ADP-Ribosylation of Proteins

Front Matter....Pages I-XXI
Front Matter....Pages 1-1
Multiple Aspects of ADP-Ribosylation Reactions....Pages 2-8
ADP-Ribosylation as a Cellular Control Mechanism....Pages 9-29
Front Matter....Pages 31-31
Size Distribution of Branched Polymers of ADP-Ribose Generated in Vitro and in Vivo....Pages 32-36
Studies on the Structure of Poly(ADP-Ribose) by HPLC. Separation of in Vitro Generated Polymer Chains, Analysis of Chain Length, and Branching....Pages 37-40
Probable Helical Conformation of Poly(ADP-Ribose)....Pages 41-46
Immobilized Poly(ADP-Ribose) Synthetase: Preparation and Properties....Pages 47-51
The Domain Structure of Poly(ADP-Ribose) Synthetase and Its Role in Accurate Transcription Initiation....Pages 52-59
DNA-Poly(ADP-Ribose) Polymerase Complex: Isolation of the DNA Wrapping the Enzyme Molecule....Pages 60-68
The Role of Lysine Residues in the Catalytic Function and DNA Binding of Poly(ADP-Ribose) Polymerase as Determined by the Covalent Modification of the Enzyme Protein with Methyl Acetimidate....Pages 69-73
ADP-Ribosyltransferase from Hen Liver Nuclei: Purification, Properties, and Evidence for ADP-Ribosylation-Induced Suppression of Cyclic AMP-Dependent Phosphorylation....Pages 74-81
Poly(ADP-Ribos)ylation of Nuclear Enzymes....Pages 82-92
Kinetic Mechanism of Poly(ADP-Ribose) Polymerase....Pages 93-97
Specificity of Poly(ADP-Ribose) Synthetase Inhibitors....Pages 98-105
Inhibition of ADP-Ribosylation Reaction by 2′, 5′-Oligoadenylates....Pages 106-110
Activity Gels of Poly(ADP-Ribose) Polymerase: Phylogenetic Studies and Variations in Human Blood Cells....Pages 111-115
The Relationship Between DNA Strand Breaks and ADP-Ribosylation....Pages 116-123
Mechanism of Ethanol Stimulation of Poly(ADP-Ribose) Synthetase....Pages 124-128
Specific Proteolytic Processing of Poly(ADP-Ribose) Polymerase in Human Lymphocytes....Pages 129-138
Cytoplasmic Poly(ADP-Ribose) Synthetase in Rat Spermatogenic Cells....Pages 139-147
Poly(ADP-Ribose) Polymerase Associated with Cytoplasmic Free mRNP Particles: Effect of RNase A....Pages 148-153
Front Matter....Pages 31-31
Effect of DNA Intercalators on Poly(ADP-Ribose) Glycohydrolase Activity....Pages 154-158
5′-ADP-3″Deoxypentos-2″-Ulose. A Novel Product of ADP-Ribosyl Protein Lyase....Pages 159-166
Glutamyl Ribose-5-Phosphate Storage Disease: Clinical Description and Characterization of the Stored Material....Pages 167-177
Front Matter....Pages 179-179
Effect of Poly(ADP-Ribosyl)ation on Native Polynucleosomes, H1-Depleted Polynucleosomes, Core Particles, and H1-DNA Complexes....Pages 180-189
Poly(ADP-Ribose) Glycohydrolase Activity Causes Recondensation of Relaxed Poly(ADP-Ribosyl)ated Polynucleosomes....Pages 190-196
Kinetics of Nucleosomal Histone H1 Hyper(ADP-Ribosylation) and Polynucleosomes Relaxation....Pages 197-206
DNA Strand Breaks and Poly(ADP-Ribosylated) Mediation of Transcriptionally Active Chromatin and Transforming Gene Stability....Pages 207-216
Poly(ADP-Ribose) in Nucleoids....Pages 217-221
ADP-Ribosylation of Nuclear Matrix Proteins. Association of Poly(ADP-Ribose) Synthetase with the Nuclear Matrix....Pages 222-229
Psoralen-Probing of Chromatin Organization in Intact Cells Undergoing DNA Excision Repair....Pages 230-234
ADP-Ribosylation, DNA Repair, and Chromatin Organization....Pages 235-241
Front Matter....Pages 243-243
Is There a Role for ADP-Ribosylation in DNA Repair?....Pages 244-251
Poly(ADP-Ribosyl)ation, DNA Repair, and Chromatin Structure....Pages 252-263
Isolation and Identification of Mono- and Poly(ADP-Ribosyl) Proteins Formed in Intact Cells in Association with DNA Repair....Pages 264-271
Mono(ADP-Ribosyl) Histone H1 in Alkylated Hepatoma Cells: Unusual Acceptor Site....Pages 272-276
ADP-Ribosylation Reactions in Biological Responses to DNA Damage....Pages 277-283
DNA Ligase II of Mammalian Cells....Pages 284-288
Isolation of a DNA Ligase Mutant from L1210 Cells....Pages 289-292
Environmental Stress and the Regulation of Poly(ADP-Ribose) Metabolism....Pages 293-297
Tumor Promoter Phorbol-Myristate-Acetate Induces a Prooxidant State which Causes the Accumulation of Poly(ADP-Ribose) in Fibroblasts....Pages 298-302
Front Matter....Pages 243-243
Kinetic Studies of the ADP-Ribosylation of HSP-83 in Chicken Embryo Fibroblast Cells....Pages 303-308
