Alcohol and Aldehyde Metabolizing Systems. Enzymology and Subcellular Organelles

Content: 
Johnson Research Foundation Colloquia, Page ii
Front Matter, Page iii
Copyright, Page iv
LIST OF PARTICIPANTS, Pages xi-xv
PREFACE, Page xvii, Ronald G. Thurman
A COMPARISON OF THE ENZYMICALLY CATALYZED OXIDATION OF GLYCERALDEHYDE-3-PHOSPHATE AND LACTATE, Pages 1-15, M.G. Rossmann
MECHANISM OF ACTION OF LIVER ALCOHOL DEHYDROGENASE, Pages 17-32, C.-I. Brändén
EXTRAPOLATION OF MECHANISM STUDIES ON GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE TO THE TREATMENT OF AVIAN MUSCULAR DYSTROPHY, Pages 33-41, Jane H. Park, Edward J. Hill, Ta-hsu Chou, Richard Pinson, Charles R. Park, Virgil LeQuire, Robert Roelofs
KINETICS AND MECHANISM OF ACTIVATED LIVER ALCOHOL DEHYDROGENASE, Pages 43-51, R.T. Dworschack, B.V. Plapp
SOLVENT ISOTOPE EFFECTS IN THE YEAST ALCOHOL DEHYDROGENASE REACTION, Pages 53-62, Judith P. Klinman, Katherine M. Welsh, Donald J. Creighton
KINETICS OF NATIVE AND CHEMICALLY ACTIVATED HUMAN LIVER ALCOHOL DEHYDROGENASES, Pages 63-70, A. Dubied, J.-P. von Wartburg, D.P. Bohlken, B.V. Plapp
SUBSTRATE SPECIFICITY AND THE HYDROPHOBIC SITE OF LIVER ALCOHOL DEHYDROGENASE (L-ADH), Pages 71-78, A.D. Winer
PROPERTIES OF HORSE LIVER ALCOHOL DEHYDROGENASE SS, Pages 79-85, C.N. Ryzewski, R. Pietruszko
ROOM AND LOW TEMPERATURE SPECTRAL IDENTIFICATION OF THE COBALT BINDINGS SITES IN LIVER ALCOHOL DEHYDROGENASE, Pages 87-101, Henry R. Drott
HETEROGENEITY IN THE RAPIDLY EXCHANGING METALS OF HORSE LIVER ALCOHOL DEHYDROGENASE, Pages 103-107, R.A. Harvey, A. Barry
MAGNETIC RESONANCE STUDIES OF THE INTERACTIONS OF IMIDAZOLE AND OTHER LIGANDS WITH COBALT SUBSTITUTED ALCOHOL DEHYDROGENASE FROM LIVER, Pages 109-117, J. Maitland Young, Albert S. Mildvan
WATER PROTON RELAXATION AND SPECTRAL STUDIES OF ALCOHOL DEHYDROGENASE PARTIALLY SUBSTITUTED WITH COBALT, Pages 119-122, H.R. Drott, R.A. Harvey, A.S. Mildvan, J.M. Young
INTERACTION AND ACTIVITIES OF NAD+ AND NAD+ ANALOGS WITH FOUR DEHYDROGENASES, Pages 123-136, Robert J. Suhadolnik, Michael B. Lennon
MODIFICATION OF TRYPTOPHAN IN LIVER ALCOHOL DEHYDROGENASE, Pages 137-143, Edyth L. Malin, J. Maitland Young
STRUCTURAL AND FUNCTIONAL CHANGES IN DIFFERENT ALCOHOL DEHYDROGENASES DURING EVOLUTION, Pages 145-155, Hans Jörnvall
METAL ION EFFECTORS OF HORSE LIVER ALDEHYDE DEHYDROGENASES, Pages 157-166, R. Venteicher, L. Mope, T. Yonetani
INTERACTION OF DISULFIRAM WITH HORSE LIVER ALDEHYDE DEHYDROGENASE, Pages 167-174, Charles G. Sanny, Henry Weiner
INTRACELLULAR LOCATION OF 3,4-DIHYDROXYPHENYLACETALDEHYDE AND ACETALDEHYDE OXIDATION IN RAT LIVER, Pages 175-183, A.W. Tank, H. Weiner
LOCALIZATION AND PROPERTIES OF ALDEHYDE REDUCTASE, Pages 185-194, J.P. von Wartburg, Margret M. Ris, B. Wermuth
HUMAN LIVER ALDEHYDE DEHYDROGENASE, Pages 195-202, R. Pietruszko, N.J. Greenfield, C.R. Edson
INHIBITION OF RAT-LIVER ALDEHYDE DEHYDROGENASES IN VITRO AND IN VIVO BY DISULFIRAM, CYANAMIDE AND THE ALCOHOL-SENSITIZING COMPOUND COPRINE, Pages 203-212, O. Tottmar, H. Marchner, P. Lindberg
