Analysis and purification methods in combinatorial chemistry

Analysis and Puri.cation Methods in Combinatorial Chemistry......Page 4
Copyright......Page 5
CONTENTS......Page 6
PREFACE......Page 10
CONTRIBUTORS......Page 12
PART I ANALYSIS FOR FEASIBILITY AND 
OPTIMIZATION OF LIBRARY SYNTHESIS......Page 16
CHAPTER 1 QUANTITATIVE ANALYSIS IN 
ORGANIC SYNTHESIS WITH NMR 
SPECTROSCOPY Laura H. Lucas and Cynthia K. Larive......Page 18
CHAPTER 2 19F GEL-PHASE NMR 
SPECTROSCOPY FOR REACTION
 MONITORING AND QUANTIFICATION 
OF RESIN LOADING Joseph M. Salvino......Page 52
CHAPTER 3 THE APPLICATION OF SINGLE-BEAD
 FTIR AND COLOR TEST FOR REACTION 
MONITORING AND BUILDING BLOCK
 VALIDATION IN COMBINATORIAL 
LIBRARY SYNTHESIS Jason J. Cournoyer, Clinton A. Krueger, Janice V.Wade,
and Bing Yan......Page 68
CHAPTER 4 HR-MAS NMR ANALYSIS OF 
COMPOUNDS ATTACHED TO 
POLYMER SUPPORTS Meritxell Guinó and Yolanda R. de Miguel......Page 86
CHAPTER 5 MULTIVARIATE TOOLS FOR REAL-TIME
 MONITORING AND OPTIMIZATION OF 
COMBINATORIAL MATERIALS AND 
PROCESS CONDITIONS Radislav A. Potyrailo, Ronald J. Wroczynski,
John P. Lemmon,William P. Flanagan,
and Oltea P. Siclovan......Page 102
CHAPTER 6 MASS SPECTROMETRY AND SOLUBLE 
POLYMERIC SUPPORT Christine Enjalbal, Frederic Lamaty, Jean Martinez,
and Jean-Louis Aubagnac......Page 140
PART II HIGH-THROUGHPUT ANALYSIS FOR LIBRARY
 QUALITY CONTROL......Page 152
CHAPTER 7 HIGH-THROUGHPUT NMR TECHNIQUES 
FOR COMBINATORIAL CHEMICAL 
LIBRARY ANALYSIS Ting Hou and Daniel Raftery......Page 154
CHAPTER 8 MICELLAR ELECTROKINETIC
 CHROMATOGRAPHY AS A TOOL FOR 
COMBINATORIAL CHEMISTRY ANALYSIS:
THEORY AND APPLICATIONS Peter J. Simms......Page 190
CHAPTER 9 CHARACTERIZATION OF SPLIT-POOL 
ENCODED COMBINATORIAL 
LIBRARIES Jing Jim Zhang and William L. Fitch......Page 224
PART III HIGH-THROUGHPUT PURIFICATION TO
 IMPROVE LIBRARY QUALITY......Page 268
CHAPTER 10 STRATEGIES AND METHODS FOR 
PURIFYING ORGANIC COMPOUNDS 
AND COMBINATORIAL LIBRARIES Jiang Zhao, Lu Zhang, and Bing Yan......Page 270
CHAPTER 11 HIGH-THROUGHPUT PURIFICATION:
TRIAGE AND OPTIMIZATION Jill Hochlowski......Page 296
CHAPTER 12 PARALLEL HPLC IN HIGH THROUGHPUT
ANALYSIS AND 
PURIFICATION Ralf God and Holger Gumm......Page 322
PART IV ANALYSIS FOR COMPOUND STABILITY AND 
DRUGABILITY......Page 336
CHAPTER 13 ORGANIC COMPOUND STABILITY 
IN LARGE, DIVERSE PHARMACEUTICAL
 SCREENING COLLECTION Kenneth L. Morand and Xueheng Cheng......Page 338
CHAPTER 14 QUARTZ CRYSTAL MICROBALANCE IN 
BIOMOLECULAR RECOGNITION Ming-Chung Tseng, I-Nan Chang, and Yen-Ho Chu......Page 366
CHAPTER 15 HIGH-THROUGHPUT PHYSICOCHEMICA L
PROFILING: POTENTIAL AND 
LIMITATIONS Bernard Faller......Page 384
CHAPTER 16 SOLUBILITY IN THE DESIGN OF
 COMBINATORIAL LIBRARIES Christopher Lipinski......Page 422
CHAPTER 17 HIGH-THROUGHPUT DETERMINATION 
OF LOGDVALUES BY LC/MS METHOD Jenny D. Villena, Ken Wlasichuk, Donald E. Schmidt Jr.,
and James J. Bao......Page 450
INDEX......Page 472
CHEMICAL ANALYSIS......Page 476