Advanced Research on Animal Cell Technology

Front Matter....Pages i-ix
Front Matter....Pages 1-1
Extracellular Matrix and Cell Differentiation....Pages 3-13
Structure and Function of the Heparan Sulfate Proteoglycans....Pages 15-24
Role Played by GAP Junctions in Cell-Cell Communication....Pages 25-37
Fibronectin-Mediated Cellular (Inter)Actions....Pages 39-61
Front Matter....Pages 63-63
Use of Cell Lines in Biotechnology....Pages 65-73
Why Not Use Primary Cells?....Pages 75-92
Front Matter....Pages 93-93
Technology of Mass Cultivation: An Overview....Pages 95-106
Cell Culture in Hollow Fibre Bioreactors....Pages 107-117
Perfusion Culture....Pages 119-145
Good Manufacturing Practice in the Production of Biologicals by Cell Cultures....Pages 147-156
Biosensors....Pages 157-172
Front Matter....Pages 173-173
Effects of Retinoids on Growth and Differentiation....Pages 175-185
Phosphoinositide metabolism and control of cell proliferation....Pages 187-200
Somatic Cell Genetic Analysis of Growth Control....Pages 201-213
Promoter Organization of Eukaryotic Protein-Coding Genes....Pages 215-229
Front Matter....Pages 231-231
Tailoring of an Anti-Human Placental Alkaline Phosphatase Immunoglobulin Using Genetic Engineering....Pages 233-249
Vaccinia Virus as an Expression Vector....Pages 251-260
Expression and Integration of Exogenous DNA Sequences Transfected Into Mammalian Cells....Pages 261-275
Cooperation of Oncogenes in Malignant Transformation....Pages 277-299
Front Matter....Pages 301-301
Molecular Dissection of the Cell Cycle....Pages 303-314
Front Matter....Pages 301-301
Use of Microbeads for Cell Transplantation....Pages 315-327
Influence of Epigenetic Factors on Epidermal Differentiation and Morphogenesis....Pages 329-343
The Characterization of Fibroblast Growth Factor and its Biological Effect in Vitro and in Vivo....Pages 345-366
Culture of Hybridomas — A Survey....Pages 367-400
Applications of Chromatography in Downstream Processing....Pages 401-421