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ویرایش: 2 نویسندگان: Julius M. Cruse MD PhD, Robert E. Lewis سری: ISBN (شابک) : 0849315670, 9780849315671 ناشر: CRC Press سال نشر: 2003 تعداد صفحات: 792 زبان: English فرمت فایل : PDF (درصورت درخواست کاربر به PDF، EPUB یا AZW3 تبدیل می شود) حجم فایل: 33 مگابایت
در صورت تبدیل فایل کتاب Atlas of Immunology, Second Edition به فرمت های PDF، EPUB، AZW3، MOBI و یا DJVU می توانید به پشتیبان اطلاع دهید تا فایل مورد نظر را تبدیل نمایند.
توجه داشته باشید کتاب اطلس ایمونولوژی، ویرایش دوم نسخه زبان اصلی می باشد و کتاب ترجمه شده به فارسی نمی باشد. وبسایت اینترنشنال لایبرری ارائه دهنده کتاب های زبان اصلی می باشد و هیچ گونه کتاب ترجمه شده یا نوشته شده به فارسی را ارائه نمی دهد.
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به تمام زیر تخصص های ایمونولوژیکی، مانند پیوند، خودایمنی،
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سلول T می باشد. هیچ نشریه دیگری وسعت و جزئیات مفاهیم مصور
ایمونولوژیک را به عنوان اطلس ایمونولوژی، ویرایش دوم
ارائه نمی دهد. تصاویر بصری اطلاعات ایمنی را در دسترس آسان
قرار می دهد.
Easy access to visual images of immunological
information!
Illustrating every essential basic concept in immunology,
this profusely illustrated text is an invaluable resource. It
includes figures pertinent to all of the immunological
subspecialties, such as transplantation, autoimmunity,
immunophysiology, immunopathology, antigen presentation, and
the T-cell receptor, to name just a few. No other publication
provides the breadth and detail of illustrated immunological
concepts as Atlas of Immunology, Second Edition. It
puts visual images of immunological information within easy
reach.
Atlas of Immunology, Second Edition Table of Contents Editorial Staff Authors Preface Acknowledgments Illustration Credits Atlas of Immunology, Second Edition Table of Contents file://1567_FM.pdf Chapter 1: History of Immunology Rhazes (Abu Bakr Muhammad ibn Zakariya) Girolamo Fracastoro Lady Mary Wortley Montagu Edward Jenner Louis Pasteur Julius Cohnheim Heinrich Hermann Robert Koch Elie Metchnikoff Alexandre Besredka Paul Ehrlich August von Wassermann Hans Buchner Svante Arrhenius Ehrlich side chain theory Jules Jean Baptiste Vincent Bordet Emil Adolph von Behring Shibasaburo Kitasato Karl Landsteiner Charles Robert Richet Paul Jules Portier Clemens Freiherr von Pirquet Gaston Ramon Bela Schick Arthur Fernandez Coca Robert Anderson Cooke Felix Haurowitz Jacques Oudin Almroth Edward Wright Carl Prausnitz-Giles Nicolas Maurice Arthus Albert Calmette Michael Heidelberger Arne W. Tiselius Elvin Abraham Kabat Henry Hallett Dale John Richardson Marrack William Dameshek Orjan Thomas Gunnersson Ouchterlony Merrill Chase Philip Levine Jules Freund Hans Zinsser Max Theiler Gregory Shwartzman Robin Coombs Albert Hewett Coons Pierre Grabar Herman Nathaniel Eisen Milan Hasek Gustav Joseph Victor Nossal Ernest Witebsky Noel Richard Rose Peter Alfred Gorer Peter Brian Medawar Ray David Owen Frank James Dixon Niels Kaj Jerne David Wilson Talmage Joshua Lederberg Henry Sherwood Lawrence Jan Gosta Waldenstràm Daniel Bovet Frank MacFarlane Burnet George Davis Snell Jean Baptiste Gabriel Dausset Baruj Benacerraf Henry George Kunkel Astrid Elsa Fagraeus-Wallbom Rosalyn Sussman Yalow J.F.A.P. Miller Robert Alan Good James Gowans Rodney Robert Porter Gerald Maurice Edelman Richard K. Gershon Kimishige Ishizaka and Terako Ishizaka Georges J.F. Kohler Cesar Milstein Susumu Tonegawa E. Donnall Thomas and Joseph E. Murray Rolf Zinkernagel (right) (1944– ) and Peter Doherty (left) Atlas of Immunology, Second Edition Table of Contents file://1567_FM.pdf Chapter 2: Molecules, Cells, and Tissues of the Immune Response 4-1BB 4-1BB ligand (4-1BBL) 88 Monocytes A stimulated macrophage Accessory molecules Acquired immunity ACT- 2 Activated leukocyte cell adhesion molecule (ALCAM/ activated lymphocyte activated macrophage Activation Activation phase Activation protein-1 (AP-1): Activation-induced cell death (AICD): Active immunity Acute inflammation acute inflammatory response Acute phase proteins Acute-phase reactants acute-phase response (APR) Acyclic adenosine monophosphate (cAMP): Acyclic guanosine monophosphate ( cGMP): Adaptor proteins Addressin Adenoids Adenosine adherent cell Adhesins Adhesion molecule assays: Adhesion molecules Adhesion receptors Adrenergic receptors Afferent lymphatic vessels agonist Agonist peptides allele Allelic dropout: allophenic mouse Alveolar macrophage An endocytic vesicle ANAE (a-naphthyl acetate esterase): Angiogenesis Angiogenesis factor: Angiogenic factors: Angiogenin Angiopoietins/ Tie2: Angry macrophage Annexin V binding: Annexins (lipocortins) Antagonists Antigen receptors: Antigen-specific cells Antiheat shock protein antibodies AP-1: APO-1 Apolipoprotein (APO-E) Apolipoprotein E Apoptosis Apoptosis and necrosis Apoptosis, caspase pathway: Apoptosis, suppressors: Appendix, vermiform Armed macrophages Artificial passive immunity Artificially acquired immunity β cells β-pleated sheet β barrel β lysin B cell corona B cells B220 B7.1 costimulatory molecule B7.2 costimulatory molecule B7: BALT: Basophil-derived kallikrein (BK-A) Basophilic Basophils Benign lymphadenopathy Birbeck granules blast cell Blast transformation Blastogenesis Blk: Bone marrow Bone marrow cells Boyden chamber Bystander effects Bystander lysis Cadherins Caecal tonsils CAM (cell adhesion molecules): Cartwheel nucleus Caspase substrates: Caspases Catalase Cationic proteins CD (cluster of differentiation): CD antigens CD molecules CD11: CD11a: CD13 CD16 CD166) CD21 CD22 CD33 CD34 CD34 CD40 ligand CD40-L: CD40: CD42a CD42b CD42c CD42d CD44 CD45 CD45R CD45RA CD45RB CD45RO CD56 CD57 CD62E CD62L, CD62P CD9 Cell adhesion molecules (CAMs) Cell surface receptors and ligands: Cellular immunity: Cellular immunology Central lymphoid organs Centroblasts Centrocytes CFU-S (colony-forming units, spleen) Chaperones chemoattractant Chemokinesis Chemotactic deactivation Chemotactic factors chemotactic peptide Chemotactic receptors Chemotaxis circulating dendritic cell Circulating lymphocytes, Cisterna chyli: Clathrin clone clotting system Cluster of differentiation (CD): CMI coagulation system Coated pit Coated vesicles codon Collagen Colony-forming unit (CFU) Colony-forming units, spleen (CFU-S): Common lymphoid progenitors Complementarity Consensus sequence Contact system: Cords of Billroth cortex Cytochrome c: cytoskeleton Cytosolic aspartate- specific proteases ( CASPases): dark zone Death domains Defensins Dendritic cells (DC) Dendritic epidermal cell: deoxynucleotidyl-transferase [TdT]): Deoxyribonuclease Deoxyribonuclease I Deoxyribonuclease II Dermatopathic lymphadenitis Diacylglycerol (DAG), Diapedesis Diploid Diversity DNA fingerprinting DNA laddering: DNA library DNA ligase DNA nucleotidylexotransferase ( terminal DNA polymerase DNA polymerase I DNA polymerase II DNA polymerase III DNA-dependent RNA polymerase Dominant phenotype: draining lymph node E-cadherin E-selectin (CD62E) Early induced responses Edema effector lymphocyte efferent lymphatic vessel ELAM-1 (endothelial leukocyte adhesion molecule-1) Embryonic stem (ES) cells EMF-1 (embryo fibroblast protein-1) Emperipolesis ENA-78 (epithelial derived neutrophil attractant-78) end cell Endocrine: Endocytosis Endogenous endoplasmic reticulum endosome Endothelial leukocyte adhesion molecule-1 (ELAM-1) Endothelin Eosinophil and neutrophil chemotactic activities: Eosinophil cationic protein (ECP) Eosinophil chemotactic factors eosinophil differentiation factor Eosinophil granule major basic protein (EGMBP) Eosinophils eph receptors and ephrins: Ephrin/eph: epithelioid cell epithelioid cell erythroid progenitor Erythropoiesis Erythropoietin eukaryote Exercise and immunity: Exocytosis Exogenous exon. Extravasation Exudate Exudation F- actin: f-Met peptides Facultative phagocytes family Fas (AP0-1/CD95) Fas ligand: FasL/Fas toxicity: Fatty acids and immunity: Fibrin Fibrinogen Fibrinopeptides Fibronectin Fibrosis FLIP/FLAM fluid mosaic model Follicles follicles Follicular center cells Follicular dendritic cells Follicular hyperplasia Formyl-methionyl-leucyl-phenylalanine formylmethionine Fragmentins Functional immunity: G protein-coupled receptor family G proteins GATA-2 gene Gatekeeper effect GEF: gene bank Gene cloning Gene conversion Gene mapping generative lymphoid organ Genetic code Genetic polymorphism Genome: Genomic DNA genotype Germ line Germinal centers Germinal follicle: GlyCAM- 1 Golgi apparatus Golgi complex: Granulocyte granuloma Granzymes: Gravity and immunity: Guanine nucleotide exchange factors (GEFs) Hageman factor (HF) Hairpin loop Haploid hCG (human choriogonadotrophic hormone) Heat shock protein antibodies: Heat shock proteins (hsp): helix: Hematopoiesis Hematopoietic lineage Hematopoietic system Hematopoietic- inducing microenvironment ( HIM) hemocytoblast Hemophilia hemostatic plug Heparan sulfate Heparin Herd immunity: Heterozygosity Heterozygous High endothelial postcapillary venules High endothelial venules ( HEV) Highly polymorphic histiocyte Hof Homing receptors Homing- cell adhesion molecule ( H- CAM) Homologous recombination human T lymphocyte humoral Humoral antibody Humoral immune response Hyperplasia: ICAM- 1 ( intercellular adhesion molecule- 1) ICAM-2: ICAM-3: Ikaros Immature dendritic cells Immune cell motility: Immune inflammation Immune system anatomy: Immune: Immunity Immunoblast: Immunochemistry Immunocompetent Immunocyte Immunocytochemistry Immunologic (or immunological) immunological reaction immunologically activated cell immunologically competent cell immunologist Immunology Immunophysiology Immunoreceptor tyrosine- based activation motif Immunoreceptor tyrosine- based inhibition motif Immunotoxin- induced apoptosis: Inducible NO synthase (iNOS) Inflammation Inflammatory cells inflammatory macrophage inflammatory mediator Innate defense system Innate immunity Innocent bystander Insulin-like growth factor-II (IGF-II) Insulin-like growth factors Integrin family of leukocyte adhesive proteins: Integrins Integrins, HGF/SF activation of: Intercellular adhesion molecule-1 (ICAM-1) Intercellular adhesion molecule-2 (ICAM-2) Intercellular adhesion molecule-3 (ICAM-3) Interdigitating reticular cells: Interstitial dendritic cells Interstitial fluid Intervening sequence: intron inverted repeat Iron and immunity: Ischemia Isoforms isoschizomer ITAMs: K (killer) cells K562 cells karyotype Killer activatory receptors (KARs) Kilobase (kb): Kupffer cell L-plastin (LPL) L-selectin (CD62L) Lactoferrin Lactoperoxidase LAG-3 LAM-1 (leukocyte adhesion molecule-1) Laminin laminin receptor LAMP 1 LAMP 1 and LAMP 2 LAMP 2 Langerhans cells Large granular lymphocytes (LGL): large lymphocyte Large pyroninophilic blast cells Late-phase reaction (LPR) LCA (leukocyte common antigen): LCAM Lectin-like receptors Lectins Leu-CAM: Leukocidin Leukocyte activation, Leukocyte adhesion molecule-1 Leukocyte adhesion molecules Leukocyte adhesion proteins Leukocyte chemotaxis inhibitors Leukocyte functional antigens (LFAs) Leukocyte integrins: Leukocytes Leukocytosis Leukopenia Leukotaxis LFA-1, LFA-2, LFA-3: LFA-2 LFA-3 LGL (large granular lymphocyte or null cell): Ligand light zone long-lived lymphocyte LPAM-1 LPR Lymph Lymph gland: lymph node Lymphadenitis Lymphadenopathy lymphatic system Lymphatic vessels Lymphatics lymphoblast lymphocyte Lymphocyte activation Lymphocyte chemotaxis: Lymphocyte function- associated antigen- 1 ( LFA- 1) Lymphocyte function- associated antigen- 3 ( LFA- 3) Lymphocyte function-associated antigen-2 (LFA-2): Lymphocyte homing Lymphocyte receptor repertoire: Lymphocyte trafficking Lymphocytopenic center: Lymphocytosis Lymphocytotrophic lymphoid lymphoid cell Lymphoid cell series: Lymphoid follicle: Lymphoid lineage Lymphoid nodules ( Lymphoid organs lymphoid progenitor cell Lymphoid system Lymphoid tissues Lymphopenia Lymphopoiesis Lymphoreticular Lymphorrhages lysosome MAC-1 Macrophage chemotactic and activating factor Macrophage chemotactic factor (MCF) Macrophage cytophilic antibody Macrophage functional assays Macrophage immunity: Macrophage inflammatory peptide-2 (MIP-2) Macrophage inflammatory protein- 1- Macrophage-activating factor (MAF) Macrophage/monocyte chemotaxis: Macrophages MadCAM-1 mannose receptor Mannose-binding lectin (MBL) Mantle Mantle zone marginal zone Margination Mast cells medulla medullary cord medullary sinuses Megakaryocytes MEL-14 MEL-14 antibody microenvironment Microfilaments microglial cell Microtubules: mitochondria moesin monocyte–phagocyte system Mononuclear cells mononuclear phagocyte system Mononuclear phagocyte: Mucins Myeloid cell series Myeloperoxidase N-linked oligosaccharide NAP-2 (neutrophil activating protein-2): NAP: naphthyl acetate esterase) Nasopharyngeal-associated lymphoreticular tissue Native immunity Natural immunity: Natural killer (NK) cells naïve naïve lymphocyte Negative induction apoptosis: neural cell adhesion molecule-L1 (NCAM-L1) Neuropeptides Neuropilin Neuropilin Neutropenia neutrophil neutrophil leukocyte Neutrophil microbicidal assay Neutrophils chemotaxis: NF-κB Nitric oxide (NO) Nitric oxide (NO) Nitric oxide synthetase NK 1.1 NK cell: NK-T NK1-T NK1.1 nonadherent cell Nonproductive rearrangement Nonspecific esterase Nonspecific immunity: Nonspecific T lymphocyte helper factor Nonsterile immunity: Nuclear matrix proteins (NMPs) null cell null cell compartment Nutrition and immunity: open reading frame (ORF) Opsonin Opsonization opsonophagocytosis, Oxygen-dependent killing: Oxygen-independent killing: P-selectin (CD62P) PAF palindrome Paracortex Passive immunity PECAM ( CD31): Pentraxin Pentraxins Periarteriolar lymphoid sheath Peripheral blood mononuclear cells Peripheral lymphoid organs Peyer's patches Phagocytes Phagocytosis phagolysosome phagolysosome phagosome pharyngeal tonsils Phorbol ester(s): Phosphatase Phosphatidylinositol bisphosphate Pinocytosis Plasma cells Plasminogen plasminogen activator platelet Platelet endothelial cell adhesion molecule-1 (PECAM-1) Platelet-derived growth factor (PDGF) Platelet-derived growth factor receptor (PDGF-R) pluripotent stem cell PMN Polyclonal Polygenic Polymorphonuclear leukocytes (PMNs) Positive induction apoptosis: Postcapillary venules Preemptive immunity Prekallikrein primary follicle Primary granule: Primary lymphoid organs Primary lysosome Primary nodule: Productive rearrangement progenitor cell Programmed cell death Protective antigens Protective immunity Protein kinase C (PKC) Protein S Pseudoalleles Pseudogene Pseudopodia Ras: Reactive nitrogen intermediates Reactive oxygen intermediates (ROIs) reactive oxygen species (ROS): receptor Receptor-associated tyrosine kinases recirculating pool Recirculation of lymphocytes recognition phase Recombinant DNA