Apoptosis Senescence and Cancer

Front Matter....Pages I-XVII
Front Matter....Pages 1-1
The Intrinsic Pathway of Apoptosis....Pages 3-30
The Extrinsic Pathway of Apoptosis....Pages 31-54
Mitotic Catastrophe....Pages 55-72
Autophagy and Autophagic Cell Death....Pages 73-91
Regulation and Function of Detachment-Induced Cell Death (Anoikis) in Cancer Progression and Metastasis....Pages 93-107
Front Matter....Pages 109-122
Structure and Function of the Telomere....Pages 123-123
Overview of Senescence....Pages 125-144
Contributions of Telomerase to Tumorigenesis....Pages 145-157
The Role of Telomeres in Genomic Instability....Pages 159-171
Front Matter....Pages 173-189
Overview of the DNA Damage Checkpoint....Pages 191-191
DNA-Dependent Protein Kinase in Repair, Apoptosis, Telomere Maintenance, and Chemotherapy....Pages 193-221
Front Matter....Pages 223-241
Resistance/Signaling Pathways....Pages 243-263
Ceramide and Multidrug Resistance....Pages 265-278
Chemo- and Radiosensitization Through Inhibition of PI3K/Akt Signaling....Pages 279-279
The Advancement of Epidermal Growth Factor Receptor Inhibitors in Cancer Therapy....Pages 281-298
Front Matter....Pages 299-312
Antimetabolites....Pages 313-334
Topoisomerase I Poisons and Apoptotic Topoisomerase I-DNA Complexes....Pages 335-357
Front Matter....Pages 359-359
Perturbations of Cellular Functions by Topoisomerase II Inhibitors....Pages 361-382
The Significance of Poly-Targeting in Apoptosis Induction by Alkylating Agents and Platinum Drugs....Pages 383-406
Contributions of Apoptosis and Senescence to Cytotoxicity Produced by Microtubule-Stabilizing Agents....Pages 359-359
Tyrosine Kinase Inhibitors....Pages 407-422
Front Matter....Pages 423-463
Monoclonal Antibodies in Lymphomas....Pages 465-476
Role of Apoptosis in Anti-Angiogenic Cancer Therapies....Pages 477-508
Photodynamic Therapy-Induced Apoptosis....Pages 509-509
Modulation of TRAIL Signaling for Cancer Therapy....Pages 511-536
Back Matter....Pages 537-555
....Pages 557-578