ADP-Ribose Transfer Reactions: Mechanisms and Biological Significance

Front Matter....Pages i-xvi
Amino Acid-Specific ADP-Ribosylation: Purification and Properties of an Erythrocyte ADP-Ribosylarginine Hydrolase....Pages 1-6
ADP-Ribosyltransferase and Endogenous Acceptor Proteins in Animal Muscle Tissues: ADP-Ribosylation of Ca 2+ -Dependent ATPase in Rabbit Skeletal Muscle Sarcoplasmic Reticulum and the Effect of Basic Peptides....Pages 7-12
Endogenous ADP-Ribosylation of Proteins at Cysteine Residues....Pages 13-17
Reversible ADP-Ribosylation of Dinitrogenase Reductase from Rhodospirillum rubrum Regulates the Activity of the Enzyme In Vivo and In Vitro ....Pages 18-25
Phospho ADP-Ribosylation and Phospho Adenylation of Proteins....Pages 26-31
ADP-Ribosyl Transferase of Mitochondria and of Cytoplasmic Ribonucleoprotein Particles Containing Silent Messenger RNA....Pages 32-38
 In Vitro Evidence for Poly(ADP-Ribosyl)ation of DNA Polymerase α-Primase and Phosphorylation of Poly(ADP-Ribose) Synthetase by Protein Kinase C....Pages 39-46
Poly(ADP-Ribose) Glycohydrolase and ADP-Ribosyl Group Turnover....Pages 47-52
 In Vitro ADP-Ribosylation Utilizing 2′Deoxy-NAD + as a Substrate....Pages 53-56
Reconstitution of an In Vitro Poly(ADP-Ribose) Turnover System....Pages 57-61
Effect of Selected Octadeoxyribonucleotides and 6-Amino-1,2 Benzopyrone on Poly(ADP-Ribose) Transferase Activity....Pages 62-66
Two Tests of the Direction of Elongation of Poly(ADP-ribose): Residues are Added at the Polymerase-Proximal Terminus....Pages 67-70
Biosynthesis and Degradation of Poly(ADP-Ribose) Synthetase....Pages 71-75
Monoclonal Antibodies Against Poly(ADP-Ribose) Polymerase: Epitope Mapping, Inhibition of Activity and Interspecies Immunoreactivity....Pages 76-80
Poly(ADP-Ribose) Polymerase: Determination of Content from TCA-Precipitated Cells, Existence of Species-Specific Isoforms and Changes During the Growth Cycle....Pages 81-84
ADP-Ribosylation in Mitochondria: Enzymatic and Non Enzymatic Reactions....Pages 85-88
Localization of the Zinc-Binding Sites in the DNA-Binding Domain of the Bovine Poly(ADP-Ribose) Polymerase....Pages 89-93
Heterogeneity of Polyclonal Antisera to ADP-Ribose and Their Use as Probes for ADP-Ribosylation in Human Tumor Cells....Pages 94-100
ADP-Ribosylating Activity in Sulfolobus solfataricus ....Pages 101-104
Alteration of Poly(ADP-Ribose) Metabolism by Ethanol: Kinetic Mechanism of Action....Pages 105-108
The Effect of Benzamides on the Activity of Nuclear ADP-Ribosyl Transferase and the Accumulation of Poly(ADP-Ribose) In Vivo ....Pages 109-112
Carba-Nicotinamide Adenine Dinucleotide: Synthesis and Enzymological Application of a Novel Inhibitor of ADP-ribosyl Transfer....Pages 113-118
Purification and Properties of Two Forms of Poly(ADP-Ribose) Glycohydrolase....Pages 119-124
Poly(ADP-Ribosyl)ation in Free Cytoplasmic mRNA-Protein Complexes....Pages 125-129
New Inhibitors of Poly(ADP-Ribose) Synthetase....Pages 130-133
Monoclonal Antibodies to Human Placental Poly(ADP-Ribose) Synthetase....Pages 134-138
Characterization of the Human Autoantibody Response to Poly(ADP-Ribose) Polymerase....Pages 139-144
 In Vivo Automodification of Poly(ADP-Ribose) Polymerase and DNA Repair....Pages 145-150
ADP-Ribosylation and Chromatin Function....Pages 151-157
Modulation of Chromatin Structure by Poly(ADP-Ribosyl)ation....Pages 158-164
Automodified Poly(ADP-Ribose) Synthetase Detected in Rat Liver Cells is Selectively Attached to a Nuclear Matrix-Like Structure....Pages 165-172
Studies on the Nuclear Distribution of ADP-Ribose Polymers....Pages 173-178
A Proposed Molecular Mechanism of Nucleosome Unfolding. Effect of Poly(ADP-Ribose) on DNA-Histone H4 Interaction....Pages 179-183
