Anticarcinogenesis and Radiation Protection 2

Front Matter....Pages i-xv
Cancer - Facts, Dilemmas and Mysteries....Pages 1-12
Environmental Causes of Cancer....Pages 13-20
The Evolution of Mutation Rates and Its Implications for Antimutagenesis....Pages 21-24
Phenotypic Complementation of Cells from Human Hereditary Diseases with Defects in Cellular Responses to DNA Damage, by Single Human Chromosomes....Pages 25-31
Secondary Tumors....Pages 33-37
Strategies for the Prevention of Treatment-Induced Secondary Cancer....Pages 39-45
The Expression of Bacterial DNA Repair Genes in Eukaryotic Cells and Vice Versa....Pages 47-56
Molecular Basis of Mutagenesis in Escherichia Coli K12 Deficient for DNA Polymerase I: Special Role of the Gtcg Sequence....Pages 57-60
Oxidative Mutagenesis by the Glutathione-Gamma-Glutamyl Transpeptidase System: Mechanism and Possible Relevance to Hepatocarcinogenesis....Pages 61-71
The Significance of Thymidine Kinase in Determining Resistance to Mutagenesis in Friend Mouse Leukemia Cells....Pages 73-77
Single-Strand DNA Shuttle Vectors for Analyzing DNA-Damage Processing....Pages 79-84
Janus Neutron Irradiation of a Mouse Cell Line Containing a Shuttle Vector Plasmid....Pages 85-92
Analysis of Constitutive and TCDD-Inducible Expression of Genes in the [Ah] Battery....Pages 93-98
Molecular Analysis of Tumorigenesis in Drosophila ....Pages 99-106
Tumor Suppressor Genes and the Age-Dependence of Cancer Incidence....Pages 107-109
Expression and Regional Induction of c-fos Gene in the Central Nervous System After Brain Injury....Pages 111-115
Molecular Genetics of Oncogene Activation and Gene Loss in Carcinogen-Induced Animal Tumours....Pages 117-122
Phorbol Ester Tumor Promoters and the Anti-Tumor-Promoter Dexamethasone Share a Molecular Target: Modulation of the Transcription Factor Ap-1 by a Novel Type of Interaction....Pages 123-127
Transformation of Human Fibroblasts by N-RAS Oncogene....Pages 129-134
The Retinoblastoma Gene: Its Role in Retinal Tumors and Non-Ocular Tumors....Pages 135-135
Wilms Tumour - A Developmental Anomaly....Pages 137-139
Formation of 8-Hydroxydeoxyguanosine in DNA and Carcinogenesis....Pages 141-144
Measurement of Long-Term Effects of Oxidative Drug Metabolism in Erythrocytes....Pages 145-149
Selection of γ-Glutamyl Transpeptidase-Positive Hepatocytes as a Function of GSH Depletion, Oxidative Stress and Alterations of Integrins....Pages 151-154
Biological Monitoring of Exposure to Polycyclic Aromatic Hydrocarbons....Pages 155-169
Cellular and Molecular Analysis of Immune Response to Tumor Cells: Demand for IL-2 and IL-4 in the Generation of Specific Anti-Tumor Cytotoxicity....Pages 171-175
Murine Monoclonal Antibody BG-9 as a Tool for Detection of Human Prostate Tumors....Pages 177-180
Factors Influencing the Transfer of Radionuclides in Agricultural Food Chains....Pages 181-199
Role of Energy Distribution in DNA on the Mutagenic Effects of Internal Emitters....Pages 201-210
Lung Cancer Risk from Exposure to Environmental Radon....Pages 211-221
Malignant Disease after Iodine-131 Therapy....Pages 223-225
Intervention Procedures for Radionuclides....Pages 227-228
Free Radical Chemistry of Ergothioneine, A Potential Radioprotector and Antimutagen....Pages 229-235
H-Atom Abstraction by Thiyl Radicals....Pages 237-241
Oxygen and Radical Scavengers in Radiation-Inactivation of Trypsin in Vitro ....Pages 243-246
Chemical Repair of Trypsin-Histidinyl Radical....Pages 247-251
Relationship Between Thiol-Induced Repair and Repair by Enzymes....Pages 253-260
Protection of Nuclear Enzymes by Aminothiols....Pages 261-268
Strategies for Protection and Experiments on Repair of Irradiated Sulfhydryl Enzymes....Pages 269-274
Antimutagenic and Anticarcinogenic Mechanisms of Aminothiols....Pages 275-285
Effect of an Aminothiol (WR-1065) on Radiation-Induced Mutagenesis and Cytotoxicity in Two Repair-Deficient Mammalian Cell Lines....Pages 287-295
Application of an in Vivo Mutagenesis System to Assess Aminothiol Effects on Neutron-Induced Genotoxic Damage in Mouse Splenocytes....Pages 297-301
The Effects of Aminophosphate Wr-2721 on the Isolated Perfused Heart and Isolated Uterus of the Rat....Pages 303-310
Variations of Glutathione Concentrations and of Cytosolic Enzyme Activities in the Liver of Rats Treated with 2-Acetylaminofluorene and/or N-Acetylcysteine....Pages 311-314
Mechanisms of Chemoprotection against Aflatoxin-Induced Hepatocarcinogenesis by Oltipraz....Pages 315-322
Influence of Pretreatment with Selenious Yeast on Radiation Sensitivity....Pages 323-326
Plant Antioxidants as Anticarcinogens....Pages 327-336
Toxic Effects of Oxygen and Antioxidants in Cho Cells and Rat Embryos in Culture....Pages 337-344
The Effects of Superoxide Dismutases on Isolated Smooth Muscle of the Rat....Pages 345-349
Antioxidative System in the Liver of Rats Subjected to Combined Irradiation Injury....Pages 351-355
Tumor Antipromoters: Sarcophytols A and B, (–)–Epigallocatechin Gallate (EGCG), and Morusin....Pages 357-362
Sarcophytols and Protease Inhibitors Suppress H 2 O 2 Formation and Oxidative DNA Damage....Pages 363-372
Autocrine Secretion and Carcinogenesis....Pages 373-381
Altered Structure of Steroid Receptors in Kidney Malignancy....Pages 383-388
Diet, Breast Cancer and Sex Hormone Metabolism....Pages 389-400
The Effect of Glucocorticoid and Antiglucocorticoid Hormones on the Growth of Mouse Melanoma Cells....Pages 401-403
Hormones and Antioxidant Defense....Pages 405-413
The Effect of Dexamethasone on the Antioxidant Enzymes in the Blood of Rats....Pages 414-416
Role of Cognitive Processes in Immuno-Modulation in Cancer Disease....Pages 417-422
Psychostress and Imbalance of Hormones as Risk Factors in Cancer Induction....Pages 423-428
Central Nervous System and Cancer....Pages 429-435
Epidemiological Evidence for the Role of the Central Nervous System in Cancer Causation....Pages 437-449
Personality and Cancer: Prediction and Prophylaxis....Pages 451-458
Back Matter....Pages 459-465