Aminopyridines and Similarly Acting Drugs: Effects on Nerves, Muscles and Synapses. Proceedings of a IUPHAR Satellite Symposium in Conjunction with the 8th International Congress of Pharmacology, Paris, France, July 27–29, 1981

Content: 
ADVANCES IN THE BIOSCIENCES, Page ii
Front Matter, Page iii
Copyright, Page iv
PREFACE, Page v, PAUL LECHAT
ACKNOWLEDGEMENTS, Page vi
LIST OF PARTICIPANTS, Pages xiii-xvi
Historical Review, Pages 3-7, P. Lechat
General Review on Potassium Currents in Excitable Membranes of Nerve and Muscle, Pages 11-27, H. Meves
Effects of Aminopyridines on Potassium Currents of the Nodal Membrane, Pages 29-41, W. Ulbricht, H.-H. Wagner, J. Schmidtmayer
Properties and Physiological Roles of K+ Currents in Frog Myelinated Nerve Fibres as Revealed by 4-Amino Pyridine, Pages 43-51, J.M. Dubois
Effects of Aminopyridines on Ionic Currents and Ionic Channel Noise in Unmyelinated Axons, Pages 53-68, Y. Pichon, H. Meves, M. Pelhate
3- and 4-Aminopyridine in Synaptic Transmission at the Squid Giant Synapse, Pages 69-79, R. Llinás, K. Walton, M. Sugimori, S. Simon
DISCUSSION OF THE FIRST SESSION, Pages 81-83
General Principles of Synaptic Transmission, Pages 87-93, S. Thesleff
Effects of Aminopyridines on Neuromuscular Transmission, Pages 95-116, J. Molgo
Effects of 4-Aminopyridine on Transmission in Excitatory and Inhibitory Synapses in the Spinal Cord, Pages 117-125, E. Jankowska
The Influence of 4-Aminopyridine on Parasympathetic Transmission, Pages 127-139, F.F. Foldes, Y. Ohta, Y. Shiwaku, E.S. Vizi, K. Morita, J.J. Van Dijk
DISCUSSION OF THE SECOND SESSION, Pages 141-142
Structure - Activity Relationships Amongst Aminopyridines, Pages 145-162, I.G. Marshall
Aminopyridine as a Tool to Investigate the Mechanism of Acetylcholine Release at the Nerve Electroplaque Junction, Pages 163-172, Y. Dunant, F. Clostre, G.J. Jones, F. Loctin, D. Muller
Intramembrane Particles Changes: A Constant Feature of the Release Mechanism, Pages 173-182, M. Israël, R. Manaranche, B. Lesbats, T. Gulik-Krzywicki
Effect of Aminopyridine and Related Drugs on Catecholamine Release, Pages 183-198, S.M. Kirpekar, M.T. Schiavone, J.C. Prat
Some Differences in the Blockade of Potassium Permeabilities by Apamin and the Aminopyridines, Pages 199-206, D.H. Jenkinson
DISCUSSION OF THE THIRD SESSION, Pages 207-208
The Action of Morphine Dependence on the Convulsive Effect of 4-Aminopyridine and Other Drugs, Page 211, V. Aleman Aleman, D. Martinez De Munoz
Antagonism to Dopaminergic Stereotypy, and Convulsant and Hypertensive Effects by 2-Amino-4-Methylpyridine, Page 212, F. Bergmann
4-Aminopyridine (4AP) Enhances Acetylcholine Output from the Rat Cerebral Cortex in vivo, Page 213, R. Corradetti, P. Mantovani, G. Pepeu, K. Löffelholz
4-Aminopyridine as a Tool to Elucidate Different Actions of Botulinum A and Tetanus Toxin at the Mouse Neuromuscular Junction, Page 214, F. Dreyer, A. Schmitt
Antagonism of the Myoneural Activity of Antibiotics, Local Anesthetics and General Anesthetics By 4-APYR, Page 215, F.F. Foldes, D.B.S. Rao, H. Nagashima, K. Thomas, I. Leung, G. Bikhazi
Increased Tetanic Fade Produced by 3,4-Diaminopyridine in the Presence of Neuromuscular Blocking Agents, Page 216, A.J. Gibb, I.G. Marshall, W.C. Bowman
Effect of 4-Aminopyridine on the Electrical Activity of the Hippocampus and the Cerebellum, Page 217, G. Gogolák, K. Czech, Ch. Stumpf
Cardiac Effects of 4-Aminoquinoline on Mammalian and Amphibian Isolated Preparations An Electrophysiological Study, Page 218, S. Guerrero, L. Novakovic, J. Campos, M. Penna
Facilitatory Effects of Aminopyridines on Synaptic Transmission in the Sixth Abdominal Ganglion of the Cockroach, Page 219, B. Hue, M. Pelhate, J.J. Callec, J. Chanelet
The Effect of 3-,4-AP and 3,4-DAP on the Evoked Activity of the Pyramidal Cell Layer (CA 1,2) of the Hippocampus An in vitro Study, Page 220, U. Kuhnt, M. Szente
Fast and Slow Automatic Activity of Squid Giant Axons Induced by 4-Aminopyridine, Page 221, E. Lammel, K. Mandrek
The Ability of 4-Aminopyridine and 3,4-Diaminopyridine to Cross the Blood-Brain Barrier can Account for Their Difference in Toxicity, Page 222, M. Lemeignan, H. Millart, N. Letteron, D. Lamiable, J. Josso, H. Choisy, P. Lechat
Action of 4AP and TEA on Presynaptic Currents in Mammalian Motor Endings, Page 223, A. Mallart, J.L. Brigant
Protein Synthesis in Brain Subcellular Fractions Effect of 4-Amino-Pyridine, Page 224, D. Martinez de Munoz