CORRELATION BETWEEN THE ACTIVITY OF ACETALDEHYDE DEHYDROGENASE AND THE STRUCTURE OF MITOCHONDRIA, Pages 213-221, In-Young Lee, Britton Chance
INDUCTION OF CYTOSOLIC ALDEHYDE DEHYDROGENASE ISOZYMES: INFLUENCE ON ACETALDEHYDE METABOLISM, Pages 223-234, D.R. Petersen, A.C. Collins, R.A. Deitrich
THE PLASTIC AND FLUID NATURE OF THE MITOCHONDRIAL ENERGY TRANSDUCING MEMBRANE, Pages 235-260, C.R. Hackenbrock, M. Höchli
PEROXIDE GENERATION IN MITOCHONDRIA AND UTILIZATION BY CATALASE, Pages 261-274, B. Chance, A. Boveris, N. Oshino
METABOLISM OF H2O2 AND FATTY ACIDS BY RAT LIVER PEROXISOMES: IMPLICATIONS FOR ETHANOL DETOXIFICATION, Pages 275-289, P.B. Lazarow
SOME EFFECTS OF AGING AND LIPID-LOWERING DRUGS ON LIPID METABOLISM AND THE HEPATIC ENDOPLASMIC RETICULUM, Pages 291-306, E. Spring-Mills, D.L. Schmucker, A.L. Jones
ON THE QUESTION OF WHETHER CYTOCHROME P-450 CATALYZES ETHANOL OXIDATION: STUDIES WITH PURIFIED FORMS OF THE CYTOCHROME FROM RABBIT LIVER MICROSOMES, Pages 307-322, Kostas P. Vatsis, Minor J. Coon
EVIDENCE FOR THE DIRECT INVOLVEMENT OF HEPATIC CYTOCHROME P450 IN ETHANOL METABOLISM, Pages 323-334, Gerald T. Miwa, Wayne Levin, Paul E. Thomas, Anthony Y.H. Lu
ADVANTAGES OF GAS CHROMATOGRAPHIC DETERMINATION OF ACETALDEHYDE IN STUDIES WITH ETHANOL AND A RECONSTITUTED ENZYME SYSTEM CONTAINING ELECTROPHORETICALLY HOMOGENEOUS PHENOBARBITAL-INDUCIBLE CYTOCHROME P-450 FROM RABBIT LIVER MICROSOMES, Pages 335-340, K.P. Vatsis, R.G. Thurman
RECONSTITUTION OF THE HEPATIC MICROSOMAL ETHANOL OXIDIZING SYSTEM (MEOS) IN CONTROL RATS AND AFTER ETHANOL FEEDING, Pages 341-350, Kunihiko Ohnishi, Charles S. Lieber
MICROSOMAL ELECTRON TRANSPORT REACTIONS: THE FORMATION AND UTILIZATION OF HYDROGEN PEROXIDE AS RELATED TO ALCOHOL METABOLISM, Pages 351-360, J. Werringloer, N. Chacos, R.W. Estabrook, I. Roots, A.G. Hildebrandt
STUDIES ON THE CHARACTERIZATION OF THE ENZYME COMPONENTS PARTICIPATING IN THE HEPATIC-MICROSOMAL OXIDATION OF ALIPHATIC ALCOHOLS, Pages 361-371, K.P. Vatsis, B. Chance, M.P. Schulman
QUANTITATION OF PATHWAYS RESPONSIBLE FOR NADPH-DEPENDENT METHANOL, ETHANOL, AND BUTANOL OXIDATION BY HEPATIC MICROSOMES, Pages 373-380, H.J. Brentzel, R.G. Thurman
CATALASE AND ALCOHOL DEHYDROGENASE-MEDIATED OXIDATION OF ETHANOL IN HEPATIC MICROSOMES OF ACATALASEMIC MICE, Pages 381-391, K.P. Vatsis, M.P. Schulman
ANALYSIS OF MITOCHONDRIAL AND MICROSOMAL CYTOCHROMES IN HUMAN LIVER BIOPSY, Pages 393-402, N. Sato, T. Kamada, H. Abe, B. Hagihara, B. Chance
A NOVEL ROUTE FOR THE METABOLISM OF ETHANOL; THE OXIDATION OF ETHANOL BY HYDROXYL FREE RADICALS, Pages 403-412, Gerald Cohen
FOLATE DEFICIENCY AND METHANOL POISONING IN THE RAT, Pages 413-418, A.B. Makar, T.R. Tephly
THE MONKEY AS A MODEL IN METHANOL POISONING, Pages 419-428, G. Martin-Amat, K.E. McMartin, A.B. Makar, G. Baumbach, P. Cancilla, M.M. Hayreh, S.S. Hayreh, T.R. Tephly
METHANOL POISONING: ROLE OF FORMATE METABOLISM IN THE MONKEY, Pages 429-440, K.E. McMartin, G. Martin-Amat, A.B. Makar, T.R. Tephly
MITOCHONDRIAL INJURY IN EXPERIMENTAL CHRONIC ALCOHOLISM, Pages 441-450, O.R. Koch, A. Boveris, A.O.M. Stoppani
INDEX, Pages 451-454