2nd International Adalat® Symposium: New Therapy of Ischemic Heart Disease

Front Matter....Pages I-XVIII
Introduction....Pages 1-1
Present Basis of Coronary Therapy....Pages 2-10
Front Matter....Pages 11-11
Pharmacology of Nifedipine....Pages 12-19
The Chemistry of Nifedipine....Pages 20-26
Pharmacokinetics of Adalat in Animal Experiments....Pages 27-32
Investigations on the Metabolism and Protein Binding of Nifedipine....Pages 33-39
Experimental Pharmacological Investigations of Effects of Nifedipine on Atrioventricular Conduction in Comparison with Those of Other Coronary Vasodilators....Pages 40-48
Studies on the Extracardial Effects of Nifedipine in Anesthetized Dogs....Pages 49-54
Front Matter....Pages 55-55
Adalat, a Powerful Ca-Antagonistic Drug....Pages 56-65
Ca-Dependent Changes in Coronary Smooth Muscle Tone and the Action of Ca-Antagonistic Compounds with Special Reference to Adalat....Pages 66-76
Myocardial Oxygen Consumption under the Influence of Nifedipine (Adalat) in the Anesthetized Dog....Pages 77-81
Hemodynamic Effects of Adalat in the Unanesthetized Dog....Pages 82-91
Investigations on the Development of Collaterals, Coronary Flow, Tachyphylaxis and Steal Phenomenon in Dogs after Application of Adalat....Pages 92-100
The Effect of Adalat on the Mechanical and Electrical Activity of Isolated Rat Cardiac Muscle, with Special Reference to Calcium Antagonism of the Compound....Pages 101-110
Front Matter....Pages 111-111
Hemodynamic Studies on Adalat in Healthy Volunteers and in Patients....Pages 112-123
Pharmacokinetics of Nifedipine- 14 C in Man....Pages 124-127
Hemodynamic Studies on the New Coronary Therapeutic Drug Nifedipine (BAY a 1040)....Pages 128-139
Effect of Nifedipine (Adalat) on Myocardial Oxygen Extraction and Lactate Metabolism and ST-T Segment Changes in Patients with Coronary Insufficiency during Artificial Stimulation of the Heart....Pages 140-144
Hemodynamic Effect of Nifedipine (Adalat) in Patients Catheterized for Coronary Artery Disease....Pages 145-153
Front Matter....Pages 155-155
Comparison of the Effects of Adalat with Other Substances on Myocardial Ischemia under Loading Conditions....Pages 156-163
Front Matter....Pages 155-155
Left Ventricular Hemodynamics in Patients at Rest before and after Nifedipine (Adalat)....Pages 164-168
Adalat and Beta Blockers; the Mechanism Studied with Two Series of Work Tests in Two Groups of Patients with Angina Pectoris....Pages 169-173
Adalat (Nifedipine) under Loading Conditions....Pages 174-177
Results of a Comparative Study with Adalat: Phonomechano-Cardiograms in Normal Persons and Patients with Coronary Heart Disease....Pages 178-203
Myocardial Circulation under Adalat in Different Phases of Coronary Diseases....Pages 204-210
Front Matter....Pages 211-211
Coronary and Left Ventricular Dynamics under Nifedipine in Comparison to Nitrates, Beta-Blocking Agents and Dipyridamole....Pages 212-224
Effect of Adalat (Nifedipine) on Left Ventricular Hemodynamics in Angina Pectoris (Comparative Study with Propranolol)....Pages 225-233
The Effect of Adalat on Coronary Circulation after Sublingual Administration....Pages 234-235
Loading Tolerance after Adalat and Duration of Effect in Postmyocardial Infarction Studied in a Double-Blind Trial....Pages 236-242
The Cardiopulmonary Loading Capacity in Healthy Persons and Patients with Coronary Heart Disease after Application of Adalat....Pages 243-247
Remarks on Changes of ST Segment Depression during the Day....Pages 248-250
Hemodynamic Study of Nifedipine Using Doppler Flowmetry....Pages 251-257
Front Matter....Pages 259-259
Clinical-Therapeutic and Hemodynamic Studies with Adalat, a New Coronary Active Substance....Pages 260-266
Influence of Different Doses of Adalat on Angina Pectoris Induced by Exercise....Pages 267-273
Nifedipine in the Treatment of Ischemic Heart Disease....Pages 274-280
Clinical Observations on the Efficacy of Adalat Compared with a Pentaerythrityl Tetranitrate Preparation....Pages 281-284
Clinical Studies on the Combined Effect of Various Antihypertensive Agents and Adalat....Pages 285-289
Response of Intraocular Pressure in Normal Subjects and Glaucoma Patients to Single and Repeated Doses of the Coronary Drug Adalat....Pages 290-302
Extracardial Effects of Nifedipine (Adalat): Measurements of Liver Blood Flow in Animals and Humans and of Peripheral Circulation in the Lower Limbs....Pages 303-310
The Influence of Adalat on Pulmonary Pressure....Pages 311-314
Front Matter....Pages 259-259
Comparison of the Effect of Adalat and Propranolol on Exercise Tolerance in Patients with Angina Pectoris....Pages 315-319
Front Matter....Pages 321-321
Nifedipine in Angina Pectoris: A Multicentric Clinical Trial....Pages 322-328
An Interim Report on a Cooperative Double-Blind Clinical Trial with Nifedipine....Pages 329-332
Results of a Double-Blind Study with Adalat under Short- and Long-Term Treatment....Pages 333-340
Long-Term Therapy with Adalat. A Preliminary Report....Pages 341-347
Survey and Summary of Results Obtained during the World-Wide Clinical Investigations of Adalat (Nifedipine)....Pages 348-360
Closing Remarks....Pages 361-364
Back Matter....Pages 365-370