37th Hemophilia Symposium

Front Matter....Pages I-XXXIV
Johann Lukas Schoenlein Prize 2006....Pages 1-2
Front Matter....Pages 3-3
HIV Infection and Causes of Death in Patients with Hemophilia in Germany (Year 2005/2006 Survey)....Pages 5-16
Hemophilia Registry of the Medical Committee of the Swiss Hemophilia Association — Update and Annual Survey 2006....Pages 17-21
Front Matter....Pages 23-23
Detection of Factor VIII-Specific Memory B Cells in Patients with Hemophilia A and Factor VIII Inhibitors....Pages 25-36
Novel Strategies for FVIII: Half-life Prolongation....Pages 37-37
Front Matter....Pages 39-39
Predictive Parameters of Fitness in Hemophiliac Children....Pages 41-44
Hemophilia and Exercise Project (HEP) Conception and Contents of a “Programmed Sports Therapy” for Hemophilic Patients....Pages 45-59
Results of German Hemophiliacs Self-Assessment of Health and Social Status: With Emphasis on Orthopedic Function....Pages 60-63
Front Matter....Pages 65-65
Developing a German Hemophilia Register....Pages 67-67
Front Matter....Pages 69-69
Thrombin Generation in Children with Hemophilia and VWD — Comparing a Fluorimetric Method and ROTEM....Pages 71-74
Thrombin Generation in Severely Obese Children....Pages 75-80
Protein C Promoter Genotypes Associate with Susceptibility, Development of Sepsis, and Lower Blood Pressure in Young Children with Systemic Meningococcemia....Pages 81-87
Life of Teenage Hemophiliacs....Pages 88-91
Front Matter....Pages 93-93
Monocytes Enhance rVIIa Induced Thrombin Generation in Absence of Platelets and Microparticles....Pages 95-105
Mutation Detection Rate in Female Patients with Reduced Factor VIII Activity and Negative Family History for Hemophilia A....Pages 106-108
Investigation of Underlying Reasons of Factor VIII Deficiency in Hemophilia A Patients with Undetectable Mutations in the F8 Gene....Pages 109-113
Monitoring of Antiplatelet Therapy Using Whole Blood Aggregometry: Experiences and Approaches to Dose Adaptation....Pages 114-115
Front Matter....Pages 117-117
No Complications in Switching from Recombinate to Advate — a Prospective Surveillance in 22 Children....Pages 119-121
Epidemiology and Treatment of Hemophilia A, B and von Willebrand Disease of Type 3 in the Eastern Part of German....Pages 122-124
Database Management System for a Hemophilia Comprehensive Care Center....Pages 125-126
Front Matter....Pages 117-117
Hepatocellular Carcinoma in Patients with Hemophilia and Chronic Hepatitis C Infection....Pages 127-129
Elucidation of Gross Genomic Rearrangements Involving Large Deletions in the Clotting Factor VIII Gene....Pages 130-137
The Centro American Hemophilia Registry, of the CARS Hemophilia Group — Update September 2006....Pages 138-141
Two Examples of the Influence of Psychological Stress on the von Willebrand Factor Activity....Pages 142-144
Efficacy of Chronic Hepatitis C Treatment in Hemophilic Patients During the Last 10 Years: a Single Center Experience....Pages 145-148
Dynamic of Thrombin Generation in Patients with Severe Hemophilia A....Pages 149-151
Hemophilia and Exercise Project (HEP): Effects of a Two-Year Sports Therapy on Physical Activity Behavior and Bleeding Frequency by Persons with Hemophilia....Pages 152-152
Hemophilia Summer Camp in Germany, 1996–2005....Pages 153-153
Impact of Hemophilia on the Psychological Health of Hemophilia Patients in Romania....Pages 154-159
Starter-Kit for Patients Suffering from Hemophilia — A Project Initiated by the German Hemophilia Assistant Committee....Pages 160-162
Documentation in Hemophilia Treatment....Pages 163-164
Short-time Prophylaxis with FEIBA in Three Patients with Hemophilia A and High Titer Inhibitors....Pages 165-167
Successful Treatment of a Patient with High Titer Acquired Factor VIII Inhibitor (114 BU) with Rituximab....Pages 171-173
Preoperative Arterial Embolization of a Hemophilic Pseudo Tumor before Osteosynthesis in a Patient with Hemophilia A and Pathological Femoral Fracture....Pages 174-177
Successful Liver Transplantation in Two Patients with Severe Hemophilia A....Pages 178-180
Out from the Cold: Severe Erythema and Clumped Red Cells....Pages 181-183
Acquired Glanzmann Thrombasthenia in a Patient with Myelodysplastic Syndrome....Pages 184-186
Case Report of an Acquired Inhibitor Against Factor XIII....Pages 187-189
Elbow Endoprosthesis in Hemophilic Arthropathy....Pages 190-192
Pseudohomozygous APC Resistance Report on Two Patients and a Novel Mutation in the Factor V Gene....Pages 193-197
Front Matter....Pages 117-117
Pseudo-Homozygous APC Resistance Due to Coinheritance of Heterozygous Factor V — R506Q and Type I Deficiency Associated with Thrombosis....Pages 198-200
Three Cases of In-stent Thrombosis in Patients with Clopidogrel Non-response....Pages 201-201
Thrombin Generation in Pregnancy....Pages 205-211
Thrombin Generation — Comparison of ROTEM and Technothrombin TGA....Pages 212-216
Multiple Electrode Aggregometry in Patients on Chronic Aspirin and/or Clopidogrel Treatment....Pages 217-217
Endogenous Thrombin Potential in Women with Recurrent Miscarriage and/or Repeated In-Vitro-Fertilization Failure....Pages 218-220
One Year TTP Diagnosis in the Central Laboratory of the University of Mainz....Pages 221-225
Venous Thromboembolism — A Metabolic Disease?....Pages 229-230
Structural Investigation of Two Novel Mutations in Coagulation Factor V by Molecular Modeling....Pages 231-233
High Levels of Human Factor IX Transgene Expression in Mice Increase Blood Procoagulant Activity....Pages 234-237
Factor VII Deficiency: Clinical Manifestation and Molecular Genetics of 718 Subjects with FVII Gene Mutations....Pages 238-246
Therapeutical Options for Congenital FVII Deficiency — The HK 7 Project of the International Greifswald Registry of the Congenital FVII Deficiency (GR-HK-7)....Pages 247-251
Characterization of a Mutation in Exon 1 of the FVII Gene — a Case of RNA Editing?....Pages 252-255
Analysis of the Biological Importance of the VKORC1 Gene via Knock-Out Mice....Pages 256-258
 In Vivo-Assay for Warfarin-Resistance by Coexpression of VKORC1 and Vitamin K-Dependent Coagulation Factors....Pages 259-260
Functional Promoter Polymorphism in the VKORC1 Gene is no Major Genetic Determinant for Vitamin K Dependent Coagulation Factor Activity....Pages 261-263
Influence of VKORC1 Haplotypes on Cardiovascular Disease....Pages 264-265
Creation and Characterization of a Knock-Out Mouse for the VKORC1L1 -Gene....Pages 266-268
Novel Variants in VKORC1 — the Target Protein of Cumarin-Type Anticoagulants — in Rodents from Warfarin-Resistance Areas in Europe, Asia and America....Pages 269-270
Recombinant Expression and 3D-Modelling of C1-Inhibitor Mutants....Pages 271-272
Front Matter....Pages 117-117
Five Novel Mutations in F13B Gene Resulting in Mild FXIII Deficiency....Pages 273-274
Idiopathic Thrombocytopenic Purpura in Children: Predictive Factors for the Outcome....Pages 275-279
Preoperative DDAVP-Testing in Patients with von Willebrand Disease....Pages 280-282
Back Matter....Pages 283-286