ADP-Ribosylation Reactions

Front Matter....Pages i-xxxvi
Front Matter....Pages 1-1
Structure and function of the human poly(ADP-ribose) polymerase....Pages 3-13
Cloning of Poly(ADP-ribose) Polymerase cDNA from Lower Eukaryotes....Pages 14-19
Molecular Biology of Human Nuclear NAD + : ADPRibosyl-transferase (polymerizing)....Pages 20-29
Strategies for Studying the Functions of PADPRP Genes on Human Chromosomes 1 and 13....Pages 30-37
Expression of the DNA-Binding Domain of Human Poly(ADP-Ribose) Polymerase as a Trans- Dominant Inhibitor of Poly(ADP-Ribosyl)ation in Transfected Eucaryotic Cell Lines....Pages 38-46
Directed Mutagenesis of Glutamic Acid 988 of Poly(ADP-ribose) Polymerase....Pages 47-52
Chicken poly(ADP-ribose) polymerase. Complete protein sequence deduced from cDNA,comparison with mammalian enzyme sequences....Pages 53-57
Nuclear poly(ADPR)Polymerase expression and activity in rat astrocytes culture: effects of bFGF....Pages 58-61
Molecular Cloning of the Rat Poly (ADP-Ribose) Polymerase Gene and Preliminary Characterization of its Promoter and 5’-Flanking Regions....Pages 62-68
Structure and Organization of the Mouse pADPRT Gene....Pages 69-72
Strategies for Expressing Analogs of PADPRP in Eukaryotic Cells....Pages 73-76
Expression and Characterization of PADPRP and a Novel Glucocorticoid-PADPRP “Finger Swapped” Protein from Escherichia coli ....Pages 77-80
Tumor Promoters, But Not EGF, Increase Nuclear Poly(ADP-Ribose) Polymerase Gene Expression in Rat Hepatocytes Initiated in Utero with DMN and Cultured After Birth in Low-Calcium Synthetic Medium....Pages 81-85
Expression of the gene for poly(ADP-ribose) polymerase and DNA polymerase beta in rat tissues and in proliferating cells....Pages 86-91
Expression of poly (ADP-ribose) polymerase in differentiating HL-60 cells....Pages 92-94
Front Matter....Pages 95-95
A Novel Model of Enzymatic Repair of UV-Induced DNA Damage in Human Cells....Pages 97-105
Poly(ADP—Ribose)Polymerase in Xenopus laevis....Pages 106-112
ADP-Ribosylation is Involved in the Integration of Exogenous DNA into the Mammalian Cell Genome, but is not Required for the Episomal Replication or Expression of Autonomously Replicating Plasmids....Pages 113-117
Inhibitors of Poly(ADP-Ribose) Polymerase Block the Infection of Mammalian Cells by Retroviral Vectors....Pages 118-124
Detection and Analysis of NAD Binding Proteins Including Poly(ADP-Ribose) Polymerase Immobilized on the Membrane....Pages 125-128
Front Matter....Pages 95-95
An in Vitro Replication System for Autonomously Replicating Mammalian Origin-Enriched Sequences....Pages 129-132
Variation in Poly(ADP-ribose) Polymerase Activity and 2’, 5’-Oligoadenylates Core Concentration in Estrogen-Stimulated Uterus and Liver of Immature and Adult Rats....Pages 133-136
Possible involvement of poly(ADP-ribose) polymerase in the brain function....Pages 137-140
Inhibition of interferon-γ-dependent induction of major histocompatibility complex class II antigen by expressing exogenous poly(ADP-ribose) synthetase gene.....Pages 141-144
ADP-ribose Polymers Bind Specifically and Non-covalently to Histones....Pages 145-148
Poly (3’-deoxyADP-ribosyl)ation of Proteins in Liver Chromatin Isolated from Rats Fed with Hepatocarcinogens....Pages 149-152
ADP-ribose Polymer Metabolism: Implications for Human Nutrition....Pages 153-162
Some aspects of nuclear and cytoplasmic ADP-ribosylation. Biological and pharmacological perspectives.....Pages 163-172
DNA Base Excision Repair Stimulates Poly(ADP-Ribose) Synthesis....Pages 173-177
Studies on Poly(ADP-Ribosyl)ation in DNA Amplification and Mammalian Longevity....Pages 178-184
DNA Topoisomerase I and Poly(ADP-Ribose) Polymerase in the Early Stages of Hepatocarcinogenesis....Pages 185-190
Poly(ADP-ribose) polymerase inhibitors induce murine melanoma cell differentiation by a mechanism independent of alterations in cAMP levels and protein kinase A activity....Pages 191-194
Enhancement of antimetabolite cytotoxicity by 3-aminobenzamide in Chinese hamster ovary cells is independent of poly(ADP-ribose) polymerase inhibition.....Pages 195-198
Evidence for the Participation of Poly(ADPribosyl)ation in Collagenase Gene Expression in Rabbit Synovial Fibroblasts after Treatment with Active Oxygen Released by Xanthin/Xanthinoxidase....Pages 199-202
Enhancement of Oncogene-Mediated Transformation in Cloned Rat Embryo Fibroblast (CREF) Cells by 3-Aminobenzamide....Pages 203-210