Recombinant DNA technology Red pulp Regulatory T cells resident macrophage Respiratory burst resting lymphocytes Restriction endonuclease restriction map Reticular cells reticuloendothelial system (RES) Reticulum cell: RFLP (restriction fragment length polymorphism): ribosome Rosette Round cells Russell body Saccharated iron oxide Scavenger receptors Scr homology-3 (SH-3) domain: Second signals secondary follicle Secondary granule Secondary lymphoid organs Secondary lymphoid tissues secondary lysosome Selectins serum spreading factors SH-2 domain: Short-lived lymphocytes Signal transduction Small G proteins small lymphocyte SOD specific granule Specific immunity spleen Src homology-2 (SH-2) domain: Stem cells Stem-cell factor (SCF) Stress proteins stromal cell Stromal cells Substrate adhesion molecules (SAM) superoxide anion Superoxide dismutase suppressor macrophage Surface phagocytosis T cell: T cells TATA box: TdT Tenascin Terminal transferase: tertiary granule The immune system Theliolymphocytes thoracic duct Thoracic duct drainage Thorotrast (thorium dioxide thrombocyte thymus Thymus-dependent areas Tingible body Tingible body macrophages Tissue-fixed macrophage: TLR1-10: Toll-like receptors Tonsils Totipotent TPA Transudation trophoblast Tuftsin Tyrosine kinase Ubiquitin Ubiquitination unidentified reading frame (URF) Uropod Vascular addressins Vascular cell adhesion molecule-1 (VCAM-1) vasoactive intestinal peptide (VIP) veiled cell Vermiform appendix Very late activation antigens (VLA molecules) Veto cells Viscosity vitamin A Vitamin A and immunity: Vitamin B and immunity: Vitamin C and immunity: Vitamin D and immunity: Vitamin E and immunity: Vitronectin VLA receptors Waldeyer's ring Weibel-Palade bodies wheal and flare reaction White pulp Zinc Zinc and immunity: Zippering Zymogen αβ T cells α-1 antitrypsin (A1AT): α helix Atlas of Immunology, Second Edition Table of Contents file://1567_FM.pdf Chapter 3: Antigens and Immunogens 2,4-dinitrophenyl (DNP) group Abrin Active immunization adjuvant adjuvant granuloma alloantigen alum granuloma Alum-precipitated antigen Alum-precipitated toxoid: aluminum adjuvant Aluminum hydroxide gel Alums Anamnesis Anamnestic anamnestic immune response antigen antigen antigen binding site antigen clearance. Antigen clearance: Antigen unmasking, Antigen-specific suppressor cells Antigenic antigenic competition antigenic competition. antigenic determinant antigenic determinant Antigenic drift Antigenic mosaicism antigenic peptide Antigenic profile Antigenic shift Antigenic variation Antigenicity antigens APT (alum-precipitated toxoid): Aquaphor Aqueous adjuvants: Arlacel artificial antigen azoprotein Biochemical sequestration Biovin antigens booster Booster injection Booster phenomenon booster response Bovine serum albumin (BSA) BSA capsular polysaccharide Carbohydrate antigens: carrier Carrier effect: Carrier specificity CFA Challenge Chemical adjuvants Complete FreundÌs adjuvant (CFA) conformational determinant Conformational epitopes Conjugate Conjugated antigen: conjugates Continuous epitopes Cooperative determinant: copolymer crossreacting antigen Cryptodeterminant: D-amino acid polymers Denaturation Depot-forming adjuvants Determinant groups (or epitopes) Dextrans diazo salt Diazotization differentiation antigen Dinitrochlorobenzene (DNCB) Dinitrofluorobenzene Discontinuous epitopes: DNBS DNCB: DNP: Double-emulsion adjuvant Drakeol 6VR eclipsed antigen Embryonic antigens End-binders epitope Epitope spreading epitype exoantigen Forssman antibody Forssman antigen Freund's adjuvant Freund's complete adjuvant: Freund's incomplete adjuvant: Functional antigen: gene Glycosylphosphatidylinositol-(GPI)-linked membrane Halothane antigens hapten hapten Hapten conjugate response: hapten inhibition test Hapten X: Hapten–carrier conjugate Heat-aggregated protein antigen Hemocyanin heteroantigen Heterogenetic antigen: heterologous antigen heterophile antigen hidden determinant homologous antigen homopolymer Hot antigen suicide: HSA hybrid hapten Iccosomes (immune complex coated antibodies) ImD50 immune response Immunization Immunize Immunodominance immunodominant epitope Immunodominant site: Immunoenhancement immunogen Immunogenic Immunogenic carbohydrates: Immunogenicity immunologic adjuvant Immunologic competency Immunopotency Immunopotentiation Inaccessible antigens: Incomplete Freund's adjuvant (IFA) inducer determinant inductive phase Inoculation ISCOMs Keyhole limpet hemocyanin (KLH) KLH Linear determinants linear epitope Lipopolysaccharide (LPS): liposome Lymphocyte activation MDP: Memory Memory cells Memory lymphocytes Memory T cells Multiple-emulsion adjuvant Muramyl dipeptide (MDP) Mycobacterial adjuvants Mycobacterial peptidoglycolipid Negative phase NIP (4-hydroxy,5-iodo,3-nitrophenylacetyl) nonresponder Nonsequential epitopes Nontissue-specific antigen NP (4-hydroxy,3-nitrophenylacetyl) oligosaccharide determinant Original antigenic sin: Ovalbumin (OA) Parenteral Pertussis adjuvant (Phe,G)AL Phorbol ester(s) pneumococcal polysaccharide Polyclonal activators Polygenic inheritance polynucleotide primary immune response primary response Primary structure Primed primed lymphocyte private antigen private specificity public antigen (supratypic antigen) Quaternary structure repeating units Responder animals: Schlepper Secondary antibody response: secondary immune response secondary response Secondary structure sequential determinant Serum albumin Silica adjuvants: Solubilized water-in-oil adjuvant soluble antigen Squalene SSS III: superantigen Supratypic antigen Supratypic antigen: Surface antigens synthetic Synthetic polypeptide antigens T-dependent antigen: T-independent antigen: Tapioca adjuvant (historical) tertiary immune response Tertiary immunization tertiary response Tertiary structure Tetanus toxoid TFA antigens (TG)AL: thymus-dependent (TD) antigen thymus-independent (TI) antigen TNP: Toxins Transformation trinitrophenyl (picryl) group Triton X-100 Tween Tween 80 two-signal hypothesis Venom Wax D Atlas of Immunology, Second Edition Table of Contents file://1567_FM.pdf Chapter 4: Major Histocompatibility Complex allelic variants β2microglobulin (β2M) B complex B genes B locus bm mutants: C2 and B genes Calnexin Calreticulin CD4 CD4 molecule CD8 CD8 molecule centiMorgan (cM) Class I antigen Class I MHC molecules class I region class IB genes Class II antigens Class II MHC molecules class II region Class II transactivator (CIITA): Class III molecules Codominantly expressed Coisogenic Complotype DO and DM gene conversion hypothesis GPLA H-2 H-2 complex: H-2 locus H-2 restriction H-2D and H-2K H-2I region H-2L haplotype Histocompatibility histocompatibility antigen histocompatibility locus HLA nonclassical class I genes HLA HLA allelic variation: HLA class III: HLA disease association: HLA locus HLA nonclassical class I genes HLA nonclassical class I genes HLA-A HLA-D region HLA-DM HLA-DP subregion HLA-DQ subregion HLA-DR antigenic specificities HLA-DR subregion HLA-E HLA-F HLA-G HLA-H Homozygous typing cells (HTCs) Human leukocyte antigen (HLA) I region I region I-J Ir genes Ia antigens (immune-associated antigen) K region: Killer cell immunoglobulin-like receptors (KIRs) Killer inhibitory receptors (KIRs) Leukocyte groups: Loci locus major histocompatibility complex (MHC) molecule Major histocompatibility complex restriction: Major histocompatibility system: MHC MHC MHC class I molecules MHC class IB molecules MHC class II compartment (MIIC) MHC class II region MHC class II transactivator (CIITA) MHC congenic mice MHC disease associations: MHC functions: MHC genes MHC molecules MHC mutant mice MHC peptide tetramers MHC peptide-binding specificity: MHC recombinant mice MHC restriction Public specificity Qa Qa antigens Qa region: Qa-2 antigen Relative risk (RR) RhLA locus S region TL (thymic-leukemia antigen): Tla antigen Tla complex Atlas of Immunology, Second Edition Table of Contents file://1567_FM.pdf Chapter 5: Antigen Processing and Presentation agretope Agrin Anchor residues Antigen presentation Antigen processing antigen-presenting cell (APC) antigenic peptide APC B7, B7-2: Cathepsins CD1 CD2 CD20 CD21 CD22 CD28 CD8 CD8 CD8 T cells circulating dendritic cell class II vesicle (CIIV) CLIP Cognate interaction Cognate recognition Cooperation Cooperativity coreceptor costimulator Costimulatory molecules costimulatory signal Cross-priming CTLA-4 CTLA4-Ig Desetope Direct antigen presentation Erp57 granuloma HAM-1 and HAM-2 (histocompatibility antigen modifier): histotope I invariant (Ii): Immune costimulatory molecules immunological synapse Indirect antigen presentation: invariant (Ii) chain lipid raft LMP-2 and LMP-7 LMP genes MHC MHC MHC-I antigen presentation: peptide-binding cleft Professional antigen-presenting cells proteasome Proteasome genes resting lymphocytes restitope superantigen T lymphocyte–B lymphocyte cooperation TAP 1 and TAP 2 genes: Tapasin (TAP-associated protein) Tapasin: Tp44 (CD28) Transporter associated with antigen processing (TAP) transporter in antigen processing (TAP) 1 and 2 genes Atlas of Immunology, Second Edition Table of Contents file://1567_FM.pdf Chapter 6: B Lymphocyte Development and Immunoglobulin Genes 12/23 rule: Abelson murine leukemia virus ( A-MuLV) allelic exclusion, Anti-B cell receptor idiotype antibodies Antibody-secreting cells AtxBm B cell activation B cell activation: B cell antigen receptor B cell coreceptor B cell differentiation and growth factors B cell mitogens B cell tolerance B cell tyrosine kinase (Btk) B cell-specific activator protein (BSAP) B cells B lymphocyte antigen receptor B lymphocyte hybridoma B lymphocyte receptor B lymphocyte stimulatory factors B lymphocyte tolerance B lymphocytes B-1 cells B-2 cells B1a B-cells (CD5) BCDF BCGF (B cell growth factors) Bcl-2 Bcl-2 Bcl-2 proteins Bcl-XL (BCR) complex. bursa equivalent bursa of Fabricius bursacyte Bursectomy C gene C gene segment: C segment Capping capping phenomenon CD19 CD20 CD21 CD21 CD22 CD5 CD5 B cells Clonotypic Clustering: Cocapping: coding joint Colocalization Combinatorial diversity Combinatorial joining D exon D gene D gene region D gene segment D region Diversity (D) segments E2A E32 Early B cell factor (EBF) EBF (early B-cell factor) enhancer Gene rearrangement Gene segments Hematogones Igαand Igβ Iga/Ig ( CD79a/ CD79b): Immune response (Ir) genes Immunoglobulin Immunoglobulin gene superfamily: Immunoglobulin genes Inositol 1, 4, 5-triphosphate (IP3) Ir genes J exon J gene segment J region Junctional diversity: Large pre-B cells LPS LPS-binding protein (LBP) Ly antigen Ly1 B cell Ly6 Lyb Lyb-3 antigen: Lymphocyte antigen receptor complex: Lymphocyte maturation mature B cell Membrane immunoglobulin Mutant mutation N region N-addition: N-nucleotides N-region diversification: Oct-2 one gene, one enzyme theory (historical) One-turn recombination signal sequences P-addition P-nucleotides: Patching Pax-5 gene Phage antibody library: plasma cell antigen Plasma cells plasmablast plasmacyte pre-B cell receptor Pre-B cells Preprogenitor cells Protein A Pyroninophilic cells RAG-1 and RAG-2 Receptor editing Receptor-mediated endocytosis Recombination activating genes 1 and 2 (RAG-1 and RAG-2) Recombination recognition sequences signal joint signal peptide Somatic recombination Specificity Staphylococcal protein A Surface immunoglobulin: Surrogate light Syk PTK TAPA-1 Tec kinase Terminal deoxynucleotidyl transferase (TdT) Unprimed Unproductive rearrangements V gene V gene: V gene segment V gene segment: V(D)J recombinase V(D)J recombination class switching V(J) recombination: vector Virgin B cells Vpre-B Vpre-B and λ5 λ5: λ5 B cell development: Atlas of Immunology, Second Edition Table of Contents file://1567_FM.pdf Chapter 7: Immunoglobulin Synthesis, Properties, Structure, and Function 13-26 Fd' piece: 19 S antibody abzyme Active site Affinity maturation Allelic exclusion alloantibody Allogroup allotope allotope allotype Allotype suppression allotypic determinant Allotypic marker: Allotypic specificities Allotypy Am allotypic marker Amboceptor (historical): An antiidiotypic vaccine Anti-DEX antibodies Antiagglutinin Antiantibody: Antibodies Antibody affinity Antibody detection Antibody feedback antibody fragment Antibody half-life Antibody humanization Antibody repertoire Antibody specificity Antibody synthesis: Antibody titer Antibody units: Antibody-binding site Antibody-mediated suppression antigen-binding site antiidiotypic antibody Antiimmunoglobulin antibodies Antiimmunoglobulin antibodies Antiserum Antitoxin Antitoxin Antitoxin assay (historical) Antitoxin unit: antivenom Autobody Avidity avidity hypothesis B allotype B lymphocyte hybridoma b4, b5, b6, and b9 bifunctional antibody Binding protein Binding site: BiP Bispecific antibody Blocking Blocking antibody Brambell receptor (FcRB), Bystander B cells Cλ Cκ CL Cμ Cγ C region (constant region) C-terminus Catalytic antibodies catalytic antibody Cell-bound antibody (cell-fixed antibody) Cell-surface immunoglobulin Cerebrospinal fluid (CSF) immunoglobulins: CH CH1 CH2 CH3 CH4 Chaperones Chimeric antibodies CL Class switching (isotype switching) Clonal selection clonal selection theory Cµ Cohn fraction II Combining site: Complementarity-determining region (CDR) complex allotype Constant domain Constant region Cross-reacting antibody Cyanogen bromide Cytophilic antibody: Cytotoxic antibody Cytotoxicity Cytotoxicity tests: Cytotrophic antibodies D exon Designer Distribution ratio Disulfide bonds doctrine of original antigenic sin. Doctrine of original antigenic sin: Domain Effector function Ehrlich side chain theory (historical) Endoplasmic reticulum Epibody Euglobulin F(ab') Fab fragment Fab' F(ab′)2 fragment Fab″ fragment: Fabc fragment Facb fragment Fb fragment Fc fragment (fragment crystallizable) Fc piece: Fc receptor Fc receptors Fc' fragment Fcγ receptors (FcγR) FcγRI FcγRII FcγRII and FcγRIII Fcε receptor (FcεR): Fd fragment Fd piece: Fd' fragment Forbidden clone theory: fractional catabolic rate Framework regions (FR): Functional affinity Fv fragment Fv region Gene bank Gene cloning gene conversion hypothesis Gene diversity Gene rearrangement genetic code genetic switch hypothesis genome Genomic DNA genotype Globulins Gm allotype Gm allotype Gm marker: H chain (heavy chain) Half-life (T1/2) haplotype Heat-labile antibody heavy chain Heavy chain class Heavy chain class (isotype) switching Heavy chain subclass: Heteroclitic antibody Heterocytotropic antibody Heterocytotropic antibody Heterogenetic antibody: Heterophile antibody High-titer, low-avidity antibodies (HTLA) hinge region Homobody Homocytotrophic antibody homology region Homology unit: hot spot Humanization humanized antibody Humoral immunity Hybrid antibody Hypervariable regions