Androgen Action in Prostate Cancer

Front Matter....Pages i-viii
Front Matter....Pages 8-8
Androgen Action and Modulation of Prostate and Prostate Cancer Growth: An Historical Perspective....Pages 9-55
Clinical Progression to Castration-Recurrent Prostate Cancer....Pages 57-72
Differential Roles of Androgen Receptor in Prostate Development and Cancer Progression....Pages 73-89
Imaging Androgen Receptor Function In Vivo....Pages 91-120
Front Matter....Pages 122-122
Increased Expression of Genes Converting Adrenal Androgens to Testosterone in Castration-Recurrent Prostate Cancer....Pages 123-139
Androgen-Metabolic Genes in Prostate Cancer Predisposition and Progression....Pages 141-154
Effect of Steroid 5α-Reductase Inhibitors on Markers of Tumor Regression and Proliferation in Prostate Cancer....Pages 155-173
5α-Reductase Isozymes in Castration-Recurrent Prostate Cancer....Pages 175-185
Improving Intermittent Androgen-Deprivation Therapy: OFF Cycle and the Role of Steroid 5α-Reductase Inhibitors....Pages 187-204
Front Matter....Pages 206-206
Insights from AR Gene Mutations....Pages 207-240
Functional Motifs of the Androgen Receptor....Pages 241-267
The Role of the Androgen Receptor Polyglutamine Tract in Prostate Cancer: In Mice and Men....Pages 269-295
The Androgen Receptor Coactivator-Binding Interface....Pages 297-311
Front Matter....Pages 314-314
Coregulators and the Regulation of Androgen Receptor Action in Prostate Cancer....Pages 315-340
Androgen Receptor Coregulators and Their Role in Prostate Cancer....Pages 341-374
Interaction of the Androgen Receptor Ligand-Binding Domain with the N-Terminal Domain and with Coactivators....Pages 375-384
Multitasking and Interplay Between the Androgen Receptor Domains....Pages 385-404
Chromatin Remodeling and Androgen Receptor-Mediated Transcription....Pages 405-424
Front Matter....Pages 426-426
Ligand-Independent Androgen Receptor Activity....Pages 427-449
Role of IL-6 in Regulating the Androgen Receptor....Pages 451-463
Front Matter....Pages 426-426
The Role of Cyclic AMP in Regulating the Androgen Receptor....Pages 465-503
Front Matter....Pages 506-506
Cellular and Molecular Signatures of Androgen Ablation of Prostate Cancer....Pages 507-551
Tissue Levels of Androgens in Castration-Recurrent Prostate Cancer....Pages 553-568
Unique Effects of Wnt Signaling on Prostate Cancer Cells: Modulation of the Androgen Signaling Pathway by Interactions of the Androgen Receptor Gene and Protein with Key Components of the Canonical Wnt Signaling Pathway....Pages 569-586
The Role of Foxa Proteins in the Regulation of Androgen Receptor Activity....Pages 587-615
Front Matter....Pages 618-618
Androgen Receptor as a Licensing Factor for DNA Replication....Pages 619-630
Androgen-Regulated Genes in the Prostate....Pages 631-661
Mapping the Androgen Receptor Cistrome....Pages 663-680
Differential Regulation of Clusterin Isoforms by the Androgen Receptor....Pages 681-700
Androgen Regulation of Prostate Cancer Gene Fusions....Pages 701-721
Androgens and the Lipogenic Switch in Prostate Cancer....Pages 723-739
Front Matter....Pages 742-742
Molecular Biology of Novel Targets Identified Through Study of Castration-Recurrent Prostate Cancer....Pages 743-754
Selenium and Androgen Receptor in Prostate Cancer....Pages 755-780
Back Matter....Pages 781-799