A Short Guide to Clinical Pharmacokinetics

Foreword
Preface
Acknowledgements
Contents
Editors and Contributors
About the Editors
Contributors
Abbreviations
1: Introduction to Clinical Pharmacokinetics
	1.1	 Introduction
	1.2	 Overview of Clinical Pharmacokinetics (Leary and Williams 2016)
	1.3	 Pharmacokinetic Factors Determining Ideal Therapeutics
		One-Compartment Model
		Curves of Concentration Versus Time
			Zero-Order Elimination
			First-Order Elimination
		Drug Clearance (CL)
		Maintaining a Constant Steady-State Concentration (Cpss)
		Determination of CL
		Volume of Distribution (Vd)
		Vd and Clinical PK
		Half-Life (t1/2)
		Time-Course of Drug Elimination and Accumulation
			Correlation Between Vd, CL, and t1/2
		Oral Availability (F)
		Protein Binding (PB)
		pH and Pharmacokinetics
		Drug Absorption from the Stomach
		Drug Elimination in the Kidney
		Drug Delivery into Third Spaces
		Relationship Between Pharmacokinetics and Effect Kinetics
	1.4	 Pharmacokinetic Parameters
		Permeability
		Bioavailability (F)
		P-Glycoprotein (PGP)
		Volume