolog of Alzheimer Amyloid Beta Protein Precursor....Pages 47-50
Molecular Cloning and Structural Analysis of the Human Amyloid ß Protein Precursor Gene....Pages 51-53
Protease Nexin 1 Immunoreactivity in Senile Plaques in Alzheimer Disease and Aged Brain....Pages 55-58
Monoclonal Antibodies Against Senile Plaque Amyloid in Alzheimer’s Disease....Pages 59-63
Identification of Putative Amyloid A4-Splitting Enzymes with Two Endopeptidases Widely Distributed in Mammalian Cells....Pages 65-68
Proteolytic Processing of β-Protein Precursor-Related Synthetic Peptides....Pages 69-74
Degeneration of Neuronal Processes in Rats Induced by the Protease Inhibitor Leupeptin....Pages 75-78
 α 1-Antichymotrypsin Influences the Survival of Neurons....Pages 79-82
Evidence for a Neuronal Origin of Senile Plaques in Down’s Syndrome Brains....Pages 83-86
Serum Amyloid P Immunoreactivity in Cortical Tangles, Plaques and Vessels in Alzheimer’s Disease: Implications for Dysfunction of the Blood-Brain Barrier?....Pages 87-90
Monoamine Oxidase B Activity in Senile Plaque....Pages 91-94
Light and Electron Microscopic Observations of Diffuse Plaque and Its Related Conditions....Pages 95-99
β-Amyloid Plaques and Dementia: An Immunohistochemical Study....Pages 101-105
Diagnosis of Cerebral Amyloid Angiopathy with Cerebral Hemorrhage by Enzyme-Linked Immunosorbent Assay (ELISA) of Cystatin C in Cerebrospinal Fluid....Pages 107-110
Cystatin C (γ-Trace) and β-Protein Coexist in the Cerebral Amyloid Angiopathy Causing Cerebral Hemorrhage and Consequential Vascular Dementia....Pages 111-115
The Regulation of Cytoskeletal Elements in Differentiating Human Neuroblastoma and Rat Pheochromocytoma PC-12 Cells....Pages 117-122
Some Findings on Intermediate Filaments in Alzheimer’s Disease....Pages 123-127
A Unifying Hypothesis on the Etiology of Alzheimer’s Disease....Pages 129-132
Abnormal Phospholipid Metabolism in Neurodegenerative Diseases: Elevations in Glycerophosphocholine and Glycerophospho-Ethanolamine Levels in Brain of Alzheimer’s Disease But Not in Down Syndrome Patients....Pages 133-138
Alterations in Catecholamine and Peptide Neurons in the Locus Coeruleus in Dementias of Alzheimer’s and Parkinson’s Disease....Pages 139-145
The Role of Neuronal Membranes Deterioration in The Pathogenesis of Alzheimer’s Disease: An Ultrastructural Perspective....Pages 147-152
Experimental Synaptic Degeneration as a Model for the Pathogenesis of Alzheimer’s Disease: Monoclonal Antibodies and a Protein Kinase Inhibitor Block Synapse Formation and Maintenance Between Cultured CNS Neurons....Pages 153-156
Pathobiochemical Aspects of Parkinson’s Disease and Dementia of Alzheimer Type....Pages 157-163
Characterization of Alzheimer Neurofibrillary Tangle (NFT) Epitopes and the Binding Site for the Regulatory Subunit (RII) of cAMP-Dependent Protein Kinase II in Human Microtubule-Associated Protein 2 (MAP-2)....Pages 165-168
Identification and Characterization of Modified Forms of Tau in Brains with Alzheimer’s Disease....Pages 169-172
Phosphorylation of Tau Protein with a Novel Tau Protein Kinase Forming Paired Helical Filament Epitopes on Tau....Pages 173-176
Aberration of Vimentin Array in Fibroblast from Familial Alzheimer’s Disease....Pages 177-181
Regional Phospholipid Profile of Alzheimer’s Brain....Pages 183-186
Age-Related Changes in the Rate and Composition of the Slow Axonal Transport....Pages 187-190
Astroglial Gene Expression in the Hippocampus Following Partial Deafferentation in the Rat and in Alzheimer’s Disease....Pages 191-194
Blood-Brain Barrier Disturbance in Patients with Alzheimer’s Disease is Related to Vascular Factors....Pages 195-198
An Early Change of Neurofibrillary Tangle Formation....Pages 199-201
