Acute Leukemias VI: Prognostic Factors and Treatment Strategies

Front Matter....Pages I-XXXIII
Front Matter....Pages 1-1
Chromosome Translocations Play a Key Role in Leukemogenesis....Pages 3-10
Fifty-nine Cases of Acute Myeloid Leukemia with Inversion inv(16) (p13q22): Do Additional Chromosomal Aberrations Influence Prognosis?....Pages 11-16
Chromosome Abnormalities and Karyotype Evolution in the Stem Cell Compartments of AML and MDS....Pages 17-23
Karyotypic Abnormalities in Secondary Leukemia of Children....Pages 24-28
Deletion of Chromosome 6p as Primary Karyotypic Anomaly in Secondary Acute Nonlymphocytic Leukemia....Pages 29-32
Molecular Cytogenetic Analysis of 7q Abnormalities in Acute Leukemia....Pages 33-37
Unusual Karyotype 46,XX,inv(8)(p21q24),del(20)(q11q13) in a Case of Acute Leukemia M6 in a Child....Pages 38-40
Acute Myeloblastic Leukemia M2 with the 8;21 Translocation Associated with Granulocytic Sarcoma....Pages 41-43
Cytogenetic Subgroups in Childhood Acute Myeloblastic Leukemia at the Schneider Children’s Medical Center of Israel....Pages 44-53
FISH Analysis in Acute Leukemia with Initially Abnormal Karyotypes and Normal Karyotypes in Relapse....Pages 54-59
Cytogenetic Findings of Acute Leukemias in the Ukraine....Pages 60-66
Detection of Minimal Tumor Cell Populations by FICTION....Pages 67-70
Front Matter....Pages 71-71
A Cloning Strategy to Identify Genes that Functionally Interact with Bcr-Abl for Transformation....Pages 73-81
Biology and Detection of t(4;11) Leukemias....Pages 82-89
Homozygous Deletion of the p16 Gene in Childhood Acute Lymphoblastic Leukemia....Pages 90-94
CDKN2 Deletions in Leukemia-Derived Cell Lines: Detection by Fluorescence In Situ Hybridization with Interphase Cells....Pages 95-101
Diversity of the TcR-d Gene Rearrangements Indicates Subclone Formation in Acute B Cell Precursor Leukemias....Pages 102-106
Molecular Genetic Detection of Chromosomal Abnormalities at 11q23 in Patients with De Novo and Secondary Acute Leukemia....Pages 107-110
Sequence Analysis of the GAP-Related Domain of the NFI-Gene and All Three RAS Protooncogenes in Patients with Secondary Acute Leukemia....Pages 111-114
Molecular Genetic Screening of Children with Acute Leukemia by RT-PCR....Pages 115-119
Front Matter....Pages 71-71
Detection of the Wilms Tumor Gene (wt-1) mRNA in Complete Remission of AML Frequently Precedes Relapse....Pages 120-124
CBFβ/MYH11 Rearrangement in M4Eo with Inversion 16: A Novel Marker for Diagnosis of Minimal Residual Disease by RT-PCR....Pages 125-126
Detection of Minimal Residual Disease on Bone Marrow Smears by Reverse Transcriptase Polymerase Chain Reaction....Pages 127-130
Evaluation of Chimerism After Allogeneic Bone Marrow Transplantation Using Amplification of Hypervariable Regions of Human Genome by Polymerase Chain Reaction....Pages 131-135
Front Matter....Pages 137-137
Truncated Granulocyte - Colony Stimulating Factor Receptors in Severe Congenital Neutropenia Terminating in Acute Myeloid Leukemia....Pages 139-143
BCR/ABL and Signal Transduction Pathways....Pages 144-153
Interleukins (IL-1, IL-2, IL-4, IL6) and TNF Production in Children with Acute Lymphoblastic Leukemia....Pages 154-160
Insulin-Like Growth Factors and Their Specific Binding Proteins in Leukemia (ALL) and Non-Hodgkin Lymphoma....Pages 161-165
IFN-α Is an Inhibitory Cytokine of Leukemic B-Cell Precursors....Pages 166-172
