Frontiers of Biostatistical Methods and Applications in Clinical Oncology

Front Matter ....Pages i-xiii
 Challenges for Biometry in 21st Century Oncology  (Richard Simon)....Pages 1-9
 Statistical Challenges with the Advances in Cancer Therapies  (Rajeshwari Sridhara)....Pages 11-20
 Random Walk and Parallel Crossing Bayesian Optimal Interval Design for Dose Finding with Combined Drugs  (Ruitao Lin, Guosheng Yin)....Pages 21-35
 A Comparative Study of Model-Based Dose-Finding Methods for Two-Agent Combination Trials  (Akihiro Hirakawa, Hiroyuki Sato)....Pages 37-52
 Evaluation of Safety in Biomarker Driven Multiple Agent Phase IB Trial  (Motomi Mori, Racky Daffé, Byung S. Park, Jeffrey Tyner)....Pages 53-64
 Bayesian Phase II Single-Arm Designs  (Satoshi Teramukai)....Pages 65-84
 Phase III Clinical Trial Designs Incorporating Predictive Biomarkers: An Overview  (Shigeyuki Matsui)....Pages 85-103
 Bayesian, Utility-Based, Adaptive Enrichment Designs with Frequentist Error Control  (Noah Simon)....Pages 105-123
 Evaluating Personalized Medicine in Multi-marker Multi-treatment Clinical Trials: Accounting for Heterogeneity  (Xavier Paoletti, Stefan Michiels)....Pages 125-149
 The Probability of Being in Response Function and Its Applications  (Wei Yann Tsai, Xiaodong Luo, John Crowley)....Pages 151-164
 Cure-Rate Survival Models and Their Application to Cancer Clinical Trials  (Megan Othus, Alan Mitchell, Bart Barlogie, Gareth Morgan, John Crowley)....Pages 165-178
 Evaluation of Surrogate Endpoints Using a Meta-Analysis Approach with Individual Patient Data: Summary of a Gastric Cancer Meta-Analysis Project  (Koji Oba, Xavier Paoletti)....Pages 179-192
 Machine Learning Techniques in Cancer Prognostic Modeling and Performance Assessment  (Yiyi Chen, Jess A. Millar)....Pages 193-230
 Optimal Three-Group Splits Based on a Survival Outcome  (John Crowley, Alan Mitchell, Pingping Qu, Gareth Morgan, Bart Barlogie)....Pages 231-242
 A Smooth Basis for Clinical Subgroup Analysis  (Michael LeBlanc)....Pages 243-256
 Meta-Analysis of Prognostic Studies Evaluating Time-Dependent Diagnostic and Predictive Capacities of Biomarkers  (Satoshi Hattori, Xiao-Hua Zhou)....Pages 257-273
 Statistical Methodology and Engineering for Next Generation Clinical Risk Calculators  (Donna Pauler Ankerst, Andreas Strobl, Sonja Grill)....Pages 275-295
 Evaluation of Cancer Risk in Epidemiologic Studies with Genetic and Molecular Data  (Aya Kuchiba)....Pages 297-313
 Effect of Helicobacter pylori Eradication on Gastric Cancer Prevention in Korea: A Randomized Controlled Clinical Trial  (Jin Young Park, Byung-Ho Nam, Rolando Herrero, Il Ju Choi)....Pages 315-330
 Contemporary Evaluation of Breast Cancer Screening  (William E. Barlow)....Pages 331-342
 Mediation Analysis for Multiple Causal Mechanisms  (Masataka Taguri)....Pages 343-357
 Sample Size Calculation for Differential Expression Analysis of RNA-Seq Data  (Stephanie Page Hoskins, Derek Shyr, Yu Shyr)....Pages 359-379
 Efficient Study Designs and Semiparametric Inference Methods for Developing Genomic Biomarkers in Cancer Clinical Research  (Hisashi Noma)....Pages 381-400
 Supervised Dimension-Reduction Methods for Brain Tumor Image Data Analysis  (Atsushi Kawaguchi)....Pages 401-411
 An Evaluation of Gene Set Analysis for Biomarker Discovery with Applications to Myeloma Research  (Pingping Qu, Erming Tian, Bart Barlogie, Gareth Morgan, John Crowley)....Pages 413-434
Back Matter ....Pages 435-438