Alzheimer’s Disease. Epidemiology, Neuropathology, Neurochemistry, and Clinics

Front Matter....Pages I-XIX
Front Matter....Pages 1-1
Some philosophical aspects of Alzheimer’s discovery: an American perspective....Pages 3-5
The aging brain and its disorders....Pages 7-20
Front Matter....Pages 21-21
Epidemiology of Alzheimer’s disease....Pages 23-39
Descriptive and analytic epidemiology of Alzheimer’s disease....Pages 41-49
A proposed classification of familial Alzheimer’s disease based on analysis of 32 multigeneration pedigrees....Pages 51-57
Front Matter....Pages 59-59
Morphology of Alzheimer’s disease and related disorders....Pages 61-77
Morphology of white matter, subcortical, dementia in Alzheimer’s disease....Pages 79-83
Morphology of the cerebral cortex in relation to Alzheimer’s dementia....Pages 85-91
Quantitative investigations of presenile and senile changes of the human entorhinal region....Pages 93-97
Neuronal plasticity of the septo-hippocampal pathway in patients suffering from dementia of Alzheimer type....Pages 99-103
Morphology of neurofibrillary tangles and senile plaques....Pages 105-122
An in vitro model for the study of the neurofibrillary degeneration of the Alzheimer type....Pages 123-130
Molecular and cellular changes associated with neurofibrillary tangles and senile plaques....Pages 131-139
Brain abnormalities in aged monkeys: a model sharing features with Alzheimer’s disease....Pages 141-150
Aged dogs: an animal model to study beta-protein amyloidogenesis....Pages 151-168
Front Matter....Pages 169-169
Immunocytochemical and ultrastructural pathology of nerve cells in Alzheimer’s disease and related disorders....Pages 171-179
Choline-acetyltransferase immunoreactivity in the hippocampal formation of control subjects and patients with Alzheimer’s disease....Pages 181-185
Calbindin immunoreactive neurones in Alzheimer-type dementia....Pages 187-192
Front Matter....Pages 193-193
Lactate production and glycolytic enzymes in sporadic and familial Alzheimer’s disease....Pages 195-199
Impairment of cerebral glucose metabolism parallels learning and memory dysfunctions after intracerebral streptozotocin....Pages 201-209
Front Matter....Pages 193-193
Choline levels, the regulation of acetylcholine and phosphatidylcholine synthesis, and Alzheimer’s disease....Pages 211-224
Acetylcholine synthesis and membrane phospholipids....Pages 225-228
Hippocampal and cardiovascular effects of muscarinic agents....Pages 229-233
Cholinergic and monoaminergic neuromediator systems in DAT. Neuropathological and neurochemical findings....Pages 235-243
Alterations in catecholamine neurons in the locus coeruleus in dementias of Alzheimer’s and Parkinson’s disease....Pages 245-252
Tyrosine hydroxylase, tryptophan hydroxylase, biopterin and neopterin in the brains and biopterin and neopterin in sera from patients with Alzheimer’s disease....Pages 253-260
Postreceptorial enhancement of neurotransmission for the treatment of cognitive disorders....Pages 261-268
Excitatory dicarboxylic amino acid and pyramidal neurone neurotransmission of the cerebral cortex in Alzheimer’s disease....Pages 269-276
The sequence within the two polyadenylation sites of the A4 amyloid peptide precursor stimulates the translation....Pages 277-282
Alzheimer-like changes of cortical amino acid transmitters in elderly Down’s syndrome....Pages 283-288
Characteristics of learning deficit induced by ibotenic acid lesion of the frontal cortex in rats....Pages 289-293
Memory loss by glutamate antagonists: an animal model of Alzheimer’s disease?....Pages 295-299
Convulsant properties of methylxanthines, potential cognitive enhancers in dementia syndromes....Pages 301-304
Neurodegenerative diseases: CSF amines, lactate and clinical findings....Pages 305-311
Somatostatin-like immunoreactivity and neurotransmitter metabolites in the cerebrospinal fluid of patients with senile dementia of Alzheimer type and Parkinson’s disease....Pages 313-321
Nerve growth factor in serum of patients with dementia (Alzheimer type)....Pages 323-327
Neuroendocrine dysfunction in early-onset Alzheimer’s disease....Pages 329-334
Urinary excretion of salsolinol enantiomers and 1,2-dehydrosalsolinol in patients with degenerative dementia....Pages 335-339
Front Matter....Pages 341-341
Alzheimer’s disease — one, two or several?....Pages 343-356
Diagnostic criteria of Alzheimer’s disease....Pages 357-364
Front Matter....Pages 341-341
Clinical diagnosis of Alzheimer’s disease: DSM-III-R, ICD-10 — what else?....Pages 365-371
Clinical aspects and terminology of dementing syndromes....Pages 373-378
Symptoms of depression in the course of multi-infarct dementia and dementia of Alzheimer’s type....Pages 379-386
Cognitive deterioration and dementia outcome in depression: the search for prognostic factors....Pages 387-391
Diagnostic significance of language evaluation in early stages of Alzheimer’s disease....Pages 393-399
The Alzheimer patient in the family context: how to help the family to cope....Pages 401-408
Towards a clinically specific profile of severe senile primary degenerative dementia of the Alzheimer type (PDDAT)....Pages 409-414
Sequential clinical approach to differential diagnosis of dementia....Pages 415-419
Do old patients with Down’s syndrome develop premature brain atrophy?....Pages 421-427
Results of EEG brain mapping and neuroimaging methods in Senile Dementia of Alzheimer’s Typ (SDAT) and Vascular Dementia (VD)....Pages 429-435
Regulation of EEG delta activity by the cholinergic nucleus basalis....Pages 437-445
EEG- and cognitive changes in Alzheimer’s disease — a correlative follow-up study....Pages 447-458
Decreased hippocampal metabolic rate in patients with SDAT assessed by positron emission tomography during olfactory memory task....Pages 459-472
PET criteria for diagnosis of Alzheimer’s disease and other dementias....Pages 473-487
Oxygen metabolism in the degenerative dementias....Pages 489-494
Positron emission tomography for differential diagnosis of dementia: a case of familial dementia....Pages 495-500
Comparison between cerebral glucose metabolism and late evoked potentials in patients with Alzheimer’s disease....Pages 501-507
High resolution regional cerebral blood flow measurements in Alzheimer’s disease and other dementia disorders....Pages 509-516
Single photon emission computed tomography (SPECT) in Pick’s disease: two case reports....Pages 517-521
In vivo studies of hippocampal atrophy in Alzheimer’s disease....Pages 523-529
Front Matter....Pages 341-341
Outline for the evaluation of nootropic drugs....Pages 531-543
Drug treatment of dementia....Pages 545-554
Cognitive enhancing properties of antagonist β -carbolines: new insights into clinical research on the treatment of dementias?....Pages 555-564
Long term treatment of SDAT patients with pyritinol....Pages 565-574
Back Matter....Pages 575-585