Aging and Heart Failure: Mechanisms and Management

Front Matter....Pages i-xxii
Changing Demographics of the Aging Population with Heart Failure and Implications for Therapy....Pages 1-14
Biology of Aging and Implications for Heart Failure Therapy and Prevention....Pages 15-33
Hypertension and Prevention of Diastolic Heart Failure in the Aging Population....Pages 35-45
Aging and Optimal Therapy of Systolic Heart Failure in the Elderly....Pages 47-63
Atrial Fibrillation and Heart Failure in the Aging Population....Pages 65-84
Optimizing Therapy of Heart Failure in the Aging Population with Monitoring in Clinics....Pages 85-93
Cardiac Alterations in Aging, Hypertension, and Diastolic Heart Failure....Pages 95-106
Polypharmacy and Adverse Drug Reactions in the Aging Population with Heart Failure....Pages 107-116
Age-Related Changes in Vascular Biology and Implications for Heart Failure Therapy in the Aging Population....Pages 117-134
Biomarkers and Optimal Management of Heart Failure in the Aging Population....Pages 135-146
Benefits of Exercise in the Elderly....Pages 147-164
The RAAS in Heart Failure: An Update on Clinical Trials and Opportunities for Therapy....Pages 165-182
Aging and Diastolic Dysfunction: The Interplay of Inflammation and Extracellular Matrix Regulation....Pages 183-198
Reperfusion and Vasodilator Therapy in Elderly Patients with STEMI and Heart Failure: Improving Outcomes....Pages 199-220
Erythropoietin Therapy for Heart Failure....Pages 221-241
Role of Resistin in Heart Failure in the Elderly....Pages 243-247
Role of Coronary Artery Calcium in Cardiovascular Risk Stratification and Management in the Aging Population....Pages 249-257
Aging and Remodeling of the RAS and RAAS and Related Pathways: Implications for Heart Failure Therapy....Pages 259-289
Aging and Right Ventricular Failure from Pulmonary Hypertension: Effect of Right Ventricular and Pulmonary Artery Remodeling....Pages 291-304
Biomarkers of Cardiovascular Aging....Pages 305-318
Changes in the Heart That Accompany Advancing Age: Humans to Molecules....Pages 319-337
Aging-Related Changes in Cell Death and Cell Survival Pathways and Implications for Heart Failure Therapy....Pages 339-349
Aging-Related Changes in Telomeres and Telomerases and Implications for Heart Failure Therapy....Pages 351-360
Aging-Associated Alterations in Myocardial Inflammation and Fibrosis: Pathophysiological Perspectives and Clinical Implications....Pages 361-375
Aging-Related Changes in Extracellular Matrix: Implications for Ventricular Remodeling Following Myocardial Infarction....Pages 377-389
Calcium-Handling Defects and Changes in Cardiac Function in the Aging Heart....Pages 391-399
Integrins: Implications for Aging in Heart Failure Therapy....Pages 401-410
Adipokines as Novel Biomarkers in Aging and Heart Failure....Pages 411-426
Aging-Related Changes in Cellular and Molecular Mechanisms of Postinfarction Remodeling: Implications for Heart Failure Therapy....Pages 427-437
Aging-Related Changes in Mitochondrial Function and Implication for Heart Failure Therapy....Pages 439-447
Regulation of SERCA Via Oxidative Modifications: Implications for the Pathophysiology of Diastolic Dysfunction in the Aging Heart....Pages 449-456
SMP30 and Aging-Related Cardiac Remodeling and Heart Failure....Pages 457-463
Back Matter....Pages 465-475