Amyloidosis

Front Matter....Pages i-xvii
Front Matter....Pages 1-1
Protein AA and Associated Proteins in Type-AA Amyloid Substance....Pages 3-10
Heterogeneity of Human Amyloid Protein AA and SAA....Pages 11-18
Vascular AA Amyloidosis is Characterized by Special Protein AA Subspecies....Pages 19-26
The Physico-Chemical, Antigenic, and Functional Heterogeneity of Human Serum Amyloid A....Pages 27-38
Reaggregation of Bovine Amyloid a Fibril Components to β-Pleated Sheet Fibrillar Structures....Pages 39-48
Analysis of X-Ray Scattering by Human AA Fibrils Using Secondary Structure Predictions of Human SAA 1 ....Pages 49-55
Characterization of Two Distinct Serum Amyloid A Gene Products Defined by Their Complementary DNAs....Pages 57-60
Human Serum Amyloid Genes — Molecular Characterization....Pages 61-68
Kinetics of Human Serum Amyloid A....Pages 69-77
Ultrastructural Identification of AA-Type Amyloid Fibrils Using Polyclonal and Monoclonal Antibodies....Pages 79-85
Human Serum Amyloid P-Component (SAP) as an Acute Phase Reactant in the Female....Pages 87-97
Front Matter....Pages 99-99
Pathogenetic Mechanisms and Precursor Product Relationships in Murine Amyloidosis....Pages 101-108
A Possible Effect of Oral Tolerance in Casein Induced Murine Amyloidosis?....Pages 109-113
Isolation and Characterization of Amyloid Enhancing Factor (AEF)....Pages 115-121
Enhancement of Amyloid Degradation by Ascorbic Acid: In Vivo Evidence in a Murine Model....Pages 123-127
Effect of Colchicine on the Acute Phase Serum Amyloid a Protein Response and Splenic Amyloid Deposition During Experimental Murine Inflammation....Pages 129-137
Serum Amyloid A Protein (SAA) from Mink, Horse, and Man: A Comparative Study....Pages 139-147
The Time Relationship Between Amyloid Deposition and Glycosaminoglycan Accumulation During Experimental Amyloidosis....Pages 149-156
Kinetics of Selective Deposition of ApoSAA 2 During Development of Amyloidosis in Mice....Pages 157-161
 In Vivo Radioimmunodetection of Amyloid Deposits in Experimental Amyloidosis....Pages 163-174
Front Matter....Pages 99-99
Prostacyclin and Thromboxane Production from Macrophages of Amyloid Resistant and Sensitive Mice....Pages 175-185
Front Matter....Pages 187-187
Regulation of Serum Amyloid a Synthesis in Primary Mouse Hepatocyte Cultures....Pages 189-192
Immunoelectron Microscopic Study of Liver in Experimental Murine Amyloidosis Using Anti-Mouse AA Antiserum....Pages 193-199
Immunocytochemical Studies on the Site of Synthesis and Pathways of Amyloid Protein AA....Pages 201-208
A Comparison of Serum Amyloid A (SAA) Synthesis with that of the Pentraxins: Serum Amyloid P (SAP) and C-Reactive Protein (CRP)....Pages 209-215
Further Studies on the Mechanism of Action of Surface Associated Proteolytic Enzymes on Lymphocytes and Monocytes which Degrade SAA Precursor to AA-Like Products....Pages 217-223
Down-Regulation of Kupffer Cell Ectoenzymes Precedes Deposition of Amyloid Protein A....Pages 225-231
Specific Chemical Dissociation of Fibrillar and Non-Fibrillar Components of Amyloid Deposits....Pages 233-238
Front Matter....Pages 239-239
Degradation of AA-Amyloid, Clinical Experience: An Introduction....Pages 241-243
In Vivo Degradation of Protein SAA to Protein AA and Incorporation in Amyloid Fibrils....Pages 245-251
Isolation and Characterization of the Inhibitor of Amyloid Degrading Factor....Pages 253-259
Amyloid-Agarose Plate Test: Ultrastructural Changes in the Fibril and its Association with Human Neutrophil Elastase....Pages 261-265
Decreased Esterase Activity in Serum of Patients with Reactive Systemic (AA) Amyloidosis....Pages 267-272
Enhanced Degradation of Amyloid AA Proteins by Enzyme Activation: A Possible Model for a Therapeutic Approach....Pages 273-277
Does Serum Degrade Amyloid Fibrils? Failure to Confirm Enzymatic Degradation of Amyloid A Fibrils as the Basis of the so-called “Amyloid Degrading Activity” of Serum....Pages 279-284
