Animal Cell Technology: Basic & Applied Aspects: Proceedings of the Sixth International Meeting of the Japanese Association for Animal Cell Technology, Nagoya, Japan, November 9–12, 1993

Front Matter....Pages i-xv
Evaluation of Viral Safety of Biotechnology Products Derived from Cell Lines of Human or Animal Origin....Pages 1-8
Combination of Virus Removal and Inactivation for Optimization of Recovery of Protein....Pages 9-15
Strategy of Virus Removal / Inactivation of Plasma-Derived Products : Interest of Nanofiltration as a New Virus Elimination Method....Pages 17-27
Expression of the extracellular domain of the human growth hormone receptor gene by an insect-baculovirus system....Pages 29-34
Expression of Recombinant Receptors in Insect Cells....Pages 35-40
Production of a Transmission Blocking Vaccine Candidate of Rodent Malaria Plasmodium Berghei Using a Baculovirus Expression Vector System....Pages 41-45
Establishment of Human B Cell Lines Producing Antigen-specific Antibodies through SCID Mice Reconstituted with Human Peripheral Blood Lymphocytes....Pages 47-51
Production of Humanised Monoclonal Antibodies for In Vivo Imaging and Therapy....Pages 53-61
Clinical Results with Humanized and Human Monoclonal Antibodies....Pages 63-73
Clinical Applications of Human Monoclonal Antibodies....Pages 75-79
Autocrine regulation of milk protein secretion....Pages 81-86
Therapeutic Applications of Transgenic Animals....Pages 87-93
FDA Perspective on the Use of Transgenic Animals in the Manufacture of Therapeutic Products Intended for Human Use: Safety Concerns....Pages 95-98
Hepatocyte Spheroid: Differentiated Features and Potential Utilization for the Bioreactor of Artificial Liver Support....Pages 99-101
Microencapsulated Islets as a Bioartificial Pancreas....Pages 103-114
A Novel Three-Dimensional Long-Term Bone Marrow Bioreactor Culture System....Pages 115-120
Process Technology in Cellular and Tissue Engineering....Pages 121-126
Fish IGF-I and IGF-II: Age-Related and Tissue- Specific Expression and Transgenesis....Pages 127-135
Inhibition of Aquatic Birnavirus Replication Process in Fish Cells by Viral Antisense RNA....Pages 137-144
Functional Analysis of the Homology and Heterology Promoters in Fish-Cultured Cells....Pages 145-149
Dialysis Perfusion Systems for the Production and Retention of High-Valued Products from Animal Cells....Pages 151-156
Methods for Animal Cell Immobilization Using Electrostatic Droplet Generation....Pages 157-160
Using Oxygen Uptake Rates to Time Infections in the Baculovirus Expression Vector System....Pages 161-166
On-Line Monitoring and Control of Glucose, Glutamine, Lactate and Ammonium during a High-Cell-Density Cultivation of Hybridoma Cells....Pages 167-170
Cultivation of Hybridomas, Human Cancer and Human Primary Cells Using the Miniaturized Hollow Fibre Bioreactor Tecnomouse®....Pages 171-175
Electrically Controlled Production of Monoclonal Antibody by Immobilized Hybridoma....Pages 177-181
Effect of Endogenous Retrovirus Production on Hybridoma Productivity....Pages 183-190
Effect of Dissolved Oxygen Concentration on Growth and Production of Biomaterials by Animal Cell Culture....Pages 191-195
Enhanced Productivity in Insect Cell Culture by Control of the Chemical Environment....Pages 197-204
Energy Balance and Protein Synthesis in Hybridoma Culture....Pages 205-212
Application of Fish Cells Immortalized by Oncogenes — Diagnostic Method for the Detection of Fish Iridovirus ( Iridoviridae ) by Polymerase Chain Reaction....Pages 213-218
Enhancement of Cellular Productivity by Oncogene Transfection....Pages 219-224
Comparison of wild and mutant β-lactoglobulin production between mammalian cells and yeast....Pages 225-229
Enhancement of γ -Carboxylation of Recombinant Activated Protein C by Cell Fusion....Pages 231-235
Modulation of oligosaccharide structure of a pro-urokinase derivative (pro-UKΔGS1) by culture conditions....Pages 237-241
The Analysis of Antigen-Antibody Binding Using Anti-RNase A Single Chain Fv-3A21....Pages 243-247
Enhanced Transcriptional Activity by Modifying the Chicken Ovalbumin Gene Promoter in the Oviduct Cell of Chickens....Pages 249-253
Expression of a Foreign Gene Introduced Into Bovine Embryos at Early Stages of Development....Pages 255-258
Expression of Milk Protein-Cat Chimeric Genes in Transfected Bovine and Mouse Mammary Epithelial Cells....Pages 259-263
Differentiation and Death of a Small Intestinal Epithelial Cell Line IEC-6....Pages 265-271
Establishment and Characterization of α s1 -Casein-Specific T Cell Lines from Milk-Allergic Patients....Pages 273-277
Actions of Branched-Chain Amino Acids on Protein Degradation in Cultured Muscle Cells....Pages 279-285
Immortalization of Human Endothelial Cells by Temperature Sensitive Simian Virus 40....Pages 287-291
Establishment of Hepatoblastoma Cell Line, HUH-6KK for Production of Biochemicals....Pages 293-298
 In vitro culture of primary B cells specific to a short peptide....Pages 299-303
Leukemia inhibitory factor and related peptides regulate glial fibrillary acidic protein in serum-free mouse embryo (SFME) cells....Pages 305-309
Factors Affecting the Induction of Ovalbumin mRNA in Primary Cultures of Oviductal Cells in the Chicken....Pages 311-315
Manipulation of Chicken Primordial Germ Cells for Transgenic Chicken....Pages 317-324
Anchorage-Dependent Growth and Recombinant Protein Production by Chinese Hamster Ovary Cells in Serum-Free Medium....Pages 325-329
High Cell Density and Serum-Free Culture of Hybridoma Cells Using Fixed Bed Porosphere System....Pages 331-335
Replacement of Bovine Insulin with Recombinant Long R 3 IGF-1 in CHO Cells....Pages 337-343
Serum-free medium for normal human melanocytes....Pages 345-349
Intracellular Analysis of a Lymphoblastoid Cell Line Using H-NMR....Pages 351-358
Certified Serum for Productivity Enhancement....Pages 359-363
Recombinant Antibody Expression in a Fixed Bed Perfusion System....Pages 365-372
Cost Effective High Density Mammalian Cell Culture....Pages 373-382
Continuous, Automated Reconstitution of Liquid Media Concentrates....Pages 383-388
Relationship of Inactivation Techniques of the Sera to Cellular Attachment on PHEMA and Polypropylene Surfaces....Pages 389-394
Establishment of a Rat Extracorporeal Circulation System to Estimate the Performance of a Hybrid Artificial Liver....Pages 395-399
Presumption of the Concentration of Several Constituents in the Culture Broth of Mouse-Mouse Hybridoma by Near Infrared Reflectance Spectroscopy....Pages 401-405
Enhancement of Monoclonal Antibody Production Related to Metabolic Behavior in High Density Hybridoma Culture....Pages 407-412
High Density Culture of rCHO Cells Using Hollow Fiber Systems....Pages 413-416
A Hollow Fiber Bioreactor Immobilizing Hepatocyte Spheroids Rapidly Formed by Large-Scale Suspension Culture....Pages 417-421
Effect of medium additives at AcNPV infection of insect cells on recombinant ß-galactosidase production in batch and two-stage bioreactor systems....Pages 423-428
On the Enhancement of Growth Yields in Hybridoma Culture....Pages 429-433
Production of rG-CSF by CHO cell in aggregate microbeads culture....Pages 435-439
Perfusion Culture using a Macroporous Microcarrier....Pages 441-445
High Speed Stirring Culture Using Macroporous Microcarrier....Pages 447-451
Cryopreservation of Cell-Laden Collagen Microspheres....Pages 453-462
A Continuous Cell Centrifuge for Lab Scale Perfusion Processes of Mammalian Cells....Pages 463-468
Polystyrene Microcarriers Coated with a Combination of Adhesion-Promoting Peptides....Pages 469-474
Chicken Whole-Embryo Culture as a Quick and Convenient System for Searching Physiologically Active Compounds....Pages 475-479
Effect of Fruit Components on the Proliferation and Antibody Production of Human-Human Hybridoma Cell Lines....Pages 481-485
Induction of HMG-CoA reductase and malic enzyme gene expressions by polychlorinated biphenyls in rat hepatocytes cultured on EHS-gel, not on Type I collagen....Pages 487-490
Effects of Glycinin Acidic A 1a Subunit on Insulin-Involved Cellular Metabolism in Rat Adipocytes and 3T3-L1 Cells....Pages 491-495
Physiologically Functional Substances in Shellfish Toward Several Cultured Mammalian Cell Lines....Pages 497-502
Purification and Characterization of Extracted Abalone (Haliotis Discus) Bioactive Protein....Pages 503-508
Development of Artificial Skin Using Raft Culture Technique and its Application to Study the Mechanism of Oncogenesis....Pages 509-515
Integrity Test of Virus Removal Membrane through Gold Particle Method and Liquid Forward Flow Test Method....Pages 517-522
Theoretical Approach for Integrity Test of Virus Removal Filter....Pages 523-528
“The FDA Quality/Compliance Continuum… Where do Cell Culture and Molecular Biology Products Stand”....Pages 529-535
Removal of Residual DNA in Biological Products by Cuprammonium Regenerated Cellulose Hollow Fiber (BMM™)....Pages 537-541
Removability and Permeability of DNA in Protein Solution Using BMM™....Pages 543-547
Protective in Vivo Effect Against Murine Rickettsia Infection by Recombinant Myeloperoxidase Produced in CHO Cells....Pages 549-553
A Novel Anti-Tumorigenic Protein Specific to SV40- and Human Papilloma Virus-Transformed Cells -The Possible Action Mechanism-....Pages 555-559
Suppressive Lymphokines Produced by CD8 + T Cells....Pages 561-565
Characterization of Erythropoietin Receptor on Two Neuronal Cell Lines....Pages 567-574
Heterogeneity in Light-Chains of Monoclonal Antibodies Produced by Mouse Hybridomas Raised with NS-1 Myelomas....Pages 575-579
Purification and Characterization of two Molecular Forms of Bovine Complement Factor H....Pages 581-588
Purification and Characterization of Growth and Differentiation Factors from Human Osteosarcoma Cell Line, OST-1-PF....Pages 589-593
Protection Against Cowdria Ruminantium Infection in Mice with Gamma Interferon Produced in Animal Cells....Pages 595-599
A Retrovirus-Associated Antigen Expressed in Human Lung Carcinoma....Pages 601-605
Back Matter....Pages 607-615