Artificial Liver Support

Front Matter....Pages I-XXI
Mechanism of Liver Cell Destruction in Fulminant Hepatic Failure....Pages 1-7
Enzyme Patterns in Liver Failure....Pages 8-17
Synergism Among Toxic Factors and Other Endogenous Abnormalities in Hepatic Encephalopathy....Pages 18-24
On the Role of Free Phenols in the Blood of Patients in Hepatic Failure....Pages 25-31
The Biochemistry of Hepatic Detoxification....Pages 32-38
Determination of Liver Function and Liver Regeneration in Fulminant Hepatic Failure....Pages 39-45
The Development of a Haemoperfusion Device for Chronic Use....Pages 46-54
A New Charcoal Sorbent Fiber for Hemoperfusion....Pages 55-65
Agarose-Encapsulated Adsorbents I. Concept and General Properties....Pages 66-71
Agarose-Encapsulated Adsorbents II. Adsorption Characteristics....Pages 72-75
Agarose-Encapsulated Adsorbents III. In Vitro Haemocompatibility....Pages 76-81
Coating and Blood Compatibility of Amberlite XAD-4....Pages 82-88
Development of a Blood-Compatible Resin for Artificial Liver Support....Pages 89-95
Middle Molecules in the Serum of Patients and Rats with Liver Failure: Influence of Sorbent Haemoperfusion....Pages 96-102
Bilirubin Removal by Sorbent Hemoperfusion from Jaundiced Blood....Pages 103-109
Removal of Bile Acids by Various Means of Artificial Liver Support....Pages 110-114
Charcoal Haemoperfusion with PGI 2 in the Treatment of Fulminant Hepatic Failure....Pages 115-120
Hormone Losses by Charcoal Hemoperfusion....Pages 121-125
Hemoperfusion, Exchange Transfusion, Cross Circulation, Liver Perfusion, Hormones and Immobilized Enzymes....Pages 126-133
Partial Hepatectomy and Subsequent Charcoal Hemoperfusion in the Conscious Rat....Pages 134-140
Large-Pore Hemodialysis in Fulminant Hepatic Failure....Pages 141-146
Haemodialysis Procedures in Acute Liver Failure....Pages 147-152
Correction of Increased Plasma Amino Acid Levels by Dialysis with Amino Acid-Electrolyte-Glucose Solutions....Pages 153-158
Hemofiltration in Acute Liver Failure: Substition with Electrolyte Solution Versus Normal Animal Ultrafiltrate....Pages 159-163
Significance of Hepatic Energy Charge and Blood Ketone Body Ratio as Criteria of Liver Support. Indication and Efficiency in Hepatectomized Patients During Cross Dialysis....Pages 164-169
Effect of Liver Adapted Amino Acids on Portosystemic Encephalopathy in Patients with Cirrhosis of the Liver and Portosystemic Shunts....Pages 170-171
Somatostatin: A New Therapeutic Agent for Treatment of Hepatic Encephalopathy?....Pages 172-174
Continuous Flow Membrane Plasmapheresis Utilizing Cellulose Acetate Hollow Fiber in Hepatic Failure....Pages 175-180
Augmented Solute Reduction in Diseases Treated by Extracorporeal Detoxification Systems: X-Effect Hypothesis....Pages 181-188
Hemoperfusion-Induced Respiratory Distress Syndrome in an Animal Model: The Effects of Corticosteroids....Pages 189-197
Immobilized Hepatic Enzymes as a Tool in Extracorporeal Detoxification....Pages 198-201
Immobilization of Ligandin on Hollow Fiber Reactors....Pages 202-207
Detoxification of Phenols by Sulphate Conjugation: An Alternative to Glucuronidation in an Enzymatic Liver Support System....Pages 208-213
Enzymatic Methylation of Mercaptans: Applicability in an Enzyme Reactor Liver Support System....Pages 214-218
Liquid Membrane Enzyme Reactor for Artificial Liver Support....Pages 219-229
Advances in the Development of Immobilized Enzymes for Future Extracorporeal Liver Support....Pages 230-235
A Model Enzymic Extracorporeal Detoxification System. Part II....Pages 236-246
Liver Assist by Cultured Cells on Artificial Capillaries....Pages 247-253
Hemoperfusion over Small Liver Pieces for Liver Support....Pages 254-259
Hepatocellular Transplantation into the Rat Spleen: Transplantation of Hepatocytes Isolated from Cirrhotic Liver....Pages 260-267
Treatment of Acute Hepatic Failure by Extracorporeal Hemoperfusion over Human and Baboon Liver....Pages 268-273
Experience in the Treatment of Hepatic Coma by Extracorporeal Liver Perfusion....Pages 274-279
Functional Capacity of Extracorporeal Baboon Liver Perfusions....Pages 280-285
Clearance of Bilirubin and Bile Acids from the Serum of Patients Treated by Extracorporeal Baboon Liver Perfusions....Pages 286-292
The Influence of Baboon Liver Hemoperfusion on Serum Levels of Amino Acids and Free Fatty Acids in Patients with Acute Liver Failure....Pages 293-300
Surface Redox Potential and Vitality of an Extracorporeal Liver During Hemoperfusion....Pages 301-307
The Isolated Perfused Partially Hepatectomised Liver — A Source of Regeneration Stimulator Substance?....Pages 308-314
Treatment of Acute Liver Failure by Extracorporeal Baboon Liver Perfusions — Viewed by a Patient....Pages 315-316
Liver Regeneration Following Hepatic Resection Without Portal Blood....Pages 317-321
Liver Transplantation and Impending Hepatic Failure....Pages 322-327
Perspectives of Liver Transplantation in Cambridge....Pages 328-332
Back Matter....Pages 333-334