Alzheimer's disease decoded : the history, present, and future of Alzheimer's disease and dementia

Contents
About the Authors
Foreword
Preface
	References
Part I Introduction, History, and Overview
	Chapter 1 Introduction to the Brain and Nervous System
		Human Brain: Structure
		The Nervous System
		Human Brain: Building Blocks
		Human Brain: Plasticity
		Human Brain: Development
		Human Brain: Organization
		Human Brain: Memory and Integration
		Studying the Brain
		References
	Chapter 2 Dysfunction
		Normal Age-related Changes
			Smell
			Sleep
		Nervous System Damage and Neurogenesis
		Neurogenesis in Alzheimer’s and Brain Tumors
		References
	Chapter 3 Senility and Normal Aging
		Is Alzheimer’s Disease a Normal Part of Aging?
		Where did the Term “Senility” Come From and Why is it Ubiquitously Associated with Aging?
		Cognitive Reserve
		References
	Chapter 4 What is Dementia?
		What Causes Dementia and Alzheimer’s Disease?
		References
	Chapter 5 Introduction to Alzheimer’s Disease
		Clinical Symptoms
		Differential Diagnosis
		Pathological Findings
			Plaques
			Tangles
		Cerebral Amyloid Angiopathy
			Glial Cell Changes
			Neuronal and Synaptic Loss
			Macroscopic Changes
		Cause of Death
		Natural History
		References
	Chapter 6 Hypotheses of Alzheimer’s Disease
		The Amyloid Cascade Hypothesis
		The Tau Hypothesis
		The Inflammation Hypothesis
		The Insulin Resistance Hypothesis
		The Gut-brain Axis Hypothesis
		References
	Chapter 7 Epidemiology of Alzheimer’s Disease
		Gender and Ethnicity
			Brain Size and Function
			Genetics
			Hormones
			Social and Behavioral Effects
			Smoking
			Ethnicity
			Cardiovascular Disease
			Obesity and the Benefits of Exercise
			Type 2 Diabetes
			Environmental Exposures
			Global Effects
			National Effects
		References
	Chapter 8 The History of Alzheimer’s Disease
		The Characterization of the Disease by Dr. Alzheimer in the Early 1900s
		The Development of the Diagnostic Tools
		The Development of Medications
		Clinical Trials Overview
			Solanezumab
			BACE1 Inhibitors
			Other Amyloid Cascade Modulators
			Tau Targeted Strategies
		References
	Chapter 9 An Interesting Link
		Human Brain: Evolution
		Three Types of Alzheimer’s Disease
		Trisomy 21 (Down Syndrome)
		The Interesting Role of Sleep in Alzheimer’s Disease
		Circadian Rhythm and Stress Granule Formation
		References
	Chapter 10 Is Alzheimer’s Transmissible?
		Prions: Proteinacious, Infectious Particles
		Transmissible Spongiform Encephalopathies
		An Alarming Discovery
		The Worst Case Scenario
		A Blessing in Disguise?
		References
Part II Novel Therapies and Future Directions
	Chapter 11 Surgical Treatments for Dementia
		Introduction to Neurosurgery and the “Miraculous” Cures of Dementia in Select Disorders
		Surgical Clinical Trials: The Ventriculo-Peritoneal (VP) Shunt Trial
		Stem Cell Trials: Pre-clinical Data and Clinical Trials
			Deep-Brain Stimulation
		References
	Chapter 12 Is There a Link to Traumatic Brain Injury?
		Chronic Traumatic Encephalopathy
		TBI in the Military
		References
	Chapter 13 What’s Going on Now?
		Vitamin E
		Medications in the Pipeline — An Update
		Diagnosis
		Biomarkers and the Alzheimer’s Disease Neuroimaging Initiative Study
		Studying the Disease
		References
	Chapter 14 Alzheimer’s and Cancer: Partners in Mystery
		Alzheimer’s: The New Emperor?
		Alzheimer’s and Cancer: Two Wrongs That… Make a Right?
		Biological Considerations
		TP53: A Major Cell Cycle Regulator
		The Role of Estrogen
		Growth Factors
		Immune Factors
		Telomerase
		Chemotherapy and Alzheimer’s
		References
	Chapter 15 Novel Therapies
		Stem Cells
		Lifestyle Modifications
		Genetic Modification and Personalized Medicine
		Low-Level Light Therapy
		Marijuana (THC)
			THC and Neurogenesis
			THC and Inflammation
			THC and the Future of Cannabis in Alzheimer’s
		Music Therapy
		References
	Chapter 16 How Can We Solve the Problem?
		Caregiving
		Comprehensive and Integrative Care Clinics
		Risk Stratification
		Risk Reduction and Management
		Early (Correct) Diagnosis
		Prophylactic Treatment
		Diet
		Exercise
		References
	Chapter 17 Alzheimer’s: A Futuristic Perspective
		Implanting Memories into the Brain: An Artificial Hippocampus
		The Power of Optogenetics
		Home Care Robots
		Technology for Activities of Daily Living
		References
	Chapter 18 What Resources Exist?
		Global Resources
		Federal Resources (Lobbying) to Fund Alzheimer’s Research Programs and Scientists
		Organizational and Support Groups for Families
		References
Acknowledgments
Note to Readers
Glossary/Abbreviations
Index