idiotope Idiotype Idiotype network Idiotype network theory: Idiotype suppression Idiotypic determinant: Idiotypic specificity Ig IgA: IgD: IgE: IgG index IgG: IgM index IgM: γM globulin γ Macroglobulin immune network hypothesis of Jerne: Immune serum Immune serum globulin immunoglobulin Immunoglobulin δ chain immunoglobulin κ chain immunoglobulin λ chain Immunoglobulin A (IgA) Immunoglobulin alpha (α) chain immunoglobulin class Immunoglobulin class switching Immunoglobulin class switching: Immunoglobulin D (IgD) immunoglobulin domain Immunoglobulin E (IgE) immunoglobulin epsilon (ε) chain immunoglobulin fold Immunoglobulin fragment Immunoglobulin function Immunoglobulin G (IgG) immunoglobulin gamma (γ) chain Immunoglobulin genes immunoglobulin heavy chain Immunoglobulin heavy chain binding protein (BiP) Immunoglobulin heavy chain-binding protein (BiP) is immunoglobulin λ chain immunoglobulin light chain Immunoglobulin M (IgM) immunoglobulin mu (μ) chain Immunoglobulin structure: immunoglobulin subclass immunoglobulin superfamily Immunoglobulin-like domain indirect template theory (historical) instructional model instructive theory (of antibody formation) Internal image: Intrabody Inv Inv allotypes: Inv allotypic determinant: Inv marker: isoagglutinin isoallotypic determinant isotope Isotype Isotype switching isotypic determinant Isotypic exclusion Isotypic specificities Isotypic variation J chain Jerne network theory Junctional diversity Kabat-Wu plot: Kappa (κ) KM (formerly Inv) Km allotypes: L chain Lambda (λ) chain Latent allotype Leader sequence: light chain Light chain subtype Light chain type Lysins MAb MAC-1 Macroglobulin Maternal immunoglobulins Mcg isotypic determinant Monoclonal Monoclonal antibody (MAb) Monogamous bivalency monogamous multivalency. N-terminus Natural autoantibodies neonatal Fc receptor (FcRn) Neonatal immunity: network hypothesis network theory Nonprecipitating antibodies: "O" phage antibody library OKT monoclonal antibodies OKT4: OKT8: Oz isotypic determinant: Papain Papain hydrolysis paratope Passive immunization pepsin digestion Pepsin digestion pFc' fragment Phage display Phage display library: Plasma half-life (T1/2) Plasma pool Plasmin Polyclonal antibodies Polyclone proteins polyimmunoglobulin receptor Polymers polyvalent antiserum precipitating antibody precipitin Private idiotypic determinant Public idiotypic determinant (IdX or CRI) Pyroglobulins Reagin (historical): Recombination activating genes (RAG-1 and RAG-2) Recombination signal sequences (RSSs) recombinatorial germ-line theory region Restriction fragment length polymorphism (RFLP) S antibody SCAB (single chain antigen- binding proteins) ScFv Secreted immunoglobulin (sIg) Secretory piece selective theory self marker hypothesis (historical) side chain theory signal hypothesis Signal sequence: simple allotype Single domain antibodies Single-chain Fv fragment Skin-fixing antibody Somatic hypermutation Somatic mutation Switch Switch cells Switch defect disease: switch region Switch site T lymphocyte–T lymphocyte cooperation T piece: Tail peptide Telencephalin template theory (historical) Titer transfectoma Transport piece: Tryptic peptides unitarian hypothesis Univalent Univalent antibody V gene V gene segment V region subgroups V region subgroups Variability plot: variable region VH region VL region Vλ VL region Wu-Kabat plot X cell: XYZ cell theory (historical) Y cell: γ globulin γ globulin fraction Z cell: α chain δ chain κ chain μ chain Atlas of Immunology, Second Edition Table of Contents file://1567_FM.pdf Chapter 8: Antigen–Antibody Interactions Affinity Affinity constant: Agglutination Agglutination inhibition agglutination titer agglutinin agglutinogen ammonium sulfate method Antibody affinity Antibody excess immune complexes (ABICs) Antibody–antigen intermolecular forces: Antigen excess: Antigen-binding capacity antigen–antibody complex Apolar or hydrophobic bonding Association constant (KA) avidity Avidity avidity hypothesis Bacterial agglutination bentonite flocculation test Binding constant: Coprecipitation Coulombic forces Cross-absorption cross-reacting antibody cross-reacting antigen cross-reaction Cross-reactivity Danysz effect. Danysz phenomenon Dean and Webb titration Diffusion coefficient Dilution end point Dissociation constant End point End-point immunoassay Equilibrium dialysis Final serum dilution Flocculation Fluorescence quenching Hemolysis Heterocliticity Hydrogen bonds Hydrophilic Hydrophobic Immune elimination immunoreactant Immunoreaction Inhibition zone: Intrinsic affinity Intrinsic association constant Ionic L+ dose (historical): Lf dose (historical): Lf flocculating unit (historical): Lo dose (historical): Lr dose (historical): Landsteiner lattice theory Lysis multivalent Multivalent antiserum Nephelometry noncovalent forces Partial identity: Passive hemagglutination Passive hemolysis Pfeiffer phenomenon (historical) phenomenon. Polyspecificity Polyvalent Postzone precipitation Precipitation reaction: precipitin curve Precipitin reaction: precipitin test Primary interaction primary reaction prozone prozone phenomenon Quantitative gel diffusion test Quantitative precipitin reaction Radial immunodiffusion Reaction of identity: Reaction of nonidentity: Reaction of partial identity: Ring precipitation test: ring test Scatchard analysis Scatchard equation: Scatchard plot Secondary reactions Serology Sips distribution Sips plot soluble complex spur Steric repulsion steric hindrance Surface plasmon resonance (SRP) TAF Tertiary reactions Titer Toxin neutralization (by antitoxin): unitarian hypothesis Valence van der Waals forces (London forces) zone of equivalence Atlas of Immunology, Second Edition Table of Contents file://1567_FM.pdf Chapter 9: The Thymus and T Lymphocytes Activated lymphocytes Adaptive differentiation Adaptor proteins Adenosine deaminase (ADA) Anti-T cell receptor idiotype antibodies antigen recognition activation motif Apoptosis Armed effector T cells Athymic nude mice Blastogenesis blood–thymus barrier C gene segment c-myb gene Calcineurin CD1 CD1a CD1b CD1c CD2 CD29 CD2R CD3 CD3 complex CD4 CD4 molecule CD4 T cells CD40 ligand CD45 CD5 CD6 CD7 CD8 CD8 molecule CD8 T cells comprise Cell- mediated immunity ( CMI) cell-mediated immune response cloned T cell line Clonotypic Cluster of differentiation (CD) coding joint Combinatorial diversity Concanavalin A (con A) Contrasuppression CTL Cytolysin Cytolytic Cytolytic reaction Cytotoxic Cytotoxic CD8 T cells Cytotoxic T cells Cytotoxic T lymphocyte precursor (CTLp) Cytotoxic T lymphocytes (CTLs) Cytotoxic T lymphocytes (CTLs) Cytotoxicity Cytotoxicity assays Cytotoxicity tests: Cytotoxins differential signaling hypothesis Diversity (D) segments DNA nucleotidyltransferase (terminal deoxynucleotidyl transferase [TdT]) Double-negative (DN) cell Double-negative thymocytes double-positive (DP) cell Double-positive thymocytes E rosette E rosette-forming cell Epithelial thymic-activating factor (ETAF) Fc receptors on human T cells: fyn: Gene rearrangement Gene segments H7 HassallÌs corpuscles Helper CD4+ T cells Helper T cells Helper/suppressor ratio: Herbimycin A Heterodimer homodimer ICOS inducer T lymphocyte Inflammatory CD4 T cells Inositol 1, 4, 5-triphosphate (IP3) Intraepithelial T lymphocytes J gene segment J region killer T cell L3T4 L3T4+ T lymphocytes LAT: Lck, fyn, ZAP (phosphotyrosine kinases in T cells) lethal hit Leukocyte common antigen (LCA, CD45) Leukophysin LGSP (leukocyte sialoglycoprotein) Linked recognition Linker of activation in T cells (LAT) LTa Ly antigen Ly6 Lymphocyte maturation Lymphoid enhancer factor-1 (LEF-1) Lyt 1,2,3 Lyt antigens Lytic granules Mature T cells Myoid cells Negative selection Neonatal thymectomy syndrome: NF-AT: nonspecific T cell suppressor factor nonspecific T lymphocyte helper factor nude mouse Pan-T cell markers Perforin PHA pharyngeal pouch Pharyngeal pouch syndrome Phorbol ester(s) Positive selection Pre-T cell receptor (Pre-TCR) Pre-T cells Pre-T lymphocyte pro-T cell Protein kinase C prothymocyte pTa Rac resting lymphotytes rosette Runt disease Runting syndrome Second messengers (IP3 and DAG): Self-MHC restriction Self-restriction: sensitized lymphocyte Sialophorin (CD43) signal joint silencer sequence Silencers Single-positive thymocytes Snell-Bagg mice Somatic recombination Specificity SRBC Status thymolymphaticus (historical) Stromal cells Subset Suppressin suppressor cell suppressor T cell factor (TsF) Suppressor T cells (Ts cells) Suppressor/inducer T lymphocyte T cell antigen receptors: T cell antigen-specific suppressor factor: T cell clonal expansion T cell development: T cell domains T cell maturation: T cell migration: T cell nonantigen-specific helper factor γδ T cell receptor T cell receptor (TCR) T cell receptor complex T cell receptor genes T cell replacing factor (TRF) T cell rosette: T cell specificity: T cell-dependent (TD) antigen T cell-independent (TI) antigen T cells T lymphocyte (T cell) T lymphocyte clone T lymphocyte hybridoma T lymphocyte receptor: T lymphocyte subpopulation T-200 T-dependent antigen T-independent antigen T1 antigen: T3 antigen: T4 antigen: T8 antigen: Tac Tac antigen: Tc lymphocyte: TCR): TD antigen Tec kinase Terminal deoxynucleotidyl transferase (TdT) TH0 cells TH1 cells TH2 cells Thy (θ) Thy 1 antigen Thy-1 Thy-1+ dendritic cells thymectomy Thymic epithelial cells Thymic hormones Thymic hormones and peptides Thymic humoral factor(s) (THFs) Thymic leukemia antigen (TL) Thymic nurse cells Thymic stromal-derived lymphopoietin (TSLP) Thymin thymocyte Thymoma Thymopentin (TP5) Thymopoietin Thymosin α-1 (thymopoietin) Thymosine Thymulin thymus Thymus cell differentiation Thymus cell education thymus-dependent (TD) antigen Thymus-dependent areas Thymus-dependent cells thymus-independent (TI) antigen Tp44 (CD28) TR1: Traffic area Transferrin receptor (T9) Ts1, Ts3 lymphocytes Ts: TsF VT region Zeta-associated protein of 70 kDa (ZAP-70) αβ T cells αβ T cell receptor (αβ TCR): θ antigen: γδ T cell receptor (TCR): γδ T cells ζ (zeta) chain Atlas of Immunology, Second Edition Table of Contents file://1567_FM.pdf Chapter 10: Cytokines and Chemokines Adrenergic receptor agonists: Autocrine autocrine factor B cell growth factor I (BCGF-1) B cell growth factor II (BCGF-2) B cell-stimulating factor 1 (BSF-1) B cell-stimulating factor 2 (BSF-2) B-cell growth factor (BCGF): Biological response modifiers (BRM) BlyS BRMs C-C subgroup c-kit ligand C-X-C subgroup C10 Cachectin Capillary leak syndrome: CC chemokine receptor 1 (CC CKR-1) CC Chemokine receptor 2 (CC CKR-2) CC chemokine receptor 3 (CC CKR-3) CC chemokine receptor 4 ( CC CKR- 4) CD25 CFU CFU-GEMM Chemokine β receptor-like 1 chemokine receptor Chemokines Chemokines Ciliary neurotrophic factor (CNTF) Classes of cytokine receptors Colony-stimulating factors (CSF) Colony-stimulating factors (CSFs) Connective tissue-activating peptide-III (CTAP-III) CSF CSIF CXCR-4 Cytokine assays Cytokine autoantibodies: Cytokine inhibitors Cytokine receptor families Cytokine receptors Cytokine synthesis inhibitory factor: cytokine-specific subunit Differentiation factors Duffy antigen/chemokine receptor (DARC) EBI1 ECRF3 endogenous pyrogen Eotaxin Eotaxin-1 eotaxin-2 G-CSF Granulocyte chemotactic protein-2 (GCP-2) Granulocyte colony-stimulating factor (G-CSF) Granulocyte–macrophage colony-stimulating factor (GM-CSF) Granulocyte–monocyte colony-stimulating factor Granulopoietin Growth factors HCC-1 Hepatocyte-stimulating factor IL IL-1 IL-1 receptor antagonist (IL-1ra) IL-10 IL-11 IL-12 IL-12R IL-13 IL-13 IL-13 receptor IL-13 receptor complex IL-14 IL-15 IL-15 receptor IL-16 IL-17 IL-18 IL-2 IL-2 receptor IL-2 receptor (CD25): IL-3 IL-4 IL-5 IL-6 IL-6 receptor IL-7 IL-9 Immune interferon inducer inducible protein-10 (IP-10) Insulin-like growth factors (IGFs) Intercrine cytokines Interferon(s) α (IFN-α) Interferon β (IFN-β) Interferon γ (IFN-γ) inducible protein-10 (IP-10) Interferon γ (IFN-γ) Interferon regulatory factors (IRF) Interferons (IFNs) Interleukin(s) (IL) Interleukin- 1 receptor antagonist protein (IRAP) Interleukin- 13 ( IL-13) Interleukin-1 (IL-1) Interleukin-1 (IL-1) receptor Interleukin-1 receptor deficiency Interleukin-10 (IL-10) Interleukin-10 (IL-10) (cytokine synthesis inhibitory factor) Interleukin-11 (IL-11) interleukin-11 receptor Interleukin-12 receptor Interleukin-12 (IL-12) Interleukin-14 (IL-14) Interleukin-15 (IL-15) Interleukin-16 (IL-16) Interleukin-17 (IL-17) Interleukin-18 (IL-18) Interleukin-19 (IL-19) Interleukin-2 (IL-2) Interleukin-2 receptor α subunit (IL-2Rα) Interleukin-2 receptor β subunit (IL-2Rβ) Interleukin-2 receptor βγ subunit (IL-2Rβγ) Interleukin-2 receptor γ subunit (IL-2Rγ) Interleukin-2 receptor αβγ subunit (IL-α2Rβγ) Interleukin-2 receptor (IL-2R) Interleukin-20 (IL-20) Interleukin-21 (IL-21) Interleukin-22 (IL-22) Interleukin-23 (IL-23) Interleukin-3 (IL-3) Interleukin-3 receptor (IL-3R) Interleukin-4 (IL-4) (B cell growth factor) Interleukin-4 receptor (IL-4R) Interleukin-5 (IL-5) (eosinophil differentiation factor) Interleukin-5 receptor complex Interleukin-6 (IL-6) Interleukin-6 receptor Interleukin-7 (IL-7) Interleukin-8 (IL-8) Interleukin-8 (IL-8) (neutrophil-activating protein 1) Interleukin-8 receptor, type A (IL-8RA) Interleukin-8 receptor, type B (IL-8RB) Interleukin-9 (IL-9) Interleukin-9 (murine growth factor P40, T cell growth factor III) Intracellular cytokine staining JAK-STAT signaling pathway Janus kinases (Jaks) Keratinocyte growth factor (KGF) L cell conditioned medium LAF (lymphocyte-activating factor): LDCF ( lymphocyte- derived chemotactic factor) LESTR Leukemia inhibitory factor (LIF) Leukocyte inhibitory factor (LIF) Leukocyte migration inhibitory factor: Lymphocyte activation factor (LAF): Lymphocyte chemokine (BLC) Lymphocytotoxin: lymphokine Lymphotactin (Ltn) Lymphotoxin (LT) Macrophage chemotactic and activating factor (MCAF) (MCP-1) Macrophage chemotactic factors (MCF) Macrophage colony-stimulating factor (M-CSF) Macrophage inflammatory protein 1 (MIP-1) Macrophage inflammatory protein 1a (MIP-1a) Macrophage inflammatory protein-1a (MIP-1a) Macrophage inflammatory protein-2 (MIP-2) Macrophage migration inhibitory factor Macrophage-activating factor (MAF) MAF Mast cell growth factor-1 Mast cell growth factor-2 MCP-1 in atherosclerosis: Melanoma growth stimulatory activity (MGSA) MIF (macrophage/monocyte migration inhibitory factor) MIG, MIP-1 MIP-1a receptor MIP-1 (macrophage inflammatory protein-1-α): Monocyte chemoattractant of a protein-2 (MCP-2) Monocyte chemoattractant protein-1 (MCP-1) Monocyte chemoattractant protein-3 (MCP-3) Monocyte colony-stimulating factor (MCSF) Monocyte-derived neutrophil chemotactic factor: monokine N-formyl peptide receptor (FPR) NAP-1 Neutrophil-activating