Alzheimer’s and Parkinson’s Disease: Strategies for Research and Development

Front Matter....Pages i-xvi
Welcoming Address....Pages 1-3
Cholinergic Systems in the Brain and Spinal Cord: Anatomic Organization and Overview of Functions....Pages 5-16
Histopathology of the Basal Forebrain and its Targets in Alzheimer Dementia....Pages 17-23
Clinical, Pathological and Biochemical Aspects of Alzheimer’s Disease....Pages 25-36
Molecular Properties of Paired Helical Filaments and Senile Plaque Amyloid Fibers in Alzheimer’s Disease....Pages 37-42
Structural and Chemical Aspects of Cortical Pathology in Alzheimer’s Disease....Pages 43-52
Cholinergic and Non-Cholinergic Neurotransmitter Hypotheses for Alzheimer’s Disease....Pages 53-61
Brain Topochemistry of Cholinergic and Monoaminergic Parameters in Alzheimer’s Disease....Pages 63-68
The “Autocannibalism” of Choline-Containing Membrane Phospholipids in the Pathogenesis of Alzheimer’s Disease....Pages 69-73
Trophic Factors and Neurologic Disease....Pages 75-84
Neuronal Loss and Neurotransmitter Receptor Alterations in Alzheimer’s Disease....Pages 85-94
Brain Nicotinic and Muscarinic Receptors in Normal Aging and Dementia....Pages 95-108
Examination of Cholinergic and Neuropeptide Receptor Alterations in Senile Dementia of the Alzheimer’s Type (SDAT)....Pages 109-116
Quantitative Autoradiography and Histochemistry in the Human Brain Post Mortem....Pages 117-120
Increased Vasopressin Production in Senescence and Dementia Due to Kidney Changes....Pages 121-127
Clinical Heterogeneity in Patients with Dementia of the Alzheimer Type....Pages 129-134
Patterns of Cognitive Impairment in Patients with Alzheimer’s Disease and Parkinson’s Disease: Are They Similar or Different?....Pages 135-140
Risk Factors in Alzheimer’s Disease....Pages 141-146
Enhancing Communication for the Demented Patient and His Family....Pages 147-153
Reaction Times in Tasks of Varying Degrees of Complexity, An Indication of the Degree and the Evolution of Mental Deterioration: A Preliminary Study....Pages 155-159
An Intranosological Classification of Alzheimer’s Disease as a Multi-Stage Dementing Process - The Basis for Individualized Therapeutic Strategies (a developmental-semiological approach)....Pages 161-167
The Epidemiology of Alzheimer’s Type Presenile Dementia in Israel....Pages 169-175
Dementia in Parkinson Disease....Pages 177-183
Possible Dopaminergic Basis for Perceptual Motor Dysfunction....Pages 185-189
Diagnostic Methods in Alzheimer’s Disease: Magnetic Resonance Brain Imaging and CSF Neurotransmitter Markers....Pages 191-204
Neuroimaging Studies of Alzheimer’s Disease....Pages 205-209
High Resolution Mapping of Cerebral Blood Flow in Alzheimer’s Disease....Pages 211-224
Regional Cerebral Blood Flow in Dementing Disorders....Pages 225-232
The Early Stages of Presenile and Senile Alzheimer’s Disease: Initial Studies of Disease Severity and Cerebral Blood Flow....Pages 233-239
Laser Microprobe Mass Analyzer (LAMMA) — A New Approach to the Study of the Association of Aluminum and Neurofibrillary Tangle Formation....Pages 241-248
Normal Pressure Hydrocephalus (NPH) as a Cause of Pre-Senile and Senile Dementia: The Complementary Role of Radionuclide Cysternography (RNC) and Cranial Computed Tomography (CCT) in The Early Recognition of The Treatable Patients....Pages 249-255
Measles Virus Infection of Human Neural Cell Lines as a Model for Persistent Viral Infection of the Central Nervous System....Pages 257-262
Brain Iron and Dopamine D 2 Receptors in the Rat....Pages 263-269
Down’s Syndrome and Alzheimer’s Disease: Are Common Genes From Human Chromosome 21 Involved In Both Disorders?....Pages 271-283
The Natural History of Alzheimer’s Families: An Underutilized Method For Exploring Basic and Therapeutic Strategies in Age-Related Neuropsychiatric Disorders....Pages 287-297
Biological Markers For Alzheimer’s Disease....Pages 299-308
Acetylcholine Metabolism in Brain: Is it Reflected by CSF Changes?....Pages 309-316
Acetylcholinesterase activity and somatostatin-like immunoreactivity in Lumbar cerebrospinal fluid of demented patients....Pages 317-322
