Xenotransplantation: The Transplantation of Organs and Tissues Between Species

Front Matter....Pages I-XXIX
Front Matter....Pages 1-1
Introduction....Pages 3-7
Xenotransplantation — A Brief History of Clinical Experiences: 1900–1965....Pages 9-22
The Scientific Study of Xenografting: 1964–1988....Pages 23-43
Front Matter....Pages 45-45
Mechanism of Humoral Xenograft Rejection....Pages 47-67
Mechanism of Tissue Injury in Hyperacute Xenograft Rejection....Pages 69-79
Accommodation — The Role of Natural Antibody and Complement in Discordant Xenograft Rejection....Pages 81-99
Mechanism of Cellular Xenograft Rejection....Pages 101-120
Xenotolerance Through Bone Marrow Transplantation....Pages 121-138
Immunobiology of Xenografting in Rodents....Pages 139-160
Immunosuppression in Xenotransplantation....Pages 161-178
Front Matter....Pages 179-179
Histopathology of Kidney Xenograft Rejection....Pages 181-205
Histopathological, Immunofluorescent, and Electron-Microscopic Features of Hyperacute Rejection in Discordant Renal Xenotransplantation....Pages 207-230
Histopathology of Cardiac Xenograft Rejection....Pages 231-242
Ultrastructure of Hyperacute Rejection in Cardiac Xenografts....Pages 243-251
Histopathology of Liver Xenograft Rejection....Pages 253-272
Front Matter....Pages 273-273
Isolated Pancreas Islet Xenografting....Pages 275-296
Experimental Xenotransplantation of Encapsulated Cells....Pages 297-312
Experimental Xenotransplantation in Rodents — I: Plasma Exchange and Splenectomy....Pages 313-321
Experimental Xenotransplantation in Rodents — II: Skin Versus Heart Grafts....Pages 323-329
Experimental Xenotransplantation in Rodents — III: Total Lymphoid Irradiation, Cyclosporine, and Monoclonal Antibodies....Pages 331-338
Front Matter....Pages 273-273
Experimental Xenotransplantation Between Closely Related Nonprimate Species....Pages 339-363
Experimental Xenotransplantation Between Closely Related Primate Species....Pages 365-375
Experimental Xenotransplantation Between Distantly Related Nonprimate Species....Pages 377-388
Experimental Xenotransplantation in Nonhuman Primates Using Distantly Related Donor Species....Pages 389-393
Ex Vivo Organ Perfusion Studies in Xenograft Research....Pages 395-403
Effects of Formed Elements on Xenograft Rejection in an Ex Vivo Organ Perfusion Model....Pages 405-425
Front Matter....Pages 427-427
Evolutionary, Physiological, and Immunological Considerations in Defining a Suitable Donor for Man....Pages 429-438
Nonhuman Primate Blood Group Serology: Some Implications for Xenotransplantation....Pages 439-455
The Nonhuman Primate as Potential Organ Donor for Man: Virological Considerations....Pages 457-479
The Pig as Potential Organ Donor for Man....Pages 481-500
Human Antibodies to Pig Determinants and Their Association with Hyperacute Rejection of Xenografts....Pages 501-510
An Ethical Framework for Considering The Development of Xenotransplantation in Man....Pages 511-527
Front Matter....Pages 529-529
Experience with Clinical Kidney Xenotransplantation....Pages 531-540
Experience with Clinical Heart Xenotransplantation....Pages 541-557
Liver Xenotransplantation: Clinical Experience and Future Considerations....Pages 559-573
Back Matter....Pages 575-583