Acarbose for the Treatment of Diabetes Mellitus

Front Matter....Pages I-XVI
Introduction....Pages 1-2
Front Matter....Pages 3-3
Toxicology of Acarbose, with Special Reference to Long-term Carcinogenicity Studies....Pages 5-14
Discussion....Pages 15-16
The Disposition and Pharmacokinetics of Acarbose in Man....Pages 17-24
Discussion....Pages 25-26
Front Matter....Pages 27-27
The Pharmacological Rationale of Diabetes Mellitus Therapy with Acarbose....Pages 29-38
Discussion....Pages 39-40
Pharmacodynamics of Acarbose: Clinical Investigations....Pages 41-52
Discussion....Pages 53-54
Front Matter....Pages 55-55
Comparative Effects of Acarbose on Glycemia, Weight Gain, and Serum Lipids in Adult Male and Female Diabetic Wistar Fatty Rats....Pages 57-57
Effects of Low-Dose Acarbose on Glycemia, Adiposity, and Cholesterolemia in Obese and Obese Non-Insulin-Dependent Diabetic Corpulent Rats....Pages 58-58
A Preclinical Study on the Effects of Acarbose on Mice Rendered Obese with Gold Thioglucose....Pages 59-59
Enhancement of Insulin Binding and Glucose Transport by Acarbose in Adipocytes of Zucker Rats....Pages 60-60
Treatment of Streptozotocin-Diabetic Rats with Acarbose: Influence on Metabolism and Heart Function....Pages 61-61
Effects of Acarbose on Cardiac and Hepatic Metabolism in Diabetic Rats....Pages 62-62
Effects of Acarbose on Experimental Diabetic Nephropathy, Metabolic Control, and Intestinal Glycosidase Activity in Normal and Genetically Diabetic Mice....Pages 63-63
The Effectiveness of Acarbose in the Reduction of Diabetic Symptoms and Neuropathic Complications in a NIDDM Animal Model....Pages 64-65
Effect of Acarbose on the Hormonal and Metabolic Response to the Simultaneous Ingestion of Sucrose and Ethanol....Pages 66-66
Effects of Acarbose on Serum Lipids and Lipoproteins in Healthy Individuals During Prolonged Administration of a Fiber-Free Diet....Pages 67-67
Lower Triglyceride Production with Carbohydrate-Rich Diets During Treatment with Acarbose....Pages 68-68
Front Matter....Pages 55-55
Long-Term Metabolic Effects of Acarbose in Healthy Young Men....Pages 69-69
Mode of Action of the α-Glucosidase Inhibitor Acarbose in the Small Bowel: A Perfusion Study in Man....Pages 70-70
Effect of Acarbose on Fecal Short-Chain Fatty Acid Excretion in Man....Pages 71-72
Effect of Acarbose on Colonic Nitrogen Metabolism in Man....Pages 73-73
The Influence of Acarbose Dosage Scheme on Intestinal Symptoms and Intestinal Transit Time in Healthy Volunteers....Pages 74-74
The Development of a Method for Measuring Starch Absorption and Its Alteration by α-Glucosidase Inhibitors....Pages 75-75
Front Matter....Pages 77-77
Acarbose in Non-insulin-dependent Diabetes Mellitus: Short-term Studies in Combination with Oral Agents....Pages 79-91
Acarbose in Non-insulin-dependent Diabetes — Long-term Studies in Combination with Oral Agents....Pages 92-101
Discussion....Pages 102-103
Acarbose Monotherapy in the Treatment of Non-insulin-Dependent Diabetes Mellitus — a Review....Pages 104-116
Discussion....Pages 117-118
Front Matter....Pages 119-119
Acarbose Treatment of NIDDM: Multiclinic Trial for Dose Finding....Pages 121-121
Metabolic Effects of Acarbose in Normal and NIDDM Subjects....Pages 122-123
Efficacy and Tolerability of a 3-Month Treatment with Acarbose in Type II Diabetic Outpatients Treated with a High Dose of Sulfonylurea....Pages 124-124