Cytokine Serum Levels During the Course of Acute Myeloid Leukemia....Pages 173-184
Expression of FLT3 and FLT3 Ligand in Human Leukemia-Lymphoma Cell Lines....Pages 185-192
GM-CSF Dose Response Curves in Priming of AML Progenitors for Ara-C....Pages 193-196
Different Potential of G-CSF, GM-CSF, and pIXY in Priming of Myeloid Leukemic Progenitors for Ara-C....Pages 197-201
Front Matter....Pages 203-203
An Alternative Transcript of the Human GM-CSF Receptor Alpha Chain Lacking the Signal Sequence Is Found in AML Blasts and Normal Controls....Pages 205-209
Marked Effect of the Combination of a Novel Vitamin D 3 Analog, KH1060, and 9-cis-RA on Inhibition of Clonal Growth, Decreases of bcl-2 Level and Induction of Apoptosis in HL-60 Cells....Pages 210-217
Adoptive Transfer of NK Cells Can Eradicate Residual Leukemia After BMT....Pages 218-223
Characterization of Normal and Leukemic Lymphohematopoietic Precursor Cells by Three-Color Flow Cytometry and Detection of Clone-Specific Leukemia-Associated T-Cell Receptor δ Rearrangements....Pages 224-231
Monitoring Leukemic Cells During the Course of Acute Leukemia by Immunophenotyping and Genotyping....Pages 232-239
Flowcytometric Detection of Aneuploidies in Acute Lymphoblastic Leukemia (ALL) Before and After Chemotherapy....Pages 240-243
Comparison of Growth Patterns of Acute Myeloid Leukemia Cells In Vitro and In Vivo by Flow Cytometry....Pages 244-246
Front Matter....Pages 203-203
The Influence of Short Term Liquid Culture of Leukemic Blasts on Their Phenotype....Pages 247-251
Correlation of Deoxycytidine Deaminase, Thymidine Kinase and Polymerase Alpha Activity and Deoxycytidine Deaminase Gene Expression In Vivo with Clinical Response to TAD-9+GM-CSF Induction Therapy in Acute Myeloid Leukemia....Pages 252-259
CD7+CD4-CD8-Blast Cells in Acute Leukemia....Pages 260-263
Lymphoid Antigen Expression in Acute Myeloid Leukemia....Pages 264-268
CD54 Expression and Its Role in Homotypic Aggregation of the Blasts of Acute Myeloblastic (AML) and Acute Lymphoblastic Leukemia (ALL)....Pages 269-274
Adhesion Molecule Receptor Profile in Acute Leukemia....Pages 275-281
Expression of Adhesion Molecules on Blood Derived CD34 Positive Cells Immediately After Thawing and After Ex Vivo Incubation with Cytokines....Pages 282-287
Cytomorphology and Clinical Outcome in 80 Patients with AML M4Eo and Inversion 16....Pages 288-293
Prognostic Relevance of Proteolytically Inactivated Alpha 1 -Antitrypsin Excreted in the Urine of Patients with Acute Myeloid Leukemia....Pages 294-298
Studies on Plasma Coagulation in Children with ALL Undergoing Therapy Using the COALL-05-92 Protocol....Pages 299-304
Front Matter....Pages 305-305
Methods for Detection of Minimal Residual Disease....Pages 307-312
Molecular Biological Detection of Minimal Residual Disease in Acute Lymphoblastic Leukemia....Pages 313-320
Immunophenotypic Detection of Minimal Residual Disease in Acute Lymphoblastic Leukemia....Pages 321-327
Molecular Biological Detection of Minimal Residual Disease in Acute Myeloid Leukemia....Pages 328-332
Detection of Minimal Residual Disease in Cytogenetically Defined Prognostic Subgroups of AML....Pages 333-338
Front Matter....Pages 339-339
Current Approaches in the Treatment of Chronic Lymphocytic Leukemia....Pages 341-348
Fludarabine for the Treatment of Advanced Chronic Lymphocytic Leukemia: Results of a Prospective Randomized Comparison with Cyclophosphamide, Doxorubicin and Prednisone....Pages 349-357
