Anticarcinogenesis and Radiation Protection

Front Matter....Pages i-xiv
The Involvement of Free Radicals in Chemical Carcinogenesis....Pages 1-9
Autoxidation and Enzymatic Oxidation of Unsaturated Lipids....Pages 11-16
Electron vs. H-Atom Transfer in Chemical Repair....Pages 17-24
Radiation Induced Reactions of Glutathione with Oxygen and their Possible Role in Biological Systems....Pages 25-32
Potential Limitation to Hydrogen Atom Donation as a Mechanism of Repair in Chemical Models of Radiation Damage....Pages 33-39
Mechanisms of Inactivation of Oxygen Species by Carotenoids....Pages 41-46
Inhibition of Autoxidation by Vitamin E and Bilirubin....Pages 47-50
The Role of Active Oxygen and the Metabolism of Arachidonic Acid in the Formation of Clastogenic Factor by Human Monocytes....Pages 51-57
Clastogenic Factors, A Link Between Chronic Inflammation and Carcinogenesis....Pages 59-62
Role of Eicosanoids in Tumor Cell-Platelet-Endothelial Cell Interactions....Pages 63-69
The Involvement of Peroxyl Free Radicals in Tumor Initiation and Promotion....Pages 71-80
Amplification of Tissue Peroxides in Disease....Pages 81-84
Peroxisome Proliferation-Related Oxidative Stress and Hepato-Carcinogenesis....Pages 85-91
Hydroxyl Free Radical Mediated Strand Breaks in PBR322 Plasmid DNA....Pages 93-96
Radiation-Like Modification of DNA and H 2 O 2 Formation by Activated Human Polymorphonuclear Leukocytes (PMNs)....Pages 97-102
Mitochondrial DNA Damage during Mitochondrial Lipid Peroxidation....Pages 103-108
Mitigation of Singlet Oxygen ( 1 Δ g O 2 ) Damage in Biological Systems....Pages 109-113
Reactive Oxygen Species are Mutagenic to Mammalian Cells....Pages 115-119
The Expression of Bacterial DNA Alkylation Repair Enzymes in Mer - Human Cells....Pages 121-127
Drpase, A New Activity in the DNA Base Excision Repair Pathway....Pages 129-133
Mechanism of Action of Exonuclease III from Escherichia Coli....Pages 135-138
The Isolation and Preliminary Characterization of Endonoclease VIII from Escherichia Coli....Pages 139-144
Incorporation of Dihydrothymidine and its Triphosphate During DNA Replication: An Implication for the Biological Consequence of Thymine C5-C6 Bond Saturation....Pages 145-150
Oxidative Damage: DNA Repair and Inducible Resistance....Pages 151-155
5-Hydroxymethyluracil in Cellular DNA is Repaired and Sensitizes Cells to Inhibitors of Poly(ADP-Ribose) Synthesis....Pages 157-162
Metabolic Protection Against Rapid Cell Death Induced by High Level DNA Damage....Pages 163-167
Tumor Promotion: A Problem of Differential Responses of Normal and Neoplastic Cells to Trophic Stimuli....Pages 169-174
Implication of Superoxide Radical Anion in Promotion of Neoplastic Transformation in Mouse JB6 Cells by TPA....Pages 175-181
Expression of Oxidant Stress-Related Genes in Tumor Promotion of Mouse Epidermal Cells JB6....Pages 183-190
Activation of Organic Hydroperoxide Tumor Promoters to Free Radicals in Target Cells....Pages 191-197
In Vivo Stimulation of Oxy Radicals by Mouse Skin Tumor Promoters....Pages 199-205
UVB Prevention of Mouse Skin Tumor Induction by the Initiation-Promotion Protocol....Pages 207-210
A Possible Role for Free Radicals in Tumor Progression....Pages 211-219
Differential Effects of 12-O-Tetradecanoylphorbol-13-Acetate (TPA) on Normal Initiated and Transformed Cells of a Single Mouse Keratinocyte Lineage....Pages 221-225
Oncogenes and Malignant Transformation of Human Keratinocytes....Pages 227-231
Nucleophiles as Anticarcinogens....Pages 233-240
Protection from N-Nitrosodimethylamine Mediated Liver Damage by Indole-3-Carbinol, and Correlation with Nucleophilic Index Value....Pages 241-245
Ozone Carcinogenesis and Co-Carcinogenesis and its Prevention....Pages 247-252
Exercise Training Effects on Mitochondrial Enzyme Activity, Ubiquinones and Vitamin E....Pages 253-257
Cancer Mortality Inversely Related to Plasma Levels of Antioxidant Vitamins....Pages 259-267
Beta-Carotene and Chemoprevention of Cancer....Pages 269-277
Cancer Chemoprevention with Vitamin A and Beta-Carotene in Populations at High-Risk for Lung Cancer....Pages 279-283
Anticarcinogenic Actions of Protease Inhibitors....Pages 285-295
Possible Mechanisms of Action of the Anticarcinogenic Protease Inhibitors....Pages 297-301
Dietary Choline Deficiency as a New Model to Study the Possible Role of Free Radicals in Acute Cell Injury and in Carcinogenesis....Pages 303-308
Inhibition of Genotoxicity by Diallyl Sulfide and Structural Analogues....Pages 309-312
Physiologic Anticarcinogenesis: Effects of Stable Strontium on Metastatic Bone Disease....Pages 313-319
Radiation vs Chemical Damage to DNA....Pages 321-327
Radon-Induced Transformation....Pages 329-334
Radiation-Induced Neoplastic Transformation of Human Cell Hybrids....Pages 335-340
Multiple Oncogene Activation in a Radiation Carcinogenesis Model....Pages 341-344
Radiation and Asbestos Fibers: Interaction and Possible Mechanism....Pages 345-348
Role of Peroxidase in Stimulation of the Pentose Cycle of A549 Cells by Aerobic Irradiation....Pages 349-354
Toxicity and Radioprotective Efficacy of Bis (3,5-Diisopropylsalicylato) Copper II and CuCl 2 ....Pages 355-360
Modulation of Glutathione Levels and Metabolism....Pages 361-371
Inhibition of Mutagenesis and Carcinogenesis by N-Acetylcysteine....Pages 373-379
Protective Effects of Thiols on Carcinogenesis Induced in Rats by 2-Acetylaminofluorene....Pages 381-386
The Role of Thiols in Response to Radiation and Drugs....Pages 387-397
The Role of Modification of DNA Damage in the Radioprotective Action of Aminothiols....Pages 399-402
Radioprotection in Rat Spinal Cord with WR2721, WR77913 and WR3689 Following Cerebral Lateral Ventricular or Intracisternal Administration....Pages 403-406
Production and Characterization of Monoclonal Antibodies to Thiol-Modified Glutathione....Pages 407-412
Induction of Differential Hypoxia in Tissues and its Implications for Therapy....Pages 413-419
Radioprotection in Vivo: Cellular Heterogeneity and Fractionation....Pages 421-430
Pharmacological Interference with DNA Repair....Pages 431-436
DNA Strand Scission by Activated Bleomycin Group Antibiotics....Pages 437-440
Prospects for Liposomes as Drug Carriers....Pages 441-450
The Inhibitory Effect of Parvovirus H-1 on Cultured Human Cancer Cells or Transformed Cells....Pages 451-455
Evaluation of Immunomodulatory and Therapeutic Properties of Biological Response Modifiers: A Comparison of Preclinical and Clinical Studies....Pages 457-473
Circumvention of Biologic Diversity of Cancer Metastasis....Pages 475-481
Comparison of Therapeutic Potential of Cytokines....Pages 483-490
Clinical Trials using Monoclonal Antibodies....Pages 491-497
Chemoprophylaxis by Interferons or Inducers against Chemical Carcinogenesis....Pages 499-502
Back Matter....Pages 503-509