Control of Procollagen Gene Transcription and Prolyl Hydroxylase Activity by Poly(ADP-Ribose)....Pages 211-217
Poly(ADP-ribose) Synthesis in Lymphocytes of Systemic Lupus Erythematosus Patients....Pages 218-223
Possible involvement of poly(ADP-ribosyl)ation in phenobarbital promotion activity in rat hepatocarcinogenesis....Pages 224-227
1-Methylnicotinamide stimulates cell growth, causes DNA hypermethylation and inhibits induced differentiation of Friend erythroleukemia cells.....Pages 228-232
2-Aminobenzamide antagonizes DNA de-methylation which precedes induced differentiation of Friend erythroleukemia cells by N’-methylnicotinamide.....Pages 233-237
Front Matter....Pages 95-95
ADP-Ribosylation of Rubisco in Lettuce Chloroplasts.....Pages 238-241
 In Vivo Evidence in Humans of an Association Between ADP-Ribosylation Levels in Mononuclear Leukocytes and Immune Function....Pages 242-246
Evaluation of the DNA damage and inhibition of DNA repair caused by the benzamide derivative Metoclopramide in human peripheral mononuclear leukocytes.....Pages 247-250
Nuclear ADP-Ribosyltransferase as Target Antigen in Chronic Graft-Versus-Host Disease....Pages 251-255
Induction of Poly ADP-Ribosylation in Human Malignant Cells....Pages 256-259
Proteolytic Cleavage of Poly(ADP-Ribose) Polymerase in Human Leukemia Cells Treated with Etoposide and other Cytotoxic Agents....Pages 260-268
ADP-Ribosylation of Topoisomerase II in Physiological Conditions....Pages 269-275
Regulation of DNA polymerase ß by poly(ADP-ribose) polymerase....Pages 276-281
Extensive Purification of Nuclear Poly(ADP-ribose) Glycohydrolase....Pages 282-285
Poly(ADP-Ribose)Polymerase and NMN Adenylyl-Transferase Interaction: Molecular and Immuno-Logical Studies....Pages 286-289
Covalent modification of poly (ADP-Ribose) polymerase by reactive benzamides.....Pages 290-296
Alterations in Repair of DNA Damage in Poly(ADP-Ribose) Polymerase Deficient Cell Lines....Pages 297-303
Front Matter....Pages 305-305
Amino Acid Specific Modification of Poly(ADP-ribose)polymerase with Monomers and Polymers of ADP-ribose....Pages 307-311
Enzymatic properties of poly(ADP-ribose) polymerase and poly(ADP-ribose) glycohydrolase on chromatin....Pages 312-315
A New “Transition-State” Inhibitor Specific for Poly(ADP-ribose) Glycohydrolase....Pages 316-320
Histones Affect Polymer Patterns Produced by Poly(ADP-ribose)polymerase....Pages 321-324
Proteolytic Degradation of Poly(ADP-ribose)polymerase by Contaminating Proteases in Commercial Preparations of DNAse I....Pages 325-328
Inactivation of the Polymerase but not the DNA Binding Function of ADPRT by Destabilization of one of its Zn 2+ Coordination Centers by 6-Nitroso-1,2-Benzopyrone....Pages 329-333
Conversion of Poly(ADP-ribose) Polymerase Activity to NAD- Glycohydrolase During Retinoic Acid Induced Differentiation of HL60 Cells....Pages 334-337
Improved Assays of Poly(ADP-Ribose) Metabolizing Enzymes....Pages 338-342
Front Matter....Pages 305-305
Specific Inhibitors of Poly(ADP- Ribose) Synthetase....Pages 343-350
Automodification and NAD ASE Activity of Poly(ADP- Ribose) Polymerase....Pages 351-354
The Poly(ADP-ribose)-Protein Shuttle of Chromatin....Pages 355-361
Front Matter....Pages 363-363
Endogenous Mono-ADP-Ribosylation of Wild-Type and Mutant Elongation Factor 2 in Eukaryotic Cells....Pages 365-368
Heterogeneity of Adpribosylation Reaction in Sulfolobus solfataricus ....Pages 369-372
A novel C3-like ADP-ribosyltransferase produced by Clostridium limosum....Pages 373-376
The 52 kDa Adp-Ribosylated Protein in the Rat Heart Plasma Membrane: Is It G sa ?....Pages 377-380
Biochemical and Developmental Characterization of ADP-ribosylation Factors, A Family of 20 kDa Guanine Nucleotide-binding Proteins.....Pages 381-384
Nonenzymatic ADP-ribosylation of Cysteine....Pages 385-388
Molecular and Immunological Characterization of ADP-ribosylarginine Hydrolases....Pages 389-392
Characterization of the Family of Mammalian Genes Encoding ADP- ribosylation Factors....Pages 393-396
Purification and characterisation of NAD:Arginine mono ADP-Ribosyl Transferase from chicken erythrocytes; identification of some enzyme inhibitors.....Pages 397-401
Target Proteins for Arginine-Specific ADP-Ribosyltransferase in Chickens....Pages 402-405
NAD + Biosynthesis in Human Placenta: Characterization of Homogeneous NMN Adenylyltransferase....Pages 406-410