Alcohol and Aldehyde Metabolizing Systems-IV

Front Matter....Pages i-xv
Role of Hydroxyl Radicals in Microsomal Oxidation of Alcohols....Pages 1-10
On the Possible Relationship of Cytochrome P-450 to Alcohol Metabolism: Fundamental Aspects of the Microsomal Hydroxylation System, Including Properties and Interactions of the Components....Pages 11-22
Evolution of Aldehyde Reductase: An Immunological Approach to the Relatedness of Aldehyde Reductase from Different Species....Pages 23-30
Isozymes of Alcohol Dehydrogenase and Aldehyde Dehydrogenase in Japanese and their Role in Alcohol Sensitivity....Pages 31-39
On the Interaction of Human Liver Aldehyde Dehydrogenase E 1 Isoenzyme with Disulfiram and Iodoacetamide....Pages 41-49
Ethanol-Inducible Liver Cytochrome P-450 in the Rat: Relative Specificity for Ethanol Oxidation Activity in Vitro....Pages 51-56
Genetic Regulation of Alcohol Dehydrogenase, Aldehyde Dehydrogenase and Aldehyde Oxidase Isozymes in the Mouse....Pages 57-66
Isozymes of Alcohol Dehydrogenases....Pages 67-76
Carbon-13 Magnetic Resonance Probe of Coenzyme and Inhibitor Binding in Liver Alcohol Dehydrogenase....Pages 77-83
Properties of Adlehyde Dehydrogenase from Chemically-Induced Rat Hepatomas and Normal Rat Liver....Pages 85-93
Alterations of Hepatic Alcohol Metabolizing Enzyme Activities Due to Thyroid Hormones....Pages 95-108
Genetically Mediated Responses of Microsomal Ethanol Oxidation in Mice....Pages 109-115
 In Vivo Evaluation of Ambivalent Active-Site-Directed Inactivators of Liver Alcohol Dehydrogenase....Pages 117-128
Kinetic and Mechanistic Studies of Oxidation of Vitamin a Alcohol to Vitamin a Aldehyde by Horse Liver Alcohol Dehydrogenase. The Inhibition by Ethanol and Pyrazole....Pages 129-135
Mechanism of Inhibition of Mixed-Function Oxidation by Ethanol....Pages 137-150
Multifunctionality of Liver Alcohol Dehydrogenase....Pages 151-161
The Nature and Function of Aldehyde Reductases from Rat Brain....Pages 163-172
Mechanism of the Magnesium Ion Activation of the Catalytic Activity of Horse Liver Aldehyde Dehydrogenase....Pages 173-180
Kinetic Studies on NADPH-Linked Aldehyde Reductase from Human Liver....Pages 181-188
Structure of Cytochrome c Oxidase....Pages 189-195
Acetaldehyde Directly Inhibits the Conversion of Androstenedione to Testosterone in the Testes....Pages 197-210
Microsomal N-Depropargylation of Pargyline to Propiolaldehyde, an Irreversible Inhibitor of Mitochondrial Aldehyde Dehydrogenase....Pages 211-217
The Presence of 2,3-Butanediol in the Blood of Chronic Alcoholics Admitted to an Alcohol Treatment Center....Pages 219-228
Decreased Hepatotoxicity of Dimethylnitrosamine (DMN) Following Chronic Alcohol Consumption....Pages 229-235
Relationships Between Bilayer Lipid, Motional Freedom of Oxidoreductase Components, and Electron Transfer in the Mitochondrial Inner Membrane....Pages 237-243
A Possible Hemoglobin Marker of Alcoholism....Pages 245-263
Distribution of Ethanol between Blood and Dorsal Subcutaneous Air of the Rat and the Feasibility of Using this Distribution Coefficient to Estimate Blood Ethanol....Pages 265-273
Significance of the Gastrointestinal Tract in the in Vivo Metabolism of Ethanol in the Rat....Pages 275-280
Lipid Peroxidation in Alcoholic Liver Disease in Man....Pages 281-286
The Effect of Duration of Alcohol Administration on the Deposition of Trace Elements in the Fetal Rat....Pages 287-293
The Role of Folates in Methanol Toxicity....Pages 295-304
The ATP Synthesizing System of Liver Mitochondria....Pages 305-315
The Temperature Dependence of Respiration and ATPase in Rat Liver Mitochondria is Altered by Ethanol....Pages 317-344
Effect of Ethanol on Hemoperfusion and O 2 Sufficiency in Livers in Vivo ....Pages 345-353
Ethanol as a Selective Inhibitor of Microsomal Barbiturate Hydroxylation in Vitro and in Vivo....Pages 355-362
Direct Effect of Ethanol on Acid Secretion in Isolated Canine Gastric Mucosa....Pages 363-372
Effects of Chronic Ethanol Consumption on the Respiratory Chain of Rat Liver Submitochondrial Particles....Pages 373-383
Comparative Study of the Effect of Amino Acids on Ethanol Oxidation in Isolated Hepatocytes from Starved and Fed Rats....Pages 385-392
Ethanol Oxidation in Isolated Hepatocytes....Pages 393-402
Contributions of Cytosolic and Mitochondrial Acetyl-CoA Syntheses to the Activation of Lipogenic Acetate in Rat Liver....Pages 403-411