On The Nature of the Interaction Between Poly(ADP-Ribose) Polymerase and DNA....Pages 184-188
Inhibition of ADP-Ribosyl Transferase Activity Blocks the Stable Integeration of Transfected DNA into the Mammalian Cell Genome....Pages 189-193
Role of Poly(ADP-Ribose) Polymerase in Ribosomal RNA Gene Transcription....Pages 194-199
ADP-Ribosylation of HeLa Chromosomal and Nuclear Proteins: Response to DNA Damage Caused by Chemical Mutagens....Pages 200-205
Poly(ADP-Ribose) Polymerase: DNA Complexes Visualized as Looped Structures by Electron Microscopy....Pages 206-212
Poly(ADP-Ribose) May Signal Changing Metabolic Conditions to the Chromatin of Mammalian Cells....Pages 213-217
Uncoupling of DNA Excision Repair and Chromatin Rearrangements in Poly(ADP-ribose)-Depleted Cells....Pages 218-221
Highly Sensitive Method for Immunohistochemical Detection of Poly(ADP-Ribose) in Various Animal Species....Pages 222-224
Poly(ADP-Ribosyl)ation of Nuclear Proteins by Oxidant Tumor Promoters....Pages 225-234
The Cytogenetic Effects of an Inhibition of Poly(ADP-Ribose) Polymerase....Pages 235-241
Effect of 3-Aminobenzamide on the Induction of γ-Glutamyltranspeptidase Positive Foci in the Liver of Rats Treated with Various Chemical Carcinogens....Pages 242-244
A Role of Poly(ADP-Ribosyl)ation in Carcinogen-Inducible Transient DNA Amplification....Pages 245-249
Arrest of Tumor Growth by DNA-Site Inhibitors of Adenosine Diphosphoribose Transferase....Pages 250-253
Inhibition of SV40 Replication In Vitro by Poly(ADP-Ribosyl)ated Diadenosine Tetraphosphate....Pages 254-260
Killing and Mutation of Density Inhibited V-79 Cells as Affected by Inhibition of Poly(ADP-Ribose) Synthesis....Pages 261-264
Influence of Benzamide and Nalidixic Acid on the Killing and Mutations Induced in V-79 Cells by N-Methyl-N′-Nitro-N-Nitrosoguanidine....Pages 265-269
Loss of Poly(ADP-Ribose) Transferase Activity in Liver of Rats Treated with 2-Acetylaminofluorene....Pages 270-274
V-79 Cell Variants Deficient in Poly(ADP-Ribose) Polymerase....Pages 275-278
Cytotoxicity of TPA-Stimulated Granulocytes and Inhibitors of ADP-Ribosylation....Pages 279-282
3-Aminobenzamide Enhances X-Ray Induction of Chromosome Aberrations in Down Syndrome Lymphocytes....Pages 283-286
3-Methoxybenzamide, A Possible Initiator for DMBA-Induced Carcinogenesis....Pages 287-290
Synergistic Induction of Sister Chromatid Exchanges and Cell Division Delays in Ehrlich Ascites Tumor Cells Treated with Cytoxan and Caffeine In Vivo ....Pages 291-295
Inhibition of Poly(ADP-Ribosyl)ation and Sister Chromatid Exchange Induction....Pages 296-299
Differential Effect of Benzamide on Repair-Deficient and Proficient Strains of L5178Y Lymphoblasts Exposed to UVC or X-Radiations....Pages 300-303
Nicotinamide Deficiency and Sister Chromatid Exchanges....Pages 304-309
ADP-Ribosyl Transferase in the Differentiation of Protozoa and Embryonic Mouse Thymus....Pages 310-315
ADP-Ribosylation of Leukemia Cell Membrane Proteins Correlates with Granulocyte Colony Stimulating Factor Dependent Differentiation....Pages 316-320
Poly(ADP-Ribose) Transferase in Lizard Oviduct....Pages 321-325
DNA Damage Does Not Induce Lethal Depletion of NAD During Chicken Spermatogenesis....Pages 326-329
Divergence of Poly(ADP-ribose) Polymerase Activity, Poly(ADP-ribose) Levels and the Effect of Polymerase Inhibitors in Differentiating 3T3-L1 Preadipocytes....Pages 330-333
Differences in DNA Supercoiling and ADP-Ribosylation During Granulocytic and Monocytic Differentiation....Pages 334-338
Niacin Analogs That Induce Differentiation of Friend Erythroleukemia Cells are Able to Cause DNA Hypomethylation....Pages 339-344
 In Vivo Poly(ADP-ribose) Levels in Carcinogen Treated Human Promyelocytic Leukemia Cells....Pages 345-347