peptide 2 Neutrophil-activating factor-1 Neutrophil-activating protein 2 (NAP-2) Neutrophil-activating protein-1 (NAP-1) Neutrophil-attracting peptide (NAP-2) Osteoclast-activating factor (OAF) Paracrine paracrine factor Permeability factors: Permeability-increasing factor Platelet factor 4 (PF4) Platelet-activating factor receptor (PAFR) pyrogen RANTES Signal transducers and activators of transcription (STATs): signal transducer and activator of transcription (STAT) Single cysteine motif-1 (SCM-1) Skin-reactive factor (SRF) SODD (silencer of death domains): Soluble cytokine receptors Stromal cell-derived factor-1 (SDF-1) Synergism: T cell growth factor 2 T lymphocyte-conditioned medium T-cell growth factor (TCGF): T-cell growth factor 1: TACI (transmembrane activator and CAML-interactor) TGF-βs (transforming growth factor-βs) Transforming growth factor β (TGF-β): TCGF (T-cell growth factor): TGF (transforming growth factor[s]) Thymic stromal-derived lymphopoietin (TSLP) Thymus-replacing factor (TRF) TNF TNF receptor-associated factors (TRAFs) TNF-related activation-induced cytokine (TRANCE) TRAFs TRAIL (TNF-related apoptosis-inducing ligand) Transfer factor (TF) Transforming growth factor-α (TGF-α) Transforming growth factor β (TGF-β): TRF Tumor necrosis factor (TNG) family: Tumor necrosis factor α (TNF-α) Tumor necrosis factor β (TNF-β) Tumor necrosis factor receptor Tumor necrosis factor receptors (TNF receptors) Type I cytokine receptors Type I interferons (IFN-α, IFN-β) Type II interferon US28 V28 γ interferon: Atlas of Immunology, Second Edition Table of Contents file://1567_FM.pdf Chapter 11: The Complement System activation unit activation unit AH50 Alexine (or alexin) alternative complement pathway Alternative pathway C3 convertase Anaphylatoxin inhibitor (Ana INH) Anaphylatoxins Angioedema Angiogenesis factor Anti-Clq antibody Anticomplementary C globulin C1 C1 deficiencies C1 esterase inhibitor C1 inhibitor (C1 INH) deficiencies C1q C1q autoantibodies C1q binding assay for circulating immune complexes (CIC) C1q deficiency C1q receptors C1r C1s C2 (complement component 2) C2 deficiency C2a C2b C2 and B C3 (complement component 3) C3 convertase C3 convertase C3 convertase C3 deficiency C3 nephritic factor (C3NeF) C3 PA (C3 proactivator) C3 tickover: C3a C3a receptor (C3a-R) C3a/C4a receptor (C3a/C4a-R) C3a/C4a receptor (C3a/C4a-R): C3b C3b (inactivated C3b): C3b inactivator: C3b receptors: C3bi (iC3b) C3c C3d C3dg C3e C3f C3g C4 (complement component 4) C4 allotypes: C4 deficiency C4A C4a C4b C4B C4b inactivator: C4b-binding protein (C4bp) C4bi (iC4b) C4c C4d C5 (complement component 5) C5 convertase C5 deficiency C5a C5a receptor (C5a-R) C5a74des C5aR (C5 anaphylatoxin receptor) C5b C6 (complement component 6) C6 deficiency C7 (complement component 7) C7 deficiency C8 (complement component 8) C8 deficiency C9 (complement component 9) C9 deficiency Cascade reaction CD11b: CD35 CD59 CH50 unit classic pathway of complement Classical pathway: Clusterin (serum protein SP-40,40) Cobra venom factor (CVF) collectin receptor Complement (C) Complement activation Complement deficiency conditions Complement deviation (Neisser-Wechsberg phenomenon) Complement fixation complement fixation assay complement fixation inhibition test Complement fixing antibody Complement inhibitors Complement membrane attack complex: Complement multimer Complement receptor 1 (CR1) Complement receptor 2 (CR2) Complement receptor 3 (CR3) Complement receptor 4 (CR4) Complement receptor 5 (CR5) Complement receptors complement system Complotype Conglutinating complement absorption test Conglutination Conglutinin Conglutinin solid phase assay Convertase CR1: CR2, Type II complement receptor CR2: CR3 deficiency syndrome: Cytolytic cytolytic reaction Cytotoxicity DAF: Decay-accelerating factor (DAF) Decomplementation Doughnut structure EAC end piece Factor B Factor D Factor D deficiency Factor H Factor H deficiency Factor H receptor (fH-R) Factor I Factor I deficiency Factor P (properdin) HD50 Heat inactivation Hemolysin hemolytic system Hereditary angioneurotic edema (HANE) Hereditary complement deficiencies Homologous restriction factor (HRF) Hypocomplementemia iC3b-Neo: iC4b Immune adherence Immune adherence receptor Immune cytolysis Immune hemolysis Immunoconglutination Immunoconglutinin Inactivation indirect complement fixation test Inulin lectin pathway of complement activation Liberated CR1 Long homologous repeat: MAC Mannan-binding protein (Man-BP) membrane attack complex (MAC) membrane attack unit Membrane cofactor of proteolysis (MCP or CD46) Membrane cofactor protein (MCP) Membrane complement receptors mid-piece Minimal hemolytic dose (MHD) MIRL (membrane inhibitor of reactive lysis) Mo1 Neisser-Wechsberg phenomenon NFc (nephritic factor of the classical pathway) NFt (C3bBb-P stabilizing factor) Nonimmunologic classic pathway activators one-hit theory P Paroxysmal nocturnal hemoglobinuria (PNH) Pro-C3 Pro-C4 Pro-C5 Procomplementary factors Properdin (factor P) Properdin deficiency properdin pathway properdin system Protectin (CD59) RCA RCA locus (regulator of complement activation) Reactive lysis recognition unit recognition unit Regulation of complement activation (RCA) cluster Regulators of complement activity (RCA): S protein sCR1 (soluble complement receptor type 1) sex-limited protein single hit theory slp: SP-40,40 Ss protein Suramin {Antrypol, 8,8'-(carbonyl-bis-[imino-3,1-phenylenecarbonylimino])-bis-1,3,5-naphthalene trisulfonic acid} target cell terminal complement complex (TCC) Terminal complement complex deficiency Terminal complement components von Krough equation Zymosan β1A globulin β1C globulin β1E globulin β1F globulin Atlas of Immunology, Second Edition Table of Contents file://1567_FM.pdf Chapter 12: Types I, II, III, and IV Hypersensitivity Active anaphylaxis Active kinins Aggregate anaphylaxis Allergen Allergen immunotherapy: Allergic alveolitis: Allergic asthma Allergic conjunctivitis Allergic contact dermatitis allergic contact dermatitis) Allergic disease immunotherapy Allergic granulomatosis Allergic orchitis: allergic reaction allergic response Allergic rhinitis Allergoids Allergy Alternaria species ammatory drugs (NSAIDS) AnaINH Anaphylactic shock Anaphylactoid reaction Anaphylatoxin inactivator anaphylatoxin inhibitor (AnaINH) Anaphylatoxins Anaphylaxis Anergy Antianaphylaxis Antibody-dependent cell-mediated cytotoxicity (ADCC) Antihistamine Arachidonic acid (AA) and leukotrienes Arthus reaction Aspirin (ASA) acetyl salicylic acid Aspirin sensitivity reactions: Asthma Atopic Atopic allergy or atopy Atopic dermatitis Atopic hypersensitivity: Atopy Auer's colitis bacterial allergy Bacterial allergy Bacterial hypersensitivity: Bagassosis Biogenic amines Bradykinin Bronchial asthma Cell-mediated hypersensitivity Cellular allergy Cellular and humoral metal hypersensitivity: Cellular hypersensitivity Charcot-Leyden crystals Chlorodinitrobenzene (1-chlor-2,4-dinitrobenzene) Cholinergic urticaria Churg-Strauss syndrome (allergic granulomatosis) CIC Cladosporium species Cold hypersensitivity Cold urticaria Complex release activity Contact dermatitis Contact hypersensitivity Contact sensitivity (CS) (or allergic contact dermatitis) Corneal response: Corneal test Cromolyn (1,3-bis[2-carboxychromon-5-yloxy-2-hydroxypropane]) Cromolyn sodium Cutaneous anaphylaxis Cutaneous basophil hypersensitivity (Jones-Mote hypersensitivity) Cutaneous sensitization cyclooxygenase pathway Cytotropic anaphylaxis Dander antigen Degranulation Delayed-type hypersensitivity (DTH) Dermatitis venenata: Dermatographism Dermatophagoides Dermatophagoides pteronyssinus Dermatophytid reaction: Desensitization Dhobi itch DIC Disodium cromoglycate Disseminated intravascular coagulation (DIC) Drug allergy DTH DTH T cell ECF-A (eosinophil chemotactic factor of anaphylaxis) Eczema eczematoid skin reaction ed protein derivative (PPD) EIA eicosanoid Exercise-induced asthma Extrinsic asthma Fibrinoid necrosis First-use syndrome Fixed drug eruption Fluorodinitrobenzene: food allergy food and drug additive reactions, Generalized anaphylaxis H1 receptors H1, H2 blocking agents: H2 receptors Hay fever: Herxheimer reaction Histaminase Histamine Histamine-releasing factors (HRF) Hives Horse serum sensitivity House dust allergy Hypersensitivity Hypersensitivity angiitis Hypersensitivity diseases Hypersensitivity pneumonitis Hypersensitivity pneumonitis: Hypersensitivity vasculitis hypersensitivity) Hyposensitization id reaction Immediate hypersensitivity Immune complex reactions Infection infection allergy Infection hypersensitivity Intal Isoallergens Isoproterenol (dl-b-[3,4-dihydroxyphenyl]-a-isopropylaminoethanol): Kallikrein Kallikrein inhibitors kallikrein–kinin system Kininases Kininogens Kinins Koch phenomenon Latex allergy leukotriene lipoxygenase pathway Local anaphylaxis Long-acting thyroid stimulator ( LATS) Major basic protein (MBP) Mast cell activation: Mast cell tryptase Mast cell–eosinophil axis Metaproterenol (dl-b-[3,5-dihydroxyphenyl]-a-isopropylamino-ethanol) MK-571 Nonsteroidal antiin Oxazolone (4-ethoxymethylene-2-phenyloxazol-5-one) P-K reaction: Paradoxical reaction (historical) Passive anaphylaxis passive Arthus reaction Passive cutaneous anaphylaxis (PCA) Passive sensitization Passive systemic anaphylaxis Passive transfer patch test PCA Penicillin hypersensitivity Pentadecacatechol Phacoanaphylaxis Phoma species Photoallergy Picryl chloride (1-chloro-2,4,6-trinitrobenzene) Pigeon breeder's lung: PK test Plasma histamine: Platelet-activating factor (PAF) Poison ivy Poison ivy hypersensitivity pollen hypersensitivity PPD Prausnitz-Küstner (P-K) reaction (historical) prick test primary allergen Prostaglandins (PG) pseudoallergic reaction Pseudoallergy Puri Ragweed Reverse anaphylaxis Reverse passive Arthus reaction Reverse passive cutaneous anaphylaxis (RPCA) Sanarelli-Shwartzman reaction: Schultz-Dale test (historical): scratch test Secondary allergen Sensitization Serotonin (5-hydroxytryptamine) [5-HT] Serum sickness shock organ Shocking dose Shwartzman (or Shwartzman-Sanarelli) reaction Skin-sensitizing antibody Slow-reacting substance of anaphylaxis (SRS-A) SRS-A Status asthmaticus Substance P Sulfate sensitivity: Systemic anaphylaxis Theophylline (1,3, dimethylxanthine) (Thermoactinomyces vulgaris) Thromboxanes Toxic complexes triple response of Lewis Tuberculid Tuberculin Tuberculin hypersensitivity Tuberculin reaction Tuberculin test tuberculin-type reaction tuberculosis immunization Type I anaphylactic hypersensitivity Type II antibody-mediated hypersensitivity Type III immune complex-mediated hypersensitivity Type IV cell-mediated hypersensitivity Urticaria Urushiols Vascular permeability factors Vasculitis Vasoactive amines Vasoconstriction Vasodilatation Venom Vesiculation Wheal and flare reaction zirconium granuloma Atlas of Immunology, Second Edition Table of Contents file://1567_FM.pdf Chapter 13: Immunoregulation and Immunologic Tolerance Acquired tolerance Adoptive tolerance Anergic B cells: Anergy B cell tolerance B lymphocyte tolerance Brester-Cohn theory Central tolerance Clonal anergy clonal balance Clonal deletion (negative selection) Clonal expansion Clonal ignorance Clonal restriction Contrasuppression contrasuppressor cell Control tolerance Cross-sensitivity Cross-tolerance Felton phenomenon freemartin High-dose tolerance High-zone tolerance immune and neuroendocrine systems immune deviation Immune tolerance Immune–neuroendocrine axis Immunologic (or immune) paralysis Immunologic competence Immunologic enhancement Immunologic tolerance Immunological ignorance Immunological inertia Immunological suicide Immunological unresponsiveness immunomodulator Immunoregulation Infectious tolerance Liacopoulos phenomenon (nonspecific tolerance): Low-dose (or low-zone) tolerance Lymphocyte anergy Oral tolerance Paralysis Peripheral tolerance Psychoneuroimmunology Self-peptides Self-tolerance Split tolerance Stress and immunity: Sulzberger-Chase phenomenon T cell tolerance Termination of tolerance: tetraparental chimera tetraparental mouse Tolerance Tolerogen Tolerogenic Unresponsiveness Atlas of Immunology, Second Edition Table of Contents file://1567_FM.pdf Chapter 14: Autoimmunity Acanthosis nigricans Acetaldehyde adduct autoantibodies Acetylcholine receptor (AChR) antibodies Acetylcholine receptor (AChR) binding autoantibodies Addison's disease: Adrenal autoantibody (AA) Aging and immunity: Alanyl-tRNA synthetase autoantibodies Alopecia areata Altered self Alveolar basement membrane autoantibodies (ABM autoantibodies) Amino acyl tRNA synthetases Amphiphysin autoantibodies: ANA Anti-double-stranded DNA Anti-intrinsic factor autoantibodies Anti-Hu antibodies Anti-Ku autoantibodies Anti-La/SS-B autoantibodies Anti-PCNA Anti-phospholipid antibodies: Anti-PM/Scl autoantibodies Anti-RA-33 Anti-rRNP: Anti-scRNP (Ro/SS-A, La/SS-B): Anti-Sm (Smith) autoantibodies, Anti-Sm autoantibodies Anti-snRNP (Sm, U1-RNP, U2-RNP) Anti-SS-A Anti-SS-B Anti-U1 RNP autoantibodies Antibodies to histidyl t-RNA synthetase (anti-HRS) Antibodies to Mi-1 and Mi-2 Anticardiolipin antibody syndrome: Anticentriole antibodies Anticentromere autoantibody (Figure 14.47): Antiendothelial cell autoantibodies Antifibrillarin antibodies Antinuclear antibodies (ANA) Antinucleosome antibodies Antiphospholipid antibodies Antiphospholipid syndrome (APS) Antiplacental alkaline phosphatase (PLAP) antibody APECED (autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy) Asialoglycoprotein receptor (ASGP R) autoantibodies Autoagglutination Autoallergy Autoantibodies against lamin, Autoantibodies against pepsinogen Autoantibodies to gastric parietal cells autoantibodies: autoantibody Autoantigens Autoimmune adrenal failure: Autoimmune and lymphoproliferative syndrome Autoimmune cardiac disease: Autoimmune complement fixation reaction autoimmune disease Autoimmune disease animal models: Autoimmune disease spontaneous animal models: Autoimmune gastritis autoimmune hemolytic anemia Autoimmune hemophilia autoimmune hepatitis. Autoimmune lymphoproliferative syndrome (ALPS) Autoimmune neutropenia Autoimmune polyglandular syndromes autoimmune response Autoimmune skin diseases autoimmune syndrome) Autoimmune thrombocytopenic purpura Autoimmune thyroiditis: Autoimmune thyroiditis: Autoimmune tubulointerstitial nephritis Autoimmune uveoretinitis Autoimmunity Autoreactive T lymphocytes Autoreactivity Autosensitization Benign lymphoepithelial lesion Beta-2 glycoprotein-I autoantibodies: Beta-adrenergic receptor autoantibodies Brush border autoantibodies Bungarotoxin BXSB mice C1q autoantibodies Canale-Smith syndrome Carcinomatous neuropathy Cardiolipin autoantibodies: Centriole antibodies Centromere autoantibodies Chemokine