Effects of 4-Hydroxypyridine on Transmitter Release at the Neuromuscular Junction, Page 225, G. Montoya, J. Molgo, M. Lemeignan, P. Lechat
4-Aminopyridine Analogs of Novel Chemical Structure, Page 226, Y. Ohta, I. Chaudhry, I. Lalezari, F.F. Foldes
Excitatory Action of Imidazole on Evoked Transmitter Release from the Phrenic Nerve and on Potassium-stimulated 45Ca Uptake by Synaptosomes in the Rat, Page 227, J.A. Ribeiro, M.L. Dominguez, A.M. Sá-Almeida
Aminopyridine Effects on Molecular Models in Myopathic States, Page 228, G.K. Roussev, D. Paskov, T. Jirkolova
Effects of Pyridine on the Frog Rectus Abdominis Muscle, Page 229, M.J. Rowan, P.L. Chambers
4-Aminopyridine and Pre-synaptic Modulation of Transmitter Release in Aplysia, Page 230, T. Shimahara
Naloxone, 4-Aminopyridine and Physostigmine as Antagonists of Morphine in Rabbits, Page 231, R.L. Sia, P. Westra, H. Wesseling
Anti-Curare Action of 4-Aminopyridine and 4-Aminopyridine-like Substances, Page 232, V. Sobek
4-Aminopyridine Reversal of Morphine Analgesia, Page 233, A.S. Tung, B.W. Brandom
4-Aminopyridine as Antagonist of the Cardiovascular and Neuromuscular Depressant Effects of Kanamycin in Rats, Page 234, T. Uchiyama, M. Lemeignan, P. Lechat
Effects of 4-Aminopyridine on Mammalian Peripheral and Central Neurones, Page 237, M. Galvan, P. Grafe, G. ten Bruggencate
Interactions of Aminopyridines and Related Compounds with Ionic Channels in the Isolated Cockroach Axon, Page 238, M. Pelhate, B. Hue, Y. Pichon, J. Chanelet
4-Aminopyridine-induced Alteration in the Receptive Field of Cuneate and Gracile Neurones, Page 239, N.E. Saadé, N.R. Banna, A.J. Khoury, S.J. Jabbur, P.D. Wall
Effect of 4-Aminopyridine on the Desensitisation of the Rat Diaphragm Caused by Carbachol, Page 240, O. Vital Brazil, M.D. Fontana
The Effects of 4-Aminopyridine on Neuromuscular Block Produced by Succinyldicholine, Page 241, N.N. Durant, C. Lee, R.L. Katz
Chemical Modulators: Their Molecular Characteristics and Kinetics of Actions, Page 242, T. Maeno
DISCUSSION OF THE FIFTH SESSION, Pages 243-245
Effects of 4-Aminopyridine on Contractile Properties of Skeletal Muscle, Pages 249-260, K.A.P. Edman, A.R. Khan
Effects of 4-Aminopyridine on Cardiac Muscle, Pages 261-274, T. Yanagisawa, N. Taira
Effects of 4-Aminopyridine on Isometric Force [Ca++] Relations in Mammalian Slow and Fast Twitch Skinned Muscle Fibres, Page 275, R. Fink, D.G. Stephenson
4-Aminopyridine and Outward Membrane Currents in Rat Uterine Smooth Muscle at Various Stages of Pregnancy, Page 276, J.P. Savineau, J. Mironneau, Ch. Mironneau
Effects of 4-Aminopyridine on Membrane Currents in the Pace-maker Voltage Range of Sheep Cardiac Purkinje Fibres, Page 277, P.P. Van Bogaert
Is the Cardiotonic Effect of Aminopyridines and Aminopyrimidines in vitro A Consequence of Increased Extracellular pH?, Page 278, M. Shahid, I.W. Rodger
DISCUSSION OF THE SIXTH SESSION, Pages 279-283
Therapeutic Applications of Aminopyridines in Diseases of Neuromuscular Transmission, Pages 287-296, H. Lundh
Use of 4-Aminopyridine in Human Botulism, Pages 297-301, A.P. Ball, M. Snow, R. Paul
Therapeutic Applications of 4-Aminopyridine in Anaesthesia, Pages 303-311, S. Agoston, D.R.A. Uges, R.L. Sia
Effects of 3,4-Diaminopyridine in Cynomolgus Monkeys Poisoned with Type A Botulinum Toxin, Page 313, G.E. Lewis, R.M. Wood
DISCUSSION OF THE SEVENTH SESSION, Pages 315-318
Potassium Channel Block by S-Methylthiouronium, A Pharmacological Analogue of 4-Aminopyridine, Page 321, F.N. Fastier, M. Pelhate, B. Hue
Differences in Actions of 4-Aminopyridine and 4-Methyl-2-Aminopyridine, Page 322, W.E. Glover
Effects of Aminopyridines in Avian Muscular Dystrophy, Page 323, P.J. Barnard, E.A. Barnard, E.S. Allan
Comparison of the Actions of Dendrotoxin, A Facilitatory Neurotoxin, and 3,4-Diaminopyridine on Neuromuscular Transmission, Page 324, A.L. Harvey
Effects of Aminopyridines on Parasympathetic Neuro-effector Transmission in the Heart, Page 325, W. Weide, R. Lindmar, K. Löffelholz
Effects of 4-Aminopyridine on Endocrine Cells, Page 326, O. Sand, K. Hove, S. Ozawa, K. Gautvik, E. Haug
An Electroencephalographic Study of 4-Aminopyridine in Conscious Volunteers, Page 327, R.L. Sia, S. Boonstra, P. Westra, H.T.M. Haenen, H. Wesseling
DISCUSSION OF THE EIGHTH SESSION., Pages 329-331
Conclusions, Pages 335-341, W.C. Bowman
Index, Pages 343-346