Effects of 3-Aminobenzamide on Cell-Cycle Traverse and Viability of Human Cells Exposed to Agents which Induce DNA Strand-Breakage....Pages 309-320
Potentiation of the Effects of Bleomycin and 1,3-Bis(2-Chloroethyl)-1-Nitrosourea on A549 Cell Cultures by Inhibitors of Poly(ADP-Ribose) Synthetase....Pages 321-326
Cell Death Caused by the Anti-Cancer Drug Methotrexate: Does ADP-Ribosyl Transferase Have a Role to Play?....Pages 327-331
Cytogenetic, Cytotoxic, and Cell-Cycle Effects of 3-Aminobenzamide in Human Lymphoblastoid Cells Proficient or Deficient in Nucleotide Biosynthesis....Pages 332-336
Poly(ADP-Ribose) Polymerase Inhibition and the Induction of Mutation in V79 Cells....Pages 337-341
Effect of 3-Aminobenzamide on CHO Cells Replicating in Medium Containing Chloro-Deoxyuridine....Pages 342-351
Poly(ADP-Ribose) Synthesis in Lymphocytes of Persons Occupationally Exposed to Low Levels of Ionizing Radiation....Pages 352-356
Front Matter....Pages 357-357
ADP-Ribosyltransferase in Protozoan Differentiation....Pages 358-366
ADP-Ribosyltransferase Activity in Trypanosoma brucei ....Pages 367-371
ADP-Ribose: A Novel Aspect of Steroid Action....Pages 372-378
ADP-Ribosylation and Glucocorticoid-Regulated Gene Expression....Pages 379-387
Poly(ADP-Ribose) Synthetase and Cell Differentiation....Pages 388-396
Interaction of Cyclic AMP and ADP-Ribosylation in a Hormonally Responsive Cell Line....Pages 397-401
Poly(ADP-Ribose) Synthetase Inhibitor Effects on Cellular Functions....Pages 402-409
Poly(ADP-Ribose) Synthetase Inhibitors Induce Islet B-Cell Regeneration in Partially Depancreatized Rats....Pages 410-416
Regulation of Lymphocyte Proliferation by a Continuous Production and Repair of DNA Strand Breaks....Pages 417-423
Requirement for ADP-Ribosyltransferase Activity and Rejoining of DNA Strand Breaks During Lymphocyte Stimulation....Pages 424-428
Specific Inhibition of the Appearance of a T-Lymphocyte Surface Marker in Thymus Organ Cultures....Pages 429-432
Transient Formation of DNA Strand Breaks During DMSO-Induced Differentiation of Promyelocytic Cell Line, HL-60....Pages 433-439
Front Matter....Pages 357-357
Differentiation of a Myoblast Cell Line and Poly(ADP-Ribosyl)ation....Pages 440-445
Inhibitors of Poly(ADP-Ribose) Polymerase Prevent Friend Cell Differentiation....Pages 446-452
Poly(ADP)-Ribosylation of Nuclear Proteins in the Mouse Testis....Pages 453-462
Front Matter....Pages 463-463
A Role for Poly(ADP-Ribose) in Radiogenic and Chemically-Induced Malignant Transformation and Mutagenesis....Pages 464-470
Effects of 3-Aminobenzamide on the Induction of Toxicity and Transformation by Various Chemicals in BALB/3T3 Cl A 31–1 Cells....Pages 471-474
Specific Binding of Benzamide to DNA: Possible Correlation to Antitransforming Activity....Pages 475-479
Enhancement by m-Aminobenzamide of Methylazoxymethanol Acetate-Induced Hepatoma of the Small Fish “Medaka” ( Oryzias latipes )....Pages 480-483
Influence of Dietary Nicotinamide on N-Nitrosodimethylamine Carcinogenesis in Rats....Pages 484-488
Involvement of Poly(ADP-Ribosylation) Reactions in Liver Carcinogenesis of Diethylnitrosamine in Rats....Pages 489-495
Immunofluorescent Staining of Poly(ADP-Ribose) in Situ in Acetone-Fixed HeLa Cells: Its Usefulness for Clinical and Basic Sciences....Pages 496-501
Diadenosine Tetraphosphate: A New Target for Cancer Chemotherapy....Pages 502-510
Front Matter....Pages 511-511
Characterization of NAD: Arginine Mono(ADP-Ribosyl)-Transferases in Turkey Erythrocytes: Determinants of Substrate Specificity....Pages 512-517
Mono(ADP-Ribosyl)ation and Phospho(ADP-Ribosylation)Reactions in Eukaryotic Cells....Pages 518-525
Mono(ADP-Ribosylation) of Proteins at Arginine in Vivo....Pages 526-529
Calcium Transport and Mono(ADP-Ribosylation) in Mitochondria....Pages 530-535
A Cellular Mono(ADP-Ribosyl)Transferase which Modifies the Diphthamide Residue of Elongation Factor-2....Pages 536-543
Photochemical Transfer of the Nicotinamide Moiety of NAD to a Specific Residue in the Catalytic Center of Diphtheria Toxin Fragment A....Pages 544-550
ADP-Ribosylation of a Membrane Protein Catalyzed by Islet-Activating Protein, Pertussis Toxin....Pages 551-561
Why Does Cholera Toxin Need GTP to Act?....Pages 562-568
Epilogue....Pages 569-572
Back Matter....Pages 573-578