Advancements of Mass Spectrometry in Biomedical Research

Front Matter ....Pages i-xxi
 Mass Spectrometry for Proteomics-Based Investigation  (Alisa G. Woods, Izabela Sokolowska, Armand G. Ngounou Wetie, Devika Channaveerappa, Emmalyn J. Dupree, Madhuri Jayathirtha et al.)....Pages 1-26
 MALDI Profiling and Applications in Medicine  (Ed Dudley)....Pages 27-43
 Applications of Matrix-Assisted Laser Desorption Ionization In-Source Decay Mass Spectrometry  (Yue Ju)....Pages 45-54
 Proteome Imaging: From Classic to Modern Mass Spectrometry-Based Molecular Histology  (Anca-Narcisa Neagu)....Pages 55-98
 Mass Spectrometry-Based Tissue Imaging of Small Molecules  (Carly N. Ferguson, Joseph W. M. Fowler, Jonathan F. Waxer, Richard A. Gatti, Joseph A. Loo)....Pages 99-109
 Sequencing Proteins from Bottom to Top: Combining Techniques for Full Sequence Analysis of Glucokinase  (Emily R. Sekera, Troy D. Wood)....Pages 111-119
 Proteomics and Non-proteomics Approaches to Study Stable and Transient Protein-Protein Interactions  (Armand G. Ngounou Wetie, Izabela Sokolowska, Devika Channaveerappa, Emmalyn J. Dupree, Madhuri Jayathirtha, Alisa G. Woods et al.)....Pages 121-142
 Contribution of Mass Spectrometry-Based Proteomics to Discoveries in Developmental Biology  (Yutaka Hashimoto, Todd M. Greco, Ileana M. Cristea)....Pages 143-154
 Profiling Optimal Conditions for Capturing EDEM Proteins Complexes in Melanoma Using Mass Spectrometry  (Cristian V. A. Munteanu, Gabriela N. Chiriţoiu, Andrei-Jose Petrescu, Ștefana M. Petrescu)....Pages 155-167
 The Methods Employed in Mass Spectrometric Analysis of Posttranslational Modifications (PTMs) and Protein–Protein Interactions (PPIs)  (Rama R. Yakubu, Edward Nieves, Louis M. Weiss)....Pages 169-198
 Identification of Posttranslational Modifications (PTMs) of Proteins by Mass Spectrometry  (Roshanak Aslebagh, Kelly L. Wormwood, Devika Channaveerappa, Armand G. Ngounou Wetie, Alisa G. Woods, Costel C. Darie)....Pages 199-224
 Sequence Variant and Posttranslational Modification Analysis During Cell Line Selection via High-Throughput Peptide Mapping  (Chong-Feng Xu, Yan Wang, Pete Bryngelson, Zoran Sosic, Li Zang)....Pages 225-236
 Selective Derivatization of Hexahistidine-Tagged Recombinant Proteins  (Vasantha Krishna Kadambar, Artem Melman)....Pages 237-250
 Investigation of Antibody-Drug Conjugates by Mass Spectrometry  (Madhuri Jayathirtha, Costel C. Darie)....Pages 251-263
 Mass Spectrometry- and Computational Structural Biology-Based Investigation of Proteins and Peptides  (Marius Mihăşan, Kelly L. Wormwood, Izabela Sokolowska, Urmi Roy, Alisa G. Woods, Costel C. Darie)....Pages 265-287
 Strategies for Membrane Protein Analysis by Mass Spectrometry  (Rafael C. Prados-Rosales, Guillermo Aragoneses-Cazorla, Hector Estevez, Estefania Garcia-Calvo, Andres Machuca, Jose L. Luque-Garcia)....Pages 289-298
 The Potential for Ion Mobility in Pharmaceutical and Clinical Analyses  (Kelly L. Wormwood, Liulin Deng, Ahmed M. Hamid, Daniel DeBord, Laura Maxon)....Pages 299-316
 Application of Ion Mobility Mass Spectrometry in Lipidomics  (Fereshteh Zandkarimi, Lewis M. Brown)....Pages 317-326
 Mass Spectrometry in Advancement of Redox Precision Medicine  (Xiaofei Chen, Jingyun Lee, Hanzhi Wu, Allen W. Tsang, Cristina M. Furdui)....Pages 327-358
 Applications for Mass Spectrometry in the Study of Ion Channel Structure and Function  (Damien S. K. Samways)....Pages 359-375
 Immuno-Affinity Mass Spectrometry: A Novel Approaches with Biomedical Relevance  (Laura Ion, Brînduşa Alina Petre)....Pages 377-388
 Developing Well-Annotated Species-Specific Protein Databases Using Comparative Proteogenomics  (Emmalyn J. Dupree, Bernard S. Crimmins, Thomas M. Holsen, Costel C. Darie)....Pages 389-400
 Stoichiometry of Heavy Metal Binding to Peptides Involved in Alzheimer’s Disease: Mass Spectrometric Evidence  (Monica Jureschi, Ancuta Veronica Lupaescu, Laura Ion, Brînduşa Alina Petre, Gabi Drochioiu)....Pages 401-415
 Role of Mass Spectrometry in Investigating a Novel Protein: The Example of Tumor Differentiation Factor (TDF)  (Izabela Sokolowska, Armand G. Ngounou Wetie, Alisa G. Woods, Madhuri Jayathirtha, Costel C. Darie)....Pages 417-433
