A Case Approach to Perioperative Drug-Drug Interactions

Front Matter....Pages i-xliv
Front Matter....Pages 1-1
Let’s Start at the Very Beginning: Overcoming Fear and Gaining Mastery of Drug–Drug Interactions....Pages 3-8
Pharmacodynamic Interactions: Core Concepts....Pages 9-14
Pharmacokinetic Interactions: Core Concepts....Pages 15-22
A Brief Treatise on the Area Under the Curve....Pages 23-25
Front Matter....Pages 27-27
CYP2D6: Where It All Began....Pages 29-32
CYP2E1: The Anesthesia Enzyme....Pages 33-36
CYP3A4: The Workhorse....Pages 37-40
CYP1A2: The Switch-hitter....Pages 41-43
CYP2B: 2B or Not 2B?....Pages 45-47
CYP2C9: The Support Crew I....Pages 49-51
CYP2C19: The Support Crew II....Pages 53-55
Uridine 5′-diphospho-glucuronoslytransferases (UGTs): Conjugating Cousins....Pages 57-60
The Cytochrome P450 System in Disease States—A Brief Review....Pages 61-63
Front Matter....Pages 65-65
P-glycoprotein and Organic Anion-transporting Polypeptide (OATP) Transporters....Pages 67-72
The “Fatal Forty”....Pages 73-80
The Six Patterns of Pharmacokinetic Drug–Drug Interactions....Pages 81-85
The Problem with the Drug–Drug Interaction Software: A Procrustean Dilemma....Pages 87-92
Pharmacogenomics....Pages 93-101
The Pharmacoepidemiology of Drug Interactions: Why and How They Are Important....Pages 103-108
The Lawyers Can Read, Too: Cases from the Courtroom....Pages 109-114
Front Matter....Pages 115-115
Introduction....Pages 117-117
That Sums It Up....Pages 119-122
1 + 1 + 1 + 1 = ?....Pages 123-127
A Delayed Surgeon Is a Dismayed Surgeon....Pages 129-132
Relax, It’s Only Gentamicin....Pages 133-135
Jaundice After Surgery....Pages 137-140
Everybody Clear?....Pages 141-144
The Hemodynamic Hole....Pages 145-148
Alpha-2 to the Rescue but Beware Bradycardia....Pages 149-153
Hot Stuff!....Pages 155-159
Front Matter....Pages 161-161
Introduction....Pages 163-163
How to Successfully Occlude an Intravenous Line....Pages 165-168
A Curious Cause of Seizures....Pages 169-171
Magnesium Mama and the Mad Dad....Pages 173-178
Dexy’s Midnight Spinal....Pages 179-182
Front Matter....Pages 183-183
Introduction....Pages 185-186
Comfortably Numb....Pages 187-191
Naturally Occurring and Nasty....Pages 193-197
LOL-LOL: Little Old Lady—Lots of Lido....Pages 199-202
The Spinal Countdown....Pages 203-205
Front Matter....Pages 183-183
Are Drug–Drug Interactions The Smoking Guns of Local Anesthetic Toxicity? Smoking Gun I....Pages 207-210
Are Drug-Drug Interactions The Smoking Guns of Local Anesthetic Toxicity? Smoking Gun II....Pages 211-213
A Perfect Storm?....Pages 215-218
Shake Rattle and Roll....Pages 219-222
Hello, We Have a Patient With Acute Delirium and We Need an Urgent Psych Consult....Pages 223-227
Fatal Pain Relief....Pages 229-231
Lipid Lifesaver....Pages 233-236
Front Matter....Pages 237-237
Introduction....Pages 239-240
No ‘Subs’titute for Sobriety....Pages 241-244
A Needle and the Damage Done....Pages 245-247
Dad’s Not Having Much Pain....Pages 249-251
Royal Flush....Pages 253-255
The Worry That’s Always With Us: Afternoon Nap....Pages 257-259
The Bawling Baby....Pages 261-263
Sleeping Beauty....Pages 265-268
Codeine Can’t Do It....Pages 269-273
A Shuddering Interaction....Pages 275-279
Double Indemnity....Pages 281-283
Breaking the Codeine....Pages 285-288
The Ultimate Ultram Primer I: My Mood Is Better, but Boy Do I Hurt!....Pages 289-292
Front Matter....Pages 237-237
The Ultimate Ultram Primer II: I “Haight” Narcotics, but I Hate Seizures More....Pages 293-296
The Ultimate Ultram Primer III: Tremor-dol Trigger in Serotonin Syndrome....Pages 297-301
Too Much of a Good Thing....Pages 303-307
Front Matter....Pages 309-309
Introduction....Pages 311-312
Pining for Pete in the Pain Clinic....Pages 313-316