Monoamine neurotransmitter metabolites and hydroxylase Cofactor in alzheimer-type dementia and normals....Pages 323-327
Antibodies To Cholinergic Cell Bodies In Alzheimer’s Disease....Pages 329-336
Nicotinic and muscarinic binding sites on lymphocytes from Alzheimer patients....Pages 337-344
Cholinergic Muscarinic Binding By Lymphocytes: Changes With Age Antagonist Treatment And Senile Dementia....Pages 345-353
Dexamethasone suppression test in senile dementia of the Alzheimer type....Pages 355-359
Hormone-Stimulated Adenylate Cyclase Activity In Man: Studies With Peripheral Models....Pages 361-368
Anti-Haloperidol Antibodies And Their Auto-Anti-Idiotypes: Tools In The Study Of Neurological Disorders....Pages 369-374
Pharmacological Protection Against Memory Retrieval Deficits as a Method of Discovering New Therapeutic Agents....Pages 375-392
Neurochemical and Behavioral Alterations in Aging and in Animal Models of Alzheimer’s Disease....Pages 393-405
Reversal of Cerebral Metabolic Deficits in Rodent Models for Aging and Alzheimer’s Disease....Pages 407-417
Radial Maze Performance Deficits Following Lesions of Rat Basal Forebrain....Pages 419-426
The AF64A-Treated Rat as an Experimental Model for Alzheimer’s Disease : A Critical Evaluation....Pages 427-445
Histochemical and Electronmicroscopic Study of the Brain of the AF64A-Treated Rat....Pages 447-460
A Review of the Behavioral Effects of AF64A, A Cholinergic Neurotoxin....Pages 461-467
AF64A Induced Cholinotoxicity: Behavioral and Biochemical Correlates....Pages 469-477
Neurobehavioral Aspects of Some Animal Models of Age-Related Neuropsychiatry Disorders....Pages 479-485
Dysfunction of Central Cholinergic System in Hyperkinetic Rats, Following Postnatal Anoxia....Pages 487-494
Implantation of Alzheimer’s Disease Brain Tissue in Young Rat Brain: Parenchymal and Vascular Reactions....Pages 495-503
Functional Properties of Septo-hippocampal Neurons in the Rat....Pages 505-511
Micromolar Concentrations of Neurotoxic Cations Induce Phase Separation, Aggregation and Fusion in Phosphatidylserine Containing Membranes....Pages 513-518
MPTP-Induced Parkinsonian Syndromes in Humans and Animals....Pages 519-530
Human and Animal Studies With Cholinergic Agents: How Clinically Exploitable is the Cholinergic Deficiency in Alzheimer’s Disease....Pages 531-537
Pharmacological Activity of Novel Anticholinesterase Agents of Potential Use in the Treatment of Alzheimer’s Disease....Pages 539-549
Sulfonyl Fluorides as Possible Therapeutic Agents in Alzheimer’s Disease: Structure/Activity Relationships as CNS Selective Cholinesterase Inhibitors....Pages 551-556
A Novel Transdermal Therapeutic System as a Potential Treatment for Alzheimer’s Disease....Pages 557-563
Differences in the Agonist Binding Properties of Muscarinic Receptor Subpopulations in the Rat Cerebral Cortex and Myocardium....Pages 565-574
Cholinoceptor Characterization Reconsidered in the Light of Diversity of Response....Pages 575-584
Structure-Activity Relationships of RS 86 Analogues....Pages 585-592
The Lipid Regimen....Pages 593-602
Spatial Discrimination and Passive Avoidance Behavior in The Rat: Age-Related Changes and Modulation by Chronic Dietary Choline Enrichment....Pages 603-608
Hippocampal Morphometry in the Rat: Age-Related Changes and Modulation by Chronic Dietary Choline Enrichment....Pages 609-613
Nerve Growth Factor Promotes Survival of Septal Cholinergic Neurons After Injury....Pages 615-625
Can Septal Grafting Facilitate Recovery from Physiological and Behavioral Deficits Produced by Fornix Transections?....Pages 627-637
Structural Analogs of AF64A: Synthesis and their Effects on High Affinity Choline Transport and QNB Binding....Pages 639-644
In Vivo Evaluation of 125 I-Labeled Iodoclebopride and Iodoazidoclebopride Binding to the Dopamine D 2 Receptor....Pages 645-653
Monoamine Oxidase Type B Inhibitors in Human and Animal Parkinsonism....Pages 655-668
Alzheimer’s and Parkinson’s Disease: Strategies in Research and Development....Pages 669-678
Back Matter....Pages 679-710