 Mass Spectrometry-Based Biomarkers in Drug Development  (Michelle R. Robinson, Ronald A. Miller, Daniel S. Spellman)....Pages 435-449
 Combinatorial Electrophoresis and Mass Spectrometry-Based Proteomics in Breast Milk for Breast Cancer Biomarker Discovery  (Roshanak Aslebagh, Devika Channaveerappa, Brian T. Pentecost, Kathleen F. Arcaro, Costel C. Darie)....Pages 451-467
 Proteomic Approaches to Dissect Neuronal Signalling Pathways  (Heather L. Bowling, Shruti Nayak, Katrin Deinhardt)....Pages 469-475
 Mass Spectrometry for the Study of Autism and Neurodevelopmental Disorders  (Kelly L. Wormwood, Armand G. Ngounou Wetie, Jeanne P. Ryan, Costel C. Darie, Alisa G. Woods)....Pages 477-499
 Simplifying the Proteome: Analytical Strategies for Improving Peak Capacity  (Lee A. Gethings, Joanne B. Connolly)....Pages 501-513
 Exploration of Nicotine Metabolism in Paenarthrobacter nicotinovorans pAO1 by Microbial Proteomics  (Marius Mihăşan, Cornelia Babii, Roshanak Aslebagh, Devika Channaveerappa, Emmalyn J. Dupree, Costel C. Darie)....Pages 515-529
 Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) for Quantitative Proteomics  (Esthelle Hoedt, Guoan Zhang, Thomas A. Neubert)....Pages 531-539
 Mass Spectrometry Based Comparative Proteomics Using One Dimensional and Two Dimensional SDS-PAGE of Rat Atria Induced with Obstructive Sleep Apnea  (Devika Channaveerappa, Brian K. Panama, Costel C. Darie)....Pages 541-561
 2D SDS PAGE in Combination with Western Blotting and Mass Spectrometry Is a Robust Method for Protein Analysis with Many Applications  (Nancy Kendrick, Costel C. Darie, Matt Hoelter, Ginny Powers, Jon Johansen)....Pages 563-574
 Pulse SILAC Approaches to the Measurement of Cellular Dynamics  (Justin Snider, Daifeng Wang, Daniel F. Bogenhagen, John D. Haley)....Pages 575-583
 Protein Biomarkers in Major Depressive Disorder: An Update  (Alisa G. Woods, Kelly L. Wormwood, Dan V. Iosifescu, James Murrough, Costel C. Darie)....Pages 585-600
 A Pilot Exploratory Proteomics Investigation of Mental Fatigue and Mental Energy  (Emmalyn J. Dupree, Aurora Goodwin, Costel C. Darie, Ali Boolani)....Pages 601-611
 Metabolomics and Biomarker Discovery  (Kathryn Sinclair, Ed Dudley)....Pages 613-633
 Analytical Methods for Mass Spectrometry-Based Metabolomics Studies  (Siyu Wang, Ian A. Blair, Clementina Mesaros)....Pages 635-647
 Trends in Analysis of Cortisol and Its Derivatives  (Ali Boolani, Devika Channaveerappa, Emmalyn J. Dupree, Madhuri Jayathirtha, Roshanak Aslebagh, Stephanie Grobe et al.)....Pages 649-664
 Detection of Biomedically Relevant Stilbenes from Wines by Mass Spectrometry  (Veronica Andrei, Dana Copolovici, Florentina-Daniela Munteanu, Armand G. Ngounou Wetie, Iuliana Mihai, Costel C. Darie et al.)....Pages 665-684
 Mass Spectrometry as a Complementary Approach for Noncovalently Bound Complexes Based on Cyclodextrins  (Mihaela Silion, Adrian Fifere, Ana Lacramioara Lungoci, Narcisa Laura Marangoci, Sorin Alexandru Ibanescu, Radu Zonda et al.)....Pages 685-701
 Trends in Glycolipid Biomarker Discovery in Neurodegenerative Disorders by Mass Spectrometry  (Liana Dehelean, Mirela Sarbu, Alina Petrut, Alina D. Zamfir)....Pages 703-729
 Non-targeted Screening in Environmental Monitoring Programs  (Bernard S. Crimmins, Thomas M. Holsen)....Pages 731-741
 Mass Spectrometric DNA Adduct Quantification by Multiple Reaction Monitoring and Its Future Use for the Molecular Epidemiology of Cancer  (Bernhard H. Monien)....Pages 743-751
 Bottlenecks in Proteomics: An Update  (Devika Channaveerappa, Armand G. Ngounou Wetie, Costel C. Darie)....Pages 753-769
 Recent Applications of Mass Spectrometry at Clarkson University  (Madhuri Jayathirtha, Danielle Whitham, Sydney Stradtman, Costel C. Darie)....Pages 771-785
 Correction to: 2D SDS PAGE in Combination with Western Blotting and Mass Spectrometry Is a Robust Method for Protein Analysis with Many Applications  (Nancy Kendrick, Costel C. Darie, Matt Hoelter, Ginny Powers, Jon Johansen)....Pages C1-C1
Back Matter ....Pages 787-813