Amyloid and Related Disorders: Surgical Pathology and Clinical Correlations

Front Matter....Pages i-xviii
Front Matter....Pages 1-1
Aspects of the History and Nomenclature of Amyloid and Amyloidosis....Pages 3-8
Amyloid Diseases at the Molecular Level: General Overview and Focus on AL Amyloidosis....Pages 9-29
AA Amyloidosis....Pages 31-51
The Hereditary Amyloidoses....Pages 53-67
Dialysis-Associated Amyloidosis....Pages 69-80
Localized Amyloidoses and Amyloidoses Associated with Aging Outside the Central Nervous System....Pages 81-103
Cerebrovascular Amyloidoses....Pages 105-110
Front Matter....Pages 111-111
Differential Diagnosis of Amyloid in Surgical Pathology: Organized Deposits and Other Materials in the Differential Diagnosis of Amyloidosis....Pages 113-127
Light/Heavy Chain Deposition Disease as a Systemic Disorder....Pages 129-141
Non-Randall Glomerulonephritis with Non-organized Monoclonal Ig Deposits....Pages 143-153
Pathologies of Renal and Systemic Intracellular Paraprotein Storage: Crystalopathies and Beyond....Pages 155-163
Front Matter....Pages 165-165
Diagnosis of Amyloid Using Congo Red....Pages 167-173
Diagnosis of Minimal Amyloid Deposits Using the Congo Red Fluorescence Method: A Review....Pages 175-185
Thioflavin T Stain: An Easier and More Sensitive Method for Amyloid Detection....Pages 187-189
Fat Tissue Analysis in the Management of Patients with Systemic Amyloidosis....Pages 191-207
Generic Diagnosis of Amyloid: A Summary of Current Recommendations and the Editorial Comments on Chaps. 12–15....Pages 209-217
Routine Use of Amyloid Typing on Formalin-Fixed Paraffin Sections from 626 Patients by Immunohistochemistry....Pages 219-229
Amyloid Typing: Experience from a Large Referral Centre....Pages 231-238
Options for Amyloid Typing in Renal Pathology: The Advantages of Frozen Section Immunofluorescence and a Summary of General Recommendations for Immunohistochemistry (Chaps. 17–19)....Pages 239-248
Amyloid Typing: Immunoelectron Microscopy....Pages 249-260
Front Matter....Pages 165-165
Classification of Amyloidosis by Mass Spectrometry-Based Proteomics....Pages 261-272
Front Matter....Pages 273-273
Laboratory Support for Diagnosis of Amyloidosis....Pages 275-282
Bone Marrow Biopsy and Its Utility in the Diagnosis of AL Amyloidosis and Other Plasma Cell Dyscrasias....Pages 283-290
Laboratory Methods for the Diagnosis of Hereditary Amyloidoses....Pages 291-302
Front Matter....Pages 303-303
Amyloidoses of the Kidney and Genitourinary Tract....Pages 305-318
Cardiac Amyloidosis....Pages 319-337
Amyloidosis of the Gastrointestinal Tract and Liver....Pages 339-360
Peripheral Nerve Amyloidosis....Pages 361-374
Front Matter....Pages 375-375
Clinical and Pathologic Issues in Patients with Amyloidosis: Practical Comments Regarding Diagnosis, Therapy, and Solid Organ Transplantation....Pages 377-391
Emerging Therapies for Amyloidosis....Pages 393-397
Modern Therapies in AA Amyloidosis....Pages 399-403
Medicolegal Issues of Amyloidosis....Pages 405-412
Amyloidosis from the Patient’s Perspective....Pages 413-417
Back Matter....Pages 419-425