Potential Immunological Action of Purine Nucleoside Analogs....Pages 358-366
Fludarabine and Fludarabine, Mitoxantrone, Dexamethasone in the Management of Low-Grade Non-Hodgkin Lymphomas....Pages 367-374
Fludarabine in Low-Grade Lymphoma: St. Bartholomew’s Hospital Experience....Pages 375-379
Front Matter....Pages 339-339
Future Role of Purine Analogues in Oncology....Pages 380-387
Front Matter....Pages 389-389
Intracellular Effects of Anthracydines: Distribution, DNA-Binding and Genotoxicity....Pages 391-395
Specific Role of Idarubicin During Induction Therapy of Childhood Acute Myeloblastic Leukemia....Pages 396-399
Overview of Current Treatment for Acute Myeloid Leukemia....Pages 400-405
Chemotherapy for Acute Myeloid Leukemia: the State of the Art and the Contribution of Idarubicin....Pages 406-409
Phase II Trial of Idarubicin, Fludarabine, Cytosine Arabinoside and Filgrastim (G-CSF) for Treatment of Refractory, Relapsed, and Secondary Acute Myeloid Leukemia....Pages 410-415
Front Matter....Pages 417-417
Mechanisms of Regulated Drug Sensitivity....Pages 419-431
Current Status of Granulocyte Colony-Stimulating Factor and Granulocyte-Macrophage Colony-Stimulating Factor in the Management of Acute Lymphoblastic Leukemia....Pages 432-437
Peripheral Blood Stem Cell Transplantation in Acute Myeloid Leukemia....Pages 438-442
Front Matter....Pages 443-443
Growth Factors in AML: Updates....Pages 445-455
Granulocyte-Macrophage Colony-Stimulating Factor-Based Priming Concepts in Acute Myeloid Leukemia....Pages 456-460
Cancer and Leukemia Group B Studies with Hematopoietic Growth Factors in Patients with Acute Myeloid Leukemia....Pages 461-464
Preclinical Evaluation of Granulocyte-Macrophage Colony-Stimulating Factor/Interleukin 3 Fusion Protein (PIXY 321) in Acute Myeloid Leukemic Cells....Pages 465-471
Initial Trial of PIXY 321 Following Autologous Bone Marrow Transplantation....Pages 472-475
Front Matter....Pages 477-477
Fluconazole Prophylaxis of Invasive Fungal Infections During Intensive Chemotherapy for Relapsed Acute Myeloid Leukemia: Interim Analysis of a Randomized Multicenter Trial....Pages 479-484
Current Approaches in the Prevention of Invasive Aspergillosis....Pages 485-488
Early Empiric Antifungal Treatment of Infections in Neutropenic Patients Comparing Fluconazole with Amphotericin B/5-Flucytosine....Pages 489-493
Front Matter....Pages 495-495
Dependence of Asparaginase-lnduced Coagulopathy on Serum Asparaginase Activity: A Randomized Trial....Pages 497-501
Significant Differences in the Pharmacokinetics of two l -Asparaginase Preparations from Escherichia coli ....Pages 502-505
Pharmacokinetic/Pharmacodynamic Monitoring of l -Asparaginase in Children....Pages 506-511
Front Matter....Pages 495-495
Asparaginase Activities In Vitro Are Highly Sensitive to Different Buffer Conditions....Pages 512-516
Influence of l -Asparaginase Escherichia Coli and Erwinia on Antithrombin III and Coagulation Factors During Induction Therapy of Acute Lymphoblastic Leukemia in Children....Pages 517-525
Infusion Rate Does Not Influence Ifosfamide Side-Chain Metabolism....Pages 526-532
Busulfan Pharmacology in Bone Marrow Transplantation Patients....Pages 533-537
Topoisomerase II Activities in Human Leukemic Cells and Their Sensitivity to Anthracyclines and Podophyllotoxines....Pages 538-542
