ADP-Ribosylation in Animal Tissues: Structure, Function, and Biology of Mono (ADP-ribosyl) Transferases and Related Enzymes

Front Matter....Pages i-xix
Mono(Adp-Ribosyl)Transferases and Related Enzymes in Animal Tissues....Pages 1-13
ADP-Ribose....Pages 15-24
ADP-Ribosylarginine Hydrolases and ADP-Ribosyltransferases....Pages 25-33
Crystal Structure of Diphtheria Toxin Bound to Nicotinamide Adenine Dinucleotide....Pages 35-43
Selection of Diphtheria Toxin Active-Site Mutants in Yeast....Pages 45-52
Identification of the Catalytic Site of Clostridial ADP-Ribosyltransferases....Pages 53-60
A Proposed Role for Protein....Pages 61-69
ADP-Ribosylation and Early Transcription Regulation by Bacteriophage T4....Pages 71-82
Pertussis Toxin....Pages 83-86
Membrane Anchored Synthetic Peptides as a Tool for Structure-Function Analysis of Pertussis Toxin and its Target Proteins....Pages 87-91
Enhanced Degradation of Stimulatory G-Protein (Gsα) by Cholera Toxin is Mediated by ADP-Ribosylation of Gsα Protein but Not by Increased Cyclic AMP Levels....Pages 93-97
Sequence and Structural Links between Distant ADP-Ribosyltransferase Families....Pages 99-107
Molecular Cloning and Characterization of the T-CELL Mono(ADP-Ribosyl)Transferase RT6....Pages 109-120
Molecular Cloning and Characterization of A Mono(ADP-Ribosyl)Transferase from Human Testis....Pages 121-128
Molecular Cloning and Characterization of Lymphocyte and Muscle ADP-Ribosyltransferases....Pages 129-136
Molecular Cloning and Characterization of Arginine-Specific ADP-Ribosyltransferases from Chicken Bone Marrow Cells....Pages 137-144
Purification, Characterisation, and Molecular Cloning of a Chicken Erythroblast Mono(ADP-Ribosyl)Transferase....Pages 145-154
Molecular Characterisation of a Fungal Mono(ADP-Ribosyl)Transferase....Pages 155-162
Use of the EST Database Resource to Identify and Clone Novel Mono(ADP-Ribosyl)Transferase Gene Family Members....Pages 163-168
Mouse RT6 Locus 1 and RAT RT6.2 are NAD + ....Pages 169-173
Expression and Comparative Analysis of Recombinant Rat and Mouse RT6 T Cell Mono(ADP-Ribosyl)Transferases In E. Coli ....Pages 175-180
Molecular Characterization of Rat T Lymphocyte Alloantigen RT6.1 as an ADP-Ribosyltransferase....Pages 181-183
Using Secondary Structure Predictions and Site-Directed Mutagenesis to Identify and Probe the Role of Potential Active Site Motifs in the RT6 Mono(ADP-Ribosyl)Transferases....Pages 185-189
Regulation of Cytotoxic T Cell Functions by A GPI-Anchored Ecto-ADP-Ribosyltransferase....Pages 191-201
Effects of Inhibitors of ADP-Ribosylation on Macrophage Activation....Pages 203-207
The T Cell Marker RT6 in a Rat Model of Autoimmune Diabetes....Pages 209-216
Mono(ADP-Ribosyl)Transferase Genes and Diabetes in NOD Mice....Pages 217-227
Expression of The Ectoenzyme RT6 is Not Restricted to Resting Peripheral T Cells and is Differently Regulated in Normal Peripheral T Cells, Intestinal IEL, and NK Cells....Pages 229-240
Arginine-Specific Mono(ADP-Ribosyl)Transferase Activity in Human Neutrophil Polymorphs....Pages 241-244
A Newly Identified Glycosylphosphatidylinositol-Anchored Arginine-Specific ADP-Ribosyltransferase in Chicken Spleen....Pages 245-248
Role of ADP-Ribosylation in Activated Monocytes/Macrophages....Pages 249-252
Expression of RT6, but Not CD45RC, is Disturbed on Immature Peripheral T Cells In the BB Rat....Pages 253-256
Expression of RT6 on Activated RAT T Cells....Pages 257-264
Expression of the RT6 Mono(ADP-Ribosyl)Transferases is Regulated by Two Promoter Regions....Pages 265-270
“Natural” RT6-1 and RT6-2 “Knock-Out” Mice....Pages 271-274
An ADP-Ribosyltransferase from Bovine Erythrocytes Apparently Specific for Cysteine Residues....Pages 275-278
Endogenous ADP-Ribosylation of Phosphoprotein B-50/GAP-43 and other Neuronal Substrates....Pages 279-288
Endogenous Mono-ADP-Ribosylation in Retina and Peripheral Nervous System....Pages 289-295
The α7 Integrin as a Target Protein for Cell Surface Mono-ADP-Ribosylation in Muscle Cells....Pages 297-303
Regulatory Role of Arginine-Specific Mono(ADP-Ribosyl)Transferase in Muscle Cells....Pages 305-313
Activation of Toxin ADP-Ribosyltransferases by the Family of ADP-Ribosylation Factors....Pages 315-320
Possible Role of BARS-50, A Substrate of Brefeldin A-Dependent Mono-ADP-Ribosylation, in Intracellular Transport....Pages 321-330
Brefeldin A-Induced ADP-Ribosylation in the Structure and Function of the Golgi Complex....Pages 331-335
Characterization of the Endogenous Mono-ADP-Ribosylation Stimulated by Brefeldin A....Pages 337-342
Modulatory Role of GTP-Binding Proteins in the Endogenous ADP-Ribosylation of Cytosolic Proteins....Pages 343-347
ADP-Ribosylating and Glucosylating Toxins as Tools to Study Secretion in RBL Cells....Pages 349-353
Cell Surface Dynamics of GPI-Anchored Proteins....Pages 355-364
Signal Transduction Via GPI-Anchored Membrane Proteins....Pages 365-370
ADP-Ribose in Glycation and Glycoxidation Reactions....Pages 371-379
Intramolecular ADP-Ribose Transfer Reactions and Calcium Signalling....Pages 381-388
Hydrophobic Properties of NAD Glycohydrolase from Neurospora Crassa Conidia and Interaction with Dioxane....Pages 389-397
Involvement of Bovine Spleen NAD + Glycohydrolase in the Metabolism of Cyclic ADP-Ribose-Mechanism of the Cyclization Reaction....Pages 399-409
ADP-Ribosyl Cyclase and CD38....Pages 411-419
Signal Transduction Via the CD38/NAD + Glycohydrolase....Pages 421-430
Ca 2+ -Signalling in Human T-Lymphocytes....Pages 431-436
Metabolism and Actions of ADP-Riboses in Coronary Arterial Smooth Muscle....Pages 437-441
Bovine Liver Mitochondrial NAD + Glycohydrolase....Pages 443-446
Characterization of Hydrosoluble and Detergent-Solubilized Forms of Mitochondrial NAD + Glycohydrolase from Bovine Liver....Pages 447-451
Contemplations on the Evolution of PRO- and Eukaryotic Mono(ADP-Ribosyl)Transferases in the Context of the Immune System....Pages 453-458
Back Matter....Pages 459-471