You Do Not Look Well Today, Mon Ami....Pages 317-319
My Headache Is Gone, But My Leg Now Hurts....Pages 321-325
Special ‘K’ase....Pages 327-330
Not Manic About NSAIDS....Pages 331-334
Keep It Capped!....Pages 335-338
The ACE Is Not Always High....Pages 339-342
When the Smoke Clears, Relaxation Disappears....Pages 343-346
Befuddled by Aspirin....Pages 347-350
You Can’t Trick Us!....Pages 351-353
Front Matter....Pages 355-355
Introduction....Pages 357-358
The Worry That’s Always With Us: Now I’m Depressed....Pages 359-362
The Worry That’s Always With Us: Tragic but Not Rare....Pages 363-368
Lack of Sedation....Pages 369-372
A Cold Isn’t Going to Slow Me Down....Pages 373-376
Her Patients Never Wake Up on Time....Pages 377-379
Front Matter....Pages 355-355
When Enough Is Now Too Much....Pages 381-384
The Distressed Daughter....Pages 385-387
Check Check and Double Check....Pages 389-392
Doggone It—The Case Is Cancelled....Pages 393-396
Noct’ Out....Pages 397-400
Predisposed to Doze....Pages 401-403
Synergistic Sedation....Pages 405-407
Front Matter....Pages 409-409
Introduction....Pages 411-412
Blocked Again: Effects of Repeated Doses of Succinylcholine....Pages 413-416
Irreversibility Sux....Pages 417-420
Keep an “Ion” the Twitches....Pages 421-423
A Reversal of Misfortune....Pages 425-428
Stop Moving....Pages 429-432
There’s Just Not Enough Roc in the World....Pages 433-435
Slow Sux I: A Lengthy Wake-up Period After Electroconvulsive Therapy....Pages 437-441
Slow Sux II: I Remember Reviewing This for the Boards....Pages 443-447
Slow Sux III: Where Did the Twitches Go?....Pages 449-453
Weakened All Weekend....Pages 455-458
The Patient Who Could Not Raise Her Head....Pages 459-462
An Unexpected Wait....Pages 463-465
Front Matter....Pages 409-409
Diabolical Cough Syrup....Pages 467-470
Front Matter....Pages 471-471
Introduction....Pages 473-474
Full Stop....Pages 475-477
Flummoxed by the FLOX....Pages 479-481
Tales of Terror....Pages 483-485
Too Low To Go....Pages 487-489
A Fungal Story....Pages 491-493
Rejection Protection Turned Kidney Killer....Pages 495-499
Can’t Get Well....Pages 501-503
Linezolid (I): Be “VREy” Careful....Pages 505-508
Linezolid (II): Hyper and Hot....Pages 509-512
Not Sweet At All....Pages 513-516
Where Did All the Sugar Go?....Pages 517-520
Exposed! (Part 1)....Pages 521-523
Exposed! (Part 2)....Pages 525-526
Seizures on 5 West....Pages 527-530
Front Matter....Pages 531-531
Introduction....Pages 533-534
Riding the Rollercoaster....Pages 535-538
A Pressing Need for Vasopressin!....Pages 539-542
Too Young to Die....Pages 543-545
Front Matter....Pages 531-531
A Widening Gyre....Pages 547-550
Misusing Mom’s Meds....Pages 551-554
If the Patient Has No Renal Failure, Why Is Her Potassium So High?....Pages 555-561
Prazosin and the PTSD Paratrooper....Pages 563-567
Nicardipine Notes....Pages 569-571
Hypotension Harry....Pages 573-575
Too Slow to Flow....Pages 577-580
Better Sleep but Slower Heart....Pages 581-584
Extreme Blood Pressure After Ephedrine: Should We Rule Out Pheochromocytoma?....Pages 585-588
Heart-Stopping Treatment....Pages 589-592
Induction Crashes: Are There Clues in the Ashes?....Pages 593-595
The Wakeup Call: 2AM Trauma....Pages 597-600
Falling Down....Pages 601-604
A Hidden Drug....Pages 605-609
I’m Listening, I’m Listening....Pages 611-614
Jump Start My Heart....Pages 615-617
The Statin Trilogy (I): ‘Statin’ from the Beginning....Pages 619-621
The Statin Trilogy (II): Tripped and Fell at the Train ‘Statin’....Pages 623-625
The Statin Trilogy (III): Welcome to the United ‘Statins’ of America....Pages 627-629
Be Still, My Beating Heart....Pages 631-635
Front Matter....Pages 531-531
The Nice Niece....Pages 637-639