Monoclonal Antibodies Against Paired Helical Filament in Alzheimer’s Disease and Parkinsonism-Dementia Complex of Guam....Pages 203-206
Patterns of Vulnerability of Mesostriatal Neurons....Pages 207-212
Complex I Deficiency in Parkinson’s Disease and MPTP-Induced Experimental Parkinsonism....Pages 213-218
Biochemical Reactions Leading to Parkinsonian Symptoms Elicited by MPTP....Pages 219-225
Enzymological Aspects of the Actions of the Parkinsonism-Inducing Neurotoxin MPTP....Pages 227-230
Biochemical Studies on Predisposition to Parkinson’s Disease....Pages 231-240
Parkinsoism Produced by an Endogenous Substance, Tetrahydroisoquinoline, in Monkeys and Mice....Pages 241-246
Tetrahydroisoquinoline Alkaloids in Neurodegenerative Disorders - Influence of Drug Treatment....Pages 247-252
Chronic L-Dopa Therapy in Parkinson’s Disease: Can It Accelerate Degeneration of Nigrostriatal Dopaminergic Neurons?....Pages 253-256
Iron-Melanin Interaction in Substantia Nigra as the Neurotoxic Component of Parkinson’s Disease....Pages 257-262
Dopamine Immunocytochemistry in the Nigrostriatal System of Pre- and Postnatal Mice....Pages 263-266
The Effects of N-Metyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Administration to Maternal Mice on the Catecholamine System in the Brain of Postnatal Mice....Pages 267-270
Mitochondrial Abnormalities in the Nigral Neurons of Crab-Eating Monkeys with Experimental Parkinsonism....Pages 271-274
L-DOPA-Induced Facilitation of Dopamine Release VIA Presynaptic β-Adrenoceptors in Striatal Slices from MPTP-Treated C57BL Mice: Evaluation of the Action of L-DOPA in Animal Model for Parkinsonism....Pages 275-278
Functional Alterations in Striatal Cholinergic and Striato-Nigral Gaba-Ergic Neurons Following 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Administration....Pages 279-284
Hemiparkinsonism in Monkeys After Unilateral Striatum Infusion of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)....Pages 285-288
Cyclosporin a Enhances Neurotoxicity of N-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) in Mice....Pages 289-292
Effects of Various Drugs on Behavior and Striatal Dopamine Contents in MPTP-Treated Mice Exposed to Stress....Pages 293-296
Acute Effects of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) on Body Temperature of Various Strains of Mice....Pages 297-300
Effect of MPP + and TIQ on Cultured Rat Midbrain Dopaminergic Neurons....Pages 301-304
Assay System for Neurotoxicants Causing Parkinson’s Disease: 1-Methyl-4-Phenylpyridinium Ion (MPP + ) Inhibits Survival of Cultured Neurons from Substantia Nigra of Fetal Monkey( Macaca fascicularis )....Pages 305-308
The Effect of Tetrahydroisoquinoline on the Mitochondrial Respiration....Pages 309-312
Detection of Tetrahydroisoquinoline, a Parkinsonism-Related Compound, in Parkinsonian Brains and Foods by Gas Chromatography-Mass Spectrometry....Pages 313-316
Biosynthesis of N-Methylisoquinolinium Ion, a Potent Inhibitor of Catecholamine Metabolism, from 1,2,3,4-Tetrahydroisoquinoline Through N-Methyl-1,2,3,4-Tetrahydroisoquinoline in Human Brain....Pages 317-320
Importance of 1-Methyltetrahydroisoquinoline (1MeTIQ) in Parkinson’s Disease....Pages 321-324
Formation of a Novel and Neurotoxic Tetrahydroisoquinoline Derivative, 1,3-Dimethyltetrahydroisoquinoline (1, 3DiMeTIQ), a Condensation Product of Amphetamines and Acetaldehyde in Vivo....Pages 325-328
Tryptophan Metabolites in Parkinson’s Brain....Pages 329-332
A Parallel Relationship between Parkinson’s Disease and an Excess of S-Adenosylmethionine-Dependent Biological Methylation in the Brain....Pages 333-339
Dopa and Dopamine Cause the Destruction of Cultured Nerve Cells in the Presence of Iron: Possible Mechanism of the Nigral Degeneration in Parkinson’s Disease....Pages 341-344
Food-Derived Heterocyclic Amines as Potent Inhibitors of Catecholamine Metabolism....Pages 345-348
Senile Changes in the Human Olfactory Bulbs....Pages 349-352
Large Neurons in the Neostriatum and Basal Nucleus of Meynert: Simultaneous Decrease in Alzheimer’s Disease....Pages 353-356
A Comparison of “Pure” Alzheimer’s Disease and Alzheimer’s Disease Plus Vascular Lesions (Mixed Dementia) in the Elderly....Pages 357-361
Choline Acetyltransferase and Substance P Level in Alzheimer’s Disease and Multi-Infarct Dementia....Pages 363-365
A Study on Postmortem Changes in Vasopressin mRNA in Rat Brain Using a Non-Isotopic Method....Pages 367-370
Topographical Distribution, Fine Structure of Component Fibrils, and Immunoreactivity of Neuronal Inclusions in Alzheimer’s, Parkinson’s, and Pick’s Diseases....Pages 371-375
Neuronal Loss in the Substantia Nigra and Ventral Tegmental Area in Parkinson’s Disease and Alzheimer’s Disease....Pages 377-380
Characteristics of Reactive Microglia in Alzheimer’s and Parkinson’s Disease Brain Tissue....Pages 381-384
Alzheimer - Parkinson Disease Spectrum and Diffuse Lewy Body Disease....Pages 385-390
Acetylcholinesterase Histochemical Changes in the Cerebral Cortex of Alzheimer’s Disease....Pages 391-394
Basement Membrane Components in Alzheimer’s Disease....Pages 395-399
Regulation of Cerebral Cortical and Hippocampal Blood Flow by Cholinergic Fibers Originating in the Nucleus Basalis of Meynert and Septal Complex....Pages 401-406
Immune System Reaction to Model Lesions of Rat Brain....Pages 407-410
Computer-Aided Quantitative Analysis of the Distribution of Catecholamine-Containing Fibers in the Primate Prefrontal Cortex....Pages 411-414
Nigrostriatal Loop Disruption in Parkinson’s Disease and Striatonigral Degeneration....Pages 415-418
Immunocytochemical Studies of Substance P and Met-Enkephalin in the Globus Pallidus of Progressive Supranuclear Palsy....Pages 419-422
Heterogeneous Distribution of L-DOPA Immunoreactivity in Dopaminergic Neurons of the Rat Midbrain....Pages 423-426
Cholinergic Systems in Alzheimer’s Disease, Parkinson’s Disease and Progressive Supranuclear Palsy....Pages 427-444
Neurochemical Aspects of Parkinson’s Disease and the Dementing Brain Disorders: Relation to Brain Ageing....Pages 445-452
Neuropharmacology and Functional Anatomy of the Basal Ganglia: Experimental Models for Parkinson’s and Alzheimer’s Disease....Pages 453-458
Neurotransmitter Changes in Alzheimer-Type Dementia and Therapeutic Strategies....Pages 459-464
In Vitro Experimental Approach for Determination of the Central Cholinergic Neuronal Activity....Pages 465-468
Pharmacological Profile of Brain Glucose Utilization Obtained by Monitoring of Lactate Release in Vivo under the Free Moving Condition....Pages 469-472
Behavioral and Neurochemical Evaluation of Stroke-Prone Spontaneously Hypertensive Rats for Vascular Dementia-Animal Model....Pages 473-476
Acetylcholinesterase of Cerebral Microvessels Changes in Alzheimer’s Disease....Pages 477-480
Genes of Human Catecholamine-Synthesizing Enzymes....Pages 481-486
Gene Activity and Neurodegeneration in the Extrapyramidal System: A Progress Report on Molecular and Morphological Correlates....Pages 487-490
Analysis of Dopamine and Neuropeptides in 6-OHDA-Lesioned Rats....Pages 491-494
Enhancement of in Vivo Dopamine Release from the Rat Striatum by 6R-L-Erythro-5,6,7,8-Tetrahydrobiopterin as Studied by Brain Dialysis....Pages 495-498
Preparation of Antigen and Antibody to 3-Methoxy-4-Hydroxyphenyl Glycol(MHPG)....Pages 499-502
Study of Central Putative Neurotransmitters in Rodent Models of Parkinsonism....Pages 503-507
Possible Factors Responsible for Adverse Effects of Long-Term L-Dopa Therapy: Simultaneous Determinations of Dopamine Parameters in Rats....Pages 509-511
Generating and Controlling Multiparameter Data Bases for Biochemical Correlates of Disorders....Pages 513-516
NEUBA ® : A Multicolumn, Multidetector Liquid Chromatograph with Electrochemical Detection for Use in the Identification and Determination of Neurochemicals and Related Species....Pages 517-520
Examination of Central Nervous System Effects of Amphetamine Using NEUBA ® ....Pages 521-524
Application of Multi-Dimensional Liquid Chromatography (NEUBA ® ) to the Determination of Neuronal Changes in an Organism....Pages 525-528
Patterns of Tyrosine and Tryptophan Metabolites in Controls and Various Degenerative Disorders....Pages 529-535
Dementia in Parkinson’s Disease and Central Cholinergic Function....Pages 537-542
Subtypes of Nicotinic Receptors in Human Cortex: Selective Changes in Alzheimer Disease....Pages 543-551
Alterations in Muscarinic Cholinergic Receptors and the Second Messenger System in the Cerebral Cortex in Alzheimer-Type Dementia....Pages 553-558
Expression of Nicotinic Acetylcholine Receptor mRNA in the Rat Cerebral Cortex after Lesioning of the Nucleus Basalis Magnocellularis....Pages 559-562
Studies of Central Nervous System Cholinergic Receptors in Alzheimer’s Disease (AD)....Pages 563-566
Cerebellar Excitatory Amino Acid Binding Sites are Differentially Altered in Alzheimer’s Disease....Pages 567-570
Pre- and Postsynaptic Cortical Glutamatergic Binding Sites in Alzheimer’s Disease....Pages 571-574
Reduced N-Methyl-D-Aspartate (NMDA) Receptor-Ion Channel Complex in Alzheimer’s Disease Frontal Cortex....Pages 575-578
The Influence of Priming on the Behavioral Expression of Dopamine Receptor Supersensitivity in Basal Ganglia....Pages 579-584
M1 Receptors Stimulate Dopamine Release Via Protein Kinase C in the Striatum of Freely Moving Rat Studied by Brain Dialysis....Pages 585-588
Effect of MPTP on Dopamine D 2 Receptors in the Aging Mouse Striatum....Pages 589-592
Age-Dependent Effects of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) in the Rat....Pages 593-596
More Rapid Development of Supersensitivity of D-2 Receptors than D-1 Receptors as Examined by Rotational Behavior....Pages 597-600
Features of the Dopaminergic Neurotoxicity of Methamphetamine: A Comparison with MPTP....Pages 601-604
Alteration of [ 3 H] Ins (1,4,5) P 3 and [ 3 H] PDBu Binding Sites in Brains of Patients with Parkinson’s Disease and Multiple System Atrophy....Pages 605-608
The Mechanism of Action of Nerve Growth Factor....Pages 609-613
Nerve Growth Factor Promotes Survival of Cultured Cholinergic Neurons from Nucleus Basalis of Meynert of 2-Week-Old Rats....Pages 615-618
Alterations in Nerve Growth Factor Receptor Containing Neurons in Parkinson’s Disease....Pages 619-622
A Striatal-Derived DA Neuron Growth Factor: Implication in Parkinson’s Disease....Pages 623-626
Co-Localization of Cholinergic and GABAergic Traits in in Vitro Septohippocampal Neurons from Developing Rats....Pages 627-630
A Hippocampal Cell Line Expresses a Membrane-Associated Cholinergic Trophic Activity Not Attributable to Nerve Growth Factor....Pages 631-635
Interleukin-6 as a Neurotrophic Factor for Promoting Survival of Septal Cholinergic Neurons and Mesencephalic Catecholaminergic Neurons from Postnatal Rats....Pages 637-640
Distribution of NGF Receptors in Control and Alzheimer’s Disease Basal Forebrain....Pages 641-644
Trophic Effects of Hippocampus Cell Membrane Fragments on Cultured Medial Septal Cholinergic Neurons....Pages 645-648
Changes in Basal Forebrain Cholinergic Systems Following Excitotoxic Cell Death in the Hippocampus and Cerebral Neocortex....Pages 649-654
Interleukin-3 Promotes Neurite Outgrowth and Elevates Choline Acetyltransferase Activity....Pages 655-657
Memory Impairment in Rats Induced by an Active Fragment of Nerve Growth Factor Antibody....Pages 659-662
Brain’s Calculating Principle....Pages 663-666
Screening for Psychotherapeutic Chemicals by Analysis of Conscious Activity in the Mouse....Pages 667-670
Regulation of Neocortical Electrical Activity by Cholinergic and Noradrenergic Systems....Pages 671-682
Ascending Cholinergic and Monoaminergic Systems in the Brainstem: Do they Constitute a Reticular Activating System?....Pages 683-687
Role of the Medial Limbic System in the Memory Process: A Hypothesis Based on a Radioactive 2-Deoxyglucose Study....Pages 689-692
Effect of Magnetism on Learning Function....Pages 693-696
Morphological Changes of the Brain in Senescence Accelerated Mouse (SAM)-P/8, a Newly Developed Memory-Deficient Strain....Pages 697-700
Age-Related Changes in Blood-Brain Barrier ( BBB )....Pages 701-703
Effect of Aging on NADPH-Diaphorase Neurons in Laterodorsal Tegmental Nucleus and Striatum of Senescence Accelerated Mouse (SAM)....Pages 705-709
Senescence-Accelerated Mouse SAM-P/8 Shows Spontaneous Age-Related Impairment of Ability of Acquisition of Learning and Memory: An Animal Model of Disturbances in Recent Memory with Aging....Pages 711-714
An Experimental Animal Model for the Study of Cholinergic and Serotonergic Neuronal Activity in Aging Brain....Pages 715-719
Aging Effects on Schedule-Control Discrimination Learning Test in Aged Rats as a Model of Alzheimer’s Disease....Pages 721-724
Effect of the Basal Forebrain Lesions on Memory and Learning Performance in Mice....Pages 725-728
Effects of Destruction of Nucleus Basalis Meynert on Operant Study and Neurotransmitters in Rats....Pages 729-733
Characteristic of Learning Deficit Induced by Ibotenic Acid Lesion of the Frontal Cortex Related with the Nucleus Basalis of Meynert in Rats....Pages 735-738
A New Animal Model of Alzheimer’s Disease by Selective Destruction of the Cholinergic Neurons in the Basal Forebrain....Pages 739-742
Impairment of Avoidance Behavior Produced by Destruction of the Cholinergic Projection from the Pedunculopontine Nucleus to the Medial Thalamus....Pages 743-747
Impaired Spatial Learning in Rats with a Trimethyltin-Induced Hippocampal Lesion and the Effect of Fetal Septal Grafting on the Impairment....Pages 749-752
Some Effects of CNS Cholinergic Neurons on Memory and ACh Release....Pages 753-756
Carbon Monoxide (CO)-Induced Delayed Amnesia and Delayed Neuronal Death....Pages 757-760
Modifications in the Levels of Antibodies in the CSF of Parkinson’s Disease Patients Following Adrenal-to-Brain Transplantation....Pages 761-764
Autotransplantation of Parasympathetic Cholinergic Neurons into Alzheimer Model Rat Brain....Pages 765-768
Use of MPTP-Hemiparkinsonian (HP) Monkeys to Evaluate Efficacy of Tissue Implants as a Treatment for Parkinson’s Disease....Pages 769-775
Autotransplantation of Sympathetic Ganglion into the Brain of Parkinsonian Monkey....Pages 777-780
Long-Term Survival of Grafted Cells, Dopamine Synthesis/Release, Receptor Activity, and Functional Recovery after Grafting of Fetal Nigral Cells in Model Animals of Hemi-Parkinson’s Disease....Pages 781-784
Intra-Accumbens Dopaminergic Grafts Restore Methamphetamine-Induced Locomotor Hyperactivity Response and the Release and Metabolism of Dopamine in Rats Having 6-OHDA Lesions in the Ventral Tegmental Area....Pages 785-788
Investigation of MHC Antigens on Neural Graft in Mouse Parkinson’s Models....Pages 789-793
Back Matter....Pages 795-808