Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology

Front Matter....Pages i-xix
Front Matter....Pages 1-1
Molecular Biology of Adenosine Receptors....Pages 5-13
Recombinant Techniques as Applied to the Study of A 1 Adenosine Receptors....Pages 15-19
In Situ Hybridization of Adenosine Receptors in Brain....Pages 21-26
Molecular Modeling of Adenosine A 1 and A 2a Receptors....Pages 27-37
Purinoceptor Nomenclature: Challenges for the Future....Pages 39-48
Molecular Cloning and Expression of SNST1, a Renal Sodium/Nucleoside Cotransporter....Pages 49-54
Antibodies as Probes of Nitrobenzylthioinosine-Sensitive Nucleoside Transporters....Pages 55-60
Regulation of the Human A 1 Adenosine Receptor Gene....Pages 63-70
Adenosine A 2 Receptor Regulation of Striatal Gene Expression....Pages 71-76
Neuronal ATP Receptors....Pages 77-84
Possible Role of Glia in the Induction of CNS-Like Properties in Aortic Endothelial Cells: Atp-activated Channels....Pages 85-95
Modulation of Cardiomyocyte Membrane Currents by A 1 Adenosine Receptors....Pages 97-102
Regulation of Phospholipases C and D, Calcium, and Protein Kinase C by Adenosine A 1 Receptors....Pages 103-112
Adenosine Derived from Neurally Released ATP is the Physiologic Cause of Skeletal Neuromuscular Depression....Pages 113-120
Adenosine 5’-Triphosphate Receptor — Mediated Currents in Rat Intracardiac Neurons....Pages 121-131
Desensitization of A 1 Adenosine Receptors....Pages 133-138
Front Matter....Pages 139-139
Selective A 2 Adenosine Receptor Agonists with Potent Inhibitory Activity on Platelet Aggregation....Pages 141-148
Novel ATP Agonists Reveal Receptor Heterogeneity Within P 2X and P 2Y Subtypes....Pages 149-156
Adenosine Receptors:Selective Agonists and Antagonists....Pages 157-166
Front Matter....Pages 167-167
Cardiac Energetics and Adenosine Formation....Pages 169-177
Front Matter....Pages 167-167
Extracellular Hydrolysis of ATP and Formation of Adenosine in the Nervous System....Pages 179-187
P-Glycoprotein Serves as a Transporter of Cellular ATP....Pages 189-192
On the Origin of Extracellular ATP in Cardiac Blood Vessels: A Dual Role for Endothelium....Pages 193-197
Allosteric Modulation of Nucleoside Transport by Adenosine and ATP....Pages 199-206
Front Matter....Pages 207-207
Chloride Secretion in the Shark Rectal Gland: A Model for Epithelial Adenosine Receptors....Pages 211-218
Myocardial Adenosine Receptors....Pages 221-228
Coronary Adenosine Receptors: Subtypes, Localization, and Function....Pages 229-239
Biologic Activity of Adenosine A 2a Receptor Antagonists....Pages 241-248
Role of A 2a Receptors in the Hippocampus and Motor Nerve Endings....Pages 251-261
Augmentation of Extracellular Adenosine Formation as a Potential Therapeutic Strategy for Preventing Excessive Excitatory Amino Acid Transmission in the Central Nervous System....Pages 263-269
Purinoceptors on Glial Cells of the Central Nervous System: Functional and Pathologic Implications....Pages 271-280
Inhibitory Action of Adenosine and Adenine Dinucleotides on Synaptic Transmission in the Central Nervous System....Pages 281-288
Receptors for ATP at Peripheral Neuroeffector Junctions....Pages 289-295
Anatomic-Functional Correlates of Adenosine-5’-Triphosphate Triggered Vagal Depressor Reflex....Pages 297-305
Excitatory Effect of Adenosine on Cardiac Sympathetic Afferent Fibers....Pages 307-314
Mechanism of Anginal Pain: The Key Role of Adenosine....Pages 315-325
The P 2Z Receptor and Its Regulation of Macrophage Function....Pages 329-335
Effects of Purinoceptor Agonists on Insulin Secretion....Pages 337-345
Front Matter....Pages 347-347
Receptor-Mediated and Metabolic Effects of Adenosine in Ischemic and Postischemic Myocardium....Pages 351-360
Role of Activation of Ecto-5’-Nucleotidase for Cardioprotection in Ischemic Preconditioning....Pages 361-371
Front Matter....Pages 347-347
Adenosine Uptake Blockers for Cardioprotection....Pages 373-378
Endothelial Adenosine Receptors Modulate Leukocyte Adhesion: Relevance for Myocardial Reperfusion Damage....Pages 379-387
Adenosine and Brain Ischemia....Pages 391-397
Adenosine Metabolites Are a Source of Oxygen Free Radicals in the Ischemic/Reperfused Rat Brain....Pages 399-404
Hyperglycemic Ischemia and Reperfusion: Effects on Adenosine and Adenine Nucleotides....Pages 405-411
Studies on the Mechanism by Which Adenosine Receptor Antagonists Attenuate Acute Renal Failure....Pages 415-423
Front Matter....Pages 425-425
Clinical Electrophysiology of Adenosine....Pages 429-438
Myocardial Imaging during Adenosine Infusion....Pages 439-445
Intravenous Adenosine and Lidocaine in the Limitation of Infarct Size:Preliminary Safety Data....Pages 447-459
Role of Adenosine in the Phenomenon of Ischemic Preconditioning....Pages 461-475
Anticonvulsant Actions of Novel and Reference Adenosine Agonists....Pages 479-487
Behavioral Effects of Adenosine Receptor stimulation....Pages 489-498
Evidence for the Existence of Antagonistic Intramembrane Adenosine A 2a /dopamine D 2 Receptor Interactions in the Basal Ganglia: Analysis from the Network to the Molecular Level....Pages 499-507
Role of Adenosine and Adenosine Triphosphate as Anesthetic Adjuvants....Pages 511-523
Mechanisms and Therapeutic Actions of Uridine Triphosphate in the Lung....Pages 525-532
Back Matter....Pages 533-543