autoantibodies Chief cell autoantibodies: Chronic active hepatitis, autoimmune Chrysotherapy: Circulating anticoagulant Circulating lupus anticoagulant syndrome (CLAS) Cold-reacting autoantibodies Collagen (types I, II, and III) autoantibodies Collagen disease and arthritis panel: Collagen type IV autoantibodies Collagen vascular diseases Colon autoantibodies: Connective tissue disease Corticotrophin receptor autoantibodies (CRA) CREST syndrome Crithidia assay Crithidia luciliae Cytokine autoantibodies Cytoplasmic antigens Cytoskeletal antibodies Cytoskeletal autoantibodies D3TX mice Dalen-Fuchs nodule Deoxyribonucleoprotein antibodies Dermatomyositis Desmoglein Determinant spreading Diabetes insipidus Dopamine neuron autoantibodies Double-stranded DNA autoantibodies: drug-induced autoimmunity Drug-induced immune hemolytic anemia: Drug-induced lupus erythematosus: EAE EAMG (experimental autoimmune myasthenia gravis) ENA antibodies ENA autoantibodies Encephalitogenic factors Endometrial antibodies Endometrial autoantibodies Endomysial autoantibodies Endophthalmitis phacoanaphylactica Endoplasmic reticulum autoantibodies Endothelial cell autoantibodies (ECA) Entactin/nidogen autoantibodies Enteric neuronal autoantibodies Eosinophilia Ergotype EVI antibodies FANA Fas Fas ligand Fibrillarin autoantibodies Figure 14.24: GAD-65 Ganglioside autoantibodies Gastric cell cAMP stimulating autoantibodies Gastrin receptor antibodies Gastrin-producing cell autoantibodies (GPCA) Giant cell arteritis Gliadin autoantibodies gld gene Glomerular basement membrane autoantibodies Glutamic acid decarboxylase autoantibodies GM1 autoantibodies Gold therapy Golgi autoantibodies Goodpasture's antigen Goodpasture's syndrome GOR autoantibodies Granulocyte autoantibodies Granulocyte-specific antinuclear autoantibodies (GS-ANA) Granulocytopenia Guillain-Barré syndrome Hematoxylin bodies Herpes gestationis (HG) autoantibodies: Heteroantibody Heterogeneous nuclear ribonucleoprotein (RA- 33) Histone (H2A–H2B)–DNA complex autoantibodies (IgG) Histone antibodies Histone autoantibodies (non-H2A–H2B)–DNA): HLA Class I: HLA Class II: HLA-A, HLA-B, and HLA-C HLA-B HLA-B27-related arthropathies HLA-C Horror autotoxicus (historical) I-K Ibuprofen, ICA512 (IA-2) Idiopathic thrombocytopenic purpura IgG-induced autoimmune hemolysis, Immune neutropenia Immunological infertility: Indomethacin, Innocent bystander hemolysis: Insulin receptor autoantibodies Insulin resistance Insulin-dependent (type I) diabetes mellitus (IDDM) Insulitis Intercalated cell autoantibodies Intrinsic factor Intrinsic factor antibodies Islet cell autoantibodies (ICA) Jo-1 autoantibodies (Figure 14.51): Jo1 syndrome Juvenile onset diabetes Juvenile rheumatoid arthritis (JRA): Keratoconjunctivitis sicca Ki autoantibodies Kinetochore autoantibodies Ku Ku antibodies Ku autoantibodies LATS protector LE cell LE cell test LE cell "prep," LE factor Lens-induced uveitis Liver cytosol autoantibodies Liver membrane antibodies Liver membrane autoantibodies Liver–kidney microsomal antibodies Liver–kidney microsome (LKM-1) autoantibodies Liver–kidney microsome 2 (LKM-2) autoantibodies Liver–kidney microsome 3 (LKM-3) autoantibodies LM autoantibodies Long-acting thyroid stimulator (LATS) Lung autoantibodies Lupoid hepatitis Lupus anticoagulant Lupus erythematosus Lupus erythematosus and pregnancy: Lupus nephritis Lymphadenoid goiter: Lymphocytotoxic autoantibodies Marek's disease MBP Mercury and immunity: Metatype autoantibodies Mitochondrial antibodies Mitochondrial autoantibodies (MA) Mitotic spindle apparatus autoantibodies Molecular mimicry MRL-lpr/lpr mouse Multicatalytic proteinase autoantibodies: Multiple autoimmune disorders (MAD): Myelin autoantibodies: Myelin basic protein (MBP) Myelin basic protein (MBP) antibodies Myelin-associated glycoprotein (MAG) autoantibodies Myocardial autoantibodies (MyA) Myositis-associated autoantibodies Myositis-specific autoantibodies: Natural autoantibodies Nephritic factor autoantibodies: Nephritic factor: Neurological autoimmune diseases Neuromuscular junction autoimmunity: Neuronal autoantibodies Neutrophil cytoplasmic antibodies neutrophil leukocyte New Zealand black (NZB) mice New Zealand white (NZW) mice NOD (nonobese diabetic) mouse NON mouse Nucleolar autoantibodies NZB/ NZW F1 hybrid mice organ-specific antigen organ-specific autoimmune diseases, Ovary antibodies (OA) Ovary autoantibodies Oxidized low-density lipoprotein autoantibodies Paraneoplastic autoantibodies Paraneoplastic autoimmune syndromes Paraneoplastic pemphigus Parathyroid hormone autoantibodies Parietal cell antibodies Parietal cell autoantibodies Paroxysmal cold hemoglobinuria (PCH) Pathologic autoantibodies Pemphigoid Pemphigus erythematosus (Senear-Usher syndrome) Pemphigus foliaceus Pemphigus vulgaris Perinuclear factor (profillagrin) autoantibodies Pernicious anemia (PA) Phacoanaphylactic endophthalmitis: Phospholipid autoantibodies Pituitary autoantibodies Platelet autoantibodies: PM-Scl autoantibodies Polyendocrine autoimmunity: Polyendocrine deficiency syndrome (polyglandularautoimmune syndrome) Postcardiotomy syndrome Postinfectious encephalomyelitis Postinfectious iridocyclitis Primary sclerosing cholangitis (PSC) Proteolipid protein autoantibodies: Prothrombin antibodies RA cell RANA autoantibodies Reticulin autoantibodies Retina autoantibodies Rheumatoid arthritis Rheumatoid arthritis cell (RA cell) Rheumatoid factor (RF) rheumatoid nodule Rheumatoid pneumonitis Ribosomal P protein autoantibodies (RPP) RNA polymerase RNA polymerases I, II, and III autoantibodies: Ro/SS-A and La/SS-B: Scl-70 (topoisomerase I) autoantibody Scleroderma: Sedormid purpura (historical): Sequestered antigen Sex hormones and immunity: Sicca complex side effect Signal recognition particle autoantibodies against SRP Silicate autoantibodies Sjögren’s syndrome Skin autoantibodies Smooth muscle antibodies SNagg Speckled pattern Sperm antibodies Sperm autoantibodies Spliceosomal snRNP autoantibodies: Spontaneous autoimmune thyroiditis (SAT) SS-A Ro SS-A/Ro antibodies SS-B La SS-B/La antibodies Steroid cell antibodies Stiff man syndrome (SMS) Striational antibodies Striational autoantibodies (StrAb) Sympathetic nervous system autoantibodies: Sympathetic ophthalmia Systemic autoimmunity Systemic lupus erythematosus (SLE) Systemic lupus erythematosus, animal models: Systemic sclerosis: T cell vaccination (TCV) Testicular autoimmunity: Threonyl- transfer RNA synthetase autoantibodies: Threonyl-transfer RNA synthetase antibodies Thyroglobulin Thyroglobulin autoantibodies Thyroid antibodies Thyroid autoimmunity animal models: Thyrotoxicosis Thyrotropin Thyrotropin receptor autoantibodies Tissue transglutaminase autoantibodies tissue-specific antigen Topoisomerase I Tubular basement membrane autoantibodies U1 snRNP autoantibodies U2 snRNP autoantibodies Ubiquitin autoantibodies Undifferentiated connective tissue disease Vasectomy Virus infection associated autoantibodies: Vitiligo Voltage-gated-calcium channel autoantibodies: Witebsky’s criteria: xenobiotics, α2-plasmin inhibitor-plasmin complexes (α2PIPC) β-adrenergic receptor antibodies: Atlas of Immunology, Second Edition Table of Contents file://1567_FM.pdf Chapter 15: Mucosal Immunity A polyimmuoglobulin receptor Antiseptic paint Bronchial-associated lymphoid tissue (BALT) Chase-Sulzberger phenomenon: Colostrum Coproantibody cutaneous immune system cutaneous lymphocyte antigen Cutaneous sensitization Cutaneous T-cell lymphoma Gut-associated lymphoid tissue (GALT) Helicobacter pylori immunity: Immune exclusion Inductive sites Intraepidermal lymphocytes intraepithelial lymphocytes L-Selectin lamina propria Langerhans cells Local immunity M cell MadCAM-1 Maternal immunity MIC molecules microfold cells Mucosa homing Mucosa-associated lymphoid tissue (MALT) mucosal immune system Mucosal lymphoid follicles Mucosal tolerance Oral immunology: oral tolerance Oral tolerance Oral unresponsiveness Photoimmunology sacculus rotundus Secretory component (T piece) or secretory piece Secretory component deficiency Secretory IgA secretory immune system Skin immunity: Sulzberger-Chase phenomenon Thy-1+dendritic cells Transcytosis Atlas of Immunology, Second Edition Table of Contents file://1567_FM.pdf Chapter 16: Immunohematology A blood group: AB blood group: ABO blood group substances ABO blood-group antigen: absorption elution test Acquired B antigen albumin agglutinating antibody Alloimmunization Anti-D Anti-I Antiglobulin Antiglobulin antibodies antiglobulin inhibition test antiglobulin test Antiglobulin test: Antigranulocyte antibodies antiplatelet antibodies B blood group: Back typing Bakª Blood group antigens Blood grouping Bromelin C4A C4B CHAD Chido (Ch) and Rodgers (Rg) antigens Codominant Cold agglutinin Cold agglutinin syndrome Cold antibodies Cold hemagglutinin disease: Coombs' test Cryptantigens DAT Dextrans Direct agglutination direct antiglobulin test direct Coombs' test: Donath-Landsteiner antibody dot DAT Duffy blood group Erythroblastosis fetalis: Erythrocyte autoantibodies Exchange transfusion Ficin Front typing H antigen H substance HDN: Hemagglutination hemagglutination inhibition reaction hemagglutination inhibition test hemagglutination test hemagglutinin Hemolytic anemia of the newborn: Hemolytic disease of the newborn (HDN) Hydrops fetalis Ii antigens immediate-spin crossmatch Immune antibody Immunohematology Incompatibility Incomplete antibody indirect antiglobulin test indirect Coombs' test Isohemagglutinin Isoimmunization Isophile antibody isophile antigen Kell blood group system Kernicterus Kidd blood group system Landsteiner's rule (historical): Lewis blood group system Lewisx/Sialyl-LewisxCD15/CD15S: Lutheran blood group Lw antibody McCleod phenotype MNSs blood group system Natural antibodies nonsecretor Null phenotype O antigen: O blood group P antigen P1A1 antibodies, Panagglutination para-Bombay phenotype Plasma Platelet antigens Platelet transfusion: Polyagglutination Polymorphism Polyspecific antihuman globulin (AHG) PPLO (pleuropneumonia-like organisms): public antigen (supratypic antigen) Rh null Rhesus antibody Rhesus antigen Rhesus blood group system Rhesus incompatibility RhoD immune globulin RhoGAM Rodgers (Rg) antigens saline agglutinin secretor Senescent cell antigen Serum albumin T activation: T agglutinin T antigen(s) The ABO blood group system The Bombay phenotype Thrombocytopenia Thrombocytosis TRALI ( transfusion-related acute lung injury) Transfusion Transfusion reaction(s) transfusion-associated graft-vs.-host disease (TAGVHD) U antigen universal donor universal recipient warm antibody Xga zeta potential Atlas of Immunology, Second Edition Table of Contents file://1567_FM.pdf Chapter 17: Immunological Diseases and Immunopathology Immunopathology Immunopathic Immunoparasitology BLOOD Autoimmune neutropenia Granulocyte antibodies: Agranulocytosis Idiopathic thrombocytopenic purpura ITP Aplastic anemia: Leukemia Leukemia viruses: Acute lymphoblastic leukemia (ALL) Common acute lymphoblastic leukemia antigen (CALLA) CALLA HAM HTLV chromosomal translocation B cell chronic lymphocytic leukemia/small lymphocytic lymphoma (B-CLL/SLL) Chronic lymphocytic leukemia (CLL) Follicular lymphoma Hairy cell leukemia Histiocytic lymphoma Histiocytosis X Letterer-Siwe disease White pulp disease Eosinophilic granuloma T cell leukemia T cell leukemia viruses Reticulum cell sarcoma T cell lymphoma (TCL) Mantle zone lymphoma Cutaneous T cell lymphoma Mycosis fungoides CD10 (CALLA) CD14 CD15 CD23 CD30 Myeloid antigen CD33 CD34 CD41 CD44 CD56 CD57 Acute myelogenous leukemias (AML) Lineage infidelity Chronic myelogenous leukemia (CML) Philadelphia chromosome Chronic myeloid leukemia Angioimmunoblastic lymphadenopathy (AILA) AILA Systemic immunoblastic proliferation: Immunoblastic lymphadenopathy: Immunoblastic sarcoma Plasmacytoma Hodgkin's disease BLA-36 lymphoma Castleman's disease Pseudolymphoma Lymphomatosis Biclonality: Progressive transformation of germinal centers (PTGC) Reticulosis: Reed-Sternberg cells Immunoproliferative small intestinal disease (IPSID) SKIN Allergic contact dermatitis Atopic dermatitis Bronchiectasis Bullous pemphigoid Bullous pemphigoid antigen: Dermatitis herpetiformis (DH) Pemphigus vulgaris Erythema multiforme Immunocyte Psoriasis vulgaris Sweet's syndrome (acute febrile neutrophilic dermatosis) VASCULATURE Leukocytoclastic vasculitis Hypocomplementemic vasculitis Nuclear dust (leukocytoclasis) Wegener's granulomatosis Antineutrophil cytoplasmic antibodies (ANCA) Antineutrophil cytoplasmic antibody Antineutrophil cytoplasmic autoantibodies (pANCA) Atypical antineutrophil cytoplasmic antibodies ANNA Polyarteritis nodosa Periarteritis nodosa Henoch-Schoenlein purpura Purpura Hypergammaglobulinemic purpura MUSCLE Inflammatory myopathy Dermatomyositis Polymyositis NEUROMUSCULAR Myasthenia gravis (MG) Experimental autoimmune myasthenia gravis (EAMG): Thymic medullary hyperplasia Acetycholine receptor (AChR) antibodies THYROID Chronic lymphocytic thyroiditis Hashimoto's disease (chronic thyroiditis) Thyroid autoantibodies Experimental autoimmune thyroiditis (EAT) EAT Experimental allergic thyroiditis Graves' disease (hyperthyroidism) Hyperthyroidism Thyrotoxicosis Long-acting thyroid stimulator (LATS) LUNG Usual interstitial pneumonitis Lymphocytic interstitial pneumonia (LIP) Farmer's lung Adult respiratory distress syndrome (ARDS) Adult T cell leukemia–lymphoma (ATLL) Faenia rectivirgula Extrinsic allergic alveolitis Fog fever Byssinosis Thermoactinomyces species Bagassosis Sugarcane worker's lung: Sarcoidosis Kveim reaction (historical) Asthma Charcot-Leyden crystals Intrinsic asthma Churg-Strauss syndrome (allergic granulomatosis) Bird fancier's lung Pulmonary vasculitis Hypersensitivity pneumonitis Aspergillus species MULTISYSTEM Rheumatic fever (RF) Erythema marginatum St. Vitus dance (chorea) Chorea Polyarthritis Jones criteria Aschoff bodies Takayasu's arteritis Kawasaki's disease Mucocutaneous lymph node syndrome: Acute rheumatic fever: Lymphomatoid granulomatosis MLNS (mucocutaneous lymph node syndrome): Hypersensitivity angiitis Hypersensitivity vasculitis DIGESTIVE SYSTEM Crohn's disease Gluten-sensitive enteropathy (celiac sprue, nontropical sprue) Colon antibodies Colon autoantibodies: Antigliadin antibodies (AGA) Celiac sprue (gluten-sensitive enteropathy) Celiac disease: Whipple's disease Ulcerative colitis (immunologic colitis) Inflammatory bowel disease (IBD) Immunologic colitis Erythema nodosum Regional enteritis IBD Sprue: Pernicious anemia (PA) Parietal cell antibodies LIVER Chronic active hepatitis (autoimmune) Granulomatous hepatitis Piecemeal necrosis Silicosis: Berylliosis Caplin's syndrome Cellular interstitial pneumonia Smooth muscle