Anesthetic Pharmacology: Basic Principles and Clincial Practice, Second edition

Cover......Page 1
Title......Page 2
Contents......Page 6
Contributors......Page 9
Preface......Page 16
Pharmacodynamic principles of drug action......Page 18
G-Protein coupled receptors......Page 34
Ion channels......Page 45
Signalling pathways......Page 64
Principles of pharmacokinetics......Page 74
Principles of Drug biotransformation......Page 89
Drug transport and transporters......Page 107
Target controlled infusion and closed loop......Page 120
Alternative routes of Drug distribution......Page 140
Principles of pharmacogenetics......Page 149
Pharmacodynamic drug interation in anesthesia......Page 164
Pharmacoeconomics......Page 183
Sleep and consciousness......Page 194
Synaptic transmission......Page 209
Memory, learning and cognition......Page 227
Mechanisms of pain transmission and transduction......Page 244
The generation and propagation of action potetials......Page 265
Neuromuscular function......Page 278
Vascular reactivity......Page 294
Section 2:Cardiac Rythm......Page 310
Myocardial Performance......Page 333
Autonomic function......Page 347
Immunity and inflammation......Page 362
Section 3: Essentials of anesthetic practice\rMechanism of anesthetic action......Page 376
Pharmacokinetics of inhaled anesthetics......Page 402
Clinical pharmacology of inhaled anesthetics......Page 414
Pharmacokinetics of intravenous anesthetics......Page 437
Clinical pharmacology of intavenous anesthetics......Page 461
Benzodiazepines......Page 483
Alpha 2 agonists and other sedatives and amnestics......Page 495
MOA of opioids......Page 510
Pharmacokinetics of opioids......Page 526
Clinical pharmacology of opioids......Page 548
NSAIDs......Page 565
Other ion channel and receptor ligands for analgesia......Page 580
Local anesthetics......Page 591
Antiepileptic and antipsychotics......Page 606
Neuromuscular blocking drugs......Page 625
Drugs for reversal of neuromuscular blockade......Page 650
Sympathomimetic and sympatholytic drugs......Page 665
Parasympathomimmetic and parasympatholytic drugs......Page 683
Beta blocker and other adrenoceptor antagonists......Page 693
Antiarrythmic drugs......Page 706
Positive Inotropic drugs......Page 723
Vasodilatrs......Page 741
Calcium channel Blockers......Page 758
Brnochodilators......Page 768
Pulmonary vasodilators......Page 784
Fluids and electrolytes......Page 800
Corticosteroids and anti-inflammatory drugs......Page 814
Antirejection drugs and immunosuppressants......Page 830
Antimotility and antisecretory drugs......Page 842
Antiemetics......Page 855
Insulin and antihyperglycemic drugs......Page 874
Nutritional pharmacology......Page 890
Drugs affecting coagulation and platelet function......Page 911
Obstetric pharmacology......Page 947
Antimicrobial therapy......Page 962
Section 4: Clinical applications: evidence-based\ranesthesia practice\rPreoperative drug management......Page 986
Induction of anesthesia......Page 1006
Maintenance of and emergence from anesthesia......Page 1026
Management of sedation, analgesia, and delirium......Page 1040
Postoperative analgesia......Page 1060
Control of blood pressure and vascular tone......Page 1076
Cardiac protection and pharmacologic management\rof myocardial ischemia......Page 1090
Management of patients with chronic\ralcohol or drug use......Page 1105
Drug allergy and treatment......Page 1116
Pediatric pharmacology......Page 1127
Geriatric pharmacology......Page 1138
Index......Page 1150