Front Matter....Pages 285-285
Statement Regarding Nomenclature for the Protein Known as Prealbumin, Which is also (Recently) Called Transthyretin....Pages 287-288
Family Studies of Transthyretin (Prealbumin) and its Methionine 30 Variant in Portuguese Patients with Familial Amyloidotic Polyneuropathy....Pages 289-294
Serum Concentrations of Prealbumin and Retinol Binding Protein in Familial Amyloid Patients from 15 Kinships....Pages 295-301
Pre-Albumin and Retinol Binding Protein Serum Concentrations in the Brazilian Type (Portuguese) of Familial Polyneuropathy....Pages 303-304
Clinical Investigations of Autonomic Heart Regulation and Renal Function of Familial Amyloidotic Polyneuropathy....Pages 305-311
Front Matter....Pages 285-285
Identification of Amyloid Prealbumin Variant in Familial Amyloidotic Polyneuropathy of Japanese Origin; Three Patients of Different Pedigrees....Pages 313-321
Monoclonal Antibodies to Serum Prealbumin of a Patient with Familial Amyloidotic Polyneuropathy....Pages 323-330
Salient Structural Features of Low Molecular Weight Amyloid Fibril Proteins in Familial Amyloid Polyneuropathy of Japanese Origin....Pages 331-337
Immunohistochemical Studies on Autopsied Organs of Familial Amyloid Polyneuropathy in Relation with Amyloid Protein....Pages 339-347
Studies on Blood Markers and Amyloid Fibril in the Arao Focus of Familial Amyloid Polyneuropathy....Pages 349-354
Familial Amyloidotic Polyneuropathy Type I and Type II: Characterization of Two Distinct Genetic Defects and Identification of Carriers of Each Gene....Pages 355-366
Familial Amyloidotic Polyneuropathy Type I: Characterization of the Prealbumin Amyloid Subunit and Precursor Protein....Pages 367-373
Immunohistochemical Studies on Hereditary Amyloidosis of the Finnish Type....Pages 375-377
Late Onset Hereditary Amyloidosis in a Family From Texas....Pages 379-383
Genetic Heterogeneity of Familial Amyloid Polyneuropathies of Jewish Type....Pages 385-389
Prealbumin Nature of the Amyloid in Familial Amyloid Cardiomyopathy of Danish Origin....Pages 391-399
Diagnosis of Familial Amyloidotic Polyneuropathy by Recombinant DNA Techniques....Pages 401-405
Biochemical Nature of Familial Amyloidotic Polyneuropathy and a New Diagnostic Method by Radioimmunoassay....Pages 407-414
Clinical and Pathological Studies of Familial Amyloid Polyneuropathy (FAP), with Special Reference to Nephropathy and Cardiopathy....Pages 415-428
Cardiac Disorders and Autonomic Nervous System Involvement in Familial Amyloidosis....Pages 429-434
Treatment of Orthostatic Hypotension in Familial Amyloid Polyneuropathy with L-Threo-3,4-Dihydroxyphenylserine....Pages 435-440
Review of Clinical Records and Therapeutic Trials in Familial Anyloidotic Polyneuropathy (Type 1) in Japan....Pages 441-445
Front Matter....Pages 447-447
Light Chain Variable Region Subgroups of Monoclonal Immunoglobulins in Amyloidosis AL....Pages 449-462
Structural Studies of the Variable Region of Immunoglobulin Light-Chain-Type Amyloid Fibril Proteins....Pages 463-475
Amyloidogenicity and Subgroups of Human Lambda Bence Jones Proteins....Pages 477-481
Front Matter....Pages 447-447
Appearance of Systemic Amyloidosis in Myeloma with Amyloidogenic Bence Jones Protein....Pages 483-489
Complete Primary Structure of an Immunoglobulin λII-Chain Derived Amyloid Fibril Protein (HAR)....Pages 491-496
Some Structural Factors Involved in Amyloid Fibril Formation by Lambda VI Light Chain Proteins....Pages 497-502
Polymorphism in a Kappa I Primary (AL) Amyloid Protein (BAN)....Pages 503-507
Analysis of the Monoclonal Components in Systemic AL-Amyloidosis....Pages 509-515
Structural and Immunologic Studies of a Kappa Amyloid Fibril Protein....Pages 517-524
Molecular Heterogeneity and γ-Carboxyglutamic Acid Content of Bence-Jones Proteins: Possible Relevance to Amyloidogenicity....Pages 525-534
Aberrant Immunoglobulin Synthesis in AL Amyloid....Pages 535-542