Metabolic Control in Type II Diabetes with Long-Term Acarbose Therapy: A Double-Blind Study....Pages 125-125
Clinical Trial to Investigate the Efficacy and Tolerability of Acarbose in Type II Diabetic Patients Treated with Diet Alone....Pages 126-126
Comparison of the Action of an α-Glucosidase Inhibitor (Acarbose) and a Sulfonylurea Preparation (Glisoxepide) in Non-insulin-dependent Diabetics....Pages 127-127
Efficacy of the Glucosidase Inhibitor Acarbose Compared to the Sulfonylurea Glisoxepide on Metabolic Control in Diet-Treated Type II Diabetics....Pages 128-128
Multicenter Clinical Trial up to 15 Months: Efficacy and Tolerability of Acarbose in Glibenclamide-Treated Type II Diabetics with Secondary Sulfonylurea Failure Versus Glibenclamide Therapy Alone....Pages 129-129
Acarbose Does Not Affect Glibenclamide Pharmacokinetics in Type II Diabetic Patients....Pages 130-130
Front Matter....Pages 119-119
Effect of Acarbose in Type II Diabetics Treated with Diet Alone, with Diet, and with Sulfonylurea, Diet, and Insulin....Pages 131-131
The Long-Term Effects of Acarbose on Type II Diabetics on Diet or Oral Agents....Pages 132-132
Long-Term Effects of Acarbose Treatment on Postprandial Glucose, Pancreatic and Gut Hormone Responses and Fasting Serum Lipids in Non-insulin-Dependent Diabetics on Sulphonylureas....Pages 133-133
Acarbose in the Treatment of NIDDM Patients with Hyperlipidemia....Pages 134-134
Effectiveness and Tolerability of the α-Glucosidase Inhibitor Acarbose in NIDDM Patients with Elevated Liver Enzyme Activity....Pages 135-135
Effect of Acarbose on Blood Glucose and Insulin Response to a Sucrose Load in Subjects with Reactive Hypoglycemia....Pages 136-136
Relapse-Reducing Effects of Acarbose After Weight Reduction in Severely Obese Subjects....Pages 137-137
Front Matter....Pages 139-139
Acarbose Treatment in Insulin-Dependent (Type I) Diabetes Mellitus....Pages 141-152
Discussion....Pages 153-155
Acarbose Treatment and Sulfonylurea Secondary Failure....Pages 156-161
Discussion....Pages 162-162
Clinical Studies with Acarbose for the Control of Hyperglycemia which is the Major Pathogenetic Factor of the Complications of Diabetes Mellitus....Pages 163-168
Discussion....Pages 169-170
Front Matter....Pages 171-171
Inhibition of α-Glucosidase by Acarbose as an Additional Tool for Glycemia Control in Insulin-Dependent Diabetics on Conventional Insulin Therapy....Pages 173-173
Acarbose in Insulin-Dependent Diabetes Mellitus: Efficacy and Tolerance....Pages 174-174
Nonrandomized Follow-up Study with Acarbose Treatment and Pre- and Post-treatment with Placebo in Type I Diabetic Children....Pages 175-175
Effects of Acarbose on Glycemic Control in IDDM under Feedback Control with Artificial Endocrine Pancreas....Pages 176-176
Effects of Sucrose Meal on Insulin Requirement in IDDM and its Modulation by Acarbose....Pages 177-177
Effects of Acarbose on Insulin Sensitivity and Liver Uptake in Patients with Type I Diabetes....Pages 178-179
Comparative Metabolic Availability of Glucose and Sucrose and the Effect of Acarbose on Sucrose Utilization During Exercise in Type I Diabetic Patients....Pages 180-181
Front Matter....Pages 171-171
Acarbose Treatment in Insulin-Dependent Diabetics....Pages 182-182
Panel Discussion: Future Aspects of α-Glucosidase Inhibition....Pages 183-193
Back Matter....Pages 185-198