Activation-Inactivation of Poly(ADP-Ribose) Transferase of Mammalian Cells Exposed to DNA Damaging Agents....Pages 348-352
Aspects of NAD Metabolism in Prokaryotes and Eukaryotes....Pages 353-360
An Approach to the Selective Targeting of NAD Consuming Reactions in Cultured Mammalian Cells....Pages 361-365
Pyridine Nucleotide Metabolism as a Target for Cancer Chemotherapy....Pages 366-371
Pivotal Role of Poly(ADP-Ribose) Polymerase Activation in the Pathogenesis of Immunodeficiency and in the Therapy of Chronic Lymphocytic Leukemia....Pages 372-377
Active Transport of Nicotinamide and the Adenine Moiety of NAD by Metabolically Controlled NAD Catabolism....Pages 378-385
The Effect of Extracellular Calcium on NAD Metabolism in Human Diploid Cells....Pages 386-389
Reduced Tumor Progression In Vivo by an Inhibitor of Poly(ADP-Ribose) Synthetase (3-Aminobenzamide) in Combination with X-Rays or the Cytostatic Drug DTIC....Pages 390-395
Cytotoxic Effects of 3-Aminobenzamide in CHO-K1 Cells Treated with Purine Antimetabolites....Pages 396-402
Hyperthermia and Poly(ADP-ribose) Metabolism....Pages 403-407
Comparison of Low Dose Nicotinamide Versus Benzamide, Administered Per Os “ as Radiosensitizers in a C3H Mammary Carcinoma....Pages 408-410
Viral Hepatitis in Mice and ADP-Ribose Metabolism....Pages 411-413
GTP-binding Proteins, Substrates of Pertussis Toxin-Catalyzed ADP-Ribosylation, as Mediators of Receptor-Coupled Signal Transduction....Pages 414-421
 Clostridium botulinum Exoenzyme C3 ADP-Ribosylates and Functionally Modifies p21.bot in PC12 Cells Without Affecting Neurosecretion....Pages 422-429
ADP-Ribosylation of Human c-Ha- ras Protein by Hen Liver ADP-Ribosyl Transferase....Pages 430-432
Mono(ADP-Ribosyl)ation in Rat Liver Mitochondria....Pages 433-436
Botulinum Neurotoxins ADP-Ribosylate A Novel GTP-Binding Protein (Gb)....Pages 437-444
C3: A Novel Botulinum ADP-Ribosyltransferase Modifies a Putative 21 kDa G-Protein....Pages 445-449
Stimulation of Choleragen Enzymatic Activities by GTP and a Membrane Protein from Bovine Brain....Pages 450-453
Activation of the NAD Glycohydrolase, NAD:Agmatine and NAD:G sα ADP-Ribosyltransferase and Auto-ADP-Ribosylation Activities of Choleragen by Guanyl Nucleotide and Soluble Proteins Purified from Bovine Brain....Pages 454-457
Active Sites and Homology of Diphtheria Toxin and Pseudomonas aeruginosa Exotoxin A....Pages 458-462
The Cloning of the cDNA and the Gene for Human Poly(ADP-Ribose) Polymerase: Status on the Biological Function(s) Using Recombinant Probes....Pages 463-477
Adenosine Diphosphate Ribosylation of Elongation Factor-2 as a Therapeutic Target: Genetic Construction and Selective Action of a Diphtheria Toxin-Related Interleukin-2 Fusion Protein....Pages 478-486
Molecular Structure of Poly(ADP-Ribose) Synthetase....Pages 487-493
The Biological Function(s) of Poly(ADP-ribose) Polymerase as Observed by Transient Expression of the cDNA and Transcriptional Regulation of the Gene....Pages 494-501
Rapid Isolation of ADP-Ribosyl Transferase by Specific Precipitation and Partial Sequencing of its DNA-Binding Domain....Pages 502-504
Sequence Analysis of the DNA Associated with Poly(ADP-Ribose) Polymerase Molecules....Pages 505-510
Molecular Cloning of cDNA for Human Placental Poly(ADP-Ribose) Polymerase and Decreased Expression of its Gene during Retinoic Acid-Induced Granulocytic Differentiation of HL-60 Cells....Pages 511-514
Isolation of a cDNA Clone Encoding Bovine Poly(ADP-Ribose) Synthetase by Immunological Screening of a cDNA Expression Library and its Application as a Probe....Pages 515-519
Radiation Sensitivity of Human Cells and the Poly(ADP-Ribose) Polymerase Gene....Pages 520-524
Back Matter....Pages 525-527