Cyclo Killer: Qu’est-ce que c’est?....Pages 641-644
Blurry-Eyed with Rapid Heart Beats....Pages 645-648
Front Matter....Pages 649-649
Introduction....Pages 651-652
Seize the Day....Pages 653-656
The Third and Final Complication....Pages 657-660
An Interaction with the Furniture....Pages 661-664
Macrolide Mishap for Little Miss Muffett....Pages 665-668
From Asymptomatic to Symptomatic: A Cause of Nosebleed....Pages 669-673
The Consequences of Not Following a Cardiac Diet....Pages 675-679
Clopidogrel (I): Bagel Brunch....Pages 681-684
Clopidogrel (II): Conferring over the Kung Pao....Pages 685-687
Front Matter....Pages 689-689
Introduction....Pages 691-691
Beaned....Pages 693-695
Addisonian Adjustment....Pages 697-699
Tea Time....Pages 701-703
No Fits at Uffizi....Pages 705-707
Quit Steroids Quit Kidneys....Pages 709-712
The Fall Guy (I)....Pages 713-716
The Fall Guy (2)....Pages 717-719
Front Matter....Pages 689-689
The Topic of the Day....Pages 721-723
Bounce Back....Pages 725-728
Call the Cath Lab!....Pages 729-732
The Imatinib Inquiry: A Theoretical Case (for Now)....Pages 733-736
A HAART-breaking Tale....Pages 737-740
Front Matter....Pages 741-741
Introduction....Pages 743-744
Phenytoin (I): Going Crazy!....Pages 745-748
Phenytoin (II): The Wrong Drug for the Schizophrenic....Pages 749-752
Dizzy and Depressed....Pages 753-755
The Funeral Is on Monday....Pages 757-761
This Antacid Is Making Me Sick!....Pages 763-765
Young at Heart....Pages 767-769
Shiver Yes, Die No....Pages 771-774
Clip and Dip....Pages 775-778
Blue Fog....Pages 779-783
Confiscated Contraceptives....Pages 785-788
Gotta Love Derm....Pages 789-792
Desperate for a Drink....Pages 793-796
Front Matter....Pages 797-797
Introduction....Pages 799-801
Delusion at Heart....Pages 803-806
Front Matter....Pages 797-797
At Long Last....Pages 807-811
Metha-don’t!....Pages 813-818
Flash Fire....Pages 819-823
I Am Dizzy When I Stand Up....Pages 825-828
Front Matter....Pages 829-829
Introduction....Pages 831-832
High Fat Diet (I): No Juice For The Ketotic Kid....Pages 833-835
Protein Huffing and Puffing....Pages 837-840
Salty Sam....Pages 841-845
A Peak Potassium Problem....Pages 847-849
Awake?....Pages 851-853
Tropical Punch Packing a Real Knockout....Pages 855-857
When the Fire Won’t Go Out....Pages 859-861
Peppermint Patty....Pages 863-865
From Bleeding Gums to Green Thumbs: A True Story....Pages 867-870
Delicious but Malicious....Pages 871-874
I Just Can’t Lick This Problem....Pages 875-878
Sommelier’s Surprise....Pages 879-882
Dairy Carefully....Pages 883-886
Cold and Sick, Sick and Cold....Pages 887-890
TPN (I): A Review and Two Interactions....Pages 891-894
Front Matter....Pages 829-829
TPN (II): A Traumatic Case of Increased Metabolism....Pages 895-898
Skin and Bones....Pages 899-902
Enough to Make You Sick....Pages 903-907
Determined and Desperate to Diet....Pages 909-911
Front Matter....Pages 913-913
Introduction....Pages 915-916
Caffeine Crash....Pages 917-920
Sad Sequelae....Pages 921-923
The Scary Side of Ginkgo Biloba Is No Match for an Anesthesia Superstar: Seizures....Pages 925-927
The Scary Side of Ginkgo Biloba Is No Match for an Anesthesia Superstar: Sugar....Pages 929-931
The Scary Side of Ginkgo Biloba Is No Match for an Anesthesia Superstar: Subdural....Pages 933-935
“Khat” Unaware....Pages 937-939
Pain on the Plane....Pages 941-943
Ca va, c’est Kava....Pages 945-947
Summertime and the Herbals are Hot....Pages 949-951
Garlic I: More Than Just Bad Breath....Pages 953-955
Garlic II: A Girl Named Allicin....Pages 957-959
“Danshen” the Night Away....Pages 961-964
Caught Yellow-Handed....Pages 965-968
St. John: Not Such a Saint....Pages 969-971
Hearing the News....Pages 973-975
Back Matter....Pages 977-1016