Use of 13 C NMR for Investigation of Ethanol Metabolism in Perfused Liver....Pages 413-418
Changes in Liver Inorganic Pyrophosphate Content during Ethanol Metabolism....Pages 419-431
Acetaldehyde and Acetate Production during Ethanol Metabolism in Perfused Rat Liver....Pages 433-440
Breath Acetaldehyde Levels after Ethanol Consumption....Pages 441-449
Determination of Hepatic Acetaldehyde and its Biphasic Relationship to the Ethanol Concentration in Rats....Pages 451-457
Breath Acetaldehyde: Evidence of Acetaldehyde Production by Oropharynx Microflora and by Lung Microsomes....Pages 459-467
The Effect of Chronic Ethanol Consumption on Pathways of Ethanol Metabolism....Pages 469-474
Aldehyde Dehydrogenase Inhibitors and Voluntary Ethanol Drinking by Rats....Pages 475-480
Rate-Determining Factors for Ethanol Metabolism in Vivo during Fasting....Pages 481-487
Biochemical, Morphological and Clinical Correlates of Alcoholic Liver Disease....Pages 489-496
Isolation of a Lipocyte-Rich Fraction from Rat Liver Nonparenchymal Cells....Pages 497-508
Effects of Chronic Ethanol Feeding on Rat Hepatocytes....Pages 509-517
The Effect of Ethanol on the Metabolism of Prostaglandins and Related Compounds....Pages 519-525
Alcohol Dehydrogenase in Cultured Human Skin Fibroblasts Human Fibroblast Alcohol Dehydrogenase....Pages 527-532
Kinetics and Control of Alcohol Oxidation in Rats....Pages 533-541
Inhibition of the Synthesis of Macromolecules by Ethanol in Regenerating Rat Liver....Pages 543-549
Psychotropic Drug Metabolism in Fetal Alcohol Syndrome....Pages 551-560
Chronic Ethanol Ingestion and Glycogen Metabolism in Male and Female Rats....Pages 561-568
Effects of Alcohol on γ-Glutamyl Transpeptidase (GGTP)....Pages 569-577
The Effect of Chronic Ethanol Consumption on the Rate of Whole Animal and Perfused Liver Oxygen Consumption....Pages 579-586
Dependence of Mitochondrial and Cytosolic ATP Systems on the Metabolic State of Perfused Rat Liver....Pages 587-593
Stimulation of Ethanol Metabolism by Catecholamines....Pages 595-599
Increased Biliary Glutathione Disulfide (GSSG) Release in Chronically Ethanol-Treated Rats....Pages 601-618
The Role of Liver Cytosolic Aldehyde Dehydrogenase in Ethanol Metabolism in DBA and C57Bl Mice....Pages 619-625
Low Acetaldehyde Levels in Blood, Breath and Cerebrospinal Fluid of Intoxicated Humans as Assayed by Improved Methods....Pages 627-634
Alcoholic Liver Disease Associated with Increased Gamma-Glutamyltransferase Activities in Serum and Liver....Pages 635-645
Ethanol Elimination is Inherited in the Rat....Pages 647-654
Effect of Acute and Chronic Ethanol Intoxication on Hepatic Regeneration....Pages 655-661
Calcium Homeostasis and Compartmentation in Liver....Pages 663-670
Mechanism of the Swift Increase in Alcohol Metabolism (“SIAM”) in the Rat....Pages 671-688
Reversal of Tolerance to Ethanol Associated with the Induction of Physical Dependence on Ethanol in the Rat....Pages 689-695
Acetaldehyde Hydrate and Carbonic Anhydrase: Possible Roles in the Inhibition of Brain Aldehyde Dehydrogenase....Pages 697-704
Effects of Aliphatic Alcohols and Aldehydes on Fluidity of Spin-Labeled Synaptosomal Plasma Membranes....Pages 705-713
The Effects of Ethanol on Developing Catecholamine Neurons....Pages 715-719
A Comparison of Behavioral and Neurochemical Effects on Ethanol and Chlordiazepoxide....Pages 721-727
Biochemical Correlates of Tolerance in Rodents and in Drosophila. Possible Role of Alcohol Dehydrogenase, Aldehyde Dehydrogenase and Superoxide Dismutase....Pages 729-737
Multiple Aldehyde Reductases of Human Brain....Pages 739-748
Receptor and Membrane Function in the Alcohol Tolerant/Dependent Animal....Pages 749-759
Cross-Tolerance between Ethanol and Morphine....Pages 761-770
Reversal of Ethanol Tolerance and Cross-Tolerance to Pentobarbital in the Rat....Pages 771-777
Brain Neurotransmitter Receptor Systems in Alcohol Treated Mice and in Mice Genetically Selected for Differences in Sensitivity to Alcohol....Pages 779-786
Effect of Ethanol and Acetaldehyde on Membrane-Bound Enzymes in Rat Brain....Pages 787-795
Tetrahydropapaveroline Inhibits Dopamine Uptake in Rat Brain Synaptosomes....Pages 797-805
Ethanol Induced Changes on in Vitro Protein Synthesis during the Development and Maturation of Brain Tissue....Pages 807-812
Back Matter....Pages 813-821
....Pages 823-835