antibodies Primary biliary cirrhosis (PBC) PBC Hepatitis immunopathology panel Soluble liver antigen antibodies Hepatitis B Serum hepatitis (hepatitis B) Delta agent (hepatitis D virus [HDV]) Hepatitis non-A, non-B (C) (NAN BH) Non-A non-B hepatitis: Hepatitis serology PANCREAS Insulin-dependent diabetes mellitus (IDDM), type 1 Diabetes mellitus, insulin dependent (type I): Acanthosis nigricans Immune complex disease (ICD) Immune complex pneumonitis Glomerulonephritis (GN) Membranous glomerulonephritis Membranoproliferative glomerulonephritis (MPGN) Entactin nidogen Immunotactoid glomerulopathy Acute poststreptococcal glomerulonephritis Interstitial nephritis Nephritic syndrome Nephrotic syndrome α1-microglobulin α2 macroglobulin (α2M) Proteinuria Hematuria Hypocomplementemic glomerulonephritis Masugi nephritis Heymann antigen: Heymann glomerulonephritis Heymann's nephritis: Poststreptococcal glomerulonephritis Humps IgA nephropathy (Berger's disease) Berger's disease End-stage renal disease (ESRD) Dense-deposit disease Basement membrane antibody Goodpasture's syndrome Goodpasture's antigen Linear staining NERVOUS SYSTEM Multiple sclerosis (MS) Miller-Fisher syndrome Oligoclonal response Oligoclonal bands: Myelin basic protein Experimental allergic encephalomyelitis Experimental allergic neuritis Experimental allergic orchitis Acute disseminated encephalomyelitis Experimental autoimmune encephalomyelitis Anti myelin-associated glycoprotein (MAG) antibodies Antineutrophil cytoplasmic antibodies (ANCA): Experimental autoimmune neuritis (EAN) Experimental autoimmune oophoritis Postinfectious encephalomyelitis Anti-tau antibodies EYE Sympathetic ophthalmia Vogt-Koyanagi-Harada (VKH) syndrome Cogan's syndrome Uveitis Experimental autoimmune uveitis (EAU) Mooren's ulcer Cicatrical ocular pemphigoid SPERMATOZOA Antisperm antibody CARTILAGE Relapsing polychondritis SYSTEMIC AUTOIMMUNE DISEASES Systemic lupus erythematosus (SLE) Band test Drug-induced lupus (DIL): Liquefactive degeneration MCTD Raynaud's phenomenon Mixed-connective tissue disease (MCTD) Vinyl chloride (VC) Wire loop lesion Butterfly rash LE cell Antinuclear antibodies (ANA) Anti-doublestranded DNA (Anti-dsDNA) Alopecia areata Lupus anticoagulant Discoid lupus erythematosus Rheumatoid arthritis (RA) Pannus Rheumatoid factor (RF) RF rheumatoid nodule Rheumatoid arthritis cell (RA cell) RA RANA (rheumatoid arthritis-associated nuclear antigen) Ragocyte Ragg RA-33 Perinuclear antibodies Crystallographic antibodies Phenylbutazone Ankylosing spondylitis Adjuvant disease Sjögren’s syndrome Experimental autoimmune sialoadenitis (EAS) Mikulicz's syndrome SSPE SS-A Sjögren’s syndrome (SS) systemic lupus erythematosus (SLE) SS-B Progressive systemic sclerosis (scleroderma) Tight skin-1 mouse (Tsk1) Tight skin-2 mouse (Tsk2) Anti-topoisomerase I (Scl 70) Scl-70 antibody CREST complex GAMMAPATHIES Amyloidosis Sago spleen Serum amyloid A component (SAA) Serum amyloid P component (SAP) Monoclonal immunoglobulin deposition disease (MIDD) Amyloid Protein AA Protein P Protein SAA AA amyloid Amyloid P component Multiple myeloma Ig myeloma subclasses: M protein Myeloma IgA paraproteinemia Paraprotein Myeloma protein Myeloma, IgD IgM paraproteinemia: Flame cells H-chain disease Pseudolymphomatous lymphadenitis Myelomatosis Heavy-chain diseases: Gammopathy Hypergammaglobulinemia: M component Light-chain disease Monoclonal gammopathy Plasmacytoma Monoclonal gammopathy of undetermined significance (MGUS) Plasma cell dyscrasias Plasma cell leukemia MGUS: Benign monoclonal gammopathy Heavy-chain disease Cryofibrinogenemia Polyclonal hypergammaglobulinemia Cryoglobulin Umbrella effect α Heavy-chain disease Cryoglobulinemia Dysgammaglobulinemia: γ Heavy-chain disease, Essential mixed cryoglobulinemia Purpura hyperglobulinemia: Monoclonal immunoglobulin monoclonal protein Bence-Jones ( B-J) proteins POEMS syndrome POEMS Crow-Fucase syndrome: Waldenström’s macroglobulinemia Macroglobulinemia Macroglobulin M macroglobulin Paraproteinemias Paraimmunoglobulins: Pseudoparaproteinemia Beta–gamma bridge: Paraendocrine syndromes M macroglobulin β-pleated sheet amyloid β fibrillosis Burkitt's lymphoma BLR-1/MDR-15 (Burkitt’s lymphoma receptor-1/Monocyte-derived receptor-15) Myc Epstein-Barr virus (EBV) Epstein-Barr nuclear antigen c-myb v-myb oncogene: Lymphoma belt Sezary syndrome Sezary cells Behcet's disease Transmissible spongiform encephalopathy (TSE) immunity: Mouse hepatitis virus (MHV) Chronic fatigue syndrome (CFS) Eosinophilic myalgia syndrome (EMA) Hemolytic anemia PCH HAM test: PNH cells Atlas of Immunology, Second Edition Table of Contents file://1567_FM.pdf Chapter 18: Immunodeficiencies: Congenital and Acquired Acquired agammaglobulinemia: Acquired C1 inhibitor deficiency acquired immunodeficiency Adenosine deaminase (ADA) deficiency Agammaglobulinemia (hypogammaglobulinemia) Antibody deficiency syndrome: Ataxia telangiectasia B cell leukemias Bare lymphocyte syndrome (BLS) Beige mice Bloom syndrome (BS) Bruton’s disease Bruton’s agammaglobulinemia Btk “bubble boy” C1 deficiencies: C1 inhibitor (C1 INH) deficiency: C1q deficiency C2 deficiency: C3 deficiency C4 deficiency C5 deficiency C6 deficiency C7 deficiency C8 deficiency C9 deficiency Cell-mediated immunodeficiency syndrome CGD Chediak-Higashi syndrome Chemotactic assays: Chemotactic disorders Chronic and cyclic neutropenia Chronic granulomatous disease (CGD) Chronic lymphocytic leukemia/small lymphocytic lymphoma Chronic mucocutaneous candidiasis Combined immunodeficiency Common variable antibody deficiency: Common variable immunodeficiency (CVID) Complement deficiency conditions Congenital agammaglobulinemia: Congenital immunodeficiency Copper and immunity: Copper deficiency: CR3 deficiency syndrome: Cytochrome b deficiency: Deficiency of secondary granules Deoxyguanosine: DiGeorge syndrome Duncan's syndrome: ecto-5′-nucleotidase deficiency Elevated IgE, defective chemotaxis, recurrent infection,and eczema: Epstein-Barr immunodeficiency syndrome: Gene therapy Glucose-6-phosphate dehydrogenase deficiency: Gnotobiotic Hereditary angioedema (HAE) Hereditary ataxia telangiectasia: Human immune globulin (HIG) Human SCID (hu-SCID) mouse: Hyper-IgM syndrome: Hyperimmunoglobulin E syndrome (HIE) Hyperimmunoglobulin M syndrome Hypogammaglobulinemia IgA deficiency: IgG subclass deficiency IgM deficiency syndrome Immunodeficiency Immunodeficiency animal models: An immunodeficiency associated with hereditary defective response to Epstein-Barr virus Immunodeficiency disorders Immunodeficiency from hypercatabolism of immunoglobulin Immunodeficiency from severe loss of immunoglobulinsand lymphocytes Immunodeficiency with partial albinism Immunodeficiency with T cell neoplasms Immunodeficiency with thrombocytopenia Immunodeficiency with thrombocytopenia and eczema (Wiskott-Aldrich syndrome) Immunodeficiency with thymoma Immunoglobulin A deficiency Immunoglobulin deficiency with elevated IgM Immunoincompetence Immunological deficiency state: Infantile agammaglobulinemia Infantile sex-linked hypogammaglobulinemia Interleukin-1 receptor deficiency: Intestinal lymphangiectasia: JAK3-SCID Job's syndrome κlight-chain deficiency Late-onset immune deficiency Lazy leukocyte syndrome Lesch-Nyhan syndrome Leukocyte adhesion deficiency (LAD) LFA-1 deficiency Light-chain deficiencies: lymphocytic lymphoma Major histocompatibility complex Class II deficiency (MHC II deficiency) Mantle zone lymphoma MHC class I deficiency MHC class II deficiency mouse Myeloperoxidase Myeloperoxidase (MPO) deficiency Neutrophil nicotinamide adenine dinucleotide phosphate oxidase: Nezelof's syndrome Nucleoside phosphorylase Omenn's syndrome Phagocyte disorders Phagocytic cell function deficiencies: Phagocytic dysfunction phagocytic index (PI) Primary agammaglobulinemia: Primary immunodeficiency Purine nucleoside phosphorylase (PNP) deficiency Purine nucleotide phosphorylase (PNP) Reticular dysgenesis SCID (severe combined immundeficiency) human mouse SCID (severe combined immunodeficiency) mouse SCID (severe combined immunodeficiency): Secondary immunodeficiency Selective IgA and IgG deficiency Selective IgA and IgM deficiency Selective IgA deficiency Selective IgM deficiency Selective immunoglobulin deficiency severe combined immune-deficient (SCID) mouse Severe combined immunodeficiency (Swiss-type agammaglobulinemia) Severe combined immunodeficiency syndrome (SCID) Somatic gene therapy Swiss agammaglobulinemia Swiss type agammaglobulinemia Swiss type immunodeficiency: T cell immunodeficiency syndromes (TCIS) Thymic alymphoplasia Thymic hypoplasia Thymic hypoplasia (DiGeorge syndrome) Transcobalamin II deficiency with hypogammaglobulinemia Transcobalamin II deficiency: Transient hypogammaglobulinemia of infancy Tuftsin deficiency: Wiskott-Aldrich syndrome X-linked agammaglobulinemia (Bruton’s X-linked agammaglobulinemia) X- linked hyper-IgM syndrome: X-linked (congenital) agammaglobulinemia X-linked lymphoproliferative syndrome X-linked lymphoproliferative disease (XLP) X-linked severe combined immunodeficiency (XSCID) ZAP-70 deficiency Atlas of Immunology, Second Edition Table of Contents file://1567_FM.pdf Chapter 19: Acquired Immune Deficiency Syndrome (AIDS) Acquired immune deficiency syndrome (AIDS) Acquired immunodeficiency Acute AIDS syndrome: AIDS (acquired immune deficiency syndrome) AIDS belt AIDS dementia complex: AIDS embryopathy AIDS encephalopathy AIDS enteropathy AIDS serology: AIDS treatment. AIDS treatment: AIDS virus: AIDS-related complex (ARC) ALVAC Anti-p24 Azidothymidine AZT BI-RG-587 Cytokine upregulation of HIV coreceptors: Cytomegalovirus (CMV) ddC (dideoxycytidine) ddI ( 2',3'-dideoxyinosine) Envelope glycoprotein (env) Epivir® Foscarnet Fusin Gancyclovir (9-[2-hydroxy-1(hydroxymethyl) ethoxymethyl] guanine) Gay bowel syndrome gp120 gp160 HALV (human AIDS-lymphotropic virus) (historical): Highly active anteretroviral therapy (HAART) HIV infection: HIV-1 genes HIV-1 virus structure HIV-2 HIV-2V HTLV-IV Human immunodeficiency virus (HIV) HUT 78 Intracellular immunization Kaposi's sarcoma LAV: Lentiviruses MAIDS Mycoplasma–AIDS link Neopterin Norvir® p24 antigen PCP Pediatric AIDS Pentamidine isoethionate Peptide T Persistent generalized lymphadenopathy (PGL) Pneumocystis carnii (PCP) Progressive multifocal leukoencephalopathy Quaternary syphilis Retrovir® Retrovirus Retrovirus immunity: rev protein Reverse transcriptase Ribavarin (1-8-5-D ribofuranosyl-1,2,4-triazole-3-carboxamide) RNA-directed DNA polymerase (reverse transcriptase) SAIDS (simian acquired immunodeficiency syndrome) Serpins Simian immunodeficiency virus (SIV) SIV (simian immunodeficiency virus) SRV-1 Sustiva® Tat tat gene Videx® Viracept® Viramune® VLIA (virus-like infectious agent) Window Ziagen® Zidovudine (3'-azido-3'-deoxythymidine) Atlas of Immunology, Second Edition Table of Contents file://1567_FM.pdf Chapter 20: Immunosuppression Suppression Nonspecific T cell suppressor factor Immune suppression Immunosuppression Nonspecific suppression Immunosuppressive agents NONSPECIFIC IMMUNOSUPPRESSION Corticosteroids Glucocorticoids Prednisolone (1,4-Pregnadiene-11β,17α, 21-Triol-3,20-Dione) Prednisone (1,4-Pregnadiene-17α,21-DIOL-3,11,20-Trione) 17-hydroxycorticosteroids (17-OHCS): Chemical “splenectomy”: 6-mercaptopurine (6-MP) Azathioprine Cyclophosphamide (N,N-bis-[2-choroethyl]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-amine-2-oxide) Chlorambucil (4-[bis(2-chloroethyl)amino-phenylbutyric acid) Busulfan (1,4-butanediol dimethanesulfonate) Methotrexate (N-[p-[[2,4-diamino-6-pteridinyl-methyl] methylamino] benzoyl] glutamic acid) Melphalan (l-phenylalanine mustard) Cyclosporine (cyclosporin A) (ciclosporin) Immunophilins Cyclophilin Tacrolimus: FK506 FKBP (FK-binding proteins) Rapamycin Sirolimus Sandoglobulin® Brequinar sodium (BQR) Mycophenolate mofetil RS61443 (Mycophenolate mofetil) Antimetabolite Antilymphocyte serum (ALS) or antilymphocyte globulin (ALG) Antithymocyte serum (ATS) Antithymocyte globulin (ATG) OKT®3 (Orthoclone OKT®3) Radiation and immunity: radiomimetic drug Total lymphoid irradiation (TLI) H65-RTA Immunosenescence SPECIFIC IMMUNOSUPPRESSION Anti B and T cell receptor idiotype antibodies Anti-target antigen antibodies Clonal deletion (negative selection) B cell lymphoproliferative syndrome (BLS): Polyomavirus immunity: Wasting disease: Cytotoxic drugs Cytosine arabinoside Reticuloendothelial blockade trophoblast Uromodulin Tamm-Horsfall protein Cycle-specific drugs Atlas of Immunology, Second Edition Table of Contents file://1567_FM.pdf Chapter 21: Transplantation Immunology 2-mercaptoethanol agglutination test Acute graft-vs.-host reaction Acute rejection Adoptive immunity Adoptive immunization Adoptive transfer ALG ALG (antilymphocyte globulin) Alloantiserum Allogeneic Allogeneic disease allogeneic effect Allogeneic inhibition allograft Alloimmunization Alloreactive Alloreactivity allotransplant ALS (antilymphocyte serum) Antibody screening: Antilymphocyte serum (ALS) or antilymphocyte globulin (ALG) Antithymocyte globulin (ATG): ATG autograft Autologous Autologous bone marrow transplantation (ABMT): Autologous graft Backcross Bone marrow Bone marrow cells Bone marrow chimera: Bone marrow transplantation cell tray panel chimera Chimerism Chronic graft-vs.-host disease (GVHD) Chronic rejection Corneal transplants CREGs Cross-match testing cross-matching procedure CYNAP CYNAP phenomenon: Cytotoxic T lymphocytes direct reaction donor Engraftment Enhancement Enhancing antibodies extended haplotype Fetus allograft: First-set rejection Flow cytometry graft Graft arteriosclerosis Graft facilitation Graft rejection Graft-vs.-host disease (GVHD) graft-vs.-host reaction (GVHR) Graft-vs.-leukemia (GVL): GVH disease: GVH: H-Y Haplotype Heart–lung transplantation Hematopoietic chimerism: hematopoietic stem cell Hematopoietic stem cell (HSC) transplants Heterogeneic: Heterograft: heterologous Heterotopic heterotopic graft Histocompatibility Histocompatibility antigen histocompatibility locus Histocompatibility testing HLA HLA allelic variation HLA Class III: HLA disease association HLA locus HLA nonclassical class I genes HLA oligotyping HLA tissue typing HLA-A HLA-B HLA-C HLA-D region, HLA-DM HLA-DP subregion HLA-DQ subregion HLA-DR antigenic specificities HLA-DR subregion HLA-E HLA-F HLA-G HLA-H Homograft Homograft reaction Homograft rejection Homologous chromosomes Homologous disease: Homotransplantation: Homozygous homozygous typing cell (HTC) technique Homozygous typing cells (HTCs) Host-vs.