Quantitative Cytosine Arabinoside Metabolism in HL60 and Raji Cells Using a Novel High Performance Liquid Chromatography Assay for Detection and Quantitation of 3 H-Cytosine Arabinoside and Its Metabolites....Pages 543-552
Role of Deoxycytidine Triphosphate for Feedback Regulation of Deoxycytidine Kinase and Phosphorylation of Cytosine Arabinoside in Whole Leukemic Cells....Pages 553-557
Drug Resistance Profile: Strongest Independent Prognostic Factor in Childhood Acute Lymphoblastic Leukemia in a BFM-Oriented Treatment Protocol....Pages 558-562
In Vitro Drug Sensitivity of Acute Myeloid Leukemic Cells Using the Methyl-Thazol-Tetrazolium Assay....Pages 563-567
Does P-Glycoprotein Predict Response to Chemotherapy? Expression of P-Glycoprotein in Children’s and Adults’ Leukemia—Correlation with Clinical Outcome....Pages 568-574
Clinical Relevance of P-Glycoprotein-Related Resistance in Patients with Acute Leukemia....Pages 575-586
Lack of Correlation Between Multi-Drug Resistance Expression and Clinical Response to Chemotherapy in Patients with Acute Myeloid Leukemia....Pages 587-592
Coexpression of mdr-1 and myc Genes in Relation to Prognosis in Acute Leukemia Patients....Pages 593-598
Front Matter....Pages 599-599
Risk Adapted Treatment in Childhood Acute Lymphoblastic Leukemia: Data from the Berlin-Frankfurt-Münster Group....Pages 601-610
Mechanisms of Treatment Failure in Childhood Acute Lymphoblastic Leukemia: Children’s Cancer Group Initiatives....Pages 611-628
Risk-Adapted Treatment for Acute Lymphoblastic Leukemia: Findings from St. Jude Children’s Research Hospital....Pages 629-637
Risk-Adapted Therapy for Acute Lymphocytic Leukemia: The Pediatric Oncology Group Experience....Pages 638-643
Treatment Results in Childhood B Non-Hodgkin Lymphoma with a Modified BFM Protocol in St. Petersburg....Pages 644-646
Similar Outcome in Boys with Isolated and Combined Testicular Acute Lymphoblastic Leukemia Relapse After Stratified BFM Salvage Therapy....Pages 647-651
Acute Cholecystitis Complicating Intensive Chemotherapy of Childhood Acute Lymphoblastic Leukemia....Pages 652-653
Front Matter....Pages 599-599
Prognostic Significance of Peanut Agglutinin Binding in Childhood T-Cell Acute Lymphoblastic Leukemia....Pages 654-659
Longitudinal Study of Cognitive, Motor, and Behavioral Functioning in Children Diagnosed with Acute Lymphoblastic Leukemia: A Report of Early Findings from the Childrens Cancer Group....Pages 660-673
Front Matter....Pages 675-675
Treatment of Biologically Determined Subsets of Acute Lymphoblastic Leukemia in Adults: Cancer and Leukemia Group B Studies....Pages 677-687
Treatment of Acute Lymphoblastic Leukemia in the Elderly: Results of the GIMEMA 0288> 60 Years Trial....Pages 688-694
Allogeneic and Autologous Bone Marrow Transplantation and Chemotherapy in First Remission of Adult Acute Lymphoblastic Leukemia: Results of the LALA 87 Trial of the French Group....Pages 695-699
Bone Marrow Transplantation Versus Chemotherapy in Acute Lymphoblastic Leukemia. Joint Trial of the Medical Research Council (UKALL-12) with the United States Eastern Cooperative Oncology Group E2993....Pages 700-703
Bone Marrow Transplantation for Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia....Pages 704-710
Front Matter....Pages 711-711
Childrens Cancer Group Studies in Acute Myeloid Leukemia, 1979–1995: Three Strategies That Have Worked....Pages 713-723
Intensified Early Therapy for Childhood Acute Myeloid Leukemia: Pilot Studies of the AIEOP Cooperative Group....Pages 724-729