Front Matter....Pages 543-543
Primary Systemic Amyloidosis (AL): Comparison of Melphalan-Prednisone vs. Colchicine Treatment in 101 Cases....Pages 545-557
The Life Span of Patients with Primary (AL) Amyloidosis and the Effect of Colchicine Treatment....Pages 559-565
The Impact of Colchicine on the Amyloidosis of Familial Mediterranean Fever (FMF)....Pages 567-570
Treatment of Systemic AA Amyloidosis....Pages 571-582
Splenic Function in Amyloidosis....Pages 583-590
Does the Urinary Protein Pattern in AA-Amyloid Nephropathy Differ from that in Other Nephropathies?....Pages 591-597
Classification of Amyloid Syndromes from Tissue Sections Using Antibodies Against Various Amyloid Fibril Proteins: Report of 142 Cases....Pages 599-605
Clinical, Pathological, and Functional Findings in Amyloid Nephropathy....Pages 607-612
Fine Needle Aspiration Biopsy of Abdominal Subcutaneous Fat Tissue for the Diagnosis and Typing of Amyloidosis....Pages 613-615
Non-Invasive Techniques for Demonstrating Cardiac Involvement in the Acquired Forms of Systemic Amyloidosis....Pages 617-620
Soft-Tissue Uptake of 99m Tc-Diphosphonate and 99m Tc-Pyrophosphate in Systemic AA and AL Amyloidosis....Pages 621-627
Plasma Exchange in the Treatment of Patients with Systemic Amyloidosis....Pages 629-637
Front Matter....Pages 639-639
Research in Aging and Amyloidosis....Pages 641-645
Amyloid and Aging — An Hypothesis Involving So-Called Amyloid Degrading Activity (ADA)....Pages 647-652
Senile Systemic Amyloidosis....Pages 653-658
Varied Composition and Nature of Senile Localized Amyloid: Implications for Varied Mechanisms of Pathogenesis....Pages 659-668
A New Senile Amyloid Fibril Protein and Its Putative Precursor in Senescence Accelerated Mouse (SAM)....Pages 669-677
Amyloid Deposition in the Articular Structures of Senescence Accelerated Mouse (SAM)....Pages 679-682
Antioxidants in Experimental Amyloidosis of Young and Old Mice....Pages 683-690
Front Matter....Pages 691-691
Amyloid Research as a Paradigm for Alzheimer’s Disease....Pages 693-701
Neurobiological Probes for Specific Constituents of Senile Plaques in Aging and Alzheimer’s Disease....Pages 703-708
Biochemical and Structural Studies of Paired Helical Filaments and Senile Plaque Amyloid in Alzheimer’s Disease....Pages 709-715
Alzheimer Neurofibrillary Tangle and Its Relationship with Plaque Core Amyloid....Pages 717-722
Cerebral Amyloid and Alzheimer’s Syndrome....Pages 723-732
Prion Amyloids in Scrapie and Creutzfeldt-Jakob Disease....Pages 733-742
Senile Cerebral Amyloid — Evidence for a Neuronal Origin of the Fibril Protein....Pages 743-749
Isolation and Partial Characterization of Alzheimer Neurofibrillary Tangles....Pages 751-759
Amyloid Fibrils in Hereditary Cerebral Hemorrhage with Amyloidosis (HCHWAS) is Related to Cystatin (Gamma Trace)....Pages 761-766
Cerebral Amyloid Angiopathy Causing Intracranial Hemorrhage a Clinicopathological Study of 12 Cases....Pages 767-782
The Role of Cerebral Amyloid Angiopathy in Dementia of Alzheimer’s Type (Preliminary Results)....Pages 783-788
Hereditary Central Nervous System γ-Trace Amyloid Angiopathy and Stroke in Icelandic Families....Pages 789-801
Front Matter....Pages 803-803
Amyloid Associated with Calcifying Epithelial Odontogenic Tumor — A New Type of Amyloid Fibril Protein CEOT....Pages 805-811
Front Matter....Pages 803-803
Immunological Homology of the Amyloid of Insulinoma and the Islet Amyloid of the Aged: Biochemical Characterization of the Insulinoma Amyloid....Pages 813-820
Histopathology of Cutaneous Amyloid: A Comparative Study on 144 Cases of Localized Cutaneous Amyloidosis and 20 Cases of Systemic Amyloidosis....Pages 821-828
Histological Evidence of Amyloid Deposition in Old Thrombotic Lesions and in Longterm Bioprosthetic Cardiac Valve Implants in Man: Two Recently Observed and Possibly Related Forms of Localized Amyloidosis of the Cardiovascular System....Pages 829-835
Back Matter....Pages 837-857