Anion Carriers of Mitochondrial Membranes

Front Matter....Pages I-XI
Front Matter....Pages 1-1
Purification and Characterization of Three Mitochondrial Substrate Carriers: the Phosphate, the 2-Oxoglutarate and the Dicarboxylate Carriers....Pages 3-15
Purification and Reconstitution of the 2-Oxoglutarate Carrier from Bovine Heart and Liver Mitochondria....Pages 17-34
Hydroxyapatite Chromatography as a Tool for the Isolation of Anion Carriers and Other Membrane Proteins....Pages 35-44
Purification of the Monocarboxylate Carrier by Affinity Chromatography....Pages 45-57
Recent Developments in the Extraction, Reconstitution, and Purification of the Mitochondrial Citrate Transporter from Normal and Diabetic Rats....Pages 59-69
Isolation and Functional Reconstitution of the Dicarboxylate Carrier from Bovine Liver Mitochondria....Pages 71-85
New Photoaffinity Derivatives of Malonate and Succinate to Study Mitochondrial Carrier Systems....Pages 87-97
Reaction Mechanism of the Reconstituted Aspartate/Glutamate Antiporter from Mitochondria. Reversible Switching to Uniport Function....Pages 99-110
Front Matter....Pages 111-111
Recent Studies on the Mitochondrial Phosphate Transport Protein (PTP) and on its Relationship to the ADP/ATP Translocase (AAC) and the Uncoupling Protein (UCP)....Pages 113-121
Mitochondrial Phosphate Carrier: Relation of its SH Groups to Oligomeric Organization....Pages 123-131
Recent Developments in the Study of the Conformational States and the Nucleotide Binding Sites of the ADP/ATP Carrier....Pages 133-146
Immunological and Enzymatic Approaches of the Orientation of the Membrane Bound ADP/ATP Carrier....Pages 147-157
The ATP/ADP Antiporter is Involved in the Uncoupling Effect of Fatty Acids....Pages 159-168
Molecular Aspects of the Adenine Nucleotide Carrier from Mitochondria....Pages 169-181
Kinetic Mechanisms of the Adenylic and the Oxoglutaric Carriers: a Comparison....Pages 183-195
Front Matter....Pages 197-197
Porins from Mitochondrial and Bacterial Outer Membranes: Structural and Functional Aspects....Pages 199-214
Modulation of the Mitochondrial Channel VDAC by a Variety of Agents....Pages 215-224
Bioenergetic Consequences of the Lack of Mitochondrial Porin: Identification of a Putative New Pore....Pages 225-235
Purification of Mammalian Porins....Pages 237-248
Front Matter....Pages 249-249
A Molecular Biology Study of the Uncoupling Protein of Brown Fat Mitochondria. A Contribution to the Analysis of Genes of Mitochondrial Carriers....Pages 251-260
Front Matter....Pages 249-249
On the Mechanism of Transport by the Uncoupling Protein from Brown Adipose Tissue Mitochondria....Pages 261-268
Regulation of the Amount and Activity of the Uncoupling Protein Thermogenin in Brown Adipose Tissue....Pages 269-281
Regulation of Uncoupling Protein and Formation of Thermogenic Mitochondria....Pages 283-291
Front Matter....Pages 293-293
Biogenesis of Mitochondrial Proteins....Pages 295-306
Insensitivity of Carbamoyl-Phosphate Synthetase Towards Inhibition by Carbamoyl Phosphate Makes it Unlikely that Mitochondrial Metabolite Transport Controls Ornithine Cycle Flux....Pages 307-315
Mitochondrial Adenine Nucleotide Translocation During Fatty Acid Metabolism in the Intact Cell....Pages 317-325
Control of Oxidative Phosphorylation in Yeast Mitochondria: The Role of Phosphate Carrier and pH....Pages 327-336
The Role of Pyrophosphate and the Adenine Nucleotide Transporter in the Regulation of the Intra-Mitochondrial Volume....Pages 337-348
Role of the Mitochondrial Outer Membrane in Dynamic Compartmentation of Adertine Nucleotides....Pages 349-359
Topology of Peripheral Kinases: its Importance in Transmission of Mitochondrial Energy....Pages 361-372
Control of Mitochondrial Energy Production in Vivo....Pages 373-381