A Randomized Comparative Study of Purged Autologous Bone Marrow Transplantation Versus Intensive Multiagent Consolidation Chemotherapy in First Remission of Acute Myeloid Leukemia in Children (Pediatric Oncology Group Study—POG 8821)....Pages 730-735
Prognostic Factors and Treatment in Pediatric Acute Myeloblastic Leukemia: French Trials....Pages 736-741
Childhood Acute Nonlymphoblastic Leukemia — Results of the Austrian-Hungarian Acute Myeloid Leukemia Studies IGCI-84 and 90....Pages 742-747
Results of Intensive Chemotherapy of Acute Myeloblastic Leukemia in Children According to the Berlin-Frankfurt-Münster Strategy: A Single-Institution Trial....Pages 748-753
Down’s Syndrome and Megakaryoblastic Leukemia....Pages 754-760
Front Matter....Pages 761-761
Therapeutic and Prognostic Factors in the Management of Acute Myeloid Leukemia....Pages 763-765
Prognostic Factor Analyses in Acute Myeloid Leukemia: M.D. Anderson Experience....Pages 766-768
Intensified Therapy of Acute Myeloid Leukemia: Results of the German AML Cooperative Group....Pages 769-773
Intensified Induction Therapy in Acute Myeloid Leukemia....Pages 774-781
Results of All-Trans Retinoic Acid Treatment in Acute Promyelocytic Leukemia (European Experience)....Pages 782-786
Intensified Post-Remission Chemotherapy for Adults with Acute Myeloid Leukemia: An Update of CALGB 8525....Pages 787-793
Front Matter....Pages 761-761
Postremission Therapy: The Role of Allogeneic Bone Marrow Transplantation in Acute Myelogenous Leukemia: An Analysis of the AML8A EORTC-GIMEMA Protocol....Pages 794-799
Impact of Marrow Transplantation in Acute Myeloid Leukemia in First Complete Remission: Experience from MRC AML-10 Trial....Pages 800-806
Bone Marrow Transplantation for Acute Myelogenous Leukemia....Pages 807-809
Autologous Bone Marrow Transplantation Versus Chemotherapy in Acute Myeloblastic Leukemia Patients: Argentinean Study Results....Pages 810-815
Granulocyte–Macrophage Colony-Stimulating Factor in the Therapy of Adults with De Novo Acute Myeloblastic Leukemia: An Update of a Double-Blind Randomized, Placebo-Controlled Trial....Pages 816-823
Long-term Follow Up of a Prospective Multicenter Trial with a High-Dose Cytosine Arabinoside and Daunorubicin Postremission Therapy in Adults with De Novo Acute Myeloid Leukemia....Pages 824-830
Idarubicin, Cytarabine, Etoposide Versus Risk-Adjusted Daunorubicin Plus Cytosine Arabinoside for Induction Treatment of Acute Myeloid Leukemia: A Randomized Multicenter Trial....Pages 831-836
“7+3” Versus “7+3+VP-16” as Remission Induction in Acute Myeloid Leukemia Patients Under the Age of Sixty Years: Preliminary Results of a Russian Multicenter Trial....Pages 837-845
Poor-Risk Acute Myelogenous Leukemia Patients Undergoing the Fludarabine – Cytosine Arabinoside – Filgrastim Regimen: Multidrug Resistance Expression, Granulocyte Colony-Stimulating Factor Priming Activity and Clinical Response....Pages 846-851
Granulocyte-Macrophage Colony-Stimulating Factor During and After Remission Induction Treatment for Elderly Patients with Acute Myeloid Leukemia....Pages 852-856
Prospective Comparison of Allogeneic Bone Marrow Transplantation, Intensive Consolidation Chemotherapy, and Unpurged Autologous Bone Marrow Transplantation as Post-Remission Therapy in Adult Acute Myeloid Leukemia....Pages 857-863
Late Relapses in Adult Acute Myelogenous Leukemia: A Retrospective Study of Characteristics and Outcome in 76 Cases....Pages 864-868
