Acute Lymphoblastic Leukemia in Children and Adolescents

Preface
Contents
Part I: Epidemiology and Predisposition of ALL
1: Genetic Predisposition for Acute Lymphoblastic Leukemia
	1.1	 Introduction
	1.2	 Empirical Evidence of ALL Heritability
	1.3	 Rare Variants and High-Penetrance ALL Predisposition
		1.3.1	 ALL Predisposition Syndromes
			1.3.1.1	 Overt ALL Predisposition Syndromes
				1.3.1.1.1 Ataxia–Telangiectasia (A-T)
				1.3.1.1.2 Bloom Syndrome (BSyn)
				1.3.1.1.3 Fanconi Anemia (FA)
				1.3.1.1.4 Nijmegen Breakage Syndrome (NBS)
				1.3.1.1.5 Neurofibromatosis Type 1 (NF1)
				1.3.1.1.6 Noonan Syndrome (NS) and Others
			1.3.1.2	 Covert ALL Predisposition Syndromes
				1.3.1.2.1 Familial ALL Syndromes
					PAX5 ALL Susceptibility
					ETV6 ALL Susceptibility
					IKZF1 ALL Susceptibility
					RUNX1 ALL Susceptibility
				1.3.1.2.2 Covert Syndromes with Mixed Cancer Phenotypes
					Li–Fraumeni Syndrome (LFS)
					Constitutional Mismatch Repair Deficiency (CMMRD)
		1.3.2	 ALL Predisposition in Pediatric Pancancer Studies
		1.3.3	 Not Inherited, Yet Herita