Angiogenesis in Health and Disease

Front Matter....Pages i-ix
Embryonic Development of Blood Vessels....Pages 1-15
Regulation of Embryonic Blood Vessel Formation....Pages 17-25
Role of Heterotypic Interactions Between Endothelial Cells and Parenchymal Cells in Organspecific Differentiation: A Possible Trigger for Vasculogenesis....Pages 27-41
Role of the Macrophage in the Regulation of Physiological and Pathological Angiogenesis....Pages 43-53
Endothelial Cell Heterogeneity and Differentiation....Pages 55-62
Heterogeneity in Endothelial Cells with Special Reference to their Growth Related Proteins....Pages 63-78
Basic Fibroblast Growth Factor and Endothelial Cells: Receptor Interaction, Signal Transduction, Cellular Response-Dissociation of the Mitogenic Activity of bFGF from its Plasminogen Activator-Inducing Capacity....Pages 79-89
Role of Integrins in Endothelial Cell Function....Pages 91-98
Specific Laminin Domains Mediate Endothelial Cell Adhesion, Alignment and Angiogenesis....Pages 99-110
Production of Plasminogen Activators and Matrix Metalloproteinases by Endothelial Cells: Their Role in Fibrinolysis and Local Proteolysis....Pages 111-126
Heparin Coordinately Suppresses Endothelial Cell Plasminogen Activator Inhibitor-1, Fibronectin and Thrombospondin mRNA Levels....Pages 127-133
Properties of Endothelial and Smooth Muscle Cells Grown in 3-Dimensional Collagen Lattices....Pages 135-141
Effect of Ischaemia on Endothelial Cells....Pages 143-147
Angiogenesis and Neoplastic Transformation....Pages 149-155
Vascular Proliferation in Tumours and its Influence on Cancer Therapy....Pages 157-171
The Development of the Tumour Vascular System: 2-D and 3-D Approaches to Network Formation in Human Xenografted Tumours....Pages 173-184
Tumor Induced Angiogenesis: Effect of Platelet Derived Growth Factor (PDGF), Pentoxifylline, Sodium Diethyldithiocarbamate, Epsilon Amino Caproic Acid and Tranexamic Acid....Pages 185-194
Vascular Growth in the Intermittently Ischemic Heart: A Study on Growth Factors Expression....Pages 195-206
Role of Mechanical Factors in Angiogenesis under Physiological and Pathophysiological Circumstances....Pages 207-215
Low Molecular Mass Non-Protein Angiogenic Factors and Their Role in the Disease Processes....Pages 217-230
Calcification-Linked Angiogenesis and Bone Growih....Pages 231-241
Involvement of a Low Molecular Mass Angiogenic Factor (ESAF) in the Activation of Latent Matrix Metalloproteinases....Pages 243-251
Hyaluronic Acid Promotes and Inhibits Angiogenesis....Pages 253-263
Brain Tumor Angiogenesis: Drug Delivery and New Inhibitors....Pages 265-274
Evaluation of Promoters and Inhibitors of Angiogenesis Using Basement Membrane Biosynthesis as an Index....Pages 275-285
On Promoters of Angiogenesis and Therapeutic Potential....Pages 287-293
The Development of Therapeutic Angiosuppression: Problems and Progress....Pages 295-302
Anti-Angiogenic Versus Anti-Vascular Approaches to Cancer Therapy....Pages 303-305
Assays for Angiogenic Factors....Pages 307-315
Development and Validation of a Sponge Model for Quantitative Studies on Angiogenesis....Pages 317-332
New Approaches to the Measurement of Proliferation Rates....Pages 333-337
"Factitious Angiogenesis": Endothelialization of Artificial Cardiovascular Prostheses....Pages 339-351
Mechanisms of Embryonic Blood Vessel Formation....Pages 353-354
New Tools to Study Vascularisation in the Developing Embryo....Pages 355-355
Aspects on Peptide Growth Factors and Their Receptors in Human Biopsy Specimens....Pages 357-357
Sprout Formation and Fusion in Tumor Angiogenesis: Morphological and Morphometric Studies on a Human Xenografted Melanoma....Pages 359-359
Angiogenesis and Invasiveness: Pharmacological Suppression of Neoplastic Spread of Malignant Cell in the Brain....Pages 361-362
Angiosuppression of Brain Tumors by Depletion of Copper and Penicillamine....Pages 363-364
Reactivity of MoAb E-9 Human Tumour, Foetal and Normal Tissue Vasculature....Pages 365-365
Correlation of Basement Membrane Collagen Biosynthesis with Angiogenesis in the Cam System....Pages 367-367
Vascularization and Curability of Certain Human Tumors, a Practical Approach....Pages 369-369
Immunolocalization of Basic Fibroblast Growth Factor to the Microvascu-Lature of Human Brain Tumors....Pages 371-371
A Possible Mechanism for the Anti-Proliferation of Gold Drugs on Endothelial Cells Involving Inhibition of Proto-Oncogeneproducts....Pages 373-373
Localization of Xanthine Oxido-Reductase to Microvessel Endothelium in the Synovium....Pages 375-376
Atherosclerosis as an Angiogenic Disease: Implications for the Pathogenesis and Therapy of Symptomatic Carotid Arterial Stenosis....Pages 377-378
Angiogenesis in Arthritic Disease: Effect of Hyaluronan on Endothelial Cell Migration....Pages 379-379
aFGF, EGF and Their Receptors in the Normal Gastric Mucosa and in Ulcer Healing....Pages 381-381
Diabetes Induced Vascular Changes in Human Internal Mammary Artery and Saphenous Vein Grafts....Pages 383-383
Thrombin Immobilized to ECM Promotes Vascular Smooth Muscle Cell Proliferation Via a Non-Enzymatic Domain....Pages 385-385
Radiation Induces Changes in Glycosaminoglycans of Endothelial Cells....Pages 387-387
Adhesion Molecules, Their Antibodies and an Example of a Therapeutic Application with Anti-LFA1....Pages 389-389
Quantitative Methods to Evaluate Angiogenesis and Angiosuppression: A Rapid Immunocytochemical Cytokinetic Brain Tumor Assay....Pages 391-393
Back Matter....Pages 395-402