Methods to Detect Prognostic Factors in Acute Myeloid Leukemia....Pages 869-872
Idarubicin or Mitoxantrone, VP-16, and Cytarabine for Induction/Consolidation Therapy Followed by Autologous Stem Cell Transplantation in Elderly Patients with Acute Myeloid Leukemia: A Feasibility Study....Pages 873-878
High-Dose Chemotherapy with Busulfan, Cyclophosphamide, and VP-16 as Conditioning for Allogeneic and Autologous Bone Marrow Transplantation for Patients with Acute Myeloid Leukemia....Pages 879-881
YNK01, an Oral Cytosine Arabinoside Derivative in Acute Myeloid Leukemia and Chronic Myeloid Leukemia....Pages 882-885
Front Matter....Pages 887-887
Genetic Instability and Evolution of Karyotype in Secondary Acute Myeloid Leukemia....Pages 889-892
Prognostic Value of Dysmyelopoiesis in 128 Patients with De Novo Acute Myeloid Leukemia....Pages 893-897
Incidence of Secondary Leukemias After Therapy of Childhood Hodgkin’s Disease Without Nitrogen-Mustard. Results of the German-Austrian Study Group....Pages 898-904
Intensive Therapy of Myelodysplastic Syndromes and Secondary Leukemias: Preliminary Findings of the French Experience....Pages 905-907
Front Matter....Pages 887-887
Preliminary Results of a Placebo-Controlled, Double-Blind Trial Evaluating Sequential HD-AraC/Mitoxantrone Induction Chemotherapy with or Without Granulocyte-Macrophage Colony-Stimulating Factor in Patients with High-Risk Myelodysplastic Syndromes....Pages 908-911
Childhood Myelodysplastic Syndromes Treated with Acute Myeloid Leukemia Regimens....Pages 912-917
Remission Rates, Survival, and Prognostic Factors in Ninety Patients with Advanced Myelodysplastic Syndromes Treated with Intensive Chemotherapy....Pages 918-922
Secondary Myelodysplastic Syndromes: Morphological Findings, Cytogenetics, and Clinical Course in 55 Patients....Pages 923-927
Myelodysplastic Syndromes or Leukemia Following MDS Treated with Allogeneic Bone Marrow Transplantation: A Survey of the Working Party on Chronic Leukemia of the European Cooperative Group for Blood and Marrow Transplantation....Pages 928-933
Cyclosporin A in the Treatment of Myelodysplastic Syndrome....Pages 934-940
Front Matter....Pages 941-941
Mediators in Sepsis and Septic Shock....Pages 943-947
Interventional Antimicrobial Strategy in Neutropenic Infections....Pages 948-954
Acyclovir and Cytomegalovirus Immunoglobulins as Prophylaxis for Cytomegalovirus Infections in Allogeneic Bone Marrow Transplant Recipients....Pages 955-959
Challenge of Alloimmunization and Refractoriness to Platelet Transfusion....Pages 960-964
Polymerase Chain Reaction for Detection of Various Aspergillus Species in Clinical Samples....Pages 965-969
Screening with Sensitive Detection Methods Allows a Reduction in the Incidence of Cytomegalovirus Disease After Allogeneic Bone Marrow Transplantation....Pages 970-976
Therapy of Sepsis Syndrome with Human Polyclonal IgM-Enriched Immunoglobulins: Interim Analysis of a Randomized Trial in Neutropenic Cancer Patients....Pages 977-982
The 10/NL Trigger for Prophylactic Platelet Transfusion in Acute Myeloid Leukemia: A Prospective Comparative Multicenter Study....Pages 983-985
Transplantation of Allogeneic Peripheral Blood Progenitor Cells Alone or in Addition to Bone Marrow....Pages 986-988
Quality of Life in Patients with Acute Myeloid Leukemia - A Longitudinal Study....Pages 989-992
Back Matter....Pages 993-997