-graft disease (HVGD) Human leukocyte antigen (HLA) HY Hyperacute rejection Hyperacute rejection Immediate spin crossmatch Immune privilege: Immunofluorescent “staining” of C4d Immunoinhibitory genes Immunoisolation immunologic barrier Immunologic enhancement Immunologic facilitation Immunological rejection Immunologically privileged sites Immunotoxin: Immunotyping: Incompatibility Indirect antigen presentation: Interallelic conversion irradiation chimera Islet cell transplantation Islets of Langerhans Isoantibody isoantigen. Isogeneic (isogenic) isograft Isoleukoagglutinins Isologous Leptin Leukoagglutinin Leukocyte transfer: Linkage disequilibrium Lymphocyte defined (LD) antigens Lymphocyte determinants Lymphocyte transfer reaction: MHC haplotype Microlymphocytotoxicity Minor histocompatibility antigens minor histocompatibility locus Minor histocompatibility peptides: Minor lymphocyte stimulatory (MIs) loci: Minor lymphocyte stimulatory (MIs) loci: Minor lymphocyte-stimulating (Mls) determinants Minor lymphocyte-stimulating genes: Minor transplantation antigens: Mixed leukocyte reaction (MLR): mixed-lymphocyte culture (MLC) mixed-lymphocyte reaction (MLR) MLC: Molecular (DNA) typing: sequence-specific priming (SSP) Mouse immunoglobulin antibodies: Multilocus probes Normal lymphocyte transfer reaction: OKT®3 (Orthoclone OKT®3) organ bank Organ brokerage, Orthoclone OKT3 Orthotopic orthotopic graft Pancreatic transplantation Parabiotic intoxication Phenotype Platelet-associated immunoglobulin (PAIgG) Polymorphism Posttransfusion graft-vs.-host disease Primed lymphocyte test (PLT): Primed lymphocyte typing (PLT) private antigen Privileged sites public antigen (supratypic antigen) Radiation bone marrow chimeras: Radiation chimera: Rejection rescue graft Second-set rejection Second-set response Secondary disease semisyngeneic graft Serological determinants Serologically defined (SD) antigens Simonsen phenomenon Single locus probes (SLPs) skin graft skin-specific histocompatibility antigen Small “blues” split thickness graft Splits Stem cells Supratypic antigen: Syngeneic Syngeneic preference syngraft take Tissue typing Toxic epidermal necrolysis Transplantation Transplantation antigens Transplantation immunology Transplantation rejection Trypan blue Trypan blue dye exclusion test Venoocclusive disease (VOD) w W,X,Y boxes (class II MHC promoter) White graft rejection Xenoantibodies Xenoantibody Xenoantigen Xenogeneic xenograft Xenoreactive Xenotransplantation Xenotype Xenozoonosis Zoonosis Atlas of Immunology, Second Edition Table of Contents file://1567_FM.pdf Chapter 22: Tumor Immunology Abrin Adoptive immunotherapy Amphiregulin An immunotoxin Antibody-dependent cell-mediated cytotoxicity (ADCC) Antibody-directed enzyme prodrug therapy (ADEPT) Antimalignin antibodies Autochthonous benign tumor Biological response modifiers (BRM) Blocking factors CA-125 CA-15-3 CA-19-9 Calcitonin CALLA Cancer Carcinoembryonic antigen (CEA) carcinogen carcinoma Carcinoma-associated antigens CD10 (CALLA) CEA Cellular oncogene: choriocarcinoma Concomitant immunity Cytotoxic T lymphocytes (CTLs) Designer lymphocytes Embryonic antigens fetal or oncofetal antigen heteroconjugate Heteroconjugate antibodies Hybrid resistance IL-2/LAK cells Immunologic enhancement (tumor enhancement) Immunologic facilitation (facilitation immunologique) Immunological escape Immunolymphoscintigraphy Immunolymphoscintigraphy Immunoscintigraphy Immunoselection Immunosurveillance Immunotherapy Interferon α (IFN-α) LAK cells Lymphokine-activated killer (LAK) cells MAGE-1 protein Magic bullet Malignant Malignolipin (historical) melanoma antigen-1 gene (MAGE-1) Melanoma-associated antigens (MAA) Metastasis Natural killer (NK) cells neoantigens neoplasm Oncofetal antigens oncogene theory Oncogenes Oncogenesis Oncogenic virus Oncomouse promoter Prostate-specific antigen (PSA) protooncogene Radioimmunoscintigraphy Ras Ras: Reverse immunology Ricin Ricinus communis Rous sarcoma virus (RSV) Sarcomas “Sneaking through” Spontaneous remission SV40 (simian virus 40) Thymicleukemia antigen (TL) TIL Tumor antigens Tumor imaging Tumor immunity: Tumor necrosis factor α (TNF-α) Tumor necrosis factor-β (TNF-β) Tumor necrosis factor receptor Tumor promoter: Tumor-associated antigens Tumor-infiltrating lymphocytes (TIL) v-myb oncogene Winn assay α-fetoprotein Atlas of Immunology, Second Edition Table of Contents file://1567_FM.pdf Chapter 23: Immunity against Microorganisms Abelson murine leukemia virus (A-MuLV) Ablastin Acquired immunity acquired immunity, Acute-phase serum Acyclovir 9 (2-hydroxyethoxy-methylguanine) adaptive immune response Adaptive immunity Adenoviruses, infection, and immunity: AIDS Antibody-dependent cell-mediated cytotoxicity (ADCC) Anticytomegalovirus (CMV) antibody Antigen masking antigenic variation Antigenic variation Arenavirus immunity: artificially acquired immunity Artificially acquired passive immunity Ascaris immunity: Australia antigen (AA) B-type virus (Aspergillus macaques) Babesiosis immunity: Bacillus anthracis immunity: Bacterial immunity: Bacterial immunoglobulin-binding proteins Bactericidin Bacteriolysin Bacteriolysis Bacteroides immunity: BFPR biological false-positive reaction Bordetella immunity: Bordetella pertussis Borrelia immunity: Borrelia immunity: Brucella immunity: Bunyaviridae immunity: Calcivirus immunity: Campylobacter immunity: Candida immunity: Canine distemper virus capsid Capsular polysaccharide Capsule swelling reaction: Cardiolipin Caseation necrosis Caseous necrosis Cat scratch disease, CD230 Cecropin Chagas' disease: Chancre immunity Chemotaxis Chemotaxis Chicken pox (varicella) Chlamydia immunity: Cholera toxin Cholera toxin Chronic active hepatitis (autoimmune) Circulatory system infections: Clostridium immunity: Coagglutination Coccidioides immunity: Coccidiodin Concomitant immunity Convalescent serum Coronavirus immunity: Corynebacterium diphtheriae immunity: Coxsackie Creutzfeldt-Jakob syndrome Cryptococcus neoformans immunity: Cryptosporidium immunity: Cryptosporidium immunity: Cytochalasins Cytomegalovirus (CMV) Cytomegalovirus (CMV) immunity: Cytopathic effect (of viruses) DANE particle Dapsone DDS syndrome Defective endogenous retroviruses: Delta agent (hepatitis D virus [HDV]) Dengue Diphtheria toxin directional flow E antigen EBNA (Epstein-Barr virus nuclear antigen): Echinococcus immunity: ECHO virus (enteric cytopathogenic human orphan virus) Effector mechanisms effector phase effector response Elephantiasis Encapsulated bacteria End-binders Endotoxin Endotoxin shock endotoxins Entamoeba histolytica antibody enterotoxin Epstein-Barr virus Epstein-Barr virus (EBV) Escherichia coli immunity: Exotoxin Fasciola immunity: Fernandez reaction Fibronectin Filarial immunity: Filovirus immunity: Flagellar antigens Flagellar antigens Flagellin Flavivirus immunity: Francisella immunity: Frei test FTA-ABS (Fluorescence treponema antibody absorption) Fungal immunity: Fungi Fusobacterium immunity: Ghon complex Group agglutination: H antigens H antigens Haemophilus immunity: Halogenation HAV HbcAg HbeAg HBLV (human B lymphotropic virus): HbsAg HBV HBx helminth Hepatitis A Hepatitis B Hepatitis B surface antigen (HbsAg) antibody Hepatitis B virus immunity: Hepatitis B virus protein X: Hepatitis C virus immunity: Hepatitis D virus: Hepatitis E virus (HEV) Hepatitis E virus immunity: Hepatitis immunopathology panel Hepatitis serology Hepatitis, non-A, non-B (C) (NANBH) Herpes simplex virus 1 and 2 (HSV 1 and 2) polyclonal antibody Herpes simplex virus immunity: Herpes zoster Herpesvirus Herpesvirus-6 immunity: Herpesvirus-8 immunity: HHV Hib (Hemophilus influenzae type b) Histoplasma immunity: Homozygote Hookworm immunity: HPV HSV Immunological memory Immunological memory: Infectious mononucleosis Infectious mononucleosis syndrome(s) influenza Influenza hemagglutinin Influenza virus immunity: Influenza viruses innate immune Innate immune mechanisms against parasites: innate immunity against intracellular bacteria innate immunity against extracellular Innate immunity against intracellular bacteria Innate or constitutive defense system: Intimin Intracellular pathogens Invasin Jarisch-Herxheimer K antigens (K) cells or ADCC (antibody-dependent cell-mediated cytotoxicity) K cells (killer cells) Ketokonazole Klebsiella immunity: Kuru Latency Legionella immunity: Leishmania Leishmaniasis Lepra cells Leptospira immunity: Lepromatous leprosy Leukocyte activation: Lipopolysaccharides Listeria: Listeria immunity: Listeria monocytogenes: Lyme disease Lymphogranuloma venereum (LGV) Lysogeny Lysozyme MAC MAIS complex: Malaria Mantoux test mechanical barriers Metronidazole mitogen Mitsuda reaction Moloney test, Mononuclear phagocytes Moro test MOTT (mycobacteria other than Mycobacterium tuberculosis) MOTT cell Mucocutaneous candidiasis: Mycobacteria immunity: Mycobacterium Mycoplasma immunity: Natural immunity against viruses Natural immunity: Natural killer (NK) cells Natural passive immunity Naturally acquired immunity Neisseria immunity: Neuraminidase neutralization Neutralization Neutralizing antibody: Newcastle disease Nocardia immunity: O antigen Onchocerciasis volvulus immunity: Opisthorchiasis–clonorchiasis immunity: opsonin Opsonins Organism-specific antibody index (OSAI) Owl eye appearance oxygen-dependent killing P1 kinase Papillomavirus immunity: Papovaviruses Parainfluenza virus (PIV) immunity: Paramyxovirus immunity: Parasite immunity: Parasites Parvovirus Parvovirus immunity: Passive immunity Pasteurella immunity: pathogen Pathogen-associated molecular pattern (PAMP) Pathogenicity Pattern recognition receptors (PRRs) peptidoglycan layer Phagocytic cells Phagocytosis Phosphocholine antibodies Picornavirus picornavirus Picornavirus immunity: Pili PMNs (polymorphonuclear neutrophils) Poliovirus Poxvirus immunity: Proteus immunity: Prion Protective immunity Protein M (M antigen) protoplast Provirus PRP antigen Pseudomonas aeruginosa immunity: Pyogenic bacteria pyogenic infection Pyogenic microorganisms Pyrogen Q fever Quellung phenomenon Quellung reaction Rabies Released antigen Reovirus immunity: Rhabdovirus immunity: Rhinovirus immunity: Rickettsia immunity: Rotavirus Sabin-Feldman dye test Salmonella immunity: Scarlet fever Schistosoma immunity: Schistosomiasis secondary granule Secretory immunoglobulin A (SigA) Septic shock: Seroconversion Serotype Shigella immunity: Shingles (Herpes zoster) Slow viruses Smallpox: somatic antigen somatic antigen, Specific immune response to extracellular bacteria: spheroplast Spherulin Staphylococcal enterotoxins (Ses) Staphylococcus immunity: Street virus Streptobacillus immunity: Streptococcal M protein Streptococcus immunity: Strongyloides immunity: Strongyloides hyperinfection: Subacute sclerosing panencephalitis Superinfection “immunity” Suramin (Antrypol, 8,8′-(carbonyl-bis -(imino-3,1-phenylenecarbonylimino))-bis-1,3,5-naphthalene trisulfonic acid) surface secretions Systemic inflammatory response syndrome (SIRS): Taenia solium immunity: TB Tetanus Tetanus toxin Theiler's virus myelitis: Theileria immunity: Togavirus immunity: TORCH panel Toxic shock syndrome Toxocara canis immunity: Toxoplasma gondii immunity: Transferrin Treponema immunity: Trichuris trichiura immunity: Tropical eosinophilia Trypanosome immunity: v-myb oncogene Varicella Varicella-zoster virus immunity: Variola (smallpox): VDRL (Venereal Disease Research Laboratory) test Vi antigen Vibrio cholerae immunity: Viral capsids Viral hemagglutination: Viral immunity: Viral interference Virion Viroid Viropathic Virulence genes virus Virus-associated hemophagocytic syndrome Virus-neutralizing capacity Yersinia immunity: Atlas of Immunology, Second Edition Table of Contents file://1567_FM.pdf Chapter 24: Vaccines and Immunization AIDS vaccines Anavenom attenuate Attenuated attenuated pathogen Attenuation autogenous vaccine bacterial vaccine bacterin BCG (Bacille Calmette-Guerin) caprinized vaccine Catch-up vaccine challenge Challenge stock Chronic progressive vaccinia (vaccinia gangrenosa) (historical): Combination vaccines Combined prophylactic: Conjugate vaccine Cowpox CRM 197 Dead vaccine: Diathelic immunization Diphtheria immunization Diphtheria toxin Diphtheria toxoid Diphtheria vaccine DPT vaccine DTaP vaccine edible vaccine Formol toxoid Generalized vaccinia Haemophilus influenzae type b vaccine (HB) HEP Hepatitis vaccine Hepatitis B vaccine: heterologous vaccine Heterotypic vaccine: HGP-30 Hib (Hemophilus influenzae type b) homologous vaccine Hookworm vaccine Human diploid cell rabies vaccine (HDCV) Hyperimmune Hyperimmunization immunizing dose (ImD50) Immunoprophylaxis Inactivated poliovirus vaccine inactivated vaccine Influenza virus vaccine International Unit of Immunological Activity killed vaccine Killed virus vaccines lapinized vaccine LD50 LEP (low egg passage) Live attenuated measles (rubeola) virus vaccine Live attenuated vaccine Live measles and mumps virus vaccine Live measles and rubella virus vaccine Live measles virus vaccine Live oral poliovirus vaccine Live rubella virus vaccine live vaccine Malaria vaccine: Mass vaccination Measles vaccine mixed vaccine MMR vaccine Multivalent vaccine: Mumps vaccine Passive immunization Pertussis vaccine Plague vaccine: Pneumococcal 7 valent conjugate vaccine Pneumococcal polysaccharide vaccine Poliomyelitis vaccines: Polyvalent pneumococcal vaccine polyvalent vaccine Postrabies vaccination encephalomyelitis Postvaccinal encephalomyelitis Provocation poliomyelitis PTAP Rabies vaccination: Rabies vaccine: rinderpest vaccines Rubella vaccine Sabin vaccine Salk vaccine Smallpox vaccination Smallpox vaccine: TAB vaccine Tetanus antitoxin Tetanus toxoid Tetanus vaccine toxoid toxoid–antitoxin floccules Triple vaccine Tuberculosis immunization Typhoid vaccination: Typhoid vaccine: Vaccinable vaccinate Vaccination Vaccination vaccine Vaccine extraimmunization Vaccinia immune globulin Varicella (chickenpox) vaccine variolation Whooping cough vaccine: Yellow fever vaccine β propiolactone Atlas of Immunology, Second Edition Table of Contents file://1567_FM.pdf Chapter 25: Therapeutic Immunology Aminophylline: antihistamine Avionics® B lymphocyte Stimulator (BlyS) Biological response modifiers (BRM) Biologicals Bombesin Botulinum toxin Campath-1 (CD52) CAMPATH-1M Chlorambucil (4-[bis(2-chloroethyl) amino-phenylbutyric acid) Cimetidine Dendritic cell immunotherapy: Despecification Diphtheria antitoxin Gas gangrene antitoxin HAMA HBIG (hepatitis B immunoglobulin) HGG HIG Human immune globulin (HIG) Hydroxychloroquine Immune serum Immune serum globulin Immunoablation Immunoaugmentive therapy (IAT) Immunomodulation immunoprotein Immunotherapy Inosiplex (Isoprinosine) Intolerance Intravenous immune globulin (IVIG) IVIG L-phenlyalanine mustard Levamisole Monoclonal antibody (Mab) therapy Naprosyn Naproxen (2-naphthaleneacetic acid, 6-methoxy-α-methyl) Nonsteroidal antiinflammatory drugs (NSAIDs) Phenylbutazone (4-butyl-1,2-diphenyl-3,5-pyrazolidenedione) Propylthiouracil Quinidine Roquinimex Serotherapy Tetanus antitoxin: Therapeutic antisera Tolmetin Vinblastine Vincristine Atlas of Immunology, Second Edition Table of Contents file://1567_FM.pdf Chapter 26: Comparative Immunology antiglutinin Avian (bird) immunity: Bacteria: Balb/ c mice bas Bony fish (teleosts): C3H/HeJ mice Canine immunity: Cartilaginous fishes: CBA mouse CBA/N mouse coelomocyte Coisogenic strains Coisogenic: Commensal mice Congenic Congenic mice: Congenic strains: “conventional (holoxenic) animals” conventional mouse Corals: e allotype Echinoderms: Encapsulation f allotype F protein Feline immunity: Fertilizin Fish immunity: Gene conversion GPLA gld gene Harderian gland Hm-1 IgR IgW IgX IgY Immunity in prokaryotes: Inbred mouse strain: Inbred strain Inbreeding Insects: Invertebrate immunity: Iridovirus immunity: Jawless fishes (cyclostomes, e.g., hagfish and lampreys): Jugular bodies L2C leukemia LCM: Low responder mice Lymphocytic choriomeningitis (LCM) Mammals: Marsupial immunity: Molluscs and Arthropods: Ovine immune system: Phagocytosis Phylogeny Phytoalexins Phytohemagglutinin (PHA) Phytoimmunity Phytomitogens Phytonicides Plant immunity: Porcine immunity: Primate (nonhuman) immune system: Protozoa Rabbit immunity: Rabbit immunoglobulin allotypes: Random breeding Recombinant inbred strains Reptile immunity: sacculus rotundus species specificity Sponges: systemic acquired resistance (SAR) T cell system T globulin TFA antigens Tunicates: Ungulate immunity: Worms: Xenopus Atlas of Immunology, Second Edition Table of Contents file://1567_FM.pdf Chapter 27: Immunological Methods and Molecular Techniques 2-mercaptoethanol agglutination test ABC method Absorption Acridine orange Adsorption Adsorption chromatography AET rosette test (historical) Affinity chromatography Agar gel Agarose Aminoethylcarbazole (AEC), Ammonium sulfate precipitation: Anti-Toxoplasma gondii antibody antibody absorption test Antigen capture assay Antigen retrieval Antigen-binding cell (ABC) assay: antiglobulin consumption test Antihistone antibodies Antisperm antibody Apheresis Ascoli's test ASLT ASO (antistreptolysin O) Autoantibody assays autofluorescence Autoradiography Bacteriophage neutralization test: BDB: Bentonite (Al2O3 4SiO2 H2O) Biolistics Biotin–avidin system: Bis-diazotized benzidine blocking test Blot Bright Brucellin Buffy coat C1q binding assay for circulating immune complexes (CIC) Capsule swelling reaction: Capture assays Cardiolipin Casoni test Cell line Cell separation methods: Cell surface molecule immunoprecipitation cell-mediated lympholysis (CML) test CFT CH50 unit Chemiluminescence Chemotactic assays: Chromatography Chromium release assay: chromogenic substrate CIE: Cleveland procedure Cloned DNA cloned enzyme donor immunoassay Coccidioidin Cold ethanol fractionation Cold target inhibition Collagen disease/lupus erythematosus diagnostic panel Competitive binding assays Competitive inhibition assay complement fixation assay complement fixation reaction Concatamer integration Confocal fluorescent microscopy conglutinating complement absorption test Conglutination conglutinin solid phase assay consumption test control Coprecipitation Counter electrophoresis: Counter migration electrophoresis: Countercurrent electrophoresis: Counterimmunoelectrophoresis (CIE) Crithidia assay Crithidia luciliae Crossed immunoelectrophoresis Cryopreservation Cryostat® Cunningham plaque technique Cytotoxicity assays Cytotoxicity tests: Density gradient centrifugation Dialysis Dick test Dim direct fluorescence antibody method Direct immunofluorescence Direct staining DNA fingerprinting DNA microarray Dot blot Double diffusion test Double immunodiffusion double-layer fluorescent antibody technique Doubling dilution Dye exclusion test dye test EA ED50 edge artifact EIA Electroimmunodiffusion Electrophoresis Electrophoretic mobility Electroporation Elek plate ELISA (enzyme-linked immunosorbent assay): ELISPOT assay EMIT end-point immunoassay Enzyme immunoassay (EIA) Enzyme labeling enzyme-linked immunosorbent assay (ELISA) enzyme-multiplied immunoassay technique Erythrocyte agglutination test: excitation filter F:P ratio FACS® Farr technique Ferritin Ferritin labeling Feulgen reaction FICA (fluoroimmunocytoadherence) Ficoll Ficoll-Hypaque FIGE: FISH (fluorescence in situ hybridization) Flow cytometry Fluorescein Fluorescein isothiocyanate (FITC) Fluorescein-labeled antibody Fluorescence Fluorescence enhancement Fluorescence microscopy Fluorescence quenching fluorescence-activated cell sorter (FACS®) fluorescent antibody fluorescent antibody technique Fluorescent protein tracing Fluorochrome Fluorography Footprinting Footprints Foreign gene Gel diffusion Gel filtration chromatography Gene knockout Genetic knockout germ-free animal gonococcal complement fixation test Hapten inhibition test heaf test Hemadsorption inhibition test: Hemagglutination hemolytic plaque assay. Heterokaryon Histamine release assay: Histoplasmin histoplasmin test hook effect Hormone immunoassays: hybrid cell hybridization Identity testing: IE: IEF IEP: IFE: immobilization test Immune cell cryopreservation Immune clearance: Immune elimination immunoabsorbent Immunoabsorption Immunoadsorbents Immunoassay Immunobeads Immunoblot (Western blot) Immunoblotting Immunocytoadherence Immunodiffusion Immunoelectroadsorption Immunoelectron microscopy Immunoelectroosmophoresis: Immunoelectrophoresis (IEP) immunoferritin method Immunofluorescence Immunogold labeling Immunogold silver staining (IGSS) Immunohistochemistry Immunomagnetic technique: Immunonephelometry Immunoosmoelectropheresis: immunoperoxidase method Immunophenotyping Immunoprecipitation immunoradiometric assay (IRMA) Immunoradiometry Indirect agglutination (passive agglutination) indirect fluorescence antibody technique indirect fluorescence antibody technique Indirect hemagglutination test: Indirect immunofluorescence Inert particle agglutination tests inhibition test In-situ hybridization In situ transcription Interfacial test: Intracellular cytokine staining Ion exchange chromatography Isoelectric focusing (IEF) Isoelectric point (pI) Isotopic labeling (radionuclide labeling) Jerne plaque assay Johnin Knockout gene knockout mouse Lancefield precipitation test lane latex fixation test Latex particles Laurell crossed immunoelectrophoresis: Laurell rocket test leading front technique Lethal dose Leukapheresis Leukocyte culture: Light scatter Limiting dilution Lissamine rhodamine (RB200) lymphocyte antigen stimulation test lymphocyte mitogen stimulation test lymphocyte toxicity assay Lymphocyte transformation Macrophage functional assays macrophage migration test Macrophage–monocyte inhibitory factor (MIF) Mancini test Membrane immunofluorescence Methyl green pyronin stain Microlymphocytotoxicity Microtiter technique: Minimal hemagglutinating dose (MHD): Minimum lethal dose (MLD) Minisatellite Mixed agglutination Mixed agglutination Mixed hemadsorption mixed lymphocyte reaction (MLR) mixed-antiglobulin reaction Molecular hybridization probe Montenegro test Multilocus probes (MLPs) Natural fluorescence Nephelometry Neuron-specific enolase (NSE) neutralization test neutrophil microbicidal assay Nick translation nitroblue tetrazolium (NBT) test Nonspecific fluorescence Northern blotting Nylon wool Oakley-Fulthorpe test Old tuberculin (OT) OT (historical) Ouchterlony test Oudin test Outbreeding P-80 Pan keratin antibodies Pancreatic islet cell hormones: Panning PAP (peroxidase–antiperoxidase) technique paper radioimmunosorbent test (PRIST) PAS: Passive agglutination passive agglutination test Passive cutaneous anaphylaxis (PCA) patch test Paternity testing Paul-Bunnell test PCR Percoll® peroxidase–antiperoxidase (PAP) technique PFC (plaque-forming cell) PFU phage neutralization assay Phycoerythrin Plaque technique: Plaque-forming assay: plaque-forming cell (PFC) assay plaque-forming cell (PFC) assay Plaque-forming cells Plasmapheresis plasmid Polyethylene glycol assay for CIC polymerase chain reaction (PCR) prick test Protein B Protein blotting: Protein separation techniques: Protoplast fusion Pulsed-field gel electrophoresis quantitative precipitin reaction Quenching: Quin-2 radioallergosorbent test (RAST) Radioallergosorbent test: Radioimmunoassay (RIA) Radioimmunodiffusion Radioimmunodiffusion test: Radioimmunoelectrophoresis radioimmunoprecipitation assay ( RIPA) radioimmunosorbent test (RIST) Radiolabeling: Raji cell assay Ramon test (historical) RB200: Rebuck skin window Recombinant DNA technology red cell-linked antigen antiglobulin test Reiter complement fixation test (historical) Restriction fragment length polymorphism (RFLP) Reverse Mancini technique: reverse plaque method Reverse radioimmunodiffusion Reverse transcriptase polymerase chain reaction RFLP (restriction fragment length polymorphism) Rhodamine isothiocyanate RIA: Rieckenberg reaction RIST: RNA splicing RNAse protection assay Rocket electrophoresis Romer reaction (historical): Rose-Waaler test: RPR (rapid plasma reagin) test S S value (Sverdberg unit) Salt precipitation Salting out sandwich ELISA sandwich immunoassay Sandwich methodology: sandwich technique Schick test SDS-PAGE sedimentation coefficient Sedimentation pattern Sephadex® Sepharose® Sequence-specific priming (SSP) Serial dilution Serial passage sheep red blood cell agglutination test shift assay sia test (historical) Single diffusion test Single immunodiffusion (Mancini technique) Single locus probes (SLPs) Single radial immunodiffusion Site-directed mutagenesis skin test skin window Slide agglutination test Slide flocculation test: Slot blot analysis solid-phase radioimmunoassay Southern blotting Southwestern blot Spectratyping Spectrotype: Spot ELISA SRY Stormont test: Strain Streptolysin O test: STS: Svedberg unit T cell hybridomas: Takatsy method Tandem immunoelectrophoresis Tanned red cells tanned red cell test Taq polymerase Test dosing Texas red tine test TPHA: TPI: Trace labeling: Transcription Transduction Transfection Transgenes Transgenic transgenic animal Transgenic line Transgenic mice transgenic mouse Transgenic organisms Transgenics Treponema pallidum hemagglutination assay Treponema pallidum immobilization test Trypanosome adhesion test: tube agglutination test tuberculin test TUNEL assay (TdT-dependent dUTP-biotin nick end labeling) TUNEL-based assays, Turbidimetry Two-dimensional gel electrophoresis Ultracentrifugation Ultrafiltration vaginal mucous agglutination test Viability techniques virus neutralization test Vollmer test (historical) Waaler-Rose test: Wassermann reaction Weil-Felix reaction Western blot (immunoblot) Widal reaction Winn assay Zonal centrifugation Zone electrophoresis Zygosity λ cloning vector Atlas of Immunology, Second Edition Table of Contents file://1567_FM.pdf Chapter 28: Diagnostic Immunohistochemistry 200-4 nuclear matrix protein Actin Adrenocorticotrophic hormone (ACTH) antibody AE1/AE3 pan-cytokeratin monoclonal antibody ALZ-50 Anti-Ki- 67 (MIB) Anti-bcl-2 primary antibody Anti-BCL-6 (PG-B6p) mouse monoclonal antibody: Anti-BRST-2 (GCDFP-15) monoclonal antibody Anti-BRST-3 (B72.3) monoclonal antibody Anti-CD1a Anti-CD34 Anti-CD43 Anti-CD45R (Leukocyte common antigen) Anti-CD5 monoclonal antibody Anti-CD68 (human macrophage marker) Anti-Ewing's sarcoma marker (CD99) Anti-GM1 antibodies Anti-high molecular weight human cytokeratin antibodies Anti-LN1 Anti-low molecular weight cytokeratin Anti-p53 primary antibody (clone Bp53-11) Anti-Purkinje cell antibody Anti-Ri antibody Anti-T cell (CD45RO) Antibroad-spectrum cytokeratin Anticytomegalovirus antibody Antidesmin antibody Antiepithelial membrane antigen (EMA) antibody Antiestrogen receptor antibodies Antifactor VIII Antiglial fibrillary acidic protein (GFAP) antibody Antigrowth hormone (GH) antibody Antihepatitis B virus core antigen (HBcAg) antibody Antihuman α-smooth muscle actin Antihuman chorionic gonadotropin (HCG) antibody Antihuman cytokeratin (CAM 5.2) (cytokeratin 8,18) Antihuman cytokeratin 7 antibody Antihuman cytokeratin-20 monoclonal antibody Antihuman follicle-stimulating hormone (FSH) antibody Antihuman gastrin Antihuman glucagon antibody Antihuman hemoglobin Antihuman kappa light chain Antihuman Ki-1 antigen, CD30 Antihuman lambda light chain Antihuman luteinizing hormone (LH) Antihuman myeloperoxidase antibody Antihuman prostatic acid phosphatase (PSAP) Antihuman synaptophysin antibody Antihuman thyroglobulin Antihuman thyroid-stimulating hormone (TSH) Antimelanoma primary antibody Antimuscle actin primary antibody Antipancreatic polypeptide (PP) antibody Antipapillomavirus Antiparathyroid hormone (PTH) antibody Antiplacental alkaline phosphatase (PLAP) antibody Antiprogesterone receptor antibody Antiprolactin antibody Antiprostate specific antigen (PSA) antibody Antisomatostatin antibody Antivimentin antibody BRST-2 (GCDFP-15), monoclonal antibody (murine) c-erb -B2 murine monoclonal antibody CA-125 CA-125 antibody CA-15-3 CA-19-9 Calcitonin (CALLA/CD10) Carcinoembryonic antigen (CEA) CD10 CD117 (c-kit) (polyclonal), rabbit: CD15 (Leu M1) CD20 primary antibody CD21 antigen CD23(1B12): CD3 CD31 (JC/70A): CD99 (HO36-1.1): Chromogranin monoclonal antibody Collagen Type IV (CIV22): Colon–ovary tumor antigen (COTA) Common acute lymphoblastic leukemia antigen Common leukocyte antigen (LCA) (CD45) Cu-18 Cyclin D1 (polyclonal), rabbit: Cytokeratin (34betaE12), mouse: Cytokeratin 7 (K72), mouse: Decorate Desmin Desmin (D33), mouse: E-Cadherin (ECH-6), mouse: epithelial cell adhesion molecule (EpCAM) Epithelial membrane antigen (EMA) estradiol Estrogen/progesterone receptor protein: Factor VIII Fascin (55k-2), mouse: GCDFP-15 (23A3), mouse: Glialfibrillary acidic protein (GFAP) Gross cystic disease fluid protein 15 (GCDFP-15) antigen Hanganitziu-Deicher antigen Human milk-fat globulin (HMFG) Immunodiagnosis Immunoglobulin Immunohistochemistry Immunoperoxidase method: Inhibin, alpha (R1), mouse: Intermediate filaments Ki-1 (CD30 antigen) Ki-67 or -780 Lactalbumin Leu-M1 (CD15) MART-1 (M2-7C10), mouse: Monoclonal antiinsulin antibody Myogenin (F5D), mouse: Myoglobin Myoglobin antibody neurofilament Neurofilament (2F11), mouse: Neuron-specific enolase (NSE) Neuron-specific enolase (NSE) antibody Nonsquamous keratin (NSK) O125 (ovarian celomic) P63 (ap53 Homolog at 3q27–29) Ab-4 (cocktail) mouse monoclonal antibody pituitary hormones Polyclonal rabbit anti-calretinin Prostate-specific antigen (PSA) Prostatic acid phosphatase (PAP)/prostatic epithelial antigen PSA (prostate-specific antigen) S-100 S-100 protein S-100 protein antibody Serotonin (5-hydroxytryptamine [5-HT]) Streptavidin Synaptophysin TTF-1 (8G7G3/a), mouse: UCHL1 antihuman T cell, CD45RO Vimentin α-1 antichymotrypsin