Base Excision Repair

Content: 
Preface
Pages xv-xvi
Sankar Mitra, R Stephen Lloyd, Priscilla K Cooper, Samuel H Wilson

Keynote: Past, present, and future aspects of base excision repair Review Article
Pages xvii-xxx
Thomas Lindahl

Session 1 multiple pathways for DNA base excision repair
Page 1
Eugenia Dogliotti

The mechanism of switching among multiple BER pathways Original Research Article
Pages 3-27
Eugenia Dogliotti, Paola Fortini, Barbara Pascucci, Eleonora Parlanti

Yeast base excision repair: Interconnections and networks Review Article
Pages 29-39
Paul W Doetsch, Natalie J Morey, Rebecca L Swanson, Sue Jinks-Robertson

BER, MGMT, and MMR in defense against alkylation-induced genotoxicity and apoptosis Review Article
Pages 41-54
Bernd Kaina, Kirsten Ochs, Sabine Grösch, Gerhard Frizz, Jochen Lips, Maja Tomicic, Torsten Dunkern, Markus Christmann

Session 2 gene targeting in the mouse for elucidating the role of BER
Page 55
Samuel H Wilson

Mammalian DNA β-polymerase in base excision repair of alkylation damage Review Article
Pages 57-74
Robert W Sobol, Samuel H Wilson

Regulation of intracellular localization of human MTH1, OGG1, and MYH proteins for repair of oxidative DNA damage Review Article
Pages 75-94
Yusaku Nakabeppu

Repair of 8-oxoguanine and oggl-incised apurinic sites in a CHO cell line Review Article
Pages 95-105
Serge Boiteux, Florence Le Page

Mammalian Ogg1/Mmh gene plays a major role in repair of the 8-hydroxyguanine lesion in DNA Review Article
Pages 107-123
Susumu Nishimura

Session 3 Complexities of BER
Pages 125-127
Michael Weinfeld

Molecular mechanism of PCNA-dependent base excision repair Review Article
Pages 129-138
Yoshihiro Matsumoto

Factors influencing the removal of thymine glycol from DNA in γ-irradiated human cells Review Article
Pages 139-149
Michael Weinfeld, James Z Xing, Jane Lee, Steven A Leadon, Priscilla K Cooper, X.Chris Le

Completion of base excision repair by mammalian DNA ligases Review Article
Pages 151-164
Alan E Tomkinson, Ling Chen, Zhiwan Dong, John B Leppard, David S Levin, Zachary B Mackey, Teresa A Motycka

Uracil-initiated base excision DNA repair synthesis fidelity in human colon adenocarcinoma loVo and Escherichia coli cell extracts Review Article
Pages 165-188
Russell J Sanderson, Samuel E Bennett, Jung-Suk Sung, Dale W Mosbaugh

Session 4 DNA glycosylases: Specificity and mechanisms
Pages 189-192
Sankar Mitra

Multiple DNA glycosylases for repair of 8-oxoguanine and their potential in Vivo functions Review Article
Pages 193-205
Tapas K Hazra, Jeff W Hill, Tadahide Izumi, Sankar Mitra

DNA substrates containing defined oxidative base lesions and their application to study substrate specificities of base excision repair enzymes Review Article
Pages 207-221
Hiroshi Ide

Mechanism of action of Escherichia coli formamidopyrimidine N-glycosylase: Role of K155 in substrate binding and product release Review Article
Pages 223-234
Lois Rabow, Radhika Venkataraman, Yoke W Kow

Thymine DNA glycosylase Review Article
Pages 235-253
Ulrike Hardeland, Marl Bentele, Teresa Lettieri, Roland Steinacher, Josef Jiricny, Primo Schär

Session 5 Mitochondrial DNA repair
Pages 255-256
Vilhelm A Bohr

Enzymology of mitochondrial base excision repair Review Article
Pages 257-271
Daniel F Bogenhagen, Kevin G Pinz, Romina M Perez-Jannotti

Base excision repair of mitochondrial DNA damage in mammalian cells Review Article
Pages 273-284
S.P Ledoux, G.L Wilson

Base excision repair in nuclear and mitochondrial DNA Review Article
Pages 285-297
Grigory L Dianov, Nadja Souza-Pinto, Simon G Nyaga, Tanja Thybo, Tinna Stevnsner, Vilhelm A Bohr

Session 6 structural implications of BER enzymes: Dragons dancing—The structural biology of DNA base excision repair
Pages 299-304
John A Tainer

Crystallizing thoughts about DNA base excision repair Review Article
Pages 305-314
Thomas Hollis, Albert Lau, Tom Ellenberger

DNA damage recognition and repair pathway coordination revealed by the structural biochemistry of DNA repair enzymes Review Article
Pages 315-347
David J Hosfield, Douglas S Daniels, Clifford D Mol, Christopher D Putnam, Sudip S Parikh, John A Tainer

Potential double-flipping mechanism by E. coli MutY Review Article
Pages 349-364
Paul G House, David E Volk, Varatharasa Thiviyanathan, Raymond C Manuel, Bruce A Luxon, David G Gorenstein, R Stephen Lloyd

Properties and functions of human uracil-DNA glycosylase from the UNG gene Review Article
Pages 365-386
Hans E Krokan, Marit Otterlei, Hilde Nilsen, Bodil Kavli, Frank Skorpen, Sonja Andersen, Camilla Skjelbred, Mansour Akbari, Per Arne Aas, Geir Slupphaug

Index
Pages 387-403