Annual Review of Pharmacology and Toxicology: 2003

Contents......Page 1
INDUCTION OF DRUG-METABOLIZING ENZYMES: A Path to the Discovery of Multiple Cytochromes P450......Page 4
PROTEIN FLEXIBILITY AND COMPUTER-AIDED DRUG DESIGN......Page 34
RETINOID RECEPTORS AND THEIR COREGULATORS......Page 49
NOVEL PHARMACOLOGICAL APPROACHES TO MANAGE INTERSTITIAL LUNG FIBROSIS IN THE TWENTY-FIRST CENTURY......Page 75
NITRIC OXIDE–RELEASING DRUGS......Page 98
2,5-HEXANEDIONE-INDUCED TESTICULAR INJURY......Page 125
HUMAN EXTRAHEPATIC CYTOCHROMES P450: Function in Xenobiotic Metabolism and Tissue-Selective Chemical Toxicity in the Respiratory and Gastrointestinal Tracts......Page 149
HORMESIS: The Dose-Response Revolution......Page 174
SIGNAL TRANSDUCTION–DIRECTED CANCER TREATMENTS......Page 197
REGULATORY MECHANISMS CONTROLLING GENE EXPRESSION MEDIATED BY THE ANTIOXIDANT RESPONSE ELEMENT......Page 230
MONOAMINE TRANSPORTERS: From Genes to Behavior......Page 258
GENETIC POLYMORPHISMS OF THE HUMAN MDR1 DRUG TRANSPORTER......Page 283
ACTIVATION OF THE ARYL HYDROCARBON RECEPTOR BY STRUCTURALLY DIVERSE EXOGENOUS AND ENDOGENOUS CHEMICALS......Page 306
TRAFFICKING OF NMDA RECEPTORS1......Page 332
TELOMERE INHIBITION AND TELOMERE DISRUPTION AS PROCESSES FOR DRUG TARGETING......Page 359
PHARMACOLOGY AND PHYSIOLOGY OF HUMAN ADRENERGIC RECEPTOR POLYMORPHISMS......Page 380
GENE THERAPY WITH VIRAL VECTORS......Page 411
K+ CHANNEL STRUCTURE-ACTIVITY RELATIONSHIPS AND MECHANISMS OF DRUG-INDUCED QT PROLONGATION......Page 438
COMPLEMENTARY AND ALTERNATIVE THERAPEUTICS: Rigorous Research is Needed to Support Claims......Page 460
CHALLENGING DOGMA: Thresholds for Genotoxic Carcinogens? The Case of Vinyl Acetate......Page 483
THE CAENORHABDITIS ELEGANS DOPAMINERGIC SYSTEM: Opportunities for Insights into Dopamine Transport and Neurodegeneration......Page 519
ALZHEIMER’S DISEASE: Molecular Understanding Predicts Amyloid-Based Therapeutics......Page 547
PROGRESS TOWARD CLINICAL APPLICATION OF THE NITRIC OXIDE–RELEASING DIAZENIUMDIOLATES......Page 587
INNATE IMMUNE RESPONSES TOMICROBIAL POISONS: Discovery and Function of the Toll-Like Receptors......Page 612
THE ROLE OF DRUG TRANSPORTERS AT THE BLOOD-BRAIN BARRIER......Page 633