Autoimmune Thyroiditis: Approaches Towards its Etiological Differentiation

Front Matter....Pages I-XXVII
Front Matter....Pages 1-1
New Insights into Autoimmune Mechanisms and the Pathogenesis of Insulin-Dependent Diabetes Mellitus....Pages 3-13
Thyroid Antibodies and Thyroid Dysfunction in Patients with Type 1 Diabetes and Their First-Degree Relatives....Pages 15-19
Association of HLA Class I and Class II Genes and Adrenal Steroid 21-Hydroxylase Gene with Subacute (de Quervain’s) and Hashimoto’s Thyroiditis: Evidence for an Altered Negative Feedback in Hashimoto’s Thyroiditis....Pages 21-28
Strongest Relative Risk for Goitrous Hashimoto’s Thyroiditis Conferred by HLA-DQB1 Gene Variation....Pages 29-39
A Search for Linkage Between Phenylthiocarbamide Tasting, the Kell Blood Group Locus and Autoantibodies to Thyroglobulin and Thyroid Peroxidase....Pages 41-46
Autoimmune Thyroiditis: Its Implications with Other Organ Systems....Pages 47-54
The Genetic Control of Thyroid Cell MHC Class II Antigen Expression....Pages 55-62
Front Matter....Pages 63-63
Clinical Applications of Thyroid Peroxidase Autoantibody Determination....Pages 65-75
Comparison Between Microsomal Antibodies by Immunofluorescence and Anti-TPO Antibodies in Healthy Individuals and Thyroid Autoimmune Diseases....Pages 77-84
Longitudinal and Cross-Sectional Studies on Anti-Thyroid Peroxidase Antibodies in Thyroid Disorders Compared to Conventional Anti-Microsomal Antibodies....Pages 85-89
Comparison of New and Conventional Assay Techniques for Measuring Thyroid Microsomal Antibodies....Pages 91-97
Further Clarification of the Significance of Thyroid Peroxidase Activity-Inhibiting Immunoglobulins in Autoimmune Thyroid Disease....Pages 99-105
Biochemical Dissection of the Reactivity of TPO Antibodies....Pages 107-121
T Cell Epitopes and Thyroid Peroxidase....Pages 123-130
Thyroid Microsome/Thyroid Peroxidase Autoantigenic Epitopes Recognized by Autoantibodies Map to the Amino Terminal, the Central Core and the Carboxyl Terminal of the Molecule....Pages 131-140
Comparison of Circulating Thyroid Microsomal, Cytotoxic and Thyroid Peroxidase Antibodies....Pages 141-146
Are TPO Antibodies and Cytotoxic Thyroid Antibodies Identical?....Pages 147-154
Studies with Recombinant Autoepitopes of Thyroid Peroxidase....Pages 155-161
Front Matter....Pages 163-163
Mechanisms by Which Iodine Induces Autoimmunity....Pages 165-174
Goiter and Autoimmune Thyroiditis in Iodine-Sufficient Areas....Pages 175-184
Front Matter....Pages 163-163
Prevalence of Postpartum Thyroiditis in two Iodine-Deficient Regions of Germany....Pages 185-195
An Immunosuppressive Factor Sharing Homology with the p15E Protein of Leukomogenic Retroviruses is Present in the Serum of Patients with Graves’ Disease....Pages 197-204
Hashimoto’s Thyroiditis and Enteropathogenic Yersinia enterocolitica ....Pages 205-213
 Yersinia enterocolitica and Thyroid Disease....Pages 215-219
Front Matter....Pages 221-221
Regulation of ICAM-1 Expression on Human Thyroid Follicular Cells....Pages 223-230
Interleukin 6: A Pathogenic Factor in Autoimmune Thyroid Diseases?....Pages 231-234
Endotoxins Do not Mimick the Effect of Interleukin-1 in Secondary Cultures of Human Thyroid Cells....Pages 235-237
Blocking the Induction of HLA Class II Expression by Thyroid Epithelial Cells In Vitro....Pages 239-247
Analysis of Intrathyroidal Cytokine Production in Thyroid Disease....Pages 249-257
Lymphokine-Mediated Induction of HLA-DR Antigen Expression on Thyroid Follicular Cells In Vitro by Autologous Mononuclear Leukocytes and by Cytomegalovirus Infection....Pages 259-270
Thyroid Dysfunction After High-Dose Interleukin-2 Therapy: An Update....Pages 271-283
Human Recombinant Interleukin-1 beta Decreases Plasma Thyroid Hormone and TSH Levels in the Rat....Pages 285-291
Thyroid Autoimmunity Induced by Interferon Therapy....Pages 293-298
Effects of Interferon- γ and Interleukin-2 on Xenotransplanted Human Thyroid Tissue....Pages 299-